[3H]-Flunitrazepam-labeled Benzodiazepine Binding Sites in the Hippocampal Formation in Autism: A Multiple Concentration Autoradiographic Study / Jeffrey T. GUPTILL in Journal of Autism and Developmental Disorders, 37-5 (May 2007)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 37-5 (May 2007) . - p.911-920 Titre : [3H]-Flunitrazepam-labeled Benzodiazepine Binding Sites in the Hippocampal Formation in Autism: A Multiple Concentration Autoradiographic Study Type de document : Texte imprimé et/ou numérique Auteurs : Jeffrey T. GUPTILL, Auteur ; Anne B. BOOKER, Auteur ; Terrell T. GIBBS, Auteur ; Thomas L. KEMPER, Auteur ; Gene J. BLATT, Auteur ; Margaret L. BAUMAN, Auteur Année de publication : 2007 Article en page(s) : p.911-920 Langues : Anglais (eng) Mots-clés : Developmental-disorder Autoradiography Hippocampus GABAergic-receptors Hippocampal-circuitry Index. décimale : PER Périodiques Résumé : Increasing evidence indicates that the GABAergic system in cerebellar and limbic structures is affected in autism. We extended our previous study that found reduced [3H]flunitrazepam-labeled benzodiazepine sites in the autistic hippocampus to determine whether this reduction was due to a decrease in binding site number (B max) or altered affinity (K d) to bind to the ligand. Quantitation of hippocampal lamina demonstrated a 20% reduction in B max indicating a trend toward a decreased number of benzodiazepine binding sites in the autistic group but normal K d values. A reduction in the number of hippocampal benzodiazepine binding sites suggests alterations in the modulation of GABAA receptors in the presence of GABA in the autistic brain, possibly resulting in altered inhibitory functioning of hippocampal circuitry. En ligne : http://dx.doi.org/10.1007/s10803-006-0226-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=140 [article] [3H]-Flunitrazepam-labeled Benzodiazepine Binding Sites in the Hippocampal Formation in Autism: A Multiple Concentration Autoradiographic Study [Texte imprimé et/ou numérique] / Jeffrey T. GUPTILL, Auteur ; Anne B. BOOKER, Auteur ; Terrell T. GIBBS, Auteur ; Thomas L. KEMPER, Auteur ; Gene J. BLATT, Auteur ; Margaret L. BAUMAN, Auteur . - 2007 . - p.911-920. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 37-5 (May 2007) . - p.911-920 Mots-clés : Developmental-disorder Autoradiography Hippocampus GABAergic-receptors Hippocampal-circuitry Index. décimale : PER Périodiques Résumé : Increasing evidence indicates that the GABAergic system in cerebellar and limbic structures is affected in autism. We extended our previous study that found reduced [3H]flunitrazepam-labeled benzodiazepine sites in the autistic hippocampus to determine whether this reduction was due to a decrease in binding site number (B max) or altered affinity (K d) to bind to the ligand. Quantitation of hippocampal lamina demonstrated a 20% reduction in B max indicating a trend toward a decreased number of benzodiazepine binding sites in the autistic group but normal K d values. A reduction in the number of hippocampal benzodiazepine binding sites suggests alterations in the modulation of GABAA receptors in the presence of GABA in the autistic brain, possibly resulting in altered inhibitory functioning of hippocampal circuitry. En ligne : http://dx.doi.org/10.1007/s10803-006-0226-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=140

Altered posterior cingulate cortical cyctoarchitecture, but normal density of neurons and interneurons in the posterior cingulate cortex and fusiform gyrus in autism / Adrian L. OBLAK in Autism Research, 4-3 (June 2011)  

Public ISBD [article]  inAutism Research > 4-3 (June 2011) . - p.200-211 Titre : Altered posterior cingulate cortical cyctoarchitecture, but normal density of neurons and interneurons in the posterior cingulate cortex and fusiform gyrus in autism Type de document : Texte imprimé et/ou numérique Auteurs : Adrian L. OBLAK, Auteur ; Douglas L. ROSENE, Auteur ; Thomas L. KEMPER, Auteur ; Margaret L. BAUMAN, Auteur ; Gene J. BLATT, Auteur Année de publication : 2011 Article en page(s) : p.200-211 Langues : Anglais (eng) Mots-clés : neuropathology  gamma-aminobutyric acid  neurochemistry ;neuroanatomy Index. décimale : PER Périodiques Résumé : Autism is a developmental disorder with prenatal origins, currently estimated to affect 1 in 91 children in the United States. Social-emotional deficits are a hallmark of autism and early neuropathology studies have indicated involvement of the limbic system. Imaging studies demonstrate abnormal activation of the posterior cingulate cortex (PCC), a component of the limbic system. Abnormal activation has also been noted in the fusiform gyrus (FFG), a region important for facial recognition and a key element in social interaction. A potential imbalance between excitatory and inhibitory interneurons in the cortex may contribute to altered information processing in autism. Furthermore, reduced numbers of GABA receptors have previously been reported in the autistic brain. Thionin-stained sections were used to qualitatively assess cytoarchitectonic patterning and quantitatively determine the density of neurons and immunohistochemistry was used to determine the densities of a subset of GABAergic interneurons utilizing parvalbumin-and calbindin-immunoreactivity. In autism, the PCC displayed altered cytoarchitecture with irregularly distributed neurons, poorly demarcated layers IV and V, and increased presence of white matter neurons. In contrast, no neuropathology was observed in the FFG. There was no significant difference in the density of thionin, parvalbumin, or calbindin interneurons in either region and there was a trend towards a reduced density of calbindin neurons in the PCC. This study highlights the presence of abnormal findings in the PCC, which appear to be developmental in nature and could affect the local processing of social–emotional behaviors as well as functioning of interrelated areas. En ligne : http://dx.doi.org/10.1002/aur.188 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=127 [article] Altered posterior cingulate cortical cyctoarchitecture, but normal density of neurons and interneurons in the posterior cingulate cortex and fusiform gyrus in autism [Texte imprimé et/ou numérique] / Adrian L. OBLAK, Auteur ; Douglas L. ROSENE, Auteur ; Thomas L. KEMPER, Auteur ; Margaret L. BAUMAN, Auteur ; Gene J. BLATT, Auteur . - 2011 . - p.200-211. Langues : Anglais (eng) in Autism Research > 4-3 (June 2011) . - p.200-211 Mots-clés : neuropathology  gamma-aminobutyric acid  neurochemistry ;neuroanatomy Index. décimale : PER Périodiques Résumé : Autism is a developmental disorder with prenatal origins, currently estimated to affect 1 in 91 children in the United States. Social-emotional deficits are a hallmark of autism and early neuropathology studies have indicated involvement of the limbic system. Imaging studies demonstrate abnormal activation of the posterior cingulate cortex (PCC), a component of the limbic system. Abnormal activation has also been noted in the fusiform gyrus (FFG), a region important for facial recognition and a key element in social interaction. A potential imbalance between excitatory and inhibitory interneurons in the cortex may contribute to altered information processing in autism. Furthermore, reduced numbers of GABA receptors have previously been reported in the autistic brain. Thionin-stained sections were used to qualitatively assess cytoarchitectonic patterning and quantitatively determine the density of neurons and immunohistochemistry was used to determine the densities of a subset of GABAergic interneurons utilizing parvalbumin-and calbindin-immunoreactivity. In autism, the PCC displayed altered cytoarchitecture with irregularly distributed neurons, poorly demarcated layers IV and V, and increased presence of white matter neurons. In contrast, no neuropathology was observed in the FFG. There was no significant difference in the density of thionin, parvalbumin, or calbindin interneurons in either region and there was a trend towards a reduced density of calbindin neurons in the PCC. This study highlights the presence of abnormal findings in the PCC, which appear to be developmental in nature and could affect the local processing of social–emotional behaviors as well as functioning of interrelated areas. En ligne : http://dx.doi.org/10.1002/aur.188 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=127

Epilogue / Margaret L. BAUMAN

Public ISBD contenu dans The Neurobiology of Autism / Margaret L. BAUMAN Titre : Epilogue Type de document : Texte imprimé et/ou numérique Auteurs : Margaret L. BAUMAN, Auteur ; Thomas L. KEMPER, Auteur Année de publication : 2006 Importance : p.387-391 Langues : Anglais (eng) Index. décimale : SCI-D SCI-D - Neurosciences Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=793 contenu dans The Neurobiology of Autism / Margaret L. BAUMAN Epilogue [Texte imprimé et/ou numérique] / Margaret L. BAUMAN, Auteur ; Thomas L. KEMPER, Auteur . - 2006 . - p.387-391. Langues : Anglais (eng) Index. décimale : SCI-D SCI-D - Neurosciences Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=793

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Structural brain anatomy in autism : what is the evidence? / Margaret L. BAUMAN

Public ISBD contenu dans The Neurobiology of Autism / Margaret L. BAUMAN Titre : Structural brain anatomy in autism : what is the evidence? Type de document : Texte imprimé et/ou numérique Auteurs : Margaret L. BAUMAN, Auteur ; Thomas L. KEMPER, Auteur Année de publication : 2006 Importance : p.121-135 Langues : Anglais (eng) Index. décimale : SCI-D SCI-D - Neurosciences Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=791 contenu dans The Neurobiology of Autism / Margaret L. BAUMAN Structural brain anatomy in autism : what is the evidence? [Texte imprimé et/ou numérique] / Margaret L. BAUMAN, Auteur ; Thomas L. KEMPER, Auteur . - 2006 . - p.121-135. Langues : Anglais (eng) Index. décimale : SCI-D SCI-D - Neurosciences Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=791

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The Cerebellum in Autism Spectrum Disorders / Margaret L. BAUMAN

Public ISBD in The Neuroscience of Autism Spectrum Disorders / Joseph D. BUXBAUM Titre : The Cerebellum in Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Margaret L. BAUMAN, Auteur ; Thomas L. KEMPER, Auteur Année de publication : 2013 Importance : p.289-295 Langues : Anglais (eng) Index. décimale : SCI-D SCI-D - Neurosciences Résumé : Autism spectrum disorders (ASD) are a group of behaviorally defined disorders characterized by impaired social interaction, delayed and disordered language, isolated areas of interest and an insistence on sameness. Although specific causes of ASD are not fully known, both genetic and environmental factors are believed to play a role. One of the most consistently abnormal regions of the autistic brain is the cerebellum. This chapter describes some of the gross and microscopic features of the cerebellum in the autistic brain and suggests possible correlations between these findings and clinical symptoms of the disorder. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=189 in The Neuroscience of Autism Spectrum Disorders / Joseph D. BUXBAUM The Cerebellum in Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Margaret L. BAUMAN, Auteur ; Thomas L. KEMPER, Auteur . - 2013 . - p.289-295. Langues : Anglais (eng) Index. décimale : SCI-D SCI-D - Neurosciences Résumé : Autism spectrum disorders (ASD) are a group of behaviorally defined disorders characterized by impaired social interaction, delayed and disordered language, isolated areas of interest and an insistence on sameness. Although specific causes of ASD are not fully known, both genetic and environmental factors are believed to play a role. One of the most consistently abnormal regions of the autistic brain is the cerebellum. This chapter describes some of the gross and microscopic features of the cerebellum in the autistic brain and suggests possible correlations between these findings and clinical symptoms of the disorder. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=189

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The Developmental Neuropathology of Autism / Thomas L. KEMPER

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The Neurobiology of Autism / Margaret L. BAUMAN

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