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Loxapine for Reversal of Antipsychotic-Induced Metabolic Disturbances: A Chart Review / Seema JAIN in Journal of Autism and Developmental Disorders, 46-4 (April 2016)

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inJournal of Autism and Developmental Disorders > 46-4 (April 2016) . - p.1344-1353

Titre :	Loxapine for Reversal of Antipsychotic-Induced Metabolic Disturbances: A Chart Review
Type de document :	Texte imprimé et/ou numérique
Auteurs :	Seema JAIN, Auteur ; Rebecca R. ANDRIDGE, Auteur ; Jessica A. HELLINGS, Auteur
Article en page(s) :	p.1344-1353
Langues :	Anglais (eng)
Mots-clés :	Loxapine Metabolic side effects Autism spectrum disorder Atypical antipsychotics
Index. décimale :	PER Périodiques
Résumé :	Loxapine substitution is a promising option for patients with autism spectrum disorder (ASD) who develop antipsychotic-induced metabolic illness. We performed a chart review of 15 adolescents and adults meeting DSM-IV-TR criteria for ASD, all with antipsychotic-associated weight gain, who received low dose loxapine in an attempt to taper or discontinue the weight gain-associated antipsychotic. Mean weight loss was ?5.7 kg, mean BMI reduction was ?1.9, and mean triglyceride reduction was ?33.7 mg/dl. At chart review, 14 of 15 subjects were rated 2 (Much Improved) or 1 (Very Much Improved) on the Clinical Global Impressions-Improvement scale (CGI-I). Low dose loxapine addition in most cases enabled taper of offending antipsychotics, significantly reversed drug-induced metabolic disturbances and improved irritability.
En ligne :	http://dx.doi.org/10.1007/s10803-015-2675-3
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=284

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