Commentary: Response to commentary by Rutter on Munafo et al. (2014) / Marcus R. MUNAFO in Journal of Child Psychology and Psychiatry, 55-10 (October 2014)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 55-10 (October 2014) . - p.1105-1106 Titre : Commentary: Response to commentary by Rutter on Munafo et al. (2014) Type de document : Texte imprimé et/ou numérique Auteurs : Marcus R. MUNAFO, Auteur ; Stanley ZAMMIT, Auteur ; Jonathan FLINT, Auteur Article en page(s) : p.1105-1106 Langues : Anglais (eng) Mots-clés : Gene–environment (G×E) interactions, locus-specific  genome wide  psychiatric phenotypes Index. décimale : PER Périodiques Résumé : Rutter's commentary (Rutter, 2014) on our article (Munafò et al., 2014) provides us the opportunity to clarify some issues that he (and therefore, we suspect, others) may have misunderstood. En ligne : http://dx.doi.org/10.1111/jcpp.12308 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=239 [article] Commentary: Response to commentary by Rutter on Munafo et al. (2014) [Texte imprimé et/ou numérique] / Marcus R. MUNAFO, Auteur ; Stanley ZAMMIT, Auteur ; Jonathan FLINT, Auteur . - p.1105-1106. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 55-10 (October 2014) . - p.1105-1106 Mots-clés : Gene–environment (G×E) interactions, locus-specific  genome wide  psychiatric phenotypes Index. décimale : PER Périodiques Résumé : Rutter's commentary (Rutter, 2014) on our article (Munafò et al., 2014) provides us the opportunity to clarify some issues that he (and therefore, we suspect, others) may have misunderstood. En ligne : http://dx.doi.org/10.1111/jcpp.12308 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=239

Joint developmental trajectories of internalizing and externalizing disorders between childhood and adolescence / Michel G. NIVARD in Development and Psychopathology, 29-3 (August 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-3 (August 2017) . - p.919-928 Titre : Joint developmental trajectories of internalizing and externalizing disorders between childhood and adolescence Type de document : Texte imprimé et/ou numérique Auteurs : Michel G. NIVARD, Auteur ; Gitta H. LUBKE, Auteur ; Conor V. DOLAN, Auteur ; David M. EVANS, Auteur ; Beate ST. POURCAIN, Auteur ; Marcus R. MUNAFO, Auteur ; Christel M. MIDDELDORP, Auteur Article en page(s) : p.919-928 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract This study sought to identify trajectories of DSM-IV based internalizing (INT) and externalizing (EXT) problem scores across childhood and adolescence and to provide insight into the comorbidity by modeling the co-occurrence of INT and EXT trajectories. INT and EXT were measured repeatedly between age 7 and age 15 years in over 7,000 children and analyzed using growth mixture models. Five trajectories were identified for both INT and EXT, including very low, low, decreasing, and increasing trajectories. In addition, an adolescent onset trajectory was identified for INT and a stable high trajectory was identified for EXT. Multinomial regression showed that similar EXT and INT trajectories were associated. However, the adolescent onset INT trajectory was independent of high EXT trajectories, and persisting EXT was mainly associated with decreasing INT. Sex and early life environmental risk factors predicted EXT and, to a lesser extent, INT trajectories. The association between trajectories indicates the need to consider comorbidity when a child presents with INT or EXT disorders, particularly when symptoms start early. This is less necessary when INT symptoms start at adolescence. Future studies should investigate the etiology of co-occurring INT and EXT and the specific treatment needs of these severely affected children. En ligne : http://dx.doi.org/10.1017/s0954579416000572 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=312 [article] Joint developmental trajectories of internalizing and externalizing disorders between childhood and adolescence [Texte imprimé et/ou numérique] / Michel G. NIVARD, Auteur ; Gitta H. LUBKE, Auteur ; Conor V. DOLAN, Auteur ; David M. EVANS, Auteur ; Beate ST. POURCAIN, Auteur ; Marcus R. MUNAFO, Auteur ; Christel M. MIDDELDORP, Auteur . - p.919-928. Langues : Anglais (eng) in Development and Psychopathology > 29-3 (August 2017) . - p.919-928 Index. décimale : PER Périodiques Résumé : Abstract This study sought to identify trajectories of DSM-IV based internalizing (INT) and externalizing (EXT) problem scores across childhood and adolescence and to provide insight into the comorbidity by modeling the co-occurrence of INT and EXT trajectories. INT and EXT were measured repeatedly between age 7 and age 15 years in over 7,000 children and analyzed using growth mixture models. Five trajectories were identified for both INT and EXT, including very low, low, decreasing, and increasing trajectories. In addition, an adolescent onset trajectory was identified for INT and a stable high trajectory was identified for EXT. Multinomial regression showed that similar EXT and INT trajectories were associated. However, the adolescent onset INT trajectory was independent of high EXT trajectories, and persisting EXT was mainly associated with decreasing INT. Sex and early life environmental risk factors predicted EXT and, to a lesser extent, INT trajectories. The association between trajectories indicates the need to consider comorbidity when a child presents with INT or EXT disorders, particularly when symptoms start early. This is less necessary when INT symptoms start at adolescence. Future studies should investigate the etiology of co-occurring INT and EXT and the specific treatment needs of these severely affected children. En ligne : http://dx.doi.org/10.1017/s0954579416000572 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=312

Practitioner Review: A critical perspective on gene–environment interaction models – what impact should they have on clinical perceptions and practice? / Marcus R. MUNAFO in Journal of Child Psychology and Psychiatry, 55-10 (October 2014)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 55-10 (October 2014) . - p.1092-1101 Titre : Practitioner Review: A critical perspective on gene–environment interaction models – what impact should they have on clinical perceptions and practice? Type de document : Texte imprimé et/ou numérique Auteurs : Marcus R. MUNAFO, Auteur ; Stanley ZAMMIT, Auteur ; Jonathan FLINT, Auteur Article en page(s) : p.1092-1101 Langues : Anglais (eng) Mots-clés : Genetics  genome-wide association studies  heritability  gene × environment interaction  psychiatric disorder Index. décimale : PER Périodiques Résumé : Background Psychiatric disorders run in families, and early twin, family and adoption studies confirmed that this was due in part to shared genetic inheritance. While candidate gene studies largely failed to reliably identify genetic variants associated with psychiatric disorders, genome-wide association studies are beginning to do so. However, the proportion of phenotypic variance explained remains well below what would be expected from previous heritability estimates. Scope We review possible reasons for this ‘missing heritability’, and whether incorporating gene by environment interactions into our models will substantially improve our understanding of the aetiology of psychiatric disorders, and inform clinical perceptions and practice. Findings We discuss potential limitations of the gene by environment interaction approach. In particular, we discuss whether these are likely to be a major contributor to psychiatric disorders at the level of the specific interaction (as opposed to at an aggregate level). Conclusions Gene by environment interaction studies offered initial promise that a far greater proportion of phenotypic variance could be explained by incorporating measures of environmental exposures into genetic studies. However, in our opinion, there are few (if any) clear examples of gene by environment interactions in psychiatry, and their scope for informing either our understanding of disease pathology or clinical practice remains limited at present. En ligne : http://dx.doi.org/10.1111/jcpp.12261 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=238 [article] Practitioner Review: A critical perspective on gene–environment interaction models – what impact should they have on clinical perceptions and practice? [Texte imprimé et/ou numérique] / Marcus R. MUNAFO, Auteur ; Stanley ZAMMIT, Auteur ; Jonathan FLINT, Auteur . - p.1092-1101. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 55-10 (October 2014) . - p.1092-1101 Mots-clés : Genetics  genome-wide association studies  heritability  gene × environment interaction  psychiatric disorder Index. décimale : PER Périodiques Résumé : Background Psychiatric disorders run in families, and early twin, family and adoption studies confirmed that this was due in part to shared genetic inheritance. While candidate gene studies largely failed to reliably identify genetic variants associated with psychiatric disorders, genome-wide association studies are beginning to do so. However, the proportion of phenotypic variance explained remains well below what would be expected from previous heritability estimates. Scope We review possible reasons for this ‘missing heritability’, and whether incorporating gene by environment interactions into our models will substantially improve our understanding of the aetiology of psychiatric disorders, and inform clinical perceptions and practice. Findings We discuss potential limitations of the gene by environment interaction approach. In particular, we discuss whether these are likely to be a major contributor to psychiatric disorders at the level of the specific interaction (as opposed to at an aggregate level). Conclusions Gene by environment interaction studies offered initial promise that a far greater proportion of phenotypic variance could be explained by incorporating measures of environmental exposures into genetic studies. However, in our opinion, there are few (if any) clear examples of gene by environment interactions in psychiatry, and their scope for informing either our understanding of disease pathology or clinical practice remains limited at present. En ligne : http://dx.doi.org/10.1111/jcpp.12261 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=238

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