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Auteur Jie WU |
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Association between MTHFR Gene Polymorphisms and the Risk of Autism Spectrum Disorders: A Meta-Analysis / Danhua PU in Autism Research, 6-5 (October 2013)
[article]
Titre : Association between MTHFR Gene Polymorphisms and the Risk of Autism Spectrum Disorders: A Meta-Analysis Type de document : Texte imprimé et/ou numérique Auteurs : Danhua PU, Auteur ; Yiping SHEN, Auteur ; Jie WU, Auteur Article en page(s) : p.384-392 Langues : Anglais (eng) Mots-clés : methylenetetrahydrofolate reductase polymorphism autism spectrum disorders folic acidl meta-analysis Index. décimale : PER Périodiques Résumé : Methylenetetrahydrofolate reductase (MTHFR) is essential for DNA biosynthesis and the epigenetic process of DNA methylation, and its gene polymorphisms have been implicated as risk factors for birth defects, neurological disorders, and cancers. However, reports on the association of MTHFR polymorphisms with autism spectrum disorders (ASD) are inconclusive. Therefore, we investigated the relationship of the MTHFR polymorphisms (C677T and A1298C) and the risk of ASD by meta-analysis. Up to December 2012, eight case-control studies involving 1672 patients with ASD and 6760 controls were included for meta-analysis. The results showed that the C677T polymorphism was associated with significantly increased ASD risk in all the comparison models [T vs. C allele (frequency of allele): odds ratio (OR)?=?1.42, 95% confidence interval (CI): 1.09–1.85; CT vs. CC (heterozygote): OR?=?1.48, 95% CI: 1.09–2.00; TT vs. CC (homozygote): OR?=?1.86, 95% CI: 1.08–3.20; CT+TT vs. CC (dominant model): OR?=?1.56, 95% CI: 1.12–2.18; and TT vs. CC+CT (recessive model): OR?=?1.51, 95% CI: 1.02–2.22], whereas the A1298C polymorphism was found to be significantly associated with reduced ASD risk but only in a recessive model (CC vs. AA+AC: OR?=?0.73, 95% CI: 0.56–0.97). In addition, we stratified the patient population based on whether they were from a country with food fortification of folic acid or not. The meta-analysis showed that the C677T polymorphism was found to be associated with ASD only in children from countries without food fortification. Our study indicated that the MTHFR C677T polymorphism contributes to increased ASD risk, and periconceptional folic acid may reduce ASD risk in those with MTHFR 677CT polymorphism. En ligne : http://dx.doi.org/10.1002/aur.1300 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=218
in Autism Research > 6-5 (October 2013) . - p.384-392[article] Association between MTHFR Gene Polymorphisms and the Risk of Autism Spectrum Disorders: A Meta-Analysis [Texte imprimé et/ou numérique] / Danhua PU, Auteur ; Yiping SHEN, Auteur ; Jie WU, Auteur . - p.384-392.
Langues : Anglais (eng)
in Autism Research > 6-5 (October 2013) . - p.384-392
Mots-clés : methylenetetrahydrofolate reductase polymorphism autism spectrum disorders folic acidl meta-analysis Index. décimale : PER Périodiques Résumé : Methylenetetrahydrofolate reductase (MTHFR) is essential for DNA biosynthesis and the epigenetic process of DNA methylation, and its gene polymorphisms have been implicated as risk factors for birth defects, neurological disorders, and cancers. However, reports on the association of MTHFR polymorphisms with autism spectrum disorders (ASD) are inconclusive. Therefore, we investigated the relationship of the MTHFR polymorphisms (C677T and A1298C) and the risk of ASD by meta-analysis. Up to December 2012, eight case-control studies involving 1672 patients with ASD and 6760 controls were included for meta-analysis. The results showed that the C677T polymorphism was associated with significantly increased ASD risk in all the comparison models [T vs. C allele (frequency of allele): odds ratio (OR)?=?1.42, 95% confidence interval (CI): 1.09–1.85; CT vs. CC (heterozygote): OR?=?1.48, 95% CI: 1.09–2.00; TT vs. CC (homozygote): OR?=?1.86, 95% CI: 1.08–3.20; CT+TT vs. CC (dominant model): OR?=?1.56, 95% CI: 1.12–2.18; and TT vs. CC+CT (recessive model): OR?=?1.51, 95% CI: 1.02–2.22], whereas the A1298C polymorphism was found to be significantly associated with reduced ASD risk but only in a recessive model (CC vs. AA+AC: OR?=?0.73, 95% CI: 0.56–0.97). In addition, we stratified the patient population based on whether they were from a country with food fortification of folic acid or not. The meta-analysis showed that the C677T polymorphism was found to be associated with ASD only in children from countries without food fortification. Our study indicated that the MTHFR C677T polymorphism contributes to increased ASD risk, and periconceptional folic acid may reduce ASD risk in those with MTHFR 677CT polymorphism. En ligne : http://dx.doi.org/10.1002/aur.1300 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=218