Characterizing restricted and unusual interests in autistic youth / Luke D. SMILLIE ; Thomas W. FRAZIER ; Antonio Y. HARDAN ; Gail A. ALVARES ; Andrew J. O. WHITEHOUSE ; Mirko ULJAREVIĆ in Autism Research, 16-2 (February 2023)  

Public ISBD [article]  inAutism Research > 16-2 (February 2023) . - p.394-405 Titre : Characterizing restricted and unusual interests in autistic youth Type de document : Texte imprimé et/ou numérique Auteurs : Luke D. SMILLIE, Auteur ; Thomas W. FRAZIER, Auteur ; Antonio Y. HARDAN, Auteur ; Gail A. ALVARES, Auteur ; Andrew J. O. WHITEHOUSE, Auteur ; Mirko ULJAREVIĆ, Auteur Article en page(s) : p.394-405 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract A broad range of interests characterized by unusual content and/or intensity, labeled as circumscribed interests (CI), are a core diagnostic feature of autism. Recent evidence suggests that a distinction can be drawn between interests that, although characterized by unusually high intensity and/or inflexibility, are otherwise common in terms of their content (e.g., an interest in movies or animals), labeled as restricted interests (RI), and interests that are generally not salient outside of autism (e.g., an interest in traffic lights or categorization), labeled as unusual interests (UI). The current study aimed to further characterize RI and UI by exploring their association with age, sex, IQ, and social motivation, as well as to examine differences in the adaptive benefits and negative impacts of these two subdomains. Parents of 1892 autistic children and adolescents (Mage = 10.82, SDage = 4.14; 420 females) completed an online survey including the Dimensional Assessment of Restricted and Repetitive Behaviors and the Social Communication Questionnaire. Both RI and UI were found to be highly frequent. Sex-based differences were observed in the content, but not intensity, of CI such that females were more likely to show interests with a social component. Finally, RI and UI showed distinct patterns of association with age, sex, IQ, and social motivation, as well as metrics of adaptive benefits and negative impacts. Findings afford a more nuanced understanding of sex-based differences in CI and, crucially, provide preliminary evidence that RI and UI represent distinct constructs that should be studied independently in future research. En ligne : https://doi.org/10.1002/aur.2863 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=4960 [article] Characterizing restricted and unusual interests in autistic youth [Texte imprimé et/ou numérique] / Luke D. SMILLIE, Auteur ; Thomas W. FRAZIER, Auteur ; Antonio Y. HARDAN, Auteur ; Gail A. ALVARES, Auteur ; Andrew J. O. WHITEHOUSE, Auteur ; Mirko ULJAREVIĆ, Auteur . - p.394-405. Langues : Anglais (eng) in Autism Research > 16-2 (February 2023) . - p.394-405 Index. décimale : PER Périodiques Résumé : Abstract A broad range of interests characterized by unusual content and/or intensity, labeled as circumscribed interests (CI), are a core diagnostic feature of autism. Recent evidence suggests that a distinction can be drawn between interests that, although characterized by unusually high intensity and/or inflexibility, are otherwise common in terms of their content (e.g., an interest in movies or animals), labeled as restricted interests (RI), and interests that are generally not salient outside of autism (e.g., an interest in traffic lights or categorization), labeled as unusual interests (UI). The current study aimed to further characterize RI and UI by exploring their association with age, sex, IQ, and social motivation, as well as to examine differences in the adaptive benefits and negative impacts of these two subdomains. Parents of 1892 autistic children and adolescents (Mage = 10.82, SDage = 4.14; 420 females) completed an online survey including the Dimensional Assessment of Restricted and Repetitive Behaviors and the Social Communication Questionnaire. Both RI and UI were found to be highly frequent. Sex-based differences were observed in the content, but not intensity, of CI such that females were more likely to show interests with a social component. Finally, RI and UI showed distinct patterns of association with age, sex, IQ, and social motivation, as well as metrics of adaptive benefits and negative impacts. Findings afford a more nuanced understanding of sex-based differences in CI and, crucially, provide preliminary evidence that RI and UI represent distinct constructs that should be studied independently in future research. En ligne : https://doi.org/10.1002/aur.2863 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=4960

Commentary: The observed association between autistic severity measured by the Social Responsiveness Scale (SRS) and general psychopathology – a response to Hus et al.() / John N. CONSTANTINO in Journal of Child Psychology and Psychiatry, 54-6 (June 2013)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 54-6 (June 2013) . - p.695-697 Titre : Commentary: The observed association between autistic severity measured by the Social Responsiveness Scale (SRS) and general psychopathology – a response to Hus et al.() Type de document : Texte imprimé et/ou numérique Auteurs : John N. CONSTANTINO, Auteur ; Thomas W. FRAZIER, Auteur Article en page(s) : p.695-697 Langues : Anglais (eng) Mots-clés : Autistic disorder  diagnosis  child behavior check list  social behavior  pervasive developmental disorder Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1111/jcpp.12064 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=2001 [article] Commentary: The observed association between autistic severity measured by the Social Responsiveness Scale (SRS) and general psychopathology – a response to Hus et al.() [Texte imprimé et/ou numérique] / John N. CONSTANTINO, Auteur ; Thomas W. FRAZIER, Auteur . - p.695-697. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 54-6 (June 2013) . - p.695-697 Mots-clés : Autistic disorder  diagnosis  child behavior check list  social behavior  pervasive developmental disorder Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1111/jcpp.12064 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=2001

Confirmatory factor analytic structure and measurement invariance of quantitative autistic traits measured by the Social Responsiveness Scale-2 / Thomas W. FRAZIER in Autism, 18-1 (January 2014)  

Public ISBD [article]  inAutism > 18-1 (January 2014) . - p.31-44 Titre : Confirmatory factor analytic structure and measurement invariance of quantitative autistic traits measured by the Social Responsiveness Scale-2 Type de document : Texte imprimé et/ou numérique Auteurs : Thomas W. FRAZIER, Auteur ; Kristin R. RATLIFF, Auteur ; Chris GRUBER, Auteur ; Yi ZHANG, Auteur ; Paul A. LAW, Auteur ; John N. CONSTANTINO, Auteur Article en page(s) : p.31-44 Langues : Anglais (eng) Mots-clés : Asperger syndrome  autism  factor structure  pervasive developmental disorder Index. décimale : PER Périodiques Résumé : Understanding the factor structure of autistic symptomatology is critical to the discovery and interpretation of causal mechanisms in autism spectrum disorder. We applied confirmatory factor analysis and assessment of measurement invariance to a large (N = 9635) accumulated collection of reports on quantitative autistic traits using the Social Responsiveness Scale, representing a broad diversity of age, severity, and reporter type. A two-factor structure (corresponding to social communication impairment and restricted, repetitive behavior) as elaborated in the updated Diagnostic and Statistical Manual of Mental Disorders (5th ed.; DSM-5) criteria for autism spectrum disorder exhibited acceptable model fit in confirmatory factor analysis. Measurement invariance was appreciable across age, sex, and reporter (self vs other), but somewhat less apparent between clinical and nonclinical populations in this sample comprised of both familial and sporadic autism spectrum disorders. The statistical power afforded by this large sample allowed relative differentiation of three factors among items encompassing social communication impairment (emotion recognition, social avoidance, and interpersonal relatedness) and two factors among items encompassing restricted, repetitive behavior (insistence on sameness and repetitive mannerisms). Cross-trait correlations remained extremely high, that is, on the order of 0.66–0.92. These data clarify domains of statistically significant factoral separation that may relate to partially—but not completely—overlapping biological mechanisms, contributing to variation in human social competency. Given such robust intercorrelations among symptom domains, understanding their co-emergence remains a high priority in conceptualizing common neural mechanisms underlying autistic syndromes. En ligne : http://dx.doi.org/10.1177/1362361313500382 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=2213 [article] Confirmatory factor analytic structure and measurement invariance of quantitative autistic traits measured by the Social Responsiveness Scale-2 [Texte imprimé et/ou numérique] / Thomas W. FRAZIER, Auteur ; Kristin R. RATLIFF, Auteur ; Chris GRUBER, Auteur ; Yi ZHANG, Auteur ; Paul A. LAW, Auteur ; John N. CONSTANTINO, Auteur . - p.31-44. Langues : Anglais (eng) in Autism > 18-1 (January 2014) . - p.31-44 Mots-clés : Asperger syndrome  autism  factor structure  pervasive developmental disorder Index. décimale : PER Périodiques Résumé : Understanding the factor structure of autistic symptomatology is critical to the discovery and interpretation of causal mechanisms in autism spectrum disorder. We applied confirmatory factor analysis and assessment of measurement invariance to a large (N = 9635) accumulated collection of reports on quantitative autistic traits using the Social Responsiveness Scale, representing a broad diversity of age, severity, and reporter type. A two-factor structure (corresponding to social communication impairment and restricted, repetitive behavior) as elaborated in the updated Diagnostic and Statistical Manual of Mental Disorders (5th ed.; DSM-5) criteria for autism spectrum disorder exhibited acceptable model fit in confirmatory factor analysis. Measurement invariance was appreciable across age, sex, and reporter (self vs other), but somewhat less apparent between clinical and nonclinical populations in this sample comprised of both familial and sporadic autism spectrum disorders. The statistical power afforded by this large sample allowed relative differentiation of three factors among items encompassing social communication impairment (emotion recognition, social avoidance, and interpersonal relatedness) and two factors among items encompassing restricted, repetitive behavior (insistence on sameness and repetitive mannerisms). Cross-trait correlations remained extremely high, that is, on the order of 0.66–0.92. These data clarify domains of statistically significant factoral separation that may relate to partially—but not completely—overlapping biological mechanisms, contributing to variation in human social competency. Given such robust intercorrelations among symptom domains, understanding their co-emergence remains a high priority in conceptualizing common neural mechanisms underlying autistic syndromes. En ligne : http://dx.doi.org/10.1177/1362361313500382 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=2213

Cytoplasm-predominant Pten associates with increased region-specific brain tyrosine hydroxylase and dopamine D2 receptors in mouse model with autistic traits / Xin HE in Molecular Autism, (November 2015)  

Public ISBD [article]  inMolecular Autism > (November 2015) . - p.1-10 Titre : Cytoplasm-predominant Pten associates with increased region-specific brain tyrosine hydroxylase and dopamine D2 receptors in mouse model with autistic traits Type de document : Texte imprimé et/ou numérique Auteurs : Xin HE, Auteur ; Stetson THACKER, Auteur ; Todd ROMIGH, Auteur ; Qi YU, Auteur ; Thomas W. FRAZIER, Auteur ; Charis ENG, Auteur Article en page(s) : p.1-10 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders characterized by impairment in social communication/interaction and inflexible/repetitive behavior. Several lines of evidence support genetic factors as a predominant cause of ASD. Among those autism susceptibility genes that have been identified, the PTEN tumor suppressor gene, initially identified as predisposing to Cowden heritable cancer syndrome, was found to be mutated in a subset of ASD patients with extreme macrocephaly. However, the ASD-relevant molecular mechanism mediating the effect of PTEN mutations remains elusive. En ligne : http://dx.doi.org/10.1186/s13229-015-0056-6 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=2777 [article] Cytoplasm-predominant Pten associates with increased region-specific brain tyrosine hydroxylase and dopamine D2 receptors in mouse model with autistic traits [Texte imprimé et/ou numérique] / Xin HE, Auteur ; Stetson THACKER, Auteur ; Todd ROMIGH, Auteur ; Qi YU, Auteur ; Thomas W. FRAZIER, Auteur ; Charis ENG, Auteur . - p.1-10. Langues : Anglais (eng) in Molecular Autism > (November 2015) . - p.1-10 Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders characterized by impairment in social communication/interaction and inflexible/repetitive behavior. Several lines of evidence support genetic factors as a predominant cause of ASD. Among those autism susceptibility genes that have been identified, the PTEN tumor suppressor gene, initially identified as predisposing to Cowden heritable cancer syndrome, was found to be mutated in a subset of ASD patients with extreme macrocephaly. However, the ASD-relevant molecular mechanism mediating the effect of PTEN mutations remains elusive. En ligne : http://dx.doi.org/10.1186/s13229-015-0056-6 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=2777

Demographic and clinical correlates of autism symptom domains and autism spectrum diagnosis / Thomas W. FRAZIER in Autism, 18-5 (July 2014)  

Public ISBD [article]  inAutism > 18-5 (July 2014) . - p.571-582 Titre : Demographic and clinical correlates of autism symptom domains and autism spectrum diagnosis Type de document : Texte imprimé et/ou numérique Auteurs : Thomas W. FRAZIER, Auteur ; Eric A. YOUNGSTROM, Auteur ; Rebecca EMBACHER, Auteur ; Antonio Y. HARDAN, Auteur ; John N. CONSTANTINO, Auteur ; Paul LAW, Auteur ; Robert L. FINDLING, Auteur ; Charis ENG, Auteur Article en page(s) : p.571-582 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  autism symptoms  diagnosis  prediction Index. décimale : PER Périodiques Résumé : Demographic and clinical factors may influence assessment of autism symptoms. This study evaluated these correlates and also examined whether social communication and interaction and restricted/repetitive behavior provided unique prediction of autism spectrum disorder diagnosis. We analyzed data from 7352 siblings included in the Interactive Autism Network registry. Social communication and interaction and restricted/repetitive behavior symptoms were obtained using caregiver-reports on the Social Responsiveness Scale. Demographic and clinical correlates were covariates in regression models predicting social communication and interaction and restricted/repetitive behavior symptoms. Logistic regression and receiver operating characteristic curve analyses evaluated the incremental validity of social communication and interaction and restricted/repetitive behavior domains over and above global autism symptoms. Autism spectrum disorder diagnosis was the strongest correlate of caregiver-reported social communication and interaction and restricted/repetitive behavior symptoms. The presence of comorbid diagnoses also increased symptom levels. Social communication and interaction and restricted/repetitive behavior symptoms provided significant, but modest, incremental validity in predicting diagnosis beyond global autism symptoms. These findings suggest that autism spectrum disorder diagnosis is by far the largest determinant of quantitatively measured autism symptoms. Externalizing (attention deficit hyperactivity disorder) and internalizing (anxiety) behavior, low cognitive ability, and demographic factors may confound caregiver-report of autism symptoms, potentially necessitating a continuous norming approach to the revision of symptom measures. Social communication and interaction and restricted/repetitive behavior symptoms may provide incremental validity in the diagnosis of autism spectrum disorder. En ligne : http://dx.doi.org/10.1177/1362361313481506 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=2339 [article] Demographic and clinical correlates of autism symptom domains and autism spectrum diagnosis [Texte imprimé et/ou numérique] / Thomas W. FRAZIER, Auteur ; Eric A. YOUNGSTROM, Auteur ; Rebecca EMBACHER, Auteur ; Antonio Y. HARDAN, Auteur ; John N. CONSTANTINO, Auteur ; Paul LAW, Auteur ; Robert L. FINDLING, Auteur ; Charis ENG, Auteur . - p.571-582. Langues : Anglais (eng) in Autism > 18-5 (July 2014) . - p.571-582 Mots-clés : autism spectrum disorder  autism symptoms  diagnosis  prediction Index. décimale : PER Périodiques Résumé : Demographic and clinical factors may influence assessment of autism symptoms. This study evaluated these correlates and also examined whether social communication and interaction and restricted/repetitive behavior provided unique prediction of autism spectrum disorder diagnosis. We analyzed data from 7352 siblings included in the Interactive Autism Network registry. Social communication and interaction and restricted/repetitive behavior symptoms were obtained using caregiver-reports on the Social Responsiveness Scale. Demographic and clinical correlates were covariates in regression models predicting social communication and interaction and restricted/repetitive behavior symptoms. Logistic regression and receiver operating characteristic curve analyses evaluated the incremental validity of social communication and interaction and restricted/repetitive behavior domains over and above global autism symptoms. Autism spectrum disorder diagnosis was the strongest correlate of caregiver-reported social communication and interaction and restricted/repetitive behavior symptoms. The presence of comorbid diagnoses also increased symptom levels. Social communication and interaction and restricted/repetitive behavior symptoms provided significant, but modest, incremental validity in predicting diagnosis beyond global autism symptoms. These findings suggest that autism spectrum disorder diagnosis is by far the largest determinant of quantitatively measured autism symptoms. Externalizing (attention deficit hyperactivity disorder) and internalizing (anxiety) behavior, low cognitive ability, and demographic factors may confound caregiver-report of autism symptoms, potentially necessitating a continuous norming approach to the revision of symptom measures. Social communication and interaction and restricted/repetitive behavior symptoms may provide incremental validity in the diagnosis of autism spectrum disorder. En ligne : http://dx.doi.org/10.1177/1362361313481506 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=2339

Equivalence of symptom dimensions in females and males with autism / Thomas W. FRAZIER in Autism, 21-6 (August 2017)  

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Exploratory and Confirmatory Factor Analysis of the Autism Diagnostic Interview-Revised / Thomas W. FRAZIER in Journal of Autism and Developmental Disorders, 38-3 (March 2008)  

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Pivotal Response Treatment Parent Training for Autism: Findings from a 3-Month Follow-Up Evaluation / Grace W. GENGOUX in Journal of Autism and Developmental Disorders, 45-9 (September 2015)  

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Psychometric evaluation of the revised child and family quality of life questionnaire (CFQL-2) / Thomas W. FRAZIER in Research in Autism Spectrum Disorders, 70 (February 2020)  

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Quantitative autism symptom patterns recapitulate differential mechanisms of genetic transmission in single and multiple incidence families / Thomas W. FRAZIER in Molecular Autism, (October 2015)  

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A randomized controlled trial of Pivotal Response Treatment Group for parents of children with autism / Antonio Y. HARDAN in Journal of Child Psychology and Psychiatry, 56-8 (August 2015)  

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A Twin Study of Heritable and Shared Environmental Contributions to Autism / Thomas W. FRAZIER in Journal of Autism and Developmental Disorders, 44-8 (August 2014)  

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A Two-Year Longitudinal MRI Study of the Corpus Callosum in Autism / Thomas W. FRAZIER in Journal of Autism and Developmental Disorders, 42-11 (November 2012)  

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Understanding the heterogeneity of anxiety in autistic youth: A person-centered approach / Emily SPACKMAN in Autism Research, 15-9 (September 2022)  

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