[article]
| Titre : |
Maternal Immune-Mediated Conditions, Autism Spectrum Disorders, and Developmental Delay |
| Type de document : |
Texte imprimé et/ou numérique |
| Auteurs : |
Kristen LYALL, Auteur ; Paul ASHWOOD, Auteur ; Judy VAN DE WATER, Auteur ; Irva HERTZ-PICCIOTTO, Auteur |
| Article en page(s) : |
p.1546-1555 |
| Langues : |
Anglais (eng) |
| Mots-clés : |
Autoimmune disease Asthma Allergy Autism Developmental delay Maternal risk factors |
| Index. décimale : |
PER Périodiques |
| Résumé : |
The maternal immune system may play a role in offspring neurodevelopment. We examined whether maternal autoimmune disease, asthma, and allergy were associated with child autism spectrum disorder (ASD) and developmental delay without autism (DD) using 560 ASD cases, 391 typically developing controls, and 168 DD cases from the CHildhood Autism Risk from Genetics and the Environment (CHARGE) study. Results from conditional logistic regression demonstrated few significant associations overall. Maternal autoimmune disease was significantly associated with a modest increase in odds of developmental disorders (combined ASD + DD; OR = 1.46, 95 % CI 1.01, 2.09) but not of ASD alone. Associations with certain allergens and onset periods were also suggested. These findings suggest maternal autoimmune disease may modestly influence childhood developmental disorders (ASD + DD). |
| En ligne : |
http://dx.doi.org/10.1007/s10803-013-2017-2 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=236 |
in Journal of Autism and Developmental Disorders > 44-7 (July 2014) . - p.1546-1555
[article] Maternal Immune-Mediated Conditions, Autism Spectrum Disorders, and Developmental Delay [Texte imprimé et/ou numérique] / Kristen LYALL, Auteur ; Paul ASHWOOD, Auteur ; Judy VAN DE WATER, Auteur ; Irva HERTZ-PICCIOTTO, Auteur . - p.1546-1555. Langues : Anglais ( eng) in Journal of Autism and Developmental Disorders > 44-7 (July 2014) . - p.1546-1555
| Mots-clés : |
Autoimmune disease Asthma Allergy Autism Developmental delay Maternal risk factors |
| Index. décimale : |
PER Périodiques |
| Résumé : |
The maternal immune system may play a role in offspring neurodevelopment. We examined whether maternal autoimmune disease, asthma, and allergy were associated with child autism spectrum disorder (ASD) and developmental delay without autism (DD) using 560 ASD cases, 391 typically developing controls, and 168 DD cases from the CHildhood Autism Risk from Genetics and the Environment (CHARGE) study. Results from conditional logistic regression demonstrated few significant associations overall. Maternal autoimmune disease was significantly associated with a modest increase in odds of developmental disorders (combined ASD + DD; OR = 1.46, 95 % CI 1.01, 2.09) but not of ASD alone. Associations with certain allergens and onset periods were also suggested. These findings suggest maternal autoimmune disease may modestly influence childhood developmental disorders (ASD + DD). |
| En ligne : |
http://dx.doi.org/10.1007/s10803-013-2017-2 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=236 |
|
Maternal Immune-Mediated Conditions, Autism Spectrum Disorders, and Developmental Delay in Journal of Autism and Developmental Disorders, 44-7 (July 2014)
