| Titre : |
PI3K Signaling and miRNA Regulation in Autism Spectrum Disorders |
| Type de document : |
Texte imprimé et/ou numérique |
| Auteurs : |
Showming KWOK, Auteur ; Nikolaos MELLIOS, Auteur ; Mriganka SUR, Auteur |
| Année de publication : |
2013 |
| Importance : |
p.449-459 |
| Langues : |
Anglais (eng) |
| Index. décimale : |
SCI-D SCI-D - Neurosciences |
| Résumé : |
Despite the heterogeneity of autism spectrum disorders (ASD), dysregulation of the phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway has emerged as one potentially common and unifying theme. Multiple genes linked to syndromic or non-syndromic forms of ASD appear to interplay with small non-coding RNAs to generate a complex and interconnected molecular network that, when perturbed, results in alterations in protein synthesis and aberrant synaptic plasticity. In this chapter we attempt to elucidate the interactions between ASD-related genes and PI3K/Akt/mTOR signaling, with particular mention of the contribution of microRNAs (miRNAs), a category of non-coding RNAs with increased relevance to brain disorders. |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=189 |
PI3K Signaling and miRNA Regulation in Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Showming KWOK, Auteur ; Nikolaos MELLIOS, Auteur ; Mriganka SUR, Auteur . - 2013 . - p.449-459. Langues : Anglais ( eng)
| Index. décimale : |
SCI-D SCI-D - Neurosciences |
| Résumé : |
Despite the heterogeneity of autism spectrum disorders (ASD), dysregulation of the phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway has emerged as one potentially common and unifying theme. Multiple genes linked to syndromic or non-syndromic forms of ASD appear to interplay with small non-coding RNAs to generate a complex and interconnected molecular network that, when perturbed, results in alterations in protein synthesis and aberrant synaptic plasticity. In this chapter we attempt to elucidate the interactions between ASD-related genes and PI3K/Akt/mTOR signaling, with particular mention of the contribution of microRNAs (miRNAs), a category of non-coding RNAs with increased relevance to brain disorders. |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=189 |
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