[3H]-Flunitrazepam-labeled Benzodiazepine Binding Sites in the Hippocampal Formation in Autism: A Multiple Concentration Autoradiographic Study / Jeffrey T. GUPTILL in Journal of Autism and Developmental Disorders, 37-5 (May 2007)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 37-5 (May 2007) . - p.911-920 Titre : [3H]-Flunitrazepam-labeled Benzodiazepine Binding Sites in the Hippocampal Formation in Autism: A Multiple Concentration Autoradiographic Study Type de document : Texte imprimé et/ou numérique Auteurs : Jeffrey T. GUPTILL, Auteur ; Anne B. BOOKER, Auteur ; Terrell T. GIBBS, Auteur ; Thomas L. KEMPER, Auteur ; Gene J. BLATT, Auteur ; Margaret L. BAUMAN, Auteur Année de publication : 2007 Article en page(s) : p.911-920 Langues : Anglais (eng) Mots-clés : Developmental-disorder Autoradiography Hippocampus GABAergic-receptors Hippocampal-circuitry Index. décimale : PER Périodiques Résumé : Increasing evidence indicates that the GABAergic system in cerebellar and limbic structures is affected in autism. We extended our previous study that found reduced [3H]flunitrazepam-labeled benzodiazepine sites in the autistic hippocampus to determine whether this reduction was due to a decrease in binding site number (B max) or altered affinity (K d) to bind to the ligand. Quantitation of hippocampal lamina demonstrated a 20% reduction in B max indicating a trend toward a decreased number of benzodiazepine binding sites in the autistic group but normal K d values. A reduction in the number of hippocampal benzodiazepine binding sites suggests alterations in the modulation of GABAA receptors in the presence of GABA in the autistic brain, possibly resulting in altered inhibitory functioning of hippocampal circuitry. En ligne : http://dx.doi.org/10.1007/s10803-006-0226-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=140 [article] [3H]-Flunitrazepam-labeled Benzodiazepine Binding Sites in the Hippocampal Formation in Autism: A Multiple Concentration Autoradiographic Study [Texte imprimé et/ou numérique] / Jeffrey T. GUPTILL, Auteur ; Anne B. BOOKER, Auteur ; Terrell T. GIBBS, Auteur ; Thomas L. KEMPER, Auteur ; Gene J. BLATT, Auteur ; Margaret L. BAUMAN, Auteur . - 2007 . - p.911-920. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 37-5 (May 2007) . - p.911-920 Mots-clés : Developmental-disorder Autoradiography Hippocampus GABAergic-receptors Hippocampal-circuitry Index. décimale : PER Périodiques Résumé : Increasing evidence indicates that the GABAergic system in cerebellar and limbic structures is affected in autism. We extended our previous study that found reduced [3H]flunitrazepam-labeled benzodiazepine sites in the autistic hippocampus to determine whether this reduction was due to a decrease in binding site number (B max) or altered affinity (K d) to bind to the ligand. Quantitation of hippocampal lamina demonstrated a 20% reduction in B max indicating a trend toward a decreased number of benzodiazepine binding sites in the autistic group but normal K d values. A reduction in the number of hippocampal benzodiazepine binding sites suggests alterations in the modulation of GABAA receptors in the presence of GABA in the autistic brain, possibly resulting in altered inhibitory functioning of hippocampal circuitry. En ligne : http://dx.doi.org/10.1007/s10803-006-0226-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=140

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