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Auteur Maria JALBRZIKOWSKI
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Documents disponibles écrits par cet auteur (4)
Faire une suggestion Affiner la rechercheDeficits in Mental State Attributions in Individuals with 22q11.2 Deletion Syndrome (Velo-Cardio-Facial Syndrome) / Jennifer S. HO in Autism Research, 5-6 (December 2012)
Titre : Distinct neurocognitive profiles and clinical phenotypes associated with copy number variation at the 22q11.2 locus Type de document : texte imprimé Auteurs : Leila KUSHAN-WELLS, Auteur ; Charles H. SCHLEIFER, Auteur ; Shayne CRUZ, Auteur ; Gil D. HOFTMAN, Auteur ; Maria JALBRZIKOWSKI, Auteur ; Raquel E. GUR, Auteur ; Ruben C. GUR, Auteur ; Carrie E. BEARDEN, Auteur Article en page(s) : p.2247-2262 Index. décimale : PER Périodiques Résumé : Abstract Rare genetic variants that confer large effects on neurodevelopment and behavioral phenotypes can reveal novel gene-brain-behavior relationships relevant to autism. Copy number variation at the 22q11.2 locus offer one compelling example, as both the 22q11.2 deletion (22qDel) and duplication (22qDup) confer increased likelihood of autism spectrum disorders (ASD) and cognitive deficits, but only 22qDel confers increased psychosis risk. Here, we used the Penn Computerized Neurocognitive Battery (Penn-CNB) to characterized neurocognitive profiles of 126 individuals: 55 22qDel carriers (MAge = 19.2 years, 49.1% male), 30 22qDup carriers (MAge = 17.3 years, 53.3% male), and 41 typically developing (TD) subjects (MAge = 17.3 years, 39.0% male). We performed linear mixed models to assess group differences in overall neurocognitive profiles, domain scores, and individual test scores. We found all three groups exhibited distinct overall neurocognitive profiles. 22qDel and 22qDup carriers showed significant accuracy deficits across all domains relative to controls (episodic memory, executive function, complex cognition, social cognition, and sensorimotor speed), with 22qDel carriers exhibiting more severe accuracy deficits, particularly in episodic memory. However, 22qDup carriers generally showed greater slowing than 22qDel carriers. Notably, slower social cognition speed was uniquely associated with increased global psychopathology and poorer psychosocial functioning in 22qDup. Compared to TD, 22q11.2 copy number variants (CNV) carriers failed to show age-associated improvements in multiple cognitive domains. Exploratory analyses revealed 22q11.2 CNV carriers with ASD exhibited differential neurocognitive profiles, based on 22q11.2 copy number. These results suggest that there are distinct neurocognitive profiles associated with either a loss or gain of genomic material at the 22q11.2 locus. En ligne : https://doi.org/10.1002/aur.3049 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=518
in Autism Research > 16-12 (December 2023) . - p.2247-2262[article] Distinct neurocognitive profiles and clinical phenotypes associated with copy number variation at the 22q11.2 locus [texte imprimé] / Leila KUSHAN-WELLS, Auteur ; Charles H. SCHLEIFER, Auteur ; Shayne CRUZ, Auteur ; Gil D. HOFTMAN, Auteur ; Maria JALBRZIKOWSKI, Auteur ; Raquel E. GUR, Auteur ; Ruben C. GUR, Auteur ; Carrie E. BEARDEN, Auteur . - p.2247-2262.
in Autism Research > 16-12 (December 2023) . - p.2247-2262
Index. décimale : PER Périodiques Résumé : Abstract Rare genetic variants that confer large effects on neurodevelopment and behavioral phenotypes can reveal novel gene-brain-behavior relationships relevant to autism. Copy number variation at the 22q11.2 locus offer one compelling example, as both the 22q11.2 deletion (22qDel) and duplication (22qDup) confer increased likelihood of autism spectrum disorders (ASD) and cognitive deficits, but only 22qDel confers increased psychosis risk. Here, we used the Penn Computerized Neurocognitive Battery (Penn-CNB) to characterized neurocognitive profiles of 126 individuals: 55 22qDel carriers (MAge = 19.2 years, 49.1% male), 30 22qDup carriers (MAge = 17.3 years, 53.3% male), and 41 typically developing (TD) subjects (MAge = 17.3 years, 39.0% male). We performed linear mixed models to assess group differences in overall neurocognitive profiles, domain scores, and individual test scores. We found all three groups exhibited distinct overall neurocognitive profiles. 22qDel and 22qDup carriers showed significant accuracy deficits across all domains relative to controls (episodic memory, executive function, complex cognition, social cognition, and sensorimotor speed), with 22qDel carriers exhibiting more severe accuracy deficits, particularly in episodic memory. However, 22qDup carriers generally showed greater slowing than 22qDel carriers. Notably, slower social cognition speed was uniquely associated with increased global psychopathology and poorer psychosocial functioning in 22qDup. Compared to TD, 22q11.2 copy number variants (CNV) carriers failed to show age-associated improvements in multiple cognitive domains. Exploratory analyses revealed 22q11.2 CNV carriers with ASD exhibited differential neurocognitive profiles, based on 22q11.2 copy number. These results suggest that there are distinct neurocognitive profiles associated with either a loss or gain of genomic material at the 22q11.2 locus. En ligne : https://doi.org/10.1002/aur.3049 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=518
Titre : Reciprocal social behavior in youths with psychotic illness and those at clinical high risk Type de document : texte imprimé Auteurs : Maria JALBRZIKOWSKI, Auteur ; Kate E. KRASILEVA, Auteur ; Sarah MARVIN, Auteur ; Jamie ZINBERG, Auteur ; Angielette ANDAYA, Auteur ; Peter BACHMAN, Auteur ; Tyrone D. CANNON, Auteur ; Carrie E. BEARDEN, Auteur Article en page(s) : p.1187-1197 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Youths at clinical high risk (CHR) for psychosis typically exhibit significant social dysfunction. However, the specific social behaviors associated with psychosis risk have not been well characterized. We administer the Social Responsiveness Scale (SRS), a measure of autistic traits that examines reciprocal social behavior, to the parents of 117 adolescents (61 CHR individuals, 20 age-matched adolescents with a psychotic disorder [AOP], and 36 healthy controls) participating in a longitudinal study of psychosis risk. AOP and CHR individuals have significantly elevated SRS scores relative to healthy controls, indicating more severe social deficits. Mean scores for AOP and CHR youths are typical of scores obtained in individuals with high functioning autism (Constantino Gruber, 2005). SRS scores are significantly associated with concurrent real-world social functioning in both clinical groups. Finally, baseline SRS scores significantly predict social functioning at follow-up (an average of 7.2 months later) in CHR individuals, over and above baseline social functioning measures (p .009). These findings provide novel information regarding impairments in domains critical for adolescent social development, because CHR individuals and those with overt psychosis show marked deficits in reciprocal social behavior. Further, the SRS predicts subsequent real-world social functioning in CHR youth, suggesting that this measure may be useful for identifying targets of treatment in psychosocial interventions. En ligne : http://dx.doi.org/10.1017/S095457941300045X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=219
in Development and Psychopathology > 25-4 (November 2013) . - p.1187-1197[article] Reciprocal social behavior in youths with psychotic illness and those at clinical high risk [texte imprimé] / Maria JALBRZIKOWSKI, Auteur ; Kate E. KRASILEVA, Auteur ; Sarah MARVIN, Auteur ; Jamie ZINBERG, Auteur ; Angielette ANDAYA, Auteur ; Peter BACHMAN, Auteur ; Tyrone D. CANNON, Auteur ; Carrie E. BEARDEN, Auteur . - p.1187-1197.
Langues : Anglais (eng)
in Development and Psychopathology > 25-4 (November 2013) . - p.1187-1197
Index. décimale : PER Périodiques Résumé : Youths at clinical high risk (CHR) for psychosis typically exhibit significant social dysfunction. However, the specific social behaviors associated with psychosis risk have not been well characterized. We administer the Social Responsiveness Scale (SRS), a measure of autistic traits that examines reciprocal social behavior, to the parents of 117 adolescents (61 CHR individuals, 20 age-matched adolescents with a psychotic disorder [AOP], and 36 healthy controls) participating in a longitudinal study of psychosis risk. AOP and CHR individuals have significantly elevated SRS scores relative to healthy controls, indicating more severe social deficits. Mean scores for AOP and CHR youths are typical of scores obtained in individuals with high functioning autism (Constantino Gruber, 2005). SRS scores are significantly associated with concurrent real-world social functioning in both clinical groups. Finally, baseline SRS scores significantly predict social functioning at follow-up (an average of 7.2 months later) in CHR individuals, over and above baseline social functioning measures (p .009). These findings provide novel information regarding impairments in domains critical for adolescent social development, because CHR individuals and those with overt psychosis show marked deficits in reciprocal social behavior. Further, the SRS predicts subsequent real-world social functioning in CHR youth, suggesting that this measure may be useful for identifying targets of treatment in psychosocial interventions. En ligne : http://dx.doi.org/10.1017/S095457941300045X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=219
Titre : Trajectories of psychotic-like experiences in youth and associations with lifestyle factors Type de document : texte imprimé Auteurs : Rebecca COOPER, Auteur ; Els VAN DER VEN, Auteur ; Maria JALBRZIKOWSKI, Auteur Article en page(s) : p.5-16 Langues : Anglais (eng) Mots-clés : Psychotic-like growth mixture modeling lifestyle factors sleep exercise adolescence Index. décimale : PER Périodiques Résumé : Background Persistent and/or distressing psychotic-like experiences (PLEs) during adolescence are associated with poorer subsequent psychiatric outcomes. Modifiable lifestyle factors (such as sleep quality or regular exercise) may improve mental health outcomes; however, it is unknown how lifestyle factors are linked to trajectories of PLEs. Methods Using data from the Adolescent Brain Cognitive Development Study (N?=?10,075, age 9?10?years at baseline), we characterized trajectories of PLEs using latent growth mixture models assessed using the Prodromal Questionnaire-Brief Child Version. We examined trajectories of Total and Distress scores. We used multinomial logistic regressions to examine associations between baseline lifestyle behaviors (including self-reported screen time, physical activity and caffeine intake, and parent-reported sleep disturbances and recreational activities) and PLE trajectories. Results We identified four trajectories of distress-related PLEs: No Distress (27%), Rapid Decreasing (17%), Gradual Decreasing (36%), and Persistent Elevated Distress (21%). Compared with the No Distress trajectory, individuals in the Persistent Elevated Distress trajectory spent more time using screens (adjusted Odds Ratio [OR] 2.27, 95% confidence interval [CI] 2.03?2.53), had higher caffeine intake (OR 1.62, 95% CI 1.28?2.04), greater sleep disturbance (OR 1.58, 95% CI 1.45?1.73), participated in fewer recreational activities (OR 0.75, 95% CI 0.68?0.83) and less frequent physical activity (OR 0.81, 95% CI 0.74?0.89). Greater screen time and sleep disturbances further distinguished the most severe group from all other trajectories. Findings were similar when examining total scores. Results remained statistically significant when we included established risk factors of psychosis in each model. Conclusions Lifestyle factors associate with trajectories of PLE-related distress, providing novel tools for intervention and risk prediction. En ligne : https://doi.org/10.1111/jcpp.14179 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=577
in Journal of Child Psychology and Psychiatry > 67-1 (January 2026) . - p.5-16[article] Trajectories of psychotic-like experiences in youth and associations with lifestyle factors [texte imprimé] / Rebecca COOPER, Auteur ; Els VAN DER VEN, Auteur ; Maria JALBRZIKOWSKI, Auteur . - p.5-16.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 67-1 (January 2026) . - p.5-16
Mots-clés : Psychotic-like growth mixture modeling lifestyle factors sleep exercise adolescence Index. décimale : PER Périodiques Résumé : Background Persistent and/or distressing psychotic-like experiences (PLEs) during adolescence are associated with poorer subsequent psychiatric outcomes. Modifiable lifestyle factors (such as sleep quality or regular exercise) may improve mental health outcomes; however, it is unknown how lifestyle factors are linked to trajectories of PLEs. Methods Using data from the Adolescent Brain Cognitive Development Study (N?=?10,075, age 9?10?years at baseline), we characterized trajectories of PLEs using latent growth mixture models assessed using the Prodromal Questionnaire-Brief Child Version. We examined trajectories of Total and Distress scores. We used multinomial logistic regressions to examine associations between baseline lifestyle behaviors (including self-reported screen time, physical activity and caffeine intake, and parent-reported sleep disturbances and recreational activities) and PLE trajectories. Results We identified four trajectories of distress-related PLEs: No Distress (27%), Rapid Decreasing (17%), Gradual Decreasing (36%), and Persistent Elevated Distress (21%). Compared with the No Distress trajectory, individuals in the Persistent Elevated Distress trajectory spent more time using screens (adjusted Odds Ratio [OR] 2.27, 95% confidence interval [CI] 2.03?2.53), had higher caffeine intake (OR 1.62, 95% CI 1.28?2.04), greater sleep disturbance (OR 1.58, 95% CI 1.45?1.73), participated in fewer recreational activities (OR 0.75, 95% CI 0.68?0.83) and less frequent physical activity (OR 0.81, 95% CI 0.74?0.89). Greater screen time and sleep disturbances further distinguished the most severe group from all other trajectories. Findings were similar when examining total scores. Results remained statistically significant when we included established risk factors of psychosis in each model. Conclusions Lifestyle factors associate with trajectories of PLE-related distress, providing novel tools for intervention and risk prediction. En ligne : https://doi.org/10.1111/jcpp.14179 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=577
