Diurnal cortisol rhythms in youth from risky families: Effects of cumulative risk exposure and variation in the serotonin transporter linked polymorphic region gene / Cynthia J. WILLNER in Development and Psychopathology, 26-4 (Part 1) (November 2014)  

Public ISBD [article]  inDevelopment and Psychopathology > 26-4 (Part 1) (November 2014) . - p.999-1019 Titre : Diurnal cortisol rhythms in youth from risky families: Effects of cumulative risk exposure and variation in the serotonin transporter linked polymorphic region gene Type de document : Texte imprimé et/ou numérique Auteurs : Cynthia J. WILLNER, Auteur ; Pamela A. MORRIS, Auteur ; Dana Charles MCCOY, Auteur ; Emma K. ADAM, Auteur Année de publication : 2014 Article en page(s) : p.999-1019 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Building on research on cumulative risk and psychopathology, this study examines how cumulative risk exposure is associated with altered diurnal cortisol rhythms in an ethnically diverse, low-income sample of youth. In addition, consistent with a diathesis-stress perspective, this study explores whether the effect of environmental risk is moderated by allelic variation in the serotonin transporter linked polymorphic region (5-HTTLPR) gene. Results show that youth with greater cumulative risk exposure had flatter diurnal cortisol slopes, regardless of 5-HTTLPR genotype. However, the association of cumulative risk with average cortisol output (area under the curve [AUC]) was moderated by the 5-HTTLPR genotype. Among youth homozygous for the long allele, greater cumulative risk exposure was associated with lower cortisol AUC, driven by significant reductions in cortisol levels at waking. In contrast, there was a trend-level association between greater cumulative risk and higher cortisol AUC among youth carrying the short allele, driven by a trend-level increase in bedtime cortisol levels. Findings are discussed with regard to the relevance of dysregulated diurnal cortisol rhythms for the development of psychopathology and the implications of genetically mediated differences in psychophysiological adaptations to stress. En ligne : http://dx.doi.org/10.1017/S0954579414000558 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=242 [article] Diurnal cortisol rhythms in youth from risky families: Effects of cumulative risk exposure and variation in the serotonin transporter linked polymorphic region gene [Texte imprimé et/ou numérique] / Cynthia J. WILLNER, Auteur ; Pamela A. MORRIS, Auteur ; Dana Charles MCCOY, Auteur ; Emma K. ADAM, Auteur . - 2014 . - p.999-1019. Langues : Anglais (eng) in Development and Psychopathology > 26-4 (Part 1) (November 2014) . - p.999-1019 Index. décimale : PER Périodiques Résumé : Building on research on cumulative risk and psychopathology, this study examines how cumulative risk exposure is associated with altered diurnal cortisol rhythms in an ethnically diverse, low-income sample of youth. In addition, consistent with a diathesis-stress perspective, this study explores whether the effect of environmental risk is moderated by allelic variation in the serotonin transporter linked polymorphic region (5-HTTLPR) gene. Results show that youth with greater cumulative risk exposure had flatter diurnal cortisol slopes, regardless of 5-HTTLPR genotype. However, the association of cumulative risk with average cortisol output (area under the curve [AUC]) was moderated by the 5-HTTLPR genotype. Among youth homozygous for the long allele, greater cumulative risk exposure was associated with lower cortisol AUC, driven by significant reductions in cortisol levels at waking. In contrast, there was a trend-level association between greater cumulative risk and higher cortisol AUC among youth carrying the short allele, driven by a trend-level increase in bedtime cortisol levels. Findings are discussed with regard to the relevance of dysregulated diurnal cortisol rhythms for the development of psychopathology and the implications of genetically mediated differences in psychophysiological adaptations to stress. En ligne : http://dx.doi.org/10.1017/S0954579414000558 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=242

Diurnal cortisol rhythms in youth from risky families: Effects of cumulative risk exposure and variation in the serotonin transporter linked polymorphic region gene—ERRATUM / Cynthia J. WILLNER in Development and Psychopathology, 26-4 (Part 1) (November 2014)  

Public ISBD [article]  inDevelopment and Psychopathology > 26-4 (Part 1) (November 2014) . - p.1185-1188 Titre : Diurnal cortisol rhythms in youth from risky families: Effects of cumulative risk exposure and variation in the serotonin transporter linked polymorphic region gene—ERRATUM Type de document : Texte imprimé et/ou numérique Auteurs : Cynthia J. WILLNER, Auteur ; Pamela A. MORRIS, Auteur ; Dana Charles MCCOY, Auteur ; Emma K. ADAM, Auteur Année de publication : 2014 Article en page(s) : p.1185-1188 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1017/S0954579414000819 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243 [article] Diurnal cortisol rhythms in youth from risky families: Effects of cumulative risk exposure and variation in the serotonin transporter linked polymorphic region gene—ERRATUM [Texte imprimé et/ou numérique] / Cynthia J. WILLNER, Auteur ; Pamela A. MORRIS, Auteur ; Dana Charles MCCOY, Auteur ; Emma K. ADAM, Auteur . - 2014 . - p.1185-1188. Langues : Anglais (eng) in Development and Psychopathology > 26-4 (Part 1) (November 2014) . - p.1185-1188 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1017/S0954579414000819 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243

The dynamics of internalizing and externalizing comorbidity across the early school years / Cynthia J. WILLNER in Development and Psychopathology, 28-4 pt1 (November 2016)  

Public ISBD [article]  inDevelopment and Psychopathology > 28-4 pt1 (November 2016) . - p.1033-1052 Titre : The dynamics of internalizing and externalizing comorbidity across the early school years Type de document : Texte imprimé et/ou numérique Auteurs : Cynthia J. WILLNER, Auteur ; Lisa M. GATZKE-KOPP, Auteur ; Bethany C. BRAY, Auteur Article en page(s) : p.1033-1052 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : High rates of comorbidity are observed between internalizing and externalizing problems, yet the developmental dynamics of comorbid symptom presentations are not yet well understood. This study explored the developmental course of latent profiles of internalizing and externalizing symptoms across kindergarten, first grade, and second grade. The sample consisted of 336 children from an urban, low-income community, selected based on relatively high (61%) or low (39%) aggressive/oppositional behavior problems at school entry (64% male; 70% African American, 20% Hispanic). Teachers reported on children's symptoms in each year. An exploratory latent profile analysis of children's scores on aggression/oppositionality, hyperactivity/inattention, anxiety, and social withdrawal symptom factors revealed four latent symptom profiles: comorbid (48% of the sample in each year), internalizing (19%–23%), externalizing (21%–22%), and well-adjusted (7%–11%). The developmental course of these symptom profiles was examined using a latent transition analysis, which revealed remarkably high continuity in the comorbid symptom profile (89% from one year to the next) and moderately high continuity in both the internalizing and externalizing profiles (80% and 71%, respectively). Internalizing children had a 20% probability of remitting to the well-adjusted profile by the following year, whereas externalizing children had a 25% probability of transitioning to the comorbid profile. These results are consistent with the hypothesis that a common vulnerability factor contributes to developmentally stable internalizing–externalizing comorbidity, while also suggesting that some children with externalizing symptoms are at risk for subsequently accumulating internalizing symptoms. En ligne : http://dx.doi.org/10.1017/s0954579416000687 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 [article] The dynamics of internalizing and externalizing comorbidity across the early school years [Texte imprimé et/ou numérique] / Cynthia J. WILLNER, Auteur ; Lisa M. GATZKE-KOPP, Auteur ; Bethany C. BRAY, Auteur . - p.1033-1052. Langues : Anglais (eng) in Development and Psychopathology > 28-4 pt1 (November 2016) . - p.1033-1052 Index. décimale : PER Périodiques Résumé : High rates of comorbidity are observed between internalizing and externalizing problems, yet the developmental dynamics of comorbid symptom presentations are not yet well understood. This study explored the developmental course of latent profiles of internalizing and externalizing symptoms across kindergarten, first grade, and second grade. The sample consisted of 336 children from an urban, low-income community, selected based on relatively high (61%) or low (39%) aggressive/oppositional behavior problems at school entry (64% male; 70% African American, 20% Hispanic). Teachers reported on children's symptoms in each year. An exploratory latent profile analysis of children's scores on aggression/oppositionality, hyperactivity/inattention, anxiety, and social withdrawal symptom factors revealed four latent symptom profiles: comorbid (48% of the sample in each year), internalizing (19%–23%), externalizing (21%–22%), and well-adjusted (7%–11%). The developmental course of these symptom profiles was examined using a latent transition analysis, which revealed remarkably high continuity in the comorbid symptom profile (89% from one year to the next) and moderately high continuity in both the internalizing and externalizing profiles (80% and 71%, respectively). Internalizing children had a 20% probability of remitting to the well-adjusted profile by the following year, whereas externalizing children had a 25% probability of transitioning to the comorbid profile. These results are consistent with the hypothesis that a common vulnerability factor contributes to developmentally stable internalizing–externalizing comorbidity, while also suggesting that some children with externalizing symptoms are at risk for subsequently accumulating internalizing symptoms. En ligne : http://dx.doi.org/10.1017/s0954579416000687 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294

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