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Détail de l'auteur
Auteur Gerhard S. HELLEMANN |
Documents disponibles écrits par cet auteur (2)
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Predictive Value of Morphological Features in Patients with Autism versus Normal Controls / Heval M. OZGEN in Journal of Autism and Developmental Disorders, 43-1 (January 2013)
[article]
Titre : Predictive Value of Morphological Features in Patients with Autism versus Normal Controls Type de document : Texte imprimé et/ou numérique Auteurs : Heval M. OZGEN, Auteur ; Gerhard S. HELLEMANN, Auteur ; M. V. JONGE, Auteur ; Frits A. BEEMER, Auteur ; Herman VAN ENGELAND, Auteur Article en page(s) : p.147-155 Langues : Anglais (eng) Mots-clés : Autism Common variant Endophenotype Morphology Minor anomaly Predictive value ROC Recursive partitioning Index. décimale : PER Périodiques Résumé : We investigated the predictive power of morphological features in 224 autistic patients and 224 matched-pairs controls. To assess the relationship between the morphological features and autism, we used the receiver operator curves (ROC). In addition, we used recursive partitioning (RP) to determine a specific pattern of abnormalities that is characteristic for the difference between autistic children and typically developing controls. The present findings showed that morphological features are significantly increased in patients with autism. Using ROC and RP, some of the morphological measures also led to strong predictive accuracy. Facial asymmetry, multiple hair whorls and prominent forehead significantly differentiated patients with autism from controls. Future research on multivariable risk prediction models may benefit from the use of morphological features. En ligne : http://dx.doi.org/10.1007/s10803-012-1554-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=187
in Journal of Autism and Developmental Disorders > 43-1 (January 2013) . - p.147-155[article] Predictive Value of Morphological Features in Patients with Autism versus Normal Controls [Texte imprimé et/ou numérique] / Heval M. OZGEN, Auteur ; Gerhard S. HELLEMANN, Auteur ; M. V. JONGE, Auteur ; Frits A. BEEMER, Auteur ; Herman VAN ENGELAND, Auteur . - p.147-155.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 43-1 (January 2013) . - p.147-155
Mots-clés : Autism Common variant Endophenotype Morphology Minor anomaly Predictive value ROC Recursive partitioning Index. décimale : PER Périodiques Résumé : We investigated the predictive power of morphological features in 224 autistic patients and 224 matched-pairs controls. To assess the relationship between the morphological features and autism, we used the receiver operator curves (ROC). In addition, we used recursive partitioning (RP) to determine a specific pattern of abnormalities that is characteristic for the difference between autistic children and typically developing controls. The present findings showed that morphological features are significantly increased in patients with autism. Using ROC and RP, some of the morphological measures also led to strong predictive accuracy. Facial asymmetry, multiple hair whorls and prominent forehead significantly differentiated patients with autism from controls. Future research on multivariable risk prediction models may benefit from the use of morphological features. En ligne : http://dx.doi.org/10.1007/s10803-012-1554-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=187 Two to Ten Years: Developmental Trajectories of Joint Attention in Children With ASD Who Received Targeted Social Communication Interventions / Amanda C. GULSRUD in Autism Research, 7-2 (April 2014)
[article]
Titre : Two to Ten Years: Developmental Trajectories of Joint Attention in Children With ASD Who Received Targeted Social Communication Interventions Type de document : Texte imprimé et/ou numérique Auteurs : Amanda C. GULSRUD, Auteur ; Gerhard S. HELLEMANN, Auteur ; Stephanny FREEMAN, Auteur ; Connie KASARI, Auteur Article en page(s) : p.207-215 Mots-clés : early intervention social communication joint attention longitudinal Index. décimale : PER Périodiques Résumé : This study follows 40 children who were participants in a randomized controlled early intervention trial (Kasari et?al.) from early childhood (2–5 years of age) to elementary school age (8–10 years). To fully utilize the available longitudinal data, the general linear mixed model was the primary analytical approach. The growth trajectories of joint attention skills (pointing, coordinated joint looking, and showing) and expressive language outcomes in these children were estimated based on five time points during the measurement period. The children were grouped by diagnosis at the last follow-up (autism, autism spectrum disorder (ASD), no diagnosis) and by their original treatment group assignment (joint attention, symbolic play, control), and differences between these groups were evaluated. Results showed that joint attention skills of coordinated joint looking and showing increased over time, and pointing to share interest increased over the first year measured and decreased thereafter. These trajectories were influenced by both original treatment assignment and diagnostic status at follow-up. In addition, a cross-lagged panel analysis revealed a causal relationship between early pointing and later language development. This study highlights the longitudinal and developmental importance of measures of early core deficits in autism, and suggests that both treatment and ASD symptomatology may influence growth in these skills over time. En ligne : http://dx.doi.org/10.1002/aur.1360 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=230
in Autism Research > 7-2 (April 2014) . - p.207-215[article] Two to Ten Years: Developmental Trajectories of Joint Attention in Children With ASD Who Received Targeted Social Communication Interventions [Texte imprimé et/ou numérique] / Amanda C. GULSRUD, Auteur ; Gerhard S. HELLEMANN, Auteur ; Stephanny FREEMAN, Auteur ; Connie KASARI, Auteur . - p.207-215.
in Autism Research > 7-2 (April 2014) . - p.207-215
Mots-clés : early intervention social communication joint attention longitudinal Index. décimale : PER Périodiques Résumé : This study follows 40 children who were participants in a randomized controlled early intervention trial (Kasari et?al.) from early childhood (2–5 years of age) to elementary school age (8–10 years). To fully utilize the available longitudinal data, the general linear mixed model was the primary analytical approach. The growth trajectories of joint attention skills (pointing, coordinated joint looking, and showing) and expressive language outcomes in these children were estimated based on five time points during the measurement period. The children were grouped by diagnosis at the last follow-up (autism, autism spectrum disorder (ASD), no diagnosis) and by their original treatment group assignment (joint attention, symbolic play, control), and differences between these groups were evaluated. Results showed that joint attention skills of coordinated joint looking and showing increased over time, and pointing to share interest increased over the first year measured and decreased thereafter. These trajectories were influenced by both original treatment assignment and diagnostic status at follow-up. In addition, a cross-lagged panel analysis revealed a causal relationship between early pointing and later language development. This study highlights the longitudinal and developmental importance of measures of early core deficits in autism, and suggests that both treatment and ASD symptomatology may influence growth in these skills over time. En ligne : http://dx.doi.org/10.1002/aur.1360 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=230