[article] 
inJournal of Autism and Developmental Disorders > 44-8 (August 2014) . - p.2013-2025

Titre :	A Twin Study of Heritable and Shared Environmental Contributions to Autism
Type de document :	Texte imprimé et/ou numérique
Auteurs :	Thomas W. FRAZIER, Auteur ; Lee THOMPSON, Auteur ; Eric A. YOUNGSTROM, Auteur ; Paul LAW, Auteur ; Antonio Y. HARDAN, Auteur ; Charis ENG, Auteur ; Nathan MORRIS, Auteur
Article en page(s) :	p.2013-2025
Langues :	Anglais (eng)
Mots-clés :	Autism  Twins  Genetic  Heritability  Environment  Diagnosis
Index. décimale :	PER Périodiques
Résumé :	The present study examined genetic and shared environment contributions to quantitatively-measured autism symptoms and categorically-defined autism spectrum disorders (ASD). Participants included 568 twins from the Interactive Autism Network. Autism symptoms were obtained using the Social Communication Questionnaire and Social Responsiveness Scale. Categorically-defined ASD was based on clinical diagnoses. DeFries-Fulker and liability threshold models examined etiologic influences. Very high heritability was observed for extreme autism symptom levels ( h2g=.92?1.20 ). Extreme levels of social and repetitive behavior symptoms were strongly influenced by common genetic factors. Heritability of categorically-defined ASD diagnosis was comparatively low (.21, 95 % CI 0.15–0.28). High heritability of extreme autism symptom levels confirms previous observations of strong genetic influences on autism. Future studies will require large, carefully ascertained family pedigrees and quantitative symptom measurements.
En ligne :	http://dx.doi.org/10.1007/s10803-014-2081-2
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=236

[article] A Twin Study of Heritable and Shared Environmental Contributions to Autism [Texte imprimé et/ou numérique] / Thomas W. FRAZIER, Auteur ; Lee THOMPSON, Auteur ; Eric A. YOUNGSTROM, Auteur ; Paul LAW, Auteur ; Antonio Y. HARDAN, Auteur ; Charis ENG, Auteur ; Nathan MORRIS, Auteur . - p.2013-2025.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 44-8 (August 2014) . - p.2013-2025

Mots-clés :	Autism  Twins  Genetic  Heritability  Environment  Diagnosis
Index. décimale :	PER Périodiques
Résumé :	The present study examined genetic and shared environment contributions to quantitatively-measured autism symptoms and categorically-defined autism spectrum disorders (ASD). Participants included 568 twins from the Interactive Autism Network. Autism symptoms were obtained using the Social Communication Questionnaire and Social Responsiveness Scale. Categorically-defined ASD was based on clinical diagnoses. DeFries-Fulker and liability threshold models examined etiologic influences. Very high heritability was observed for extreme autism symptom levels ( h2g=.92?1.20 ). Extreme levels of social and repetitive behavior symptoms were strongly influenced by common genetic factors. Heritability of categorically-defined ASD diagnosis was comparatively low (.21, 95 % CI 0.15–0.28). High heritability of extreme autism symptom levels confirms previous observations of strong genetic influences on autism. Future studies will require large, carefully ascertained family pedigrees and quantitative symptom measurements.
En ligne :	http://dx.doi.org/10.1007/s10803-014-2081-2
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=236