[article]
| Titre : |
Epigenetic legacy of parental experiences: Dynamic and interactive pathways to inheritance |
| Type de document : |
Texte imprimé et/ou numérique |
| Auteurs : |
Frances A. CHAMPAGNE, Auteur |
| Article en page(s) : |
p.1219-1228 |
| Langues : |
Anglais (eng) |
| Index. décimale : |
PER Périodiques |
| Résumé : |
The quality of the environment experienced by an individual across his or her lifespan can result in a unique developmental trajectory with consequences for adult phenotype and reproductive success. However, it is also evident that these experiences can impact the development of offspring with continued effect on subsequent generations. Epigenetic mechanisms have been proposed as a mediator of both these within- and across-generation effects, and there is increasing evidence to support the role of environmentally induced changes in DNA methylation, posttranslational histone modifications, and noncoding RNAs in predicting these outcomes. Advances in our understanding of these molecular modifications contribute to increasingly nuanced perspectives on plasticity and transmission of phenotypes across generations. A challenge that emerges from this research is in how we integrate these “new” perspectives with traditional views of development, reproduction, and inheritance. This paper will highlight evidence suggestive of an epigenetic impact of the environment on mothers, fathers, and their offspring, and illustrate the importance of considering the dynamic nature of reproduction and development and inclusive views of inheritance within the evolving field of behavioral and environmental epigenetics. |
| En ligne : |
http://dx.doi.org/10.1017/s0954579416000808 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 |
in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1219-1228
[article] Epigenetic legacy of parental experiences: Dynamic and interactive pathways to inheritance [Texte imprimé et/ou numérique] / Frances A. CHAMPAGNE, Auteur . - p.1219-1228. Langues : Anglais ( eng) in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1219-1228
| Index. décimale : |
PER Périodiques |
| Résumé : |
The quality of the environment experienced by an individual across his or her lifespan can result in a unique developmental trajectory with consequences for adult phenotype and reproductive success. However, it is also evident that these experiences can impact the development of offspring with continued effect on subsequent generations. Epigenetic mechanisms have been proposed as a mediator of both these within- and across-generation effects, and there is increasing evidence to support the role of environmentally induced changes in DNA methylation, posttranslational histone modifications, and noncoding RNAs in predicting these outcomes. Advances in our understanding of these molecular modifications contribute to increasingly nuanced perspectives on plasticity and transmission of phenotypes across generations. A challenge that emerges from this research is in how we integrate these “new” perspectives with traditional views of development, reproduction, and inheritance. This paper will highlight evidence suggestive of an epigenetic impact of the environment on mothers, fathers, and their offspring, and illustrate the importance of considering the dynamic nature of reproduction and development and inclusive views of inheritance within the evolving field of behavioral and environmental epigenetics. |
| En ligne : |
http://dx.doi.org/10.1017/s0954579416000808 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 |
|
Epigenetic legacy of parental experiences: Dynamic and interactive pathways to inheritance in Development and Psychopathology, 28-4 pt2 (November 2016)
