Abandoning ASD? A response to Waterhouse, London, and Gillberg / Ralph-Axel MULLER in Autism Research, 10-7 (July 2017)  

Public ISBD [article]  inAutism Research > 10-7 (July 2017) . - p.1183-1183 Titre : Abandoning ASD? A response to Waterhouse, London, and Gillberg Type de document : texte imprimé Auteurs : Ralph-Axel MULLER, Auteur Article en page(s) : p.1183-1183 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1833 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=309 [article] Abandoning ASD? A response to Waterhouse, London, and Gillberg [texte imprimé] / Ralph-Axel MULLER, Auteur . - p.1183-1183. Langues : Anglais (eng) in Autism Research > 10-7 (July 2017) . - p.1183-1183 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1833 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=309

Attentional networks in children and adolescents with autism spectrum disorder / Brandon KEEHN in Journal of Child Psychology and Psychiatry, 51-11 (November 2010)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 51-11 (November 2010) . - p.1251-1259 Titre : Attentional networks in children and adolescents with autism spectrum disorder Type de document : texte imprimé Auteurs : Brandon KEEHN, Auteur ; Alan J. LINCOLN, Auteur ; Ralph-Axel MULLER, Auteur ; Jeanne TOWNSEND, Auteur Année de publication : 2010 Article en page(s) : p.1251-1259 Langues : Anglais (eng) Mots-clés : Autism reaction-time visual-attention alerting orienting executive-control Index. décimale : PER Périodiques Résumé : Background:  Individuals diagnosed with autism spectrum disorder (ASD) exhibit lifelong abnormalities in the adaptive allocation of visual attention. The ubiquitous nature of attentional impairments in ASD has led some authors to hypothesize that atypical attentional modulation may be a factor in the development of higher-level sociocommunicative deficits. Method:  Participants were 20 children with ASD and 20 age- and Nonverbal IQ-matched typically developing (TD) children. We used the Attention Network Test (ANT) to investigate the efficiency and independence of three discrete attentional networks: alerting, orienting, and executive control. Additionally, we sought to investigate the relationship between each attentional network and measures of sociocommunicative symptom severity in children with ASD. Results:  Results indicate that the orienting, but not alerting or executive control, networks may be impaired in children with ASD. In contrast to TD children, correlational analyses suggest that the alerting and executive control networks may not function as independently in children with ASD. Additionally, an association was found between the alerting network and social impairment and between the executive control network and IQ in children with ASD. Conclusions:  The results provide further evidence of an impairment in the visuospatial orienting network in ASD and suggest that there may be greater interdependence of alerting and executive control networks in ASD. Furthermore, decreased ability to efficiently modulate levels of alertness was related to increased sociocommunicative deficits, suggesting that domain-general attentional function may be associated with ASD symptomatology. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02257.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=110 [article] Attentional networks in children and adolescents with autism spectrum disorder [texte imprimé] / Brandon KEEHN, Auteur ; Alan J. LINCOLN, Auteur ; Ralph-Axel MULLER, Auteur ; Jeanne TOWNSEND, Auteur . - 2010 . - p.1251-1259. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 51-11 (November 2010) . - p.1251-1259 Mots-clés : Autism reaction-time visual-attention alerting orienting executive-control Index. décimale : PER Périodiques Résumé : Background:  Individuals diagnosed with autism spectrum disorder (ASD) exhibit lifelong abnormalities in the adaptive allocation of visual attention. The ubiquitous nature of attentional impairments in ASD has led some authors to hypothesize that atypical attentional modulation may be a factor in the development of higher-level sociocommunicative deficits. Method:  Participants were 20 children with ASD and 20 age- and Nonverbal IQ-matched typically developing (TD) children. We used the Attention Network Test (ANT) to investigate the efficiency and independence of three discrete attentional networks: alerting, orienting, and executive control. Additionally, we sought to investigate the relationship between each attentional network and measures of sociocommunicative symptom severity in children with ASD. Results:  Results indicate that the orienting, but not alerting or executive control, networks may be impaired in children with ASD. In contrast to TD children, correlational analyses suggest that the alerting and executive control networks may not function as independently in children with ASD. Additionally, an association was found between the alerting network and social impairment and between the executive control network and IQ in children with ASD. Conclusions:  The results provide further evidence of an impairment in the visuospatial orienting network in ASD and suggest that there may be greater interdependence of alerting and executive control networks in ASD. Furthermore, decreased ability to efficiently modulate levels of alertness was related to increased sociocommunicative deficits, suggesting that domain-general attentional function may be associated with ASD symptomatology. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02257.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=110

Brain network organization in ASD. Evidence from functional and diffusion weighted MRI / Ralph-Axel MULLER

Public ISBD in Autism imaging and Devices / Manuel F. CASANOVA Titre : Brain network organization in ASD. Evidence from functional and diffusion weighted MRI Type de document : texte imprimé Auteurs : Ralph-Axel MULLER, Auteur ; Ruth A. CARPER, Auteur Importance : p.287-318 Langues : Anglais (eng) Index. décimale : SCI-D SCI-D - Neurosciences Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=382 in Autism imaging and Devices / Manuel F. CASANOVA Brain network organization in ASD. Evidence from functional and diffusion weighted MRI [texte imprimé] / Ralph-Axel MULLER, Auteur ; Ruth A. CARPER, Auteur . - [s.d.] . - p.287-318. Langues : Anglais (eng) Index. décimale : SCI-D SCI-D - Neurosciences Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=382

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Brief Report: Eye-Movement Patterns During an Embedded Figures Test in Children with ASD / Brandon KEEHN in Journal of Autism and Developmental Disorders, 39-2 (February 2009)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 39-2 (February 2009) . - p.383-387 Titre : Brief Report: Eye-Movement Patterns During an Embedded Figures Test in Children with ASD Type de document : texte imprimé Auteurs : Brandon KEEHN, Auteur ; Alan J. LINCOLN, Auteur ; Laurie A. BRENNER, Auteur ; Ralph-Axel MULLER, Auteur ; Aurora I. RAMOS, Auteur ; Sandra P. MARSHALL, Auteur Année de publication : 2009 Article en page(s) : p.383-387 Langues : Anglais (eng) Mots-clés : Autism Reaction-time Visual-attention Visual-perception Eye-movement Eye-fixation Index. décimale : PER Périodiques Résumé : The present study examined fixation frequency and duration during an Embedded Figures Test (EFT) in an effort to better understand the attentional and perceptual processes by which individuals with autism spectrum disorder (ASD) achieve accelerated EFT performance. In particular, we aimed to elucidate differences in the patterns of eye-movement in ASD and typically developing (TD) children, thus providing evidence relevant to the competing theories of weak central coherence (WCC) and enhanced perceptual functioning. Consistent with prior EFT studies, we found accelerated response time (RT) in children with ASD. No group differences were seen for fixation frequency, but the ASD group made significantly shorter fixations compared to the TD group. Eye-movement results indicate that RT advantage in ASD is related to both WCC and enhanced perceptual functioning. En ligne : http://dx.doi.org/10.1007/s10803-008-0608-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=684 [article] Brief Report: Eye-Movement Patterns During an Embedded Figures Test in Children with ASD [texte imprimé] / Brandon KEEHN, Auteur ; Alan J. LINCOLN, Auteur ; Laurie A. BRENNER, Auteur ; Ralph-Axel MULLER, Auteur ; Aurora I. RAMOS, Auteur ; Sandra P. MARSHALL, Auteur . - 2009 . - p.383-387. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 39-2 (February 2009) . - p.383-387 Mots-clés : Autism Reaction-time Visual-attention Visual-perception Eye-movement Eye-fixation Index. décimale : PER Périodiques Résumé : The present study examined fixation frequency and duration during an Embedded Figures Test (EFT) in an effort to better understand the attentional and perceptual processes by which individuals with autism spectrum disorder (ASD) achieve accelerated EFT performance. In particular, we aimed to elucidate differences in the patterns of eye-movement in ASD and typically developing (TD) children, thus providing evidence relevant to the competing theories of weak central coherence (WCC) and enhanced perceptual functioning. Consistent with prior EFT studies, we found accelerated response time (RT) in children with ASD. No group differences were seen for fixation frequency, but the ASD group made significantly shorter fixations compared to the TD group. Eye-movement results indicate that RT advantage in ASD is related to both WCC and enhanced perceptual functioning. En ligne : http://dx.doi.org/10.1007/s10803-008-0608-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=684

Decreased BOLD Signal Variability in Middle-Aged and Older Adults on the Autism Spectrum / Stephanie PEDRAHITA in Autism Research, 19-4 (April 2026)  

Public ISBD [article]  inAutism Research > 19-4 (April 2026) . - e70208 Titre : Decreased BOLD Signal Variability in Middle-Aged and Older Adults on the Autism Spectrum Type de document : texte imprimé Auteurs : Stephanie PEDRAHITA, Auteur ; Annika LINKE, Auteur ; Michaela CORDOVA, Auteur ; Molly WILKINSON, Auteur ; Janice HAU, Auteur ; Gioia TORO, Auteur ; Kalekirstos ALEMU, Auteur ; Jiwandeep KOHLI, Auteur ; Ralph-Axel MULLER, Auteur ; Ruth CARPER, Auteur Article en page(s) : e70208 Langues : Anglais (eng) Mots-clés : aging  autism spectrum disorder  bold signal variability  development  resting state fMRI Index. décimale : PER Périodiques Résumé : ABSTRACT Autism spectrum disorder (ASD) is a lifelong neurodevelopmental disorder. Preliminary evidence suggests an increased risk for early-onset cognitive and neurological decline in ASD. While brain development in children, adolescents, and young adults with ASD diverges from neurotypical (NT) peers, it remains unclear in older adults with ASD. Understanding age-related changes of brain function in ASD is crucial to establish best practices for cognitive and health screenings and develop interventions that might reduce the risk of accelerated decline. Decreases in blood-oxygenation-level-dependent (BOLD) signal variability (BSV) in typical aging have been shown across multiple studies and are associated with poorer cognitive performance. We hypothesized that adults with ASD would show reduced BSV compared to the NT group, with steeper negative age associations in the ASD than NT group. The study assessed BSV during resting state fMRI in adults (40?70?years), 28 with ASD and 39 age-matched NT. General linear models tested diagnostic group, age, and group-by-age interactions, controlling for motion. Significant group-by-age interactions were observed for the right insular, left temporal occipital fusiform, right frontal orbital, and right inferior lateral occipital cortex, with BSV showing strong negative associations with age in the ASD but not NT adults. These findings suggest that BSV decreases may occur earlier in adults with ASD compared to their NT peers. This would be consistent with accelerated aging; however, additional longitudinal analyses are necessary to determine if the results presented truly reflect accelerated aging or arise from lifelong persistent differences in brain function. En ligne : https://doi.org/10.1002/aur.70208 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585 [article] Decreased BOLD Signal Variability in Middle-Aged and Older Adults on the Autism Spectrum [texte imprimé] / Stephanie PEDRAHITA, Auteur ; Annika LINKE, Auteur ; Michaela CORDOVA, Auteur ; Molly WILKINSON, Auteur ; Janice HAU, Auteur ; Gioia TORO, Auteur ; Kalekirstos ALEMU, Auteur ; Jiwandeep KOHLI, Auteur ; Ralph-Axel MULLER, Auteur ; Ruth CARPER, Auteur . - e70208. Langues : Anglais (eng) in Autism Research > 19-4 (April 2026) . - e70208 Mots-clés : aging  autism spectrum disorder  bold signal variability  development  resting state fMRI Index. décimale : PER Périodiques Résumé : ABSTRACT Autism spectrum disorder (ASD) is a lifelong neurodevelopmental disorder. Preliminary evidence suggests an increased risk for early-onset cognitive and neurological decline in ASD. While brain development in children, adolescents, and young adults with ASD diverges from neurotypical (NT) peers, it remains unclear in older adults with ASD. Understanding age-related changes of brain function in ASD is crucial to establish best practices for cognitive and health screenings and develop interventions that might reduce the risk of accelerated decline. Decreases in blood-oxygenation-level-dependent (BOLD) signal variability (BSV) in typical aging have been shown across multiple studies and are associated with poorer cognitive performance. We hypothesized that adults with ASD would show reduced BSV compared to the NT group, with steeper negative age associations in the ASD than NT group. The study assessed BSV during resting state fMRI in adults (40?70?years), 28 with ASD and 39 age-matched NT. General linear models tested diagnostic group, age, and group-by-age interactions, controlling for motion. Significant group-by-age interactions were observed for the right insular, left temporal occipital fusiform, right frontal orbital, and right inferior lateral occipital cortex, with BSV showing strong negative associations with age in the ASD but not NT adults. These findings suggest that BSV decreases may occur earlier in adults with ASD compared to their NT peers. This would be consistent with accelerated aging; however, additional longitudinal analyses are necessary to determine if the results presented truly reflect accelerated aging or arise from lifelong persistent differences in brain function. En ligne : https://doi.org/10.1002/aur.70208 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585

Editorial: Time to give up on Autism Spectrum Disorder? / Ralph-Axel MULLER in Autism Research, 10-1 (January 2017)  

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Eye Movement and Visual Search: Are There Elementary Abnormalities in Autism? / Laurie A. BRENNER in Journal of Autism and Developmental Disorders, 37-7 (August 2007)  

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Functional connectivity within an anxiety network and associations with anxiety symptom severity in middle-aged adults with and without autism / Ryan TUNG in Autism Research, 14-10 (October 2021)  

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Greater functional connectivity between sensory networks is related to symptom severity in toddlers with autism spectrum disorder / Bosi CHEN in Journal of Child Psychology and Psychiatry, 62-2 (February 2021)  

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Impaired downregulation of visual cortex during auditory processing is associated with autism symptomatology in children and adolescents with autism spectrum disorder / R. Joanne JAO KEEHN in Autism Research, 10-1 (January 2017)  

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Sensory Symptoms and Processing of Nonverbal Auditory and Visual Stimuli in Children with Autism Spectrum Disorder / Claire R. STEWART in Journal of Autism and Developmental Disorders, 46-5 (May 2016)  

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Sex-related patterns of intrinsic functional connectivity in children and adolescents with autism spectrum disorders / Lindsay OLSON in Autism, 24-8 (November 2020)  

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The Influence of Task Difficulty and Participant Age on Balance Control in ASD / Sarah A. GRAHAM in Journal of Autism and Developmental Disorders, 45-5 (May 2015)  

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The language network in autism: Atypical functional connectivity with default mode and visual regions / Yangfeifei GAO in Autism Research, 12-9 (September 2019)  

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Tract-specific analyses of diffusion tensor imaging show widespread white matter compromise in autism spectrum disorder / Dinesh K. SHUKLA in Journal of Child Psychology and Psychiatry, 52-3 (March 2011)  

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