Are flatter diurnal cortisol rhythms associated with major depression and anxiety disorders in late adolescence? The role of life stress and daily negative emotion / Leah D. DOANE in Development and Psychopathology, 25-3 (August 2013)  

Public ISBD [article]  inDevelopment and Psychopathology > 25-3 (August 2013) . - p.629-642 Titre : Are flatter diurnal cortisol rhythms associated with major depression and anxiety disorders in late adolescence? The role of life stress and daily negative emotion Type de document : Texte imprimé et/ou numérique Auteurs : Leah D. DOANE, Auteur ; Susan MINEKA, Auteur ; Richard E. ZINBARG, Auteur ; Michelle G. CRASKE, Auteur ; James W. GRIFFITH, Auteur ; Emma K. ADAM, Auteur Article en page(s) : p.629-642 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Alterations in hypothalamic–pituitary–adrenal (HPA) axis functioning have been associated with major depression disorder (MDD) and some anxiety disorders. Few researchers have tested the possibility that high levels of recent life stress or elevations in negative emotion may partially account for the HPA axis alterations observed in these disorders. In a sample of 300 adolescents from the Youth Emotion Project, we examined associations between MDD and anxiety disorders, dimensional measures of internalizing symptomatology, life stress, mood on the days of cortisol testing, and HPA axis functioning. Adolescents with a past MDD episode and those with a recent MDD episode comorbid with an anxiety disorder had flatter diurnal cortisol slopes than adolescents without a history of internalizing disorders. Higher reports of general distress, a dimension of internalizing symptomatology, were also associated with flatter slopes. Negative emotion, specifically sadness and loneliness, was associated with flatter slopes and partially accounted for the associations between comorbid MDD and anxiety disorders and cortisol. The associations between past MDD and cortisol slopes were not accounted for by negative emotion, dimensional variation in internalizing symptomatology, or levels of life stress, indicating that flatter cortisol slopes may also be a “scar” marker of past experiences of MDD. En ligne : http://dx.doi.org/10.1017/S0954579413000060 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=210 [article] Are flatter diurnal cortisol rhythms associated with major depression and anxiety disorders in late adolescence? The role of life stress and daily negative emotion [Texte imprimé et/ou numérique] / Leah D. DOANE, Auteur ; Susan MINEKA, Auteur ; Richard E. ZINBARG, Auteur ; Michelle G. CRASKE, Auteur ; James W. GRIFFITH, Auteur ; Emma K. ADAM, Auteur . - p.629-642. Langues : Anglais (eng) in Development and Psychopathology > 25-3 (August 2013) . - p.629-642 Index. décimale : PER Périodiques Résumé : Alterations in hypothalamic–pituitary–adrenal (HPA) axis functioning have been associated with major depression disorder (MDD) and some anxiety disorders. Few researchers have tested the possibility that high levels of recent life stress or elevations in negative emotion may partially account for the HPA axis alterations observed in these disorders. In a sample of 300 adolescents from the Youth Emotion Project, we examined associations between MDD and anxiety disorders, dimensional measures of internalizing symptomatology, life stress, mood on the days of cortisol testing, and HPA axis functioning. Adolescents with a past MDD episode and those with a recent MDD episode comorbid with an anxiety disorder had flatter diurnal cortisol slopes than adolescents without a history of internalizing disorders. Higher reports of general distress, a dimension of internalizing symptomatology, were also associated with flatter slopes. Negative emotion, specifically sadness and loneliness, was associated with flatter slopes and partially accounted for the associations between comorbid MDD and anxiety disorders and cortisol. The associations between past MDD and cortisol slopes were not accounted for by negative emotion, dimensional variation in internalizing symptomatology, or levels of life stress, indicating that flatter cortisol slopes may also be a “scar” marker of past experiences of MDD. En ligne : http://dx.doi.org/10.1017/S0954579413000060 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=210

Diurnal cortisol rhythms in youth from risky families: Effects of cumulative risk exposure and variation in the serotonin transporter linked polymorphic region gene / Cynthia J. WILLNER in Development and Psychopathology, 26-4 (Part 1) (November 2014)  

Public ISBD [article]  inDevelopment and Psychopathology > 26-4 (Part 1) (November 2014) . - p.999-1019 Titre : Diurnal cortisol rhythms in youth from risky families: Effects of cumulative risk exposure and variation in the serotonin transporter linked polymorphic region gene Type de document : Texte imprimé et/ou numérique Auteurs : Cynthia J. WILLNER, Auteur ; Pamela A. MORRIS, Auteur ; Dana Charles MCCOY, Auteur ; Emma K. ADAM, Auteur Année de publication : 2014 Article en page(s) : p.999-1019 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Building on research on cumulative risk and psychopathology, this study examines how cumulative risk exposure is associated with altered diurnal cortisol rhythms in an ethnically diverse, low-income sample of youth. In addition, consistent with a diathesis-stress perspective, this study explores whether the effect of environmental risk is moderated by allelic variation in the serotonin transporter linked polymorphic region (5-HTTLPR) gene. Results show that youth with greater cumulative risk exposure had flatter diurnal cortisol slopes, regardless of 5-HTTLPR genotype. However, the association of cumulative risk with average cortisol output (area under the curve [AUC]) was moderated by the 5-HTTLPR genotype. Among youth homozygous for the long allele, greater cumulative risk exposure was associated with lower cortisol AUC, driven by significant reductions in cortisol levels at waking. In contrast, there was a trend-level association between greater cumulative risk and higher cortisol AUC among youth carrying the short allele, driven by a trend-level increase in bedtime cortisol levels. Findings are discussed with regard to the relevance of dysregulated diurnal cortisol rhythms for the development of psychopathology and the implications of genetically mediated differences in psychophysiological adaptations to stress. En ligne : http://dx.doi.org/10.1017/S0954579414000558 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=242 [article] Diurnal cortisol rhythms in youth from risky families: Effects of cumulative risk exposure and variation in the serotonin transporter linked polymorphic region gene [Texte imprimé et/ou numérique] / Cynthia J. WILLNER, Auteur ; Pamela A. MORRIS, Auteur ; Dana Charles MCCOY, Auteur ; Emma K. ADAM, Auteur . - 2014 . - p.999-1019. Langues : Anglais (eng) in Development and Psychopathology > 26-4 (Part 1) (November 2014) . - p.999-1019 Index. décimale : PER Périodiques Résumé : Building on research on cumulative risk and psychopathology, this study examines how cumulative risk exposure is associated with altered diurnal cortisol rhythms in an ethnically diverse, low-income sample of youth. In addition, consistent with a diathesis-stress perspective, this study explores whether the effect of environmental risk is moderated by allelic variation in the serotonin transporter linked polymorphic region (5-HTTLPR) gene. Results show that youth with greater cumulative risk exposure had flatter diurnal cortisol slopes, regardless of 5-HTTLPR genotype. However, the association of cumulative risk with average cortisol output (area under the curve [AUC]) was moderated by the 5-HTTLPR genotype. Among youth homozygous for the long allele, greater cumulative risk exposure was associated with lower cortisol AUC, driven by significant reductions in cortisol levels at waking. In contrast, there was a trend-level association between greater cumulative risk and higher cortisol AUC among youth carrying the short allele, driven by a trend-level increase in bedtime cortisol levels. Findings are discussed with regard to the relevance of dysregulated diurnal cortisol rhythms for the development of psychopathology and the implications of genetically mediated differences in psychophysiological adaptations to stress. En ligne : http://dx.doi.org/10.1017/S0954579414000558 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=242

Diurnal cortisol rhythms in youth from risky families: Effects of cumulative risk exposure and variation in the serotonin transporter linked polymorphic region gene—ERRATUM / Cynthia J. WILLNER in Development and Psychopathology, 26-4 (Part 1) (November 2014)  

Public ISBD [article]  inDevelopment and Psychopathology > 26-4 (Part 1) (November 2014) . - p.1185-1188 Titre : Diurnal cortisol rhythms in youth from risky families: Effects of cumulative risk exposure and variation in the serotonin transporter linked polymorphic region gene—ERRATUM Type de document : Texte imprimé et/ou numérique Auteurs : Cynthia J. WILLNER, Auteur ; Pamela A. MORRIS, Auteur ; Dana Charles MCCOY, Auteur ; Emma K. ADAM, Auteur Année de publication : 2014 Article en page(s) : p.1185-1188 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1017/S0954579414000819 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243 [article] Diurnal cortisol rhythms in youth from risky families: Effects of cumulative risk exposure and variation in the serotonin transporter linked polymorphic region gene—ERRATUM [Texte imprimé et/ou numérique] / Cynthia J. WILLNER, Auteur ; Pamela A. MORRIS, Auteur ; Dana Charles MCCOY, Auteur ; Emma K. ADAM, Auteur . - 2014 . - p.1185-1188. Langues : Anglais (eng) in Development and Psychopathology > 26-4 (Part 1) (November 2014) . - p.1185-1188 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1017/S0954579414000819 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243

Experiences of adversity in childhood and adolescence and cortisol in late adolescence / Courtenay L. KESSLER in Development and Psychopathology, 35-3 (August 2023)  

Public ISBD [article]  inDevelopment and Psychopathology > 35-3 (August 2023) . - p.1235-1250 Titre : Experiences of adversity in childhood and adolescence and cortisol in late adolescence Type de document : Texte imprimé et/ou numérique Auteurs : Courtenay L. KESSLER, Auteur ; Suzanne VRSHEK-SCHALLHORN, Auteur ; Susan MINEKA, Auteur ; Richard E. ZINBARG, Auteur ; Michelle CRASKE, Auteur ; Emma K. ADAM, Auteur Article en page(s) : p.1235-1250 Langues : Anglais (eng) Mots-clés : cortisol  diurnal rhythm  early adversity  HPA axis Index. décimale : PER Périodiques Résumé : Early life adversity influences the diurnal cortisol rhythm, yet the relative influence of different characteristics of adversity remains unknown. In this study, we examine how developmental timing (childhood vs. adolescence), severity (major vs. minor), and domain of early life adversity relate to diurnal cortisol rhythms in late adolescence. We assessed adversity retrospectively in early adulthood in a subsample of 236 participants from a longitudinal study of a diverse community sample of suburban adolescents oversampled for high neuroticism. We used multilevel modeling to assess associations between our adversity measures and the diurnal cortisol rhythm (waking and bedtime cortisol, awakening response, slope, and average cortisol). Major childhood adversities were associated with flatter daily slope, and minor adolescent adversities were associated with greater average daily cortisol. Examining domains of childhood adversities, major neglect and sexual abuse were associated with flatter slope and lower waking cortisol, with sexual abuse also associated with higher cortisol awakening response. Major physical abuse was associated with higher waking cortisol. Among adolescent adversities domains, minor neglect, emotional abuse, and witnessing violence were associated with greater average cortisol. These results suggest severity, developmental timing, and domain of adversity influence the association of early life adversity with stress response system functioning. En ligne : http://dx.doi.org/10.1017/S0954579421001152 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=510 [article] Experiences of adversity in childhood and adolescence and cortisol in late adolescence [Texte imprimé et/ou numérique] / Courtenay L. KESSLER, Auteur ; Suzanne VRSHEK-SCHALLHORN, Auteur ; Susan MINEKA, Auteur ; Richard E. ZINBARG, Auteur ; Michelle CRASKE, Auteur ; Emma K. ADAM, Auteur . - p.1235-1250. Langues : Anglais (eng) in Development and Psychopathology > 35-3 (August 2023) . - p.1235-1250 Mots-clés : cortisol  diurnal rhythm  early adversity  HPA axis Index. décimale : PER Périodiques Résumé : Early life adversity influences the diurnal cortisol rhythm, yet the relative influence of different characteristics of adversity remains unknown. In this study, we examine how developmental timing (childhood vs. adolescence), severity (major vs. minor), and domain of early life adversity relate to diurnal cortisol rhythms in late adolescence. We assessed adversity retrospectively in early adulthood in a subsample of 236 participants from a longitudinal study of a diverse community sample of suburban adolescents oversampled for high neuroticism. We used multilevel modeling to assess associations between our adversity measures and the diurnal cortisol rhythm (waking and bedtime cortisol, awakening response, slope, and average cortisol). Major childhood adversities were associated with flatter daily slope, and minor adolescent adversities were associated with greater average daily cortisol. Examining domains of childhood adversities, major neglect and sexual abuse were associated with flatter slope and lower waking cortisol, with sexual abuse also associated with higher cortisol awakening response. Major physical abuse was associated with higher waking cortisol. Among adolescent adversities domains, minor neglect, emotional abuse, and witnessing violence were associated with greater average cortisol. These results suggest severity, developmental timing, and domain of adversity influence the association of early life adversity with stress response system functioning. En ligne : http://dx.doi.org/10.1017/S0954579421001152 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=510

Incorporating hypothalamic–pituitary–adrenal axis measures into preventive interventions for adolescent depression: Are we there yet? / Emma K. ADAM in Development and Psychopathology, 20-3 (Summer 2008)  

Public ISBD [article]  inDevelopment and Psychopathology > 20-3 (Summer 2008) . - p.975-1001 Titre : Incorporating hypothalamic–pituitary–adrenal axis measures into preventive interventions for adolescent depression: Are we there yet? Type de document : Texte imprimé et/ou numérique Auteurs : Emma K. ADAM, Auteur ; Jonathan M. SUTTON, Auteur ; Leah D. DOANE, Auteur ; Susan MINEKA, Auteur Année de publication : 2008 Article en page(s) : p.975-1001 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Altered functioning of the hypothalamic–pituitary–adrenal (HPA) axis is a robust correlate of major depression in adults, and to a lesser extent, in adolescents. Premorbid differences in HPA axis function have been found to prospectively predict the onset of adolescent depression. To what extent might our knowledge of HPA axis function in adolescents with, or at risk for, depression, help guide efforts to prevent depression in this age group? We review evidence regarding the role of the HPA axis in the development of adolescent depression, and examine whether and which HPA axis measures might be useful in guiding prevention efforts as (a) as a criterion by which to select youth at risk for depression, (b) as a predictor of which youth will be most responsive to prevention efforts, and (c) as an indicator of whether prevention/intervention efforts are working. We conclude that our current understanding of the HPA axis, and its measurement, in adolescent depression are not sufficiently precise to be of immediate practical use in improving prevention efforts. Incorporating HPA axis measures into prevention studies, however, would be immensely useful in clarifying the role of the HPA axis in adolescent depression, such that future prevention efforts might more confidently rely on HPA axis information. En ligne : http://dx.doi.org/10.1017/s0954579408000461 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=544 [article] Incorporating hypothalamic–pituitary–adrenal axis measures into preventive interventions for adolescent depression: Are we there yet? [Texte imprimé et/ou numérique] / Emma K. ADAM, Auteur ; Jonathan M. SUTTON, Auteur ; Leah D. DOANE, Auteur ; Susan MINEKA, Auteur . - 2008 . - p.975-1001. Langues : Anglais (eng) in Development and Psychopathology > 20-3 (Summer 2008) . - p.975-1001 Index. décimale : PER Périodiques Résumé : Altered functioning of the hypothalamic–pituitary–adrenal (HPA) axis is a robust correlate of major depression in adults, and to a lesser extent, in adolescents. Premorbid differences in HPA axis function have been found to prospectively predict the onset of adolescent depression. To what extent might our knowledge of HPA axis function in adolescents with, or at risk for, depression, help guide efforts to prevent depression in this age group? We review evidence regarding the role of the HPA axis in the development of adolescent depression, and examine whether and which HPA axis measures might be useful in guiding prevention efforts as (a) as a criterion by which to select youth at risk for depression, (b) as a predictor of which youth will be most responsive to prevention efforts, and (c) as an indicator of whether prevention/intervention efforts are working. We conclude that our current understanding of the HPA axis, and its measurement, in adolescent depression are not sufficiently precise to be of immediate practical use in improving prevention efforts. Incorporating HPA axis measures into prevention studies, however, would be immensely useful in clarifying the role of the HPA axis in adolescent depression, such that future prevention efforts might more confidently rely on HPA axis information. En ligne : http://dx.doi.org/10.1017/s0954579408000461 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=544

Racial discrimination and ethnic racial identity in adolescence as modulators of HPA axis activity / Emma K. ADAM in Development and Psychopathology, 32-5 (December 2020)  

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Trajectories of relationship stress and inflammatory processes in adolescence / Katherine B. EHRLICH in Development and Psychopathology, 28-1 (February 2016)  

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