Maternal prepregnancy body mass index and offspring attention-deficit/hyperactivity disorder: a quasi-experimental sibling-comparison, population-based design / Erica D. MUSSER in Journal of Child Psychology and Psychiatry, 58-3 (March 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-3 (March 2017) . - p.240-247 Titre : Maternal prepregnancy body mass index and offspring attention-deficit/hyperactivity disorder: a quasi-experimental sibling-comparison, population-based design Type de document : Texte imprimé et/ou numérique Auteurs : Erica D. MUSSER, Auteur ; Michael T. WILLOUGHBY, Auteur ; Suzanne WRIGHT, Auteur ; Elinor L. SULLIVAN, Auteur ; Diane D. STADLER, Auteur ; Brent F. OLSON, Auteur ; Robert D. STEINER, Auteur ; Joel T. NIGG, Auteur Article en page(s) : p.240-247 Langues : Anglais (eng) Mots-clés : Attention-deficit/hyperactivity disorder  maternal BMI  quasi-experimental design Index. décimale : PER Périodiques Résumé : Background High maternal prepregnancy body mass index (BMI) has been associated with increased risk of offspring attention-deficit/hyperactivity disorder (ADHD). However, whether this effect is attributable to maternal or familial level confounds has been little examined. Methods The present study sought to examine these associations, utilizing data from the medical records of a health care system which treats 350,000 patients annually and a sibling-comparison design in a sample of 4,682 children born to 3,645 mothers. Results When examining the overall maternal effect, a linear association was observed between maternal prepregnancy BMI and child ADHD [b = 0.04, 95% confidence interval (95% CI) = 0.02–0.06, p = .0003], such that a one-unit (i.e. 1 kg/m2) increase in prepregnancy BMI was associated with a 4% increase in the odds of ADHD (exp b = 1.04). However, when the model was reparameterized to take full advantage of the sibling design to allow for the examination of both maternal and child-specific effects, the child-specific prepregnancy BMI effect was not reliably different from zero (b = ?0.08, 95% CI = ?0.23 to 0.06, p = .24). In contrast, at the maternal-level, average prepregnancy BMI was a reliably non-zero predictor of child ADHD (b = 0.04, 95% CI = 0.02–0.06, p < .0001) with each one-unit increase in maternal prepregnancy BMI associated with a 4.2% increase in the odds of ADHD (exp b = 1.04, 95% CI = 1.02–1.06). Conclusions The association between maternal prepregnancy BMI and offspring ADHD may be better accounted for by familial or maternal confounds rather than a direct causal effect of BMI. En ligne : http://dx.doi.org/10.1111/jcpp.12662 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303 [article] Maternal prepregnancy body mass index and offspring attention-deficit/hyperactivity disorder: a quasi-experimental sibling-comparison, population-based design [Texte imprimé et/ou numérique] / Erica D. MUSSER, Auteur ; Michael T. WILLOUGHBY, Auteur ; Suzanne WRIGHT, Auteur ; Elinor L. SULLIVAN, Auteur ; Diane D. STADLER, Auteur ; Brent F. OLSON, Auteur ; Robert D. STEINER, Auteur ; Joel T. NIGG, Auteur . - p.240-247. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-3 (March 2017) . - p.240-247 Mots-clés : Attention-deficit/hyperactivity disorder  maternal BMI  quasi-experimental design Index. décimale : PER Périodiques Résumé : Background High maternal prepregnancy body mass index (BMI) has been associated with increased risk of offspring attention-deficit/hyperactivity disorder (ADHD). However, whether this effect is attributable to maternal or familial level confounds has been little examined. Methods The present study sought to examine these associations, utilizing data from the medical records of a health care system which treats 350,000 patients annually and a sibling-comparison design in a sample of 4,682 children born to 3,645 mothers. Results When examining the overall maternal effect, a linear association was observed between maternal prepregnancy BMI and child ADHD [b = 0.04, 95% confidence interval (95% CI) = 0.02–0.06, p = .0003], such that a one-unit (i.e. 1 kg/m2) increase in prepregnancy BMI was associated with a 4% increase in the odds of ADHD (exp b = 1.04). However, when the model was reparameterized to take full advantage of the sibling design to allow for the examination of both maternal and child-specific effects, the child-specific prepregnancy BMI effect was not reliably different from zero (b = ?0.08, 95% CI = ?0.23 to 0.06, p = .24). In contrast, at the maternal-level, average prepregnancy BMI was a reliably non-zero predictor of child ADHD (b = 0.04, 95% CI = 0.02–0.06, p < .0001) with each one-unit increase in maternal prepregnancy BMI associated with a 4.2% increase in the odds of ADHD (exp b = 1.04, 95% CI = 1.02–1.06). Conclusions The association between maternal prepregnancy BMI and offspring ADHD may be better accounted for by familial or maternal confounds rather than a direct causal effect of BMI. En ligne : http://dx.doi.org/10.1111/jcpp.12662 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303

Shared familial transmission of autism spectrum and attention-deficit/hyperactivity disorders / Erica D. MUSSER in Journal of Child Psychology and Psychiatry, 55-7 (July 2014)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 55-7 (July 2014) . - p.819-827 Titre : Shared familial transmission of autism spectrum and attention-deficit/hyperactivity disorders Type de document : Texte imprimé et/ou numérique Auteurs : Erica D. MUSSER, Auteur ; Elizabeth HAWKEY, Auteur ; Svetlana S. KACHAN-LIU, Auteur ; Paul LEES, Auteur ; Jean-Baptiste ROULLET, Auteur ; Katrina GODDARD, Auteur ; Robert D. STEINER, Auteur ; Joel T. NIGG, Auteur Article en page(s) : p.819-827 Langues : Anglais (eng) Mots-clés : Attention-deficit/hyperactivity disorder  autism spectrum disorder  shared familial transmission Index. décimale : PER Périodiques Résumé : Background To determine whether familial transmission is shared between autism spectrum disorders and attention-deficit/hyperactivity disorder, we assessed the prevalence, rates of comorbidity, and familial transmission of both disorders in a large population-based sample of children during a recent 7 year period. Methods Study participants included all children born to parents with the Kaiser Permanente Northwest (KPNW) Health Plan between 1 January 1998 and 31 December 2004 (n = 35,073). Children and mothers with physician-identified autism spectrum disorders (ASD) and/or attention-deficit/hyperactivity disorder (ADHD) were identified via electronic medical records maintained for all KPNW members. Results Among children aged 6–12 years, prevalence was 2.0% for ADHD and 0.8% for ASD; within those groups, 0.2% of the full sample (19% of the ASD sample and 9.6% of the ADHD sample) had co-occurring ASD and ADHD, when all children were included. When mothers had a diagnosis of ADHD, first born offspring were at 6-fold risk of ADHD alone (OR = 5.02, p .0001) and at 2.5-fold risk of ASD alone (OR = 2.52, p .01). Results were not accounted for by maternal age, child gestational age, child gender, and child race. Conclusions Autism spectrum disorders shares familial transmission with ADHD. ADHD and ASD have a partially overlapping diathesis. En ligne : http://dx.doi.org/10.1111/jcpp.12201 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=235 [article] Shared familial transmission of autism spectrum and attention-deficit/hyperactivity disorders [Texte imprimé et/ou numérique] / Erica D. MUSSER, Auteur ; Elizabeth HAWKEY, Auteur ; Svetlana S. KACHAN-LIU, Auteur ; Paul LEES, Auteur ; Jean-Baptiste ROULLET, Auteur ; Katrina GODDARD, Auteur ; Robert D. STEINER, Auteur ; Joel T. NIGG, Auteur . - p.819-827. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 55-7 (July 2014) . - p.819-827 Mots-clés : Attention-deficit/hyperactivity disorder  autism spectrum disorder  shared familial transmission Index. décimale : PER Périodiques Résumé : Background To determine whether familial transmission is shared between autism spectrum disorders and attention-deficit/hyperactivity disorder, we assessed the prevalence, rates of comorbidity, and familial transmission of both disorders in a large population-based sample of children during a recent 7 year period. Methods Study participants included all children born to parents with the Kaiser Permanente Northwest (KPNW) Health Plan between 1 January 1998 and 31 December 2004 (n = 35,073). Children and mothers with physician-identified autism spectrum disorders (ASD) and/or attention-deficit/hyperactivity disorder (ADHD) were identified via electronic medical records maintained for all KPNW members. Results Among children aged 6–12 years, prevalence was 2.0% for ADHD and 0.8% for ASD; within those groups, 0.2% of the full sample (19% of the ASD sample and 9.6% of the ADHD sample) had co-occurring ASD and ADHD, when all children were included. When mothers had a diagnosis of ADHD, first born offspring were at 6-fold risk of ADHD alone (OR = 5.02, p .0001) and at 2.5-fold risk of ASD alone (OR = 2.52, p .01). Results were not accounted for by maternal age, child gestational age, child gender, and child race. Conclusions Autism spectrum disorders shares familial transmission with ADHD. ADHD and ASD have a partially overlapping diathesis. En ligne : http://dx.doi.org/10.1111/jcpp.12201 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=235

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