Dépouillements

Developmental psychopathology in the post-genomics era – substantial challenges but reasons for hope / Jeffrey M. HALPERIN in Journal of Child Psychology and Psychiatry, 58-3 (March 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-3 (March 2017) . - p.219-221 Titre : Developmental psychopathology in the post-genomics era – substantial challenges but reasons for hope Type de document : Texte imprimé et/ou numérique Auteurs : Jeffrey M. HALPERIN, Auteur Article en page(s) : p.219-221 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : One only has to quickly look through the Table of Contents for this issue of JCPP to gain an appreciation of the ever-increasing influence of genetic research in the field of developmental psychopathology. Among the 13 articles in this issue that follow this editorial: two employ large family and/or twin studies to provide compelling behavioral genetic findings bolstering the importance of genes in the emergence of ADHD (Chen, Brikell, Lichtenstein, Serlachius, Kuja-Halkola, Sandin, and Larsson) and level of educational achievement in adolescents (Lewis, Asbury, and Plomin); one paper focuses on cortical development in patients with 22q11.2 deletion syndrome and its association with positive symptoms of psychosis (Radoeva, Bansal, Antshel, Fremont, Peterson, and Kates); a Commentary (Border and Keller) and Response to Commentary (Moore) debate the relative advantages and disadvantages of candidate gene versus genome-wide approaches to detecting certain genetic markers, particularly in relation to interactions with the environment; and two more focus on the identification of endophenotypes for autism spectrum disorders which will presumably facilitate the identification of genes for this complex disorder (Jones, Venema, Earl, Lowy, and Webb; Van Eylen, Boets, Cosemans, Peeters, Steyaert, Wagemans, and Noens). En ligne : http://dx.doi.org/10.1111/jcpp.12708 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303 [article] Developmental psychopathology in the post-genomics era – substantial challenges but reasons for hope [Texte imprimé et/ou numérique] / Jeffrey M. HALPERIN, Auteur . - p.219-221. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-3 (March 2017) . - p.219-221 Index. décimale : PER Périodiques Résumé : One only has to quickly look through the Table of Contents for this issue of JCPP to gain an appreciation of the ever-increasing influence of genetic research in the field of developmental psychopathology. Among the 13 articles in this issue that follow this editorial: two employ large family and/or twin studies to provide compelling behavioral genetic findings bolstering the importance of genes in the emergence of ADHD (Chen, Brikell, Lichtenstein, Serlachius, Kuja-Halkola, Sandin, and Larsson) and level of educational achievement in adolescents (Lewis, Asbury, and Plomin); one paper focuses on cortical development in patients with 22q11.2 deletion syndrome and its association with positive symptoms of psychosis (Radoeva, Bansal, Antshel, Fremont, Peterson, and Kates); a Commentary (Border and Keller) and Response to Commentary (Moore) debate the relative advantages and disadvantages of candidate gene versus genome-wide approaches to detecting certain genetic markers, particularly in relation to interactions with the environment; and two more focus on the identification of endophenotypes for autism spectrum disorders which will presumably facilitate the identification of genes for this complex disorder (Jones, Venema, Earl, Lowy, and Webb; Van Eylen, Boets, Cosemans, Peeters, Steyaert, Wagemans, and Noens). En ligne : http://dx.doi.org/10.1111/jcpp.12708 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303

Research Review: Neural response to threat in children, adolescents, and adults after child maltreatment – a quantitative meta-analysis / Tyler C. HEIN in Journal of Child Psychology and Psychiatry, 58-3 (March 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-3 (March 2017) . - p.222-230 Titre : Research Review: Neural response to threat in children, adolescents, and adults after child maltreatment – a quantitative meta-analysis Type de document : Texte imprimé et/ou numérique Auteurs : Tyler C. HEIN, Auteur ; Christopher S. MONK, Auteur Article en page(s) : p.222-230 Langues : Anglais (eng) Mots-clés : Maltreatment  meta-analysis  fMRI Index. décimale : PER Périodiques Résumé : Background Child maltreatment is common and has long-term consequences for affective function. Investigations of neural consequences of maltreatment have focused on the amygdala. However, developmental neuroscience indicates that other brain regions are also likely to be affected by child maltreatment, particularly in the social information processing network (SIPN). We conducted a quantitative meta-analysis to: confirm that maltreatment is related to greater bilateral amygdala activation in a large sample that was pooled across studies; investigate other SIPN structures that are likely candidates for altered function; and conduct a data-driven examination to identify additional regions that show altered activation in maltreated children, teens, and adults. Methods We conducted an activation likelihood estimation analysis with 1,733 participants across 20 studies of emotion processing in maltreated individuals. Results Maltreatment is associated with increased bilateral amygdala activation to emotional faces. One SIPN structure is altered: superior temporal gyrus, of the detection node, is hyperactive in maltreated individuals. The results of the whole-brain corrected analysis also show hyperactivation of the parahippocampal gyrus and insula in maltreated individuals. Conclusions The meta-analysis confirms that maltreatment is related to increased bilateral amygdala reactivity and also shows that maltreatment affects multiple additional structures in the brain that have received little attention in the literature. Thus, although the majority of studies examining maltreatment and brain function have focused on the amygdala, these findings indicate that the neural consequences of child maltreatment involve a broader network of structures. En ligne : http://dx.doi.org/10.1111/jcpp.12651 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303 [article] Research Review: Neural response to threat in children, adolescents, and adults after child maltreatment – a quantitative meta-analysis [Texte imprimé et/ou numérique] / Tyler C. HEIN, Auteur ; Christopher S. MONK, Auteur . - p.222-230. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-3 (March 2017) . - p.222-230 Mots-clés : Maltreatment  meta-analysis  fMRI Index. décimale : PER Périodiques Résumé : Background Child maltreatment is common and has long-term consequences for affective function. Investigations of neural consequences of maltreatment have focused on the amygdala. However, developmental neuroscience indicates that other brain regions are also likely to be affected by child maltreatment, particularly in the social information processing network (SIPN). We conducted a quantitative meta-analysis to: confirm that maltreatment is related to greater bilateral amygdala activation in a large sample that was pooled across studies; investigate other SIPN structures that are likely candidates for altered function; and conduct a data-driven examination to identify additional regions that show altered activation in maltreated children, teens, and adults. Methods We conducted an activation likelihood estimation analysis with 1,733 participants across 20 studies of emotion processing in maltreated individuals. Results Maltreatment is associated with increased bilateral amygdala activation to emotional faces. One SIPN structure is altered: superior temporal gyrus, of the detection node, is hyperactive in maltreated individuals. The results of the whole-brain corrected analysis also show hyperactivation of the parahippocampal gyrus and insula in maltreated individuals. Conclusions The meta-analysis confirms that maltreatment is related to increased bilateral amygdala reactivity and also shows that maltreatment affects multiple additional structures in the brain that have received little attention in the literature. Thus, although the majority of studies examining maltreatment and brain function have focused on the amygdala, these findings indicate that the neural consequences of child maltreatment involve a broader network of structures. En ligne : http://dx.doi.org/10.1111/jcpp.12651 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303

Familial aggregation of attention-deficit/hyperactivity disorder / Qi CHEN in Journal of Child Psychology and Psychiatry, 58-3 (March 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-3 (March 2017) . - p.231-239 Titre : Familial aggregation of attention-deficit/hyperactivity disorder Type de document : Texte imprimé et/ou numérique Auteurs : Qi CHEN, Auteur ; Isabell BRIKELL, Auteur ; Paul LICHTENSTEIN, Auteur ; Eva SERLACHIUS, Auteur ; Ralf KUJA-HALKOLA, Auteur ; Sven SANDIN, Auteur ; Henrik LARSSON, Auteur Article en page(s) : p.231-239 Langues : Anglais (eng) Mots-clés : Attention-deficit/hyperactivity disorder  diagnosis  family factor  sex differences  adulthood Index. décimale : PER Périodiques Résumé : Background Attention-deficit/hyperactivity disorder (ADHD) aggregates in families. To date, the strength, pattern, and characteristics of the familial aggregation have not been thoroughly assessed in a population-based family sample. Methods In this cohort study, we identified relative pairs of twins, full and half-siblings, and full and half cousins from 1,656,943 unique individuals born in Sweden between 1985 and 2006. The relatives of index persons were followed from their third birthday to 31 December 2009 for ADHD diagnosis. Birth year adjusted hazard ratio (HR), that is, the rate of ADHD in relatives of ADHD-affected index persons compared with the rate of ADHD in relatives of unaffected index persons, was estimated in the different types of relatives using Cox proportional hazards model. Results During the follow-up, 31,865 individuals were diagnosed with ADHD (male to female ratio was 3.7). The birth year adjusted HRs were as follows: 70.45 for monozygotic twins; 8.44 for dizygotic twins; 8.27 for full siblings; 2.86 for maternal half-siblings; 2.31 for paternal half-siblings; 2.24 for full cousins; 1.47 for half cousins. Maternal half-siblings had significantly higher HR than in paternal half-siblings. The HR did not seem to be affected by index person's sex. Full siblings of index persons with ADHD diagnosis present at age 18 or older had a higher rate of ADHD (HR: 11.49) than full siblings of index persons with ADHD diagnosis only before age 18 (HR: 4.68). Conclusions Familial aggregation of ADHD increases with increasing genetic relatedness. The familial aggregation is driven by not only genetic factors but also a small amount of shared environmental factors. Persistence of ADHD into adulthood indexes stronger familial aggregation of ADHD. En ligne : http://dx.doi.org/10.1111/jcpp.12616 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303 [article] Familial aggregation of attention-deficit/hyperactivity disorder [Texte imprimé et/ou numérique] / Qi CHEN, Auteur ; Isabell BRIKELL, Auteur ; Paul LICHTENSTEIN, Auteur ; Eva SERLACHIUS, Auteur ; Ralf KUJA-HALKOLA, Auteur ; Sven SANDIN, Auteur ; Henrik LARSSON, Auteur . - p.231-239. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-3 (March 2017) . - p.231-239 Mots-clés : Attention-deficit/hyperactivity disorder  diagnosis  family factor  sex differences  adulthood Index. décimale : PER Périodiques Résumé : Background Attention-deficit/hyperactivity disorder (ADHD) aggregates in families. To date, the strength, pattern, and characteristics of the familial aggregation have not been thoroughly assessed in a population-based family sample. Methods In this cohort study, we identified relative pairs of twins, full and half-siblings, and full and half cousins from 1,656,943 unique individuals born in Sweden between 1985 and 2006. The relatives of index persons were followed from their third birthday to 31 December 2009 for ADHD diagnosis. Birth year adjusted hazard ratio (HR), that is, the rate of ADHD in relatives of ADHD-affected index persons compared with the rate of ADHD in relatives of unaffected index persons, was estimated in the different types of relatives using Cox proportional hazards model. Results During the follow-up, 31,865 individuals were diagnosed with ADHD (male to female ratio was 3.7). The birth year adjusted HRs were as follows: 70.45 for monozygotic twins; 8.44 for dizygotic twins; 8.27 for full siblings; 2.86 for maternal half-siblings; 2.31 for paternal half-siblings; 2.24 for full cousins; 1.47 for half cousins. Maternal half-siblings had significantly higher HR than in paternal half-siblings. The HR did not seem to be affected by index person's sex. Full siblings of index persons with ADHD diagnosis present at age 18 or older had a higher rate of ADHD (HR: 11.49) than full siblings of index persons with ADHD diagnosis only before age 18 (HR: 4.68). Conclusions Familial aggregation of ADHD increases with increasing genetic relatedness. The familial aggregation is driven by not only genetic factors but also a small amount of shared environmental factors. Persistence of ADHD into adulthood indexes stronger familial aggregation of ADHD. En ligne : http://dx.doi.org/10.1111/jcpp.12616 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303

Maternal prepregnancy body mass index and offspring attention-deficit/hyperactivity disorder: a quasi-experimental sibling-comparison, population-based design / Erica D. MUSSER in Journal of Child Psychology and Psychiatry, 58-3 (March 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-3 (March 2017) . - p.240-247 Titre : Maternal prepregnancy body mass index and offspring attention-deficit/hyperactivity disorder: a quasi-experimental sibling-comparison, population-based design Type de document : Texte imprimé et/ou numérique Auteurs : Erica D. MUSSER, Auteur ; Michael T. WILLOUGHBY, Auteur ; Suzanne WRIGHT, Auteur ; Elinor L. SULLIVAN, Auteur ; Diane D. STADLER, Auteur ; Brent F. OLSON, Auteur ; Robert D. STEINER, Auteur ; Joel T. NIGG, Auteur Article en page(s) : p.240-247 Langues : Anglais (eng) Mots-clés : Attention-deficit/hyperactivity disorder  maternal BMI  quasi-experimental design Index. décimale : PER Périodiques Résumé : Background High maternal prepregnancy body mass index (BMI) has been associated with increased risk of offspring attention-deficit/hyperactivity disorder (ADHD). However, whether this effect is attributable to maternal or familial level confounds has been little examined. Methods The present study sought to examine these associations, utilizing data from the medical records of a health care system which treats 350,000 patients annually and a sibling-comparison design in a sample of 4,682 children born to 3,645 mothers. Results When examining the overall maternal effect, a linear association was observed between maternal prepregnancy BMI and child ADHD [b = 0.04, 95% confidence interval (95% CI) = 0.02–0.06, p = .0003], such that a one-unit (i.e. 1 kg/m2) increase in prepregnancy BMI was associated with a 4% increase in the odds of ADHD (exp b = 1.04). However, when the model was reparameterized to take full advantage of the sibling design to allow for the examination of both maternal and child-specific effects, the child-specific prepregnancy BMI effect was not reliably different from zero (b = ?0.08, 95% CI = ?0.23 to 0.06, p = .24). In contrast, at the maternal-level, average prepregnancy BMI was a reliably non-zero predictor of child ADHD (b = 0.04, 95% CI = 0.02–0.06, p < .0001) with each one-unit increase in maternal prepregnancy BMI associated with a 4.2% increase in the odds of ADHD (exp b = 1.04, 95% CI = 1.02–1.06). Conclusions The association between maternal prepregnancy BMI and offspring ADHD may be better accounted for by familial or maternal confounds rather than a direct causal effect of BMI. En ligne : http://dx.doi.org/10.1111/jcpp.12662 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303 [article] Maternal prepregnancy body mass index and offspring attention-deficit/hyperactivity disorder: a quasi-experimental sibling-comparison, population-based design [Texte imprimé et/ou numérique] / Erica D. MUSSER, Auteur ; Michael T. WILLOUGHBY, Auteur ; Suzanne WRIGHT, Auteur ; Elinor L. SULLIVAN, Auteur ; Diane D. STADLER, Auteur ; Brent F. OLSON, Auteur ; Robert D. STEINER, Auteur ; Joel T. NIGG, Auteur . - p.240-247. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-3 (March 2017) . - p.240-247 Mots-clés : Attention-deficit/hyperactivity disorder  maternal BMI  quasi-experimental design Index. décimale : PER Périodiques Résumé : Background High maternal prepregnancy body mass index (BMI) has been associated with increased risk of offspring attention-deficit/hyperactivity disorder (ADHD). However, whether this effect is attributable to maternal or familial level confounds has been little examined. Methods The present study sought to examine these associations, utilizing data from the medical records of a health care system which treats 350,000 patients annually and a sibling-comparison design in a sample of 4,682 children born to 3,645 mothers. Results When examining the overall maternal effect, a linear association was observed between maternal prepregnancy BMI and child ADHD [b = 0.04, 95% confidence interval (95% CI) = 0.02–0.06, p = .0003], such that a one-unit (i.e. 1 kg/m2) increase in prepregnancy BMI was associated with a 4% increase in the odds of ADHD (exp b = 1.04). However, when the model was reparameterized to take full advantage of the sibling design to allow for the examination of both maternal and child-specific effects, the child-specific prepregnancy BMI effect was not reliably different from zero (b = ?0.08, 95% CI = ?0.23 to 0.06, p = .24). In contrast, at the maternal-level, average prepregnancy BMI was a reliably non-zero predictor of child ADHD (b = 0.04, 95% CI = 0.02–0.06, p < .0001) with each one-unit increase in maternal prepregnancy BMI associated with a 4.2% increase in the odds of ADHD (exp b = 1.04, 95% CI = 1.02–1.06). Conclusions The association between maternal prepregnancy BMI and offspring ADHD may be better accounted for by familial or maternal confounds rather than a direct causal effect of BMI. En ligne : http://dx.doi.org/10.1111/jcpp.12662 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303

Evidence for increased behavioral control by punishment in children with attention-deficit hyperactivity disorder / Emi FURUKAWA in Journal of Child Psychology and Psychiatry, 58-3 (March 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-3 (March 2017) . - p.248-257 Titre : Evidence for increased behavioral control by punishment in children with attention-deficit hyperactivity disorder Type de document : Texte imprimé et/ou numérique Auteurs : Emi FURUKAWA, Auteur ; Brent ALSOP, Auteur ; Paula SOWERBY, Auteur ; Stephanie JENSEN, Auteur ; Gail TRIPP, Auteur Article en page(s) : p.248-257 Langues : Anglais (eng) Mots-clés : Attention-deficit hyperactivity disorder  punishment  response allocation  matching law Index. décimale : PER Périodiques Résumé : Background The behavioral sensitivity of children with ADHD to punishment has received limited theoretical and experimental attention. This study evaluated the effects of punishment on the response allocation of children with ADHD and typically developing children. Method Two hundred and ten children, 145 diagnosed with ADHD, completed an operant task in which they chose between playing two simultaneously available games. Reward was arranged symmetrically across the games under concurrent variable interval schedules. Asymmetric punishment schedules were superimposed; responses on one game were punished four times as often as responses on the other. Results Both groups allocated more of their responses to the less frequently punished alternative. Response bias increased significantly in the ADHD group during later trials, resulting in missed reward trials and reduced earnings. Conclusions Punishment exerted greater control over the response allocation of children with ADHD with increased time on task. Children with ADHD appear more sensitive to the cumulative effects of punishment than typically developing children. En ligne : http://dx.doi.org/10.1111/jcpp.12635 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303 [article] Evidence for increased behavioral control by punishment in children with attention-deficit hyperactivity disorder [Texte imprimé et/ou numérique] / Emi FURUKAWA, Auteur ; Brent ALSOP, Auteur ; Paula SOWERBY, Auteur ; Stephanie JENSEN, Auteur ; Gail TRIPP, Auteur . - p.248-257. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-3 (March 2017) . - p.248-257 Mots-clés : Attention-deficit hyperactivity disorder  punishment  response allocation  matching law Index. décimale : PER Périodiques Résumé : Background The behavioral sensitivity of children with ADHD to punishment has received limited theoretical and experimental attention. This study evaluated the effects of punishment on the response allocation of children with ADHD and typically developing children. Method Two hundred and ten children, 145 diagnosed with ADHD, completed an operant task in which they chose between playing two simultaneously available games. Reward was arranged symmetrically across the games under concurrent variable interval schedules. Asymmetric punishment schedules were superimposed; responses on one game were punished four times as often as responses on the other. Results Both groups allocated more of their responses to the less frequently punished alternative. Response bias increased significantly in the ADHD group during later trials, resulting in missed reward trials and reduced earnings. Conclusions Punishment exerted greater control over the response allocation of children with ADHD with increased time on task. Children with ADHD appear more sensitive to the cumulative effects of punishment than typically developing children. En ligne : http://dx.doi.org/10.1111/jcpp.12635 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303

Executive functioning and local-global visual processing: candidate endophenotypes for autism spectrum disorder? / Lien VAN EYLEN in Journal of Child Psychology and Psychiatry, 58-3 (March 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-3 (March 2017) . - p.258-269 Titre : Executive functioning and local-global visual processing: candidate endophenotypes for autism spectrum disorder? Type de document : Texte imprimé et/ou numérique Auteurs : Lien VAN EYLEN, Auteur ; Bart BOETS, Auteur ; Nele COSEMANS, Auteur ; Hilde PEETERS, Auteur ; Jean STEYAERT, Auteur ; Johan WAGEMANS, Auteur ; Ilse NOENS, Auteur Article en page(s) : p.258-269 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  relatives  intermediate phenotype  executive functioning  central coherence Index. décimale : PER Périodiques Résumé : Background Heterogeneity within autism spectrum disorder (ASD) hampers insight in the etiology and stimulates the search for endophenotypes. Endophenotypes should meet several criteria, the most important being the association with ASD and the higher occurrence rate in unaffected ASD relatives than in the general population. We evaluated these criteria for executive functioning (EF) and local-global (L-G) visual processing. Methods By administering an extensive cognitive battery which increases the validity of the measures, we examined which of the cognitive anomalies shown by ASD probands also occur in their unaffected relatives (n = 113) compared to typically developing (TD) controls (n = 100). Microarrays were performed, so we could exclude relatives from probands with a de novo mutation in a known ASD susceptibility copy number variant, thus increasing the probability that genetic risk variants are shared by the ASD relatives. An overview of studies investigating EF and L-G processing in ASD relatives was also provided. Results For EF, ASD relatives – like ASD probands – showed impairments in response inhibition, cognitive flexibility and generativity (specifically, ideational fluency), and EF impairments in daily life. For L-G visual processing, the ASD relatives showed no anomalies on the tasks, but they reported more attention to detail in daily life. Group differences were similar for siblings and for parents of ASD probands, and yielded larger effect sizes in a multiplex subsample. The group effect sizes for the comparison between ASD probands and TD individuals were generally larger than those of the ASD relatives compared to TD individuals. Conclusions Impaired cognitive flexibility, ideational fluency and response inhibition are strong candidate endophenotypes for ASD. They could help to delineate etiologically more homogeneous subgroups, which is clinically important to allow assigning ASD probands to different, more targeted, interventions. En ligne : http://dx.doi.org/10.1111/jcpp.12637 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303 [article] Executive functioning and local-global visual processing: candidate endophenotypes for autism spectrum disorder? [Texte imprimé et/ou numérique] / Lien VAN EYLEN, Auteur ; Bart BOETS, Auteur ; Nele COSEMANS, Auteur ; Hilde PEETERS, Auteur ; Jean STEYAERT, Auteur ; Johan WAGEMANS, Auteur ; Ilse NOENS, Auteur . - p.258-269. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-3 (March 2017) . - p.258-269 Mots-clés : Autism spectrum disorder  relatives  intermediate phenotype  executive functioning  central coherence Index. décimale : PER Périodiques Résumé : Background Heterogeneity within autism spectrum disorder (ASD) hampers insight in the etiology and stimulates the search for endophenotypes. Endophenotypes should meet several criteria, the most important being the association with ASD and the higher occurrence rate in unaffected ASD relatives than in the general population. We evaluated these criteria for executive functioning (EF) and local-global (L-G) visual processing. Methods By administering an extensive cognitive battery which increases the validity of the measures, we examined which of the cognitive anomalies shown by ASD probands also occur in their unaffected relatives (n = 113) compared to typically developing (TD) controls (n = 100). Microarrays were performed, so we could exclude relatives from probands with a de novo mutation in a known ASD susceptibility copy number variant, thus increasing the probability that genetic risk variants are shared by the ASD relatives. An overview of studies investigating EF and L-G processing in ASD relatives was also provided. Results For EF, ASD relatives – like ASD probands – showed impairments in response inhibition, cognitive flexibility and generativity (specifically, ideational fluency), and EF impairments in daily life. For L-G visual processing, the ASD relatives showed no anomalies on the tasks, but they reported more attention to detail in daily life. Group differences were similar for siblings and for parents of ASD probands, and yielded larger effect sizes in a multiplex subsample. The group effect sizes for the comparison between ASD probands and TD individuals were generally larger than those of the ASD relatives compared to TD individuals. Conclusions Impaired cognitive flexibility, ideational fluency and response inhibition are strong candidate endophenotypes for ASD. They could help to delineate etiologically more homogeneous subgroups, which is clinically important to allow assigning ASD probands to different, more targeted, interventions. En ligne : http://dx.doi.org/10.1111/jcpp.12637 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303

Infant social attention: an endophenotype of ASD-related traits? / Emily J. H. JONES in Journal of Child Psychology and Psychiatry, 58-3 (March 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-3 (March 2017) . - p.270-281 Titre : Infant social attention: an endophenotype of ASD-related traits? Type de document : Texte imprimé et/ou numérique Auteurs : Emily J. H. JONES, Auteur ; Kaitlin VENEMA, Auteur ; Rachel K. EARL, Auteur ; Rachel LOWY, Auteur ; Sara J. WEBB, Auteur Article en page(s) : p.270-281 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  infancy  endophenotype  social attention Index. décimale : PER Périodiques Résumé : Background As a neurodevelopmental disorder, symptoms of ASD likely emerge from a complex interaction between preexisting genetic vulnerabilities and the child's environment. One way to understand causal paths to ASD is to identify dimensional ASD-related traits that vary in the general population and that predispose individuals with other risk factors toward ASD. Moving beyond behavioral traits to explore underlying neurocognitive processes may further constrain the underlying genetics. Endophenotypes are quantitative, heritable, trait-related differences that are generally assessed with laboratory-based methods, can be identified in the general population, and may be more closely tied to particular causal chains that have a more restricted set of genetic roots. The most fruitful endophenotypes may be those observed in infancy, prior to the emergence of behavioral symptoms that they are hypothesized to cause. Social motivation is an ASD-related trait that is highly heritable. In this study, we investigate whether infant endophenotypes of social attention relate to familial risk for lower social motivation in the general population. Methods We examined whether infant social attention (measured using habituation, EEG power, and event-related potential tasks previously used in infants/toddlers with ASD) varies quantitatively with parental social motivation in 117 six-month-old and 106 twelve-month-old typically developing infants assessed cross-sectionally. To assess heritable aspects of social motivation, primary caregiver biological parents completed two self-report measures of social avoidance and discomfort that have shown high heritability in previous work. Results Parents with higher social discomfort and avoidance had infants who showed shorter looks to faces but not objects; reduced theta power during naturalistic social attention; and smaller P400 responses to faces versus objects. Conclusions Early reductions in social attention are continuously related to lower parental social motivation. Alterations in social attention may be infant endophenotypes of social motivation traits related to ASD. En ligne : http://dx.doi.org/10.1111/jcpp.12650 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303 [article] Infant social attention: an endophenotype of ASD-related traits? [Texte imprimé et/ou numérique] / Emily J. H. JONES, Auteur ; Kaitlin VENEMA, Auteur ; Rachel K. EARL, Auteur ; Rachel LOWY, Auteur ; Sara J. WEBB, Auteur . - p.270-281. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-3 (March 2017) . - p.270-281 Mots-clés : Autism spectrum disorders  infancy  endophenotype  social attention Index. décimale : PER Périodiques Résumé : Background As a neurodevelopmental disorder, symptoms of ASD likely emerge from a complex interaction between preexisting genetic vulnerabilities and the child's environment. One way to understand causal paths to ASD is to identify dimensional ASD-related traits that vary in the general population and that predispose individuals with other risk factors toward ASD. Moving beyond behavioral traits to explore underlying neurocognitive processes may further constrain the underlying genetics. Endophenotypes are quantitative, heritable, trait-related differences that are generally assessed with laboratory-based methods, can be identified in the general population, and may be more closely tied to particular causal chains that have a more restricted set of genetic roots. The most fruitful endophenotypes may be those observed in infancy, prior to the emergence of behavioral symptoms that they are hypothesized to cause. Social motivation is an ASD-related trait that is highly heritable. In this study, we investigate whether infant endophenotypes of social attention relate to familial risk for lower social motivation in the general population. Methods We examined whether infant social attention (measured using habituation, EEG power, and event-related potential tasks previously used in infants/toddlers with ASD) varies quantitatively with parental social motivation in 117 six-month-old and 106 twelve-month-old typically developing infants assessed cross-sectionally. To assess heritable aspects of social motivation, primary caregiver biological parents completed two self-report measures of social avoidance and discomfort that have shown high heritability in previous work. Results Parents with higher social discomfort and avoidance had infants who showed shorter looks to faces but not objects; reduced theta power during naturalistic social attention; and smaller P400 responses to faces versus objects. Conclusions Early reductions in social attention are continuously related to lower parental social motivation. Alterations in social attention may be infant endophenotypes of social motivation traits related to ASD. En ligne : http://dx.doi.org/10.1111/jcpp.12650 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303

Observed fearlessness and positive parenting interact to predict childhood callous-unemotional behaviors among low-income boys / Rebecca WALLER in Journal of Child Psychology and Psychiatry, 58-3 (March 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-3 (March 2017) . - p.282-291 Titre : Observed fearlessness and positive parenting interact to predict childhood callous-unemotional behaviors among low-income boys Type de document : Texte imprimé et/ou numérique Auteurs : Rebecca WALLER, Auteur ; Daniel S. SHAW, Auteur ; Luke W. HYDE, Auteur Article en page(s) : p.282-291 Langues : Anglais (eng) Mots-clés : Callous-unemotional  parenting  psychopathy  temperament Index. décimale : PER Périodiques Résumé : Background Callous-unemotional behaviors identify children at risk for severe and chronic antisocial behavior. Research is needed to establish pathways from temperament and parenting factors that give rise to callous-unemotional behaviors, including interactions of positive versus harsh parenting with child fearlessness. Methods Multimethod data, including parent reports and observations of parent and child behavior, were drawn from a prospective, longitudinal sample of low-income boys (N = 310) with assessments at 18, 24, and 42 months, and at ages 10–12 years old. Results Parent-reported callous-unemotional, oppositional, and attention-deficit factors were separable at 42 months. Callous-unemotional behaviors at 42 months predicted callous-unemotional behaviors at ages 10–12, accounting for earlier oppositional and attention-deficit behaviors and self-reported child delinquency at ages 10–12. Observations of fearlessness at 24 months predicted callous-unemotional behaviors at 42 months, but only when parents exhibited low observed levels of positive parenting. The interaction of fearlessness and low positive parenting indirectly predicted callous-unemotional behaviors at 10–12 via callous-unemotional behaviors at 42 months. Conclusions Early fearlessness interacts with low positive parenting to predict early callous-unemotional behaviors, with lasting effects of this person-by-context interaction on callous-unemotional behaviors into late childhood. En ligne : http://dx.doi.org/10.1111/jcpp.12666 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303 [article] Observed fearlessness and positive parenting interact to predict childhood callous-unemotional behaviors among low-income boys [Texte imprimé et/ou numérique] / Rebecca WALLER, Auteur ; Daniel S. SHAW, Auteur ; Luke W. HYDE, Auteur . - p.282-291. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-3 (March 2017) . - p.282-291 Mots-clés : Callous-unemotional  parenting  psychopathy  temperament Index. décimale : PER Périodiques Résumé : Background Callous-unemotional behaviors identify children at risk for severe and chronic antisocial behavior. Research is needed to establish pathways from temperament and parenting factors that give rise to callous-unemotional behaviors, including interactions of positive versus harsh parenting with child fearlessness. Methods Multimethod data, including parent reports and observations of parent and child behavior, were drawn from a prospective, longitudinal sample of low-income boys (N = 310) with assessments at 18, 24, and 42 months, and at ages 10–12 years old. Results Parent-reported callous-unemotional, oppositional, and attention-deficit factors were separable at 42 months. Callous-unemotional behaviors at 42 months predicted callous-unemotional behaviors at ages 10–12, accounting for earlier oppositional and attention-deficit behaviors and self-reported child delinquency at ages 10–12. Observations of fearlessness at 24 months predicted callous-unemotional behaviors at 42 months, but only when parents exhibited low observed levels of positive parenting. The interaction of fearlessness and low positive parenting indirectly predicted callous-unemotional behaviors at 10–12 via callous-unemotional behaviors at 42 months. Conclusions Early fearlessness interacts with low positive parenting to predict early callous-unemotional behaviors, with lasting effects of this person-by-context interaction on callous-unemotional behaviors into late childhood. En ligne : http://dx.doi.org/10.1111/jcpp.12666 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303

Externalizing problems in childhood and adolescence predict subsequent educational achievement but for different genetic and environmental reasons / Gary J. LEWIS in Journal of Child Psychology and Psychiatry, 58-3 (March 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-3 (March 2017) . - p.292-304 Titre : Externalizing problems in childhood and adolescence predict subsequent educational achievement but for different genetic and environmental reasons Type de document : Texte imprimé et/ou numérique Auteurs : Gary J. LEWIS, Auteur ; Kathryn ASBURY, Auteur ; Robert PLOMIN, Auteur Article en page(s) : p.292-304 Langues : Anglais (eng) Mots-clés : Education  genetics  longitudinal  twin study  behavior problems  Strengths and Difficulties Questionnaire Index. décimale : PER Périodiques Résumé : Background Childhood behavior problems predict subsequent educational achievement; however, little research has examined the etiology of these links using a longitudinal twin design. Moreover, it is unknown whether genetic and environmental innovations provide incremental prediction for educational achievement from childhood to adolescence. Methods We examined genetic and environmental influences on parental ratings of behavior problems across childhood (age 4) and adolescence (ages 12 and 16) as predictors of educational achievement at age 16 using a longitudinal classical twin design. Results Shared-environmental influences on anxiety, conduct problems, and peer problems at age 4 predicted educational achievement at age 16. Genetic influences on the externalizing behaviors of conduct problems and hyperactivity at age 4 predicted educational achievement at age 16. Moreover, novel genetic and (to a lesser extent) nonshared-environmental influences acting on conduct problems and hyperactivity emerged at ages 12 and 16, adding to the genetic prediction from age 4. Conclusions These findings demonstrate that genetic and shared-environmental factors underpinning behavior problems in early childhood predict educational achievement in midadolescence. These findings are consistent with the notion that early-childhood behavior problems reflect the initiation of a life-course persistent trajectory with concomitant implications for social attainment. However, we also find evidence that genetic and nonshared-environment innovations acting on behavior problems have implications for subsequent educational achievement, consistent with recent work arguing that adolescence represents a sensitive period for socioaffective development. En ligne : http://dx.doi.org/10.1111/jcpp.12655 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303 [article] Externalizing problems in childhood and adolescence predict subsequent educational achievement but for different genetic and environmental reasons [Texte imprimé et/ou numérique] / Gary J. LEWIS, Auteur ; Kathryn ASBURY, Auteur ; Robert PLOMIN, Auteur . - p.292-304. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-3 (March 2017) . - p.292-304 Mots-clés : Education  genetics  longitudinal  twin study  behavior problems  Strengths and Difficulties Questionnaire Index. décimale : PER Périodiques Résumé : Background Childhood behavior problems predict subsequent educational achievement; however, little research has examined the etiology of these links using a longitudinal twin design. Moreover, it is unknown whether genetic and environmental innovations provide incremental prediction for educational achievement from childhood to adolescence. Methods We examined genetic and environmental influences on parental ratings of behavior problems across childhood (age 4) and adolescence (ages 12 and 16) as predictors of educational achievement at age 16 using a longitudinal classical twin design. Results Shared-environmental influences on anxiety, conduct problems, and peer problems at age 4 predicted educational achievement at age 16. Genetic influences on the externalizing behaviors of conduct problems and hyperactivity at age 4 predicted educational achievement at age 16. Moreover, novel genetic and (to a lesser extent) nonshared-environmental influences acting on conduct problems and hyperactivity emerged at ages 12 and 16, adding to the genetic prediction from age 4. Conclusions These findings demonstrate that genetic and shared-environmental factors underpinning behavior problems in early childhood predict educational achievement in midadolescence. These findings are consistent with the notion that early-childhood behavior problems reflect the initiation of a life-course persistent trajectory with concomitant implications for social attainment. However, we also find evidence that genetic and nonshared-environment innovations acting on behavior problems have implications for subsequent educational achievement, consistent with recent work arguing that adolescence represents a sensitive period for socioaffective development. En ligne : http://dx.doi.org/10.1111/jcpp.12655 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303

Longitudinal study of cerebral surface morphology in youth with 22q11.2 deletion syndrome, and association with positive symptoms of psychosis / Petya D. RADOEVA in Journal of Child Psychology and Psychiatry, 58-3 (March 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-3 (March 2017) . - p.305-314 Titre : Longitudinal study of cerebral surface morphology in youth with 22q11.2 deletion syndrome, and association with positive symptoms of psychosis Type de document : Texte imprimé et/ou numérique Auteurs : Petya D. RADOEVA, Auteur ; Ravi BANSAL, Auteur ; Kevin M. ANTSHEL, Auteur ; Wanda FREMONT, Auteur ; Bradley S. PETERSON, Auteur ; Wendy R. KATES, Auteur Article en page(s) : p.305-314 Langues : Anglais (eng) Mots-clés : Velo-cardio-facial syndrome  psychosis  ‘cortical morphology’  prodromal Index. décimale : PER Périodiques Résumé : Background 22q11.2 deletion syndrome (22q11DS) is a genetic disorder that greatly increases risk of developing schizophrenia. We previously characterized cerebral surface morphology trajectories from late childhood to mid adolescence in a cohort of youth with 22q11DS. Herein, we extend the study period into early adulthood, and describe further the trajectories associated with severe psychiatric symptoms in this cohort. Methods Participants included 76 youth with 22q11DS and 30 unaffected siblings, assessed at three timepoints, during which high resolution, anatomic magnetic resonance images were acquired. High-dimensional, nonlinear warping algorithms were applied to images in order to derive characteristics of cerebral surface morphology for each participant at each timepoint. Repeated-measures, linear regressions using a mixed model were conducted, while covarying for age and sex. Results Alterations in cerebral surface morphology during late adolescence/early adulthood in individuals with 22q11DS were observed in the lateral frontal, orbitofrontal, temporal, parietal, occipital, and cerebellar regions. An Age x Diagnosis interaction revealed that relative to unaffected siblings, individuals with 22q11DS showed age-related surface protrusions in the prefrontal cortex (which remained stable or increased during early adulthood), and surface indentations in posterior regions (which seemed to level off during late adolescence). Symptoms of psychosis were associated with a trajectory of surface indentations in the orbitofrontal and parietal regions. Conclusions These results advance our understanding of cerebral maturation in individuals with 22q11DS, and provide clinically relevant information about the psychiatric phenotype associated with the longitudinal trajectory of cortical surface morphology in youth with this genetic syndrome. En ligne : http://dx.doi.org/10.1111/jcpp.12657 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303 [article] Longitudinal study of cerebral surface morphology in youth with 22q11.2 deletion syndrome, and association with positive symptoms of psychosis [Texte imprimé et/ou numérique] / Petya D. RADOEVA, Auteur ; Ravi BANSAL, Auteur ; Kevin M. ANTSHEL, Auteur ; Wanda FREMONT, Auteur ; Bradley S. PETERSON, Auteur ; Wendy R. KATES, Auteur . - p.305-314. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-3 (March 2017) . - p.305-314 Mots-clés : Velo-cardio-facial syndrome  psychosis  ‘cortical morphology’  prodromal Index. décimale : PER Périodiques Résumé : Background 22q11.2 deletion syndrome (22q11DS) is a genetic disorder that greatly increases risk of developing schizophrenia. We previously characterized cerebral surface morphology trajectories from late childhood to mid adolescence in a cohort of youth with 22q11DS. Herein, we extend the study period into early adulthood, and describe further the trajectories associated with severe psychiatric symptoms in this cohort. Methods Participants included 76 youth with 22q11DS and 30 unaffected siblings, assessed at three timepoints, during which high resolution, anatomic magnetic resonance images were acquired. High-dimensional, nonlinear warping algorithms were applied to images in order to derive characteristics of cerebral surface morphology for each participant at each timepoint. Repeated-measures, linear regressions using a mixed model were conducted, while covarying for age and sex. Results Alterations in cerebral surface morphology during late adolescence/early adulthood in individuals with 22q11DS were observed in the lateral frontal, orbitofrontal, temporal, parietal, occipital, and cerebellar regions. An Age x Diagnosis interaction revealed that relative to unaffected siblings, individuals with 22q11DS showed age-related surface protrusions in the prefrontal cortex (which remained stable or increased during early adulthood), and surface indentations in posterior regions (which seemed to level off during late adolescence). Symptoms of psychosis were associated with a trajectory of surface indentations in the orbitofrontal and parietal regions. Conclusions These results advance our understanding of cerebral maturation in individuals with 22q11DS, and provide clinically relevant information about the psychiatric phenotype associated with the longitudinal trajectory of cortical surface morphology in youth with this genetic syndrome. En ligne : http://dx.doi.org/10.1111/jcpp.12657 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303

The role of age of disclosure of biological origins in the psychological wellbeing of adolescents conceived by reproductive donation: a longitudinal study from age 1 to age 14 / Elena ILIOI in Journal of Child Psychology and Psychiatry, 58-3 (March 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-3 (March 2017) . - p.315-324 Titre : The role of age of disclosure of biological origins in the psychological wellbeing of adolescents conceived by reproductive donation: a longitudinal study from age 1 to age 14 Type de document : Texte imprimé et/ou numérique Auteurs : Elena ILIOI, Auteur ; Lucy BLAKE, Auteur ; Vasanti JADVA, Auteur ; Gabriela ROMAN, Auteur ; Susan GOLOMBOK, Auteur Article en page(s) : p.315-324 Langues : Anglais (eng) Mots-clés : Egg donation  donor insemination  surrogacy  disclosure  adolescence Index. décimale : PER Périodiques Résumé : Background The question of whether children should be told of their biological origins is one of the most controversial issues regarding the birth of children through donated eggs, sperm, embryos or surrogacy. Methods In the sixth phase of this longitudinal study when the children were aged 14 years, family relationships and adolescent adjustment were examined in 87 families created through reproductive donation and 54 natural conception families. The quality of family relationships was assessed by standardised interview with mothers and by standardised questionnaires and an observational measure with mothers and adolescents. Adolescent adjustment was assessed using standardised questionnaires. Systematic information on whether and when parents had told children about their biological origins was obtained at earlier phases of the study. Results There were no overall differences between disclosing families and either nondisclosing or natural conception families. However, within the disclosing families, more positive family relationships and higher levels of adolescent wellbeing were found for adolescents who had been told about their biological origins before age 7. Conclusions The earlier children born through reproductive donation are told about their biological origins, the more positive are the outcomes in terms of the quality of family relationships and psychological wellbeing at adolescence. En ligne : http://dx.doi.org/10.1111/jcpp.12667 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304 [article] The role of age of disclosure of biological origins in the psychological wellbeing of adolescents conceived by reproductive donation: a longitudinal study from age 1 to age 14 [Texte imprimé et/ou numérique] / Elena ILIOI, Auteur ; Lucy BLAKE, Auteur ; Vasanti JADVA, Auteur ; Gabriela ROMAN, Auteur ; Susan GOLOMBOK, Auteur . - p.315-324. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-3 (March 2017) . - p.315-324 Mots-clés : Egg donation  donor insemination  surrogacy  disclosure  adolescence Index. décimale : PER Périodiques Résumé : Background The question of whether children should be told of their biological origins is one of the most controversial issues regarding the birth of children through donated eggs, sperm, embryos or surrogacy. Methods In the sixth phase of this longitudinal study when the children were aged 14 years, family relationships and adolescent adjustment were examined in 87 families created through reproductive donation and 54 natural conception families. The quality of family relationships was assessed by standardised interview with mothers and by standardised questionnaires and an observational measure with mothers and adolescents. Adolescent adjustment was assessed using standardised questionnaires. Systematic information on whether and when parents had told children about their biological origins was obtained at earlier phases of the study. Results There were no overall differences between disclosing families and either nondisclosing or natural conception families. However, within the disclosing families, more positive family relationships and higher levels of adolescent wellbeing were found for adolescents who had been told about their biological origins before age 7. Conclusions The earlier children born through reproductive donation are told about their biological origins, the more positive are the outcomes in terms of the quality of family relationships and psychological wellbeing at adolescence. En ligne : http://dx.doi.org/10.1111/jcpp.12667 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304

Editorial Perspective: ‘From there to here’: adapting child and adolescent mental health interventions for low-resource settings / Gauri DIVAN in Journal of Child Psychology and Psychiatry, 58-3 (March 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-3 (March 2017) . - p.325-327 Titre : Editorial Perspective: ‘From there to here’: adapting child and adolescent mental health interventions for low-resource settings Type de document : Texte imprimé et/ou numérique Auteurs : Gauri DIVAN, Auteur Article en page(s) : p.325-327 Langues : Anglais (eng) Mots-clés : Disability  autism spectrum disorders  interventions Index. décimale : PER Périodiques Résumé : The majority of evidence for child and adolescent mental health interventions is generated in high-income countries. However, the majority of the world's children live in low- and middle-income countries, resulting in a large treatment gap for these disorders. A systematic approach to adapt evidence-based interventions so as to address cultural and contextual issues will increase an interventions acceptability and reach, allowing us to address these enormous unmet needs. En ligne : http://dx.doi.org/10.1111/jcpp.12627 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304 [article] Editorial Perspective: ‘From there to here’: adapting child and adolescent mental health interventions for low-resource settings [Texte imprimé et/ou numérique] / Gauri DIVAN, Auteur . - p.325-327. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-3 (March 2017) . - p.325-327 Mots-clés : Disability  autism spectrum disorders  interventions Index. décimale : PER Périodiques Résumé : The majority of evidence for child and adolescent mental health interventions is generated in high-income countries. However, the majority of the world's children live in low- and middle-income countries, resulting in a large treatment gap for these disorders. A systematic approach to adapt evidence-based interventions so as to address cultural and contextual issues will increase an interventions acceptability and reach, allowing us to address these enormous unmet needs. En ligne : http://dx.doi.org/10.1111/jcpp.12627 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304

Commentary: Fundamental problems with candidate gene-by-environment interaction studies – reflections on Moore and Thoemmes (2016) / Richard BORDER in Journal of Child Psychology and Psychiatry, 58-3 (March 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-3 (March 2017) . - p.328-330 Titre : Commentary: Fundamental problems with candidate gene-by-environment interaction studies – reflections on Moore and Thoemmes (2016) Type de document : Texte imprimé et/ou numérique Auteurs : Richard BORDER, Auteur ; Matthew C. KELLER, Auteur Article en page(s) : p.328-330 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Moore and Thoemmes elaborate on one particular source of difficulty in the study of candidate gene-by-environment interactions (cG × E): how different biologically plausible configurations of gene-environment covariation can bias estimates of cG × E when not explicitly modeled. However, even if cG × E investigators were able to account for the sources of bias Moore and Thoemmes elaborate, it is unlikely that conventional approaches would yield reliable results. Published cG × E findings to date have generally employed inadequate analytic procedures, have relied on samples orders of magnitude too small to detect plausible effects, and have relied on a particular candidate gene approach that has been unfruitful and largely jettisoned in mainstream genetic analyses of complex traits. Analytic procedures for the study of gene-environment interplay must evolve to meet the challenges that the genetic architecture of complex traits presents, and investigators must collaborate on grander scales if we hope to begin to understand how specific genes and environments combine to affect behavior. En ligne : http://dx.doi.org/10.1111/jcpp.12669 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304 [article] Commentary: Fundamental problems with candidate gene-by-environment interaction studies – reflections on Moore and Thoemmes (2016) [Texte imprimé et/ou numérique] / Richard BORDER, Auteur ; Matthew C. KELLER, Auteur . - p.328-330. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-3 (March 2017) . - p.328-330 Index. décimale : PER Périodiques Résumé : Moore and Thoemmes elaborate on one particular source of difficulty in the study of candidate gene-by-environment interactions (cG × E): how different biologically plausible configurations of gene-environment covariation can bias estimates of cG × E when not explicitly modeled. However, even if cG × E investigators were able to account for the sources of bias Moore and Thoemmes elaborate, it is unlikely that conventional approaches would yield reliable results. Published cG × E findings to date have generally employed inadequate analytic procedures, have relied on samples orders of magnitude too small to detect plausible effects, and have relied on a particular candidate gene approach that has been unfruitful and largely jettisoned in mainstream genetic analyses of complex traits. Analytic procedures for the study of gene-environment interplay must evolve to meet the challenges that the genetic architecture of complex traits presents, and investigators must collaborate on grander scales if we hope to begin to understand how specific genes and environments combine to affect behavior. En ligne : http://dx.doi.org/10.1111/jcpp.12669 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304

Commentary: What is the case for candidate gene approaches in the era of high-throughput genomics? A response to Border and Keller (2017) / Sarah R. MOORE in Journal of Child Psychology and Psychiatry, 58-3 (March 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-3 (March 2017) . - p.331-334 Titre : Commentary: What is the case for candidate gene approaches in the era of high-throughput genomics? A response to Border and Keller (2017) Type de document : Texte imprimé et/ou numérique Auteurs : Sarah R. MOORE, Auteur Article en page(s) : p.331-334 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Border and Keller argue that candidate gene approaches are outdated and out-of-touch with the current understanding of the genetic architecture of complex behavioral traits and should be abandoned in favor of unbiased, genome-wide approaches. Border and Keller further suggest that a candidate gene should not be selected for in-depth investigation unless identified by a well-powered genome-wide association study (GWAS). An alternative perspective is offered that candidate approaches can be sensible for developmental and deep-phenotyping studies aimed at elucidating particular biological pathways responsible for the emergence of psychological phenotypes, and that candidates should not necessarily be expected to be confirmed by, or solely selected based on, GWAS. Both candidate and whole genome strategies have limitations, and each approach is useful and valid in the quest to identify the elusive genetic architecture of complex behavioral phenotypes. En ligne : http://dx.doi.org/10.1111/jcpp.12697 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304 [article] Commentary: What is the case for candidate gene approaches in the era of high-throughput genomics? A response to Border and Keller (2017) [Texte imprimé et/ou numérique] / Sarah R. MOORE, Auteur . - p.331-334. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-3 (March 2017) . - p.331-334 Index. décimale : PER Périodiques Résumé : Border and Keller argue that candidate gene approaches are outdated and out-of-touch with the current understanding of the genetic architecture of complex behavioral traits and should be abandoned in favor of unbiased, genome-wide approaches. Border and Keller further suggest that a candidate gene should not be selected for in-depth investigation unless identified by a well-powered genome-wide association study (GWAS). An alternative perspective is offered that candidate approaches can be sensible for developmental and deep-phenotyping studies aimed at elucidating particular biological pathways responsible for the emergence of psychological phenotypes, and that candidates should not necessarily be expected to be confirmed by, or solely selected based on, GWAS. Both candidate and whole genome strategies have limitations, and each approach is useful and valid in the quest to identify the elusive genetic architecture of complex behavioral phenotypes. En ligne : http://dx.doi.org/10.1111/jcpp.12697 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304

Erratum in Journal of Child Psychology and Psychiatry, 58-3 (March 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-3 (March 2017) . - p.e1-e2 Titre : Erratum Type de document : Texte imprimé et/ou numérique Article en page(s) : p.e1-e2 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1111/jcpp.12701 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304 [article] Erratum [Texte imprimé et/ou numérique] . - p.e1-e2. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-3 (March 2017) . - p.e1-e2 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1111/jcpp.12701 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304