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28-4 pt2 - November 2016 - Epigenetics: Development, Psychopathology, Resilience, and Preventive Intervention [Texte imprimé et/ou numérique] . - 2016. Langues : Anglais (eng)
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Dépouillements


Introduction to the Special Section / Dante CICCHETTI in Development and Psychopathology, 28-4 pt2 (November 2016)
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Titre : Introduction to the Special Section Type de document : Texte imprimé et/ou numérique Auteurs : Dante CICCHETTI, Auteur Article en page(s) : p.1217-1217 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1017/s0954579416000791 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294
in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1217-1217[article] Introduction to the Special Section [Texte imprimé et/ou numérique] / Dante CICCHETTI, Auteur . - p.1217-1217.
Langues : Anglais (eng)
in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1217-1217
Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1017/s0954579416000791 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 Epigenetic legacy of parental experiences: Dynamic and interactive pathways to inheritance / Frances A. CHAMPAGNE in Development and Psychopathology, 28-4 pt2 (November 2016)
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Titre : Epigenetic legacy of parental experiences: Dynamic and interactive pathways to inheritance Type de document : Texte imprimé et/ou numérique Auteurs : Frances A. CHAMPAGNE, Auteur Article en page(s) : p.1219-1228 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The quality of the environment experienced by an individual across his or her lifespan can result in a unique developmental trajectory with consequences for adult phenotype and reproductive success. However, it is also evident that these experiences can impact the development of offspring with continued effect on subsequent generations. Epigenetic mechanisms have been proposed as a mediator of both these within- and across-generation effects, and there is increasing evidence to support the role of environmentally induced changes in DNA methylation, posttranslational histone modifications, and noncoding RNAs in predicting these outcomes. Advances in our understanding of these molecular modifications contribute to increasingly nuanced perspectives on plasticity and transmission of phenotypes across generations. A challenge that emerges from this research is in how we integrate these “new” perspectives with traditional views of development, reproduction, and inheritance. This paper will highlight evidence suggestive of an epigenetic impact of the environment on mothers, fathers, and their offspring, and illustrate the importance of considering the dynamic nature of reproduction and development and inclusive views of inheritance within the evolving field of behavioral and environmental epigenetics. En ligne : http://dx.doi.org/10.1017/s0954579416000808 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294
in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1219-1228[article] Epigenetic legacy of parental experiences: Dynamic and interactive pathways to inheritance [Texte imprimé et/ou numérique] / Frances A. CHAMPAGNE, Auteur . - p.1219-1228.
Langues : Anglais (eng)
in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1219-1228
Index. décimale : PER Périodiques Résumé : The quality of the environment experienced by an individual across his or her lifespan can result in a unique developmental trajectory with consequences for adult phenotype and reproductive success. However, it is also evident that these experiences can impact the development of offspring with continued effect on subsequent generations. Epigenetic mechanisms have been proposed as a mediator of both these within- and across-generation effects, and there is increasing evidence to support the role of environmentally induced changes in DNA methylation, posttranslational histone modifications, and noncoding RNAs in predicting these outcomes. Advances in our understanding of these molecular modifications contribute to increasingly nuanced perspectives on plasticity and transmission of phenotypes across generations. A challenge that emerges from this research is in how we integrate these “new” perspectives with traditional views of development, reproduction, and inheritance. This paper will highlight evidence suggestive of an epigenetic impact of the environment on mothers, fathers, and their offspring, and illustrate the importance of considering the dynamic nature of reproduction and development and inclusive views of inheritance within the evolving field of behavioral and environmental epigenetics. En ligne : http://dx.doi.org/10.1017/s0954579416000808 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 Insight from animal models of environmentally driven epigenetic changes in the developing and adult brain / Tiffany S. DOHERTY in Development and Psychopathology, 28-4 pt2 (November 2016)
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[article]
Titre : Insight from animal models of environmentally driven epigenetic changes in the developing and adult brain Type de document : Texte imprimé et/ou numérique Auteurs : Tiffany S. DOHERTY, Auteur ; Tania L. ROTH, Auteur Article en page(s) : p.1229-1243 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The efforts of many neuroscientists are directed toward understanding the appreciable plasticity of the brain and behavior. In recent years, epigenetics has become a core of this focus as a prime mechanistic candidate for behavioral modifications. Animal models have been instrumental in advancing our understanding of environmentally driven changes to the epigenome in the developing and adult brain. This review focuses mainly on such discoveries driven by adverse environments along with their associated behavioral outcomes. While much of the evidence discussed focuses on epigenetics within the central nervous system, several peripheral studies in humans who have experienced significant adversity are also highlighted. As we continue to unravel the link between epigenetics and phenotype, discerning the complexity and specificity of epigenetic changes induced by environments is an important step toward understanding optimal development and how to prevent or ameliorate behavioral deficits bred by disruptive environments. En ligne : http://dx.doi.org/10.1017/s095457941600081x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294
in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1229-1243[article] Insight from animal models of environmentally driven epigenetic changes in the developing and adult brain [Texte imprimé et/ou numérique] / Tiffany S. DOHERTY, Auteur ; Tania L. ROTH, Auteur . - p.1229-1243.
Langues : Anglais (eng)
in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1229-1243
Index. décimale : PER Périodiques Résumé : The efforts of many neuroscientists are directed toward understanding the appreciable plasticity of the brain and behavior. In recent years, epigenetics has become a core of this focus as a prime mechanistic candidate for behavioral modifications. Animal models have been instrumental in advancing our understanding of environmentally driven changes to the epigenome in the developing and adult brain. This review focuses mainly on such discoveries driven by adverse environments along with their associated behavioral outcomes. While much of the evidence discussed focuses on epigenetics within the central nervous system, several peripheral studies in humans who have experienced significant adversity are also highlighted. As we continue to unravel the link between epigenetics and phenotype, discerning the complexity and specificity of epigenetic changes induced by environments is an important step toward understanding optimal development and how to prevent or ameliorate behavioral deficits bred by disruptive environments. En ligne : http://dx.doi.org/10.1017/s095457941600081x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 Why is the topic of the biological embedding of experiences important for translation? / Michael RUTTER in Development and Psychopathology, 28-4 pt2 (November 2016)
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Titre : Why is the topic of the biological embedding of experiences important for translation? Type de document : Texte imprimé et/ou numérique Auteurs : Michael RUTTER, Auteur Article en page(s) : p.1245-1258 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Translational research focuses on innovation in healthcare settings, but this is a two-way process that may have implications for either treatment or prevention. Smoking and lung cancer and the fetal alcohol syndrome are used as examples. Experimental medicine that budges basic and clinical science often constitutes a key way forward. Areas of scientific progress and challenge are discussed in relation to drug action, social cognition, cognitive neuroscience, molecular genetics, gene–environment interaction, and epigenetics. Key concepts and challenges in relation to stress include toxicity, allostatic load, the hypothalamus–pituitary–adrenal axis, and objectives versus subjective stress. The reasons for the need to test causal inferences are discussed. Various kinds of “natural experiments” are discussed in illustration using the assisted conception design, the discordant monozygotic twin design, and the study of universal exposure. Animal models are discussed in relation to enrichment and deprivation effects and the effects of infant separation experiences, epigenetic effects, and the biological embedding of experiences. Translational issues are discussed in relation to the hypothalamic–pituitary–adrenal axis, epigenetics, and inflammation. In conclusion, it is suggested that there are immediate possibilities for experimental medicine but caution is needed with respect to moving into translation too quickly. En ligne : http://dx.doi.org/10.1017/s0954579416000821 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294
in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1245-1258[article] Why is the topic of the biological embedding of experiences important for translation? [Texte imprimé et/ou numérique] / Michael RUTTER, Auteur . - p.1245-1258.
Langues : Anglais (eng)
in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1245-1258
Index. décimale : PER Périodiques Résumé : Translational research focuses on innovation in healthcare settings, but this is a two-way process that may have implications for either treatment or prevention. Smoking and lung cancer and the fetal alcohol syndrome are used as examples. Experimental medicine that budges basic and clinical science often constitutes a key way forward. Areas of scientific progress and challenge are discussed in relation to drug action, social cognition, cognitive neuroscience, molecular genetics, gene–environment interaction, and epigenetics. Key concepts and challenges in relation to stress include toxicity, allostatic load, the hypothalamus–pituitary–adrenal axis, and objectives versus subjective stress. The reasons for the need to test causal inferences are discussed. Various kinds of “natural experiments” are discussed in illustration using the assisted conception design, the discordant monozygotic twin design, and the study of universal exposure. Animal models are discussed in relation to enrichment and deprivation effects and the effects of infant separation experiences, epigenetic effects, and the biological embedding of experiences. Translational issues are discussed in relation to the hypothalamic–pituitary–adrenal axis, epigenetics, and inflammation. In conclusion, it is suggested that there are immediate possibilities for experimental medicine but caution is needed with respect to moving into translation too quickly. En ligne : http://dx.doi.org/10.1017/s0954579416000821 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 Early life adversity alters normal sex-dependent developmental dynamics of DNA methylation / Renaud MASSART in Development and Psychopathology, 28-4 pt2 (November 2016)
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Titre : Early life adversity alters normal sex-dependent developmental dynamics of DNA methylation Type de document : Texte imprimé et/ou numérique Auteurs : Renaud MASSART, Auteur ; Zsofia NEMODA, Auteur ; Matthew J. SUDERMAN, Auteur ; Sheila SUTTI, Auteur ; Angela M. RUGGIERO, Auteur ; Amanda M. DETTMER, Auteur ; Stephen J. SUOMI, Auteur ; Moshe SZYF, Auteur Article en page(s) : p.1259-1272 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Studies in rodents, nonhuman primates, and humans suggest that epigenetic processes mediate between early life experiences and adult phenotype. However, the normal evolution of epigenetic programs during child development, the effect of sex, and the impact of early life adversity on these trajectories are not well understood. This study mapped the genome-wide DNA methylation changes in CD3+ T lymphocytes from rhesus monkeys from postnatal day 14 through 2 years of age in both males and females and determined the impact of maternal deprivation on the DNA methylation profile. We show here that DNA methylation profiles evolve from birth to adolescence and are sex dependent. DNA methylation changes accompany imposed weaning, attenuating the difference between males and females. Maternal separation at birth alters the normal evolution of DNA methylation profiles and targets genes that are also affected by a later stage maternal separation, that is, weaning. Our results suggest that early life events dynamically interfere with the normal developmental evolution of the DNA methylation profile and that these changes are highly effected by sex. En ligne : http://dx.doi.org/10.1017/s0954579416000833 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294
in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1259-1272[article] Early life adversity alters normal sex-dependent developmental dynamics of DNA methylation [Texte imprimé et/ou numérique] / Renaud MASSART, Auteur ; Zsofia NEMODA, Auteur ; Matthew J. SUDERMAN, Auteur ; Sheila SUTTI, Auteur ; Angela M. RUGGIERO, Auteur ; Amanda M. DETTMER, Auteur ; Stephen J. SUOMI, Auteur ; Moshe SZYF, Auteur . - p.1259-1272.
Langues : Anglais (eng)
in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1259-1272
Index. décimale : PER Périodiques Résumé : Studies in rodents, nonhuman primates, and humans suggest that epigenetic processes mediate between early life experiences and adult phenotype. However, the normal evolution of epigenetic programs during child development, the effect of sex, and the impact of early life adversity on these trajectories are not well understood. This study mapped the genome-wide DNA methylation changes in CD3+ T lymphocytes from rhesus monkeys from postnatal day 14 through 2 years of age in both males and females and determined the impact of maternal deprivation on the DNA methylation profile. We show here that DNA methylation profiles evolve from birth to adolescence and are sex dependent. DNA methylation changes accompany imposed weaning, attenuating the difference between males and females. Maternal separation at birth alters the normal evolution of DNA methylation profiles and targets genes that are also affected by a later stage maternal separation, that is, weaning. Our results suggest that early life events dynamically interfere with the normal developmental evolution of the DNA methylation profile and that these changes are highly effected by sex. En ligne : http://dx.doi.org/10.1017/s0954579416000833 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 Testing the biological embedding hypothesis: Is early life adversity associated with a later proinflammatory phenotype? / Katherine B. EHRLICH in Development and Psychopathology, 28-4 pt2 (November 2016)
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Titre : Testing the biological embedding hypothesis: Is early life adversity associated with a later proinflammatory phenotype? Type de document : Texte imprimé et/ou numérique Auteurs : Katherine B. EHRLICH, Auteur ; Kharah M. ROSS, Auteur ; Edith CHEN, Auteur ; Gregory E. MILLER, Auteur Article en page(s) : p.1273-1283 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Accumulating evidence suggests that the experience of early life adversity is a risk factor for a range of poor outcomes across development, including poor physical health in adulthood. The biological embedding model of early adversity (Miller, Chen, & Parker, 2011) suggests that early adversity might become embedded within immune cells known as monocytes/macrophages, programming them to be overly aggressive to environmental stimuli and insensitive to inhibitory signals, creating a “proinflammatory phenotype” that increases vulnerability to chronic diseases across the life span. We tested this hypothesis in the present study. Adolescent girls (n = 147) had blood drawn every 6 months across a 2.5-year period. To assess inflammatory responses to challenge, their monocytes were stimulated in vitro with a bacterial product, and production of the cytokine interleukin-6 was quantified. Hydrocortisone was added to cultures to assess the cells’ sensitivity to glucocorticoids’ anti-inflammatory signal. Using cluster analyses, we found that early life adversity was associated with greater odds of displaying a proinflammatory phenotype characterized by relatively larger interleukin-6 responses and relatively less sensitivity to glucocorticoids. In contrast, ongoing social stress was not associated with increasing odds of being categorized in the proinflammatory cluster. These findings suggest that early life adversity increases the probability of developing a proinflammatory phenotype, which, if sustained, could forecast risk for health problems later in life. En ligne : http://dx.doi.org/10.1017/s0954579416000845 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294
in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1273-1283[article] Testing the biological embedding hypothesis: Is early life adversity associated with a later proinflammatory phenotype? [Texte imprimé et/ou numérique] / Katherine B. EHRLICH, Auteur ; Kharah M. ROSS, Auteur ; Edith CHEN, Auteur ; Gregory E. MILLER, Auteur . - p.1273-1283.
Langues : Anglais (eng)
in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1273-1283
Index. décimale : PER Périodiques Résumé : Accumulating evidence suggests that the experience of early life adversity is a risk factor for a range of poor outcomes across development, including poor physical health in adulthood. The biological embedding model of early adversity (Miller, Chen, & Parker, 2011) suggests that early adversity might become embedded within immune cells known as monocytes/macrophages, programming them to be overly aggressive to environmental stimuli and insensitive to inhibitory signals, creating a “proinflammatory phenotype” that increases vulnerability to chronic diseases across the life span. We tested this hypothesis in the present study. Adolescent girls (n = 147) had blood drawn every 6 months across a 2.5-year period. To assess inflammatory responses to challenge, their monocytes were stimulated in vitro with a bacterial product, and production of the cytokine interleukin-6 was quantified. Hydrocortisone was added to cultures to assess the cells’ sensitivity to glucocorticoids’ anti-inflammatory signal. Using cluster analyses, we found that early life adversity was associated with greater odds of displaying a proinflammatory phenotype characterized by relatively larger interleukin-6 responses and relatively less sensitivity to glucocorticoids. In contrast, ongoing social stress was not associated with increasing odds of being categorized in the proinflammatory cluster. These findings suggest that early life adversity increases the probability of developing a proinflammatory phenotype, which, if sustained, could forecast risk for health problems later in life. En ligne : http://dx.doi.org/10.1017/s0954579416000845 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 Epigenetic regulation of cognition: A circumscribed review of the field / Elena L. GRIGORENKO in Development and Psychopathology, 28-4 pt2 (November 2016)
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Titre : Epigenetic regulation of cognition: A circumscribed review of the field Type de document : Texte imprimé et/ou numérique Auteurs : Elena L. GRIGORENKO, Auteur ; Sergey A. KORNILOV, Auteur ; Oksana Yu NAUMOVA, Auteur Article en page(s) : p.1285-1304 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The last decade has been marked by an increased interest in relating epigenetic mechanisms to complex human behaviors, although this interest has not been balanced, accentuating various types of affective and primarily ignoring cognitive functioning. Recent animal model data support the view that epigenetic processes play a role in learning and memory consolidation and help transmit acquired memories even across generations. In this review, we provide an overview of various types of epigenetic mechanisms in the brain (DNA methylation, histone modification, and noncoding RNA action) and discuss their impact proximally on gene transcription, protein synthesis, and synaptic plasticity and distally on learning, memory, and other cognitive functions. Of particular importance are observations that neuronal activation regulates the dynamics of the epigenome's functioning under precise timing, with subsequent alterations in the gene expression profile. In turn, epigenetic regulation impacts neuronal action, closing the circle and substantiating the signaling pathways that underlie, at least partially, learning, memory, and other cognitive processes. En ligne : http://dx.doi.org/10.1017/s0954579416000857 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294
in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1285-1304[article] Epigenetic regulation of cognition: A circumscribed review of the field [Texte imprimé et/ou numérique] / Elena L. GRIGORENKO, Auteur ; Sergey A. KORNILOV, Auteur ; Oksana Yu NAUMOVA, Auteur . - p.1285-1304.
Langues : Anglais (eng)
in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1285-1304
Index. décimale : PER Périodiques Résumé : The last decade has been marked by an increased interest in relating epigenetic mechanisms to complex human behaviors, although this interest has not been balanced, accentuating various types of affective and primarily ignoring cognitive functioning. Recent animal model data support the view that epigenetic processes play a role in learning and memory consolidation and help transmit acquired memories even across generations. In this review, we provide an overview of various types of epigenetic mechanisms in the brain (DNA methylation, histone modification, and noncoding RNA action) and discuss their impact proximally on gene transcription, protein synthesis, and synaptic plasticity and distally on learning, memory, and other cognitive functions. Of particular importance are observations that neuronal activation regulates the dynamics of the epigenome's functioning under precise timing, with subsequent alterations in the gene expression profile. In turn, epigenetic regulation impacts neuronal action, closing the circle and substantiating the signaling pathways that underlie, at least partially, learning, memory, and other cognitive processes. En ligne : http://dx.doi.org/10.1017/s0954579416000857 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 An investigation of child maltreatment and epigenetic mechanisms of mental and physical health risk / Dante CICCHETTI in Development and Psychopathology, 28-4 pt2 (November 2016)
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Titre : An investigation of child maltreatment and epigenetic mechanisms of mental and physical health risk Type de document : Texte imprimé et/ou numérique Auteurs : Dante CICCHETTI, Auteur ; Susan HETZEL, Auteur ; Fred A. ROGOSCH, Auteur ; Elizabeth D. HANDLEY, Auteur ; Sheree L. TOTH, Auteur Article en page(s) : p.1305-1317 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : In the present investigation, differential methylation analyses of the whole genome were conducted among a sample of 548 school-aged low-income children (47.8% female, 67.7% Black, M age = 9.40 years), 54.4% of whom had a history of child maltreatment. In the context of a summer research camp, DNA samples via saliva were obtained. Using GenomeStudio, Methylation Module, and the Illumina Custom Model, differential methylation analyses revealed a pattern of greater methylation at low methylation sites (n = 197 sites) and medium methylation sites (n = 730 sites) and less methylation at high methylation sites (n = 907 sites) among maltreated children. The mean difference in methylation between the maltreated and nonmaltreated children was 6.2%. The relative risk of maltreatment with known disease biomarkers was also investigated using GenoGo MetaCore Software. A large number of network objects previously associated with mental health, cancer, cardiovascular systems, and immune functioning were identified evidencing differential methylation among maltreated and nonmaltreated children. Site-specific analyses were also conducted for aldehyde dehydrogenase 2 (ALDH2), ankyrin repeat and kinase domain containing 1 (ANKK1), and nuclear receptor subfamily 3, group C, member 1 (NR3C1) genes, and the results highlight the importance of considering gender and the developmental timing of maltreatment. For ALDH2, the results indicated that maltreated girls evidenced significantly lower methylation compared to nonmaltreated girls, and maltreated boys evidenced significantly higher methylation compared to nonmaltreated boys. Moreover, early onset–not recently maltreated boys evidenced significantly higher methylation at ALDH2 compared to nonmaltreated boys. Similarly, children with early onset–nonrecent maltreatment evidenced significantly higher methylation compared to nonmaltreated children at ANKK1. The site-specific results were not altered by controlling for genotypic variation of respective genes. The findings demonstrate increased risk for adverse physical and mental health outcomes associated with differences in methylation in maltreated children and indicate differences among maltreated children related to developmental timing of maltreatment and gender in genes involved in mental health functioning. En ligne : http://dx.doi.org/10.1017/s0954579416000869 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294
in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1305-1317[article] An investigation of child maltreatment and epigenetic mechanisms of mental and physical health risk [Texte imprimé et/ou numérique] / Dante CICCHETTI, Auteur ; Susan HETZEL, Auteur ; Fred A. ROGOSCH, Auteur ; Elizabeth D. HANDLEY, Auteur ; Sheree L. TOTH, Auteur . - p.1305-1317.
Langues : Anglais (eng)
in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1305-1317
Index. décimale : PER Périodiques Résumé : In the present investigation, differential methylation analyses of the whole genome were conducted among a sample of 548 school-aged low-income children (47.8% female, 67.7% Black, M age = 9.40 years), 54.4% of whom had a history of child maltreatment. In the context of a summer research camp, DNA samples via saliva were obtained. Using GenomeStudio, Methylation Module, and the Illumina Custom Model, differential methylation analyses revealed a pattern of greater methylation at low methylation sites (n = 197 sites) and medium methylation sites (n = 730 sites) and less methylation at high methylation sites (n = 907 sites) among maltreated children. The mean difference in methylation between the maltreated and nonmaltreated children was 6.2%. The relative risk of maltreatment with known disease biomarkers was also investigated using GenoGo MetaCore Software. A large number of network objects previously associated with mental health, cancer, cardiovascular systems, and immune functioning were identified evidencing differential methylation among maltreated and nonmaltreated children. Site-specific analyses were also conducted for aldehyde dehydrogenase 2 (ALDH2), ankyrin repeat and kinase domain containing 1 (ANKK1), and nuclear receptor subfamily 3, group C, member 1 (NR3C1) genes, and the results highlight the importance of considering gender and the developmental timing of maltreatment. For ALDH2, the results indicated that maltreated girls evidenced significantly lower methylation compared to nonmaltreated girls, and maltreated boys evidenced significantly higher methylation compared to nonmaltreated boys. Moreover, early onset–not recently maltreated boys evidenced significantly higher methylation at ALDH2 compared to nonmaltreated boys. Similarly, children with early onset–nonrecent maltreatment evidenced significantly higher methylation compared to nonmaltreated children at ANKK1. The site-specific results were not altered by controlling for genotypic variation of respective genes. The findings demonstrate increased risk for adverse physical and mental health outcomes associated with differences in methylation in maltreated children and indicate differences among maltreated children related to developmental timing of maltreatment and gender in genes involved in mental health functioning. En ligne : http://dx.doi.org/10.1017/s0954579416000869 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 Childhood adversity and epigenetic regulation of glucocorticoid signaling genes: Associations in children and adults / Audrey R. TYRKA in Development and Psychopathology, 28-4 pt2 (November 2016)
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[article]
Titre : Childhood adversity and epigenetic regulation of glucocorticoid signaling genes: Associations in children and adults Type de document : Texte imprimé et/ou numérique Auteurs : Audrey R. TYRKA, Auteur ; Kathryn K. RIDOUT, Auteur ; Stephanie H. PARADE, Auteur Article en page(s) : p.1319-1331 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Early childhood experiences have lasting effects on development, including the risk for psychiatric disorders. Research examining the biologic underpinnings of these associations has revealed the impact of childhood maltreatment on the physiologic stress response and activity of the hypothalamus–pituitary–adrenal axis. A growing body of literature supports the hypothesis that environmental exposures mediate their biological effects via epigenetic mechanisms. Methylation, which is thought to be the most stable form of epigenetic change, is a likely mechanism by which early life exposures have lasting effects. We present recent evidence related to epigenetic regulation of genes involved in hypothalamus–pituitary–adrenal axis regulation, namely, the glucocorticoid receptor gene (nuclear receptor subfamily 3, group C, member 1 [NR3C1]) and FK506 binding protein 51 gene (FKBP5), after childhood adversity and associations with risk for psychiatric disorders. Implications for the development of interventions and future research are discussed. En ligne : http://dx.doi.org/10.1017/s0954579416000870 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294
in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1319-1331[article] Childhood adversity and epigenetic regulation of glucocorticoid signaling genes: Associations in children and adults [Texte imprimé et/ou numérique] / Audrey R. TYRKA, Auteur ; Kathryn K. RIDOUT, Auteur ; Stephanie H. PARADE, Auteur . - p.1319-1331.
Langues : Anglais (eng)
in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1319-1331
Index. décimale : PER Périodiques Résumé : Early childhood experiences have lasting effects on development, including the risk for psychiatric disorders. Research examining the biologic underpinnings of these associations has revealed the impact of childhood maltreatment on the physiologic stress response and activity of the hypothalamus–pituitary–adrenal axis. A growing body of literature supports the hypothesis that environmental exposures mediate their biological effects via epigenetic mechanisms. Methylation, which is thought to be the most stable form of epigenetic change, is a likely mechanism by which early life exposures have lasting effects. We present recent evidence related to epigenetic regulation of genes involved in hypothalamus–pituitary–adrenal axis regulation, namely, the glucocorticoid receptor gene (nuclear receptor subfamily 3, group C, member 1 [NR3C1]) and FK506 binding protein 51 gene (FKBP5), after childhood adversity and associations with risk for psychiatric disorders. Implications for the development of interventions and future research are discussed. En ligne : http://dx.doi.org/10.1017/s0954579416000870 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 Exploring genetic moderators and epigenetic mediators of contextual and family effects: From Gene × Environment to epigenetics / Steven R. H. BEACH in Development and Psychopathology, 28-4 pt2 (November 2016)
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[article]
Titre : Exploring genetic moderators and epigenetic mediators of contextual and family effects: From Gene × Environment to epigenetics Type de document : Texte imprimé et/ou numérique Auteurs : Steven R. H. BEACH, Auteur ; Gene H. BRODY, Auteur ; Allen W. BARTON, Auteur ; Robert A. PHILIBERT, Auteur Article en page(s) : p.1333-1346 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : In the current manuscript, we provide an overview of a research program at the University of Georgia's Center for Family Research designed to expand upon rapid and ongoing developments in the fields of genetics and epigenetics. By placing those developments in the context of translational research on family and community determinants of health and well-being among rural African Americans, we hope to identify novel, modifiable environments and biological processes. In the first section of the article, we review our earlier work on genotypic variation effects on the association between family context and mental and physical health outcomes as well as differential responses to family-based intervention. We then transition to discuss our more recent research on the association of family and community environments with epigenetic processes. In this second section of the article, we begin by briefly reviewing terminology and basic considerations before describing evidence that early environments may influence epigenetic motifs that potentially serve as mediators of long-term effects of early family and community environments on longer term health outcomes. We also provide evidence that genotype may sometimes influence epigenetic outcomes. Finally, we describe our recent efforts to use genome-wide characterization of epigenetic patterns to better understand the biological impact of protective parenting on long-term shifts in inflammatory processes and its potential implications for young adult health. As will be clear, research on epigenetics as a mediator of the connections between family/community processes and a range of health outcomes is still in its infancy, but the potential to develop important insights regarding mechanisms linking modifiable environments to biological processes and long-term health outcomes already is coming into view. En ligne : http://dx.doi.org/10.1017/s0954579416000882 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294
in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1333-1346[article] Exploring genetic moderators and epigenetic mediators of contextual and family effects: From Gene × Environment to epigenetics [Texte imprimé et/ou numérique] / Steven R. H. BEACH, Auteur ; Gene H. BRODY, Auteur ; Allen W. BARTON, Auteur ; Robert A. PHILIBERT, Auteur . - p.1333-1346.
Langues : Anglais (eng)
in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1333-1346
Index. décimale : PER Périodiques Résumé : In the current manuscript, we provide an overview of a research program at the University of Georgia's Center for Family Research designed to expand upon rapid and ongoing developments in the fields of genetics and epigenetics. By placing those developments in the context of translational research on family and community determinants of health and well-being among rural African Americans, we hope to identify novel, modifiable environments and biological processes. In the first section of the article, we review our earlier work on genotypic variation effects on the association between family context and mental and physical health outcomes as well as differential responses to family-based intervention. We then transition to discuss our more recent research on the association of family and community environments with epigenetic processes. In this second section of the article, we begin by briefly reviewing terminology and basic considerations before describing evidence that early environments may influence epigenetic motifs that potentially serve as mediators of long-term effects of early family and community environments on longer term health outcomes. We also provide evidence that genotype may sometimes influence epigenetic outcomes. Finally, we describe our recent efforts to use genome-wide characterization of epigenetic patterns to better understand the biological impact of protective parenting on long-term shifts in inflammatory processes and its potential implications for young adult health. As will be clear, research on epigenetics as a mediator of the connections between family/community processes and a range of health outcomes is still in its infancy, but the potential to develop important insights regarding mechanisms linking modifiable environments to biological processes and long-term health outcomes already is coming into view. En ligne : http://dx.doi.org/10.1017/s0954579416000882 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 Resilience to adversity and the early origins of disease / Gene H. BRODY in Development and Psychopathology, 28-4 pt2 (November 2016)
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[article]
Titre : Resilience to adversity and the early origins of disease Type de document : Texte imprimé et/ou numérique Auteurs : Gene H. BRODY, Auteur ; Tianyi YU, Auteur ; Steven R. H. BEACH, Auteur Article en page(s) : p.1347-1365 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : For the past quarter century, scientists at the Center for Family Research at the University of Georgia have conducted research designed to promote understanding of normative developmental trajectories among low socioeconomic status African American children, youths, and young adults. In this paper, we describe a recent expansion of this research program using longitudinal, epidemiological studies and randomized prevention trials to test hypotheses about the origins of disease among rural African American youths. The contributions of economic hardship, downward mobility, neighborhood poverty, and racial discrimination to allostatic load and epigenetic aging are illustrated. The health benefits of supportive family relationships in protecting youths from these challenges are also illustrated. A cautionary set of studies is presented showing that some psychosocially resilient youths demonstrate high allostatic loads and accelerated epigenetic aging, suggesting that, for some, “resilience is just skin deep.” Finally, we end on an optimistic note by demonstrating that family-centered prevention programs can have health benefits by reducing inflammation, helping to preserve telomere length, and inhibiting epigenetic aging. En ligne : http://dx.doi.org/10.1017/s0954579416000894 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294
in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1347-1365[article] Resilience to adversity and the early origins of disease [Texte imprimé et/ou numérique] / Gene H. BRODY, Auteur ; Tianyi YU, Auteur ; Steven R. H. BEACH, Auteur . - p.1347-1365.
Langues : Anglais (eng)
in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1347-1365
Index. décimale : PER Périodiques Résumé : For the past quarter century, scientists at the Center for Family Research at the University of Georgia have conducted research designed to promote understanding of normative developmental trajectories among low socioeconomic status African American children, youths, and young adults. In this paper, we describe a recent expansion of this research program using longitudinal, epidemiological studies and randomized prevention trials to test hypotheses about the origins of disease among rural African American youths. The contributions of economic hardship, downward mobility, neighborhood poverty, and racial discrimination to allostatic load and epigenetic aging are illustrated. The health benefits of supportive family relationships in protecting youths from these challenges are also illustrated. A cautionary set of studies is presented showing that some psychosocially resilient youths demonstrate high allostatic loads and accelerated epigenetic aging, suggesting that, for some, “resilience is just skin deep.” Finally, we end on an optimistic note by demonstrating that family-centered prevention programs can have health benefits by reducing inflammation, helping to preserve telomere length, and inhibiting epigenetic aging. En ligne : http://dx.doi.org/10.1017/s0954579416000894 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 Contextual adversity, telomere erosion, pubertal development, and health: Two models of accelerated aging, or one? / Jay BELSKY in Development and Psychopathology, 28-4 pt2 (November 2016)
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[article]
Titre : Contextual adversity, telomere erosion, pubertal development, and health: Two models of accelerated aging, or one? Type de document : Texte imprimé et/ou numérique Auteurs : Jay BELSKY, Auteur ; Idan SHALEV, Auteur Article en page(s) : p.1367-1383 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Two independent lines of inquiry suggest that growing up under conditions of contextual adversity (e.g., poverty and household chaos) accelerates aging and undermines long-term health. Whereas work addressing the developmental origins of health and disease highlights accelerated-aging effects of contextual adversity on telomere erosion, that informed by an evolutionary analysis of reproductive strategies highlights such effects with regard to pubertal development (in females). That both shorter telomeres early in life and earlier age of menarche are associated with poor health later in life raises the prospect, consistent with evolutionary life-history theory, that these two bodies of theory and research are tapping into the same evolutionary–developmental process whereby longer term health costs are traded off for increased probability of reproducing before dying via a process of accelerated aging. Here we make the case for such a claim, while highlighting biological processes responsible for these effects, as well as unknowns in the epigenetic equation that might instantiate these contextually regulated developmental processes. En ligne : http://dx.doi.org/10.1017/s0954579416000900 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294
in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1367-1383[article] Contextual adversity, telomere erosion, pubertal development, and health: Two models of accelerated aging, or one? [Texte imprimé et/ou numérique] / Jay BELSKY, Auteur ; Idan SHALEV, Auteur . - p.1367-1383.
Langues : Anglais (eng)
in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1367-1383
Index. décimale : PER Périodiques Résumé : Two independent lines of inquiry suggest that growing up under conditions of contextual adversity (e.g., poverty and household chaos) accelerates aging and undermines long-term health. Whereas work addressing the developmental origins of health and disease highlights accelerated-aging effects of contextual adversity on telomere erosion, that informed by an evolutionary analysis of reproductive strategies highlights such effects with regard to pubertal development (in females). That both shorter telomeres early in life and earlier age of menarche are associated with poor health later in life raises the prospect, consistent with evolutionary life-history theory, that these two bodies of theory and research are tapping into the same evolutionary–developmental process whereby longer term health costs are traded off for increased probability of reproducing before dying via a process of accelerated aging. Here we make the case for such a claim, while highlighting biological processes responsible for these effects, as well as unknowns in the epigenetic equation that might instantiate these contextually regulated developmental processes. En ligne : http://dx.doi.org/10.1017/s0954579416000900 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 Differential DNA methylation in peripheral blood mononuclear cells in adolescents exposed to significant early but not later childhood adversity / Elisa A. ESPOSITO in Development and Psychopathology, 28-4 pt2 (November 2016)
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[article]
Titre : Differential DNA methylation in peripheral blood mononuclear cells in adolescents exposed to significant early but not later childhood adversity Type de document : Texte imprimé et/ou numérique Auteurs : Elisa A. ESPOSITO, Auteur ; Meaghan J. JONES, Auteur ; Jenalee R. DOOM, Auteur ; Julia L. MACISAAC, Auteur ; Megan R. GUNNAR, Auteur ; Michael S. KOBOR, Auteur Article en page(s) : p.1385-1399 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Internationally adopted adolescents who are adopted as young children from conditions of poverty and deprivation have poorer physical and mental health outcomes than do adolescents conceived, born, and raised in the United States by families similar to those who adopt internationally. Using a sample of Russian and Eastern European adoptees to control for Caucasian race and US birth, and nonadopted offspring of well-educated and well-resourced parents to control for postadoption conditions, we hypothesized that the important differences in environments, conception to adoption, might be reflected in epigenetic patterns between groups, specifically in DNA methylation. Thus, we conducted an epigenome-wide association study to compare DNA methylation profiles at approximately 416,000 individual CpG loci from peripheral blood mononuclear cells of 50 adopted youth and 33 nonadopted youth. Adopted youth averaged 22 months at adoption, and both groups averaged 15 years at testing; thus, roughly 80% of their lives were lived in similar circumstances. Although concurrent physical health did not differ, cell-type composition predicted using the DNA methylation data revealed a striking difference in the white blood cell-type composition of the adopted and nonadopted youth. After correcting for cell type and removing invariant probes, 30 CpG sites in 19 genes were more methylated in the adopted group. We also used an exploratory functional analysis that revealed that 223 gene ontology terms, clustered in neural and developmental categories, were significantly enriched between groups. En ligne : http://dx.doi.org/10.1017/s0954579416000055 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294
in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1385-1399[article] Differential DNA methylation in peripheral blood mononuclear cells in adolescents exposed to significant early but not later childhood adversity [Texte imprimé et/ou numérique] / Elisa A. ESPOSITO, Auteur ; Meaghan J. JONES, Auteur ; Jenalee R. DOOM, Auteur ; Julia L. MACISAAC, Auteur ; Megan R. GUNNAR, Auteur ; Michael S. KOBOR, Auteur . - p.1385-1399.
Langues : Anglais (eng)
in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1385-1399
Index. décimale : PER Périodiques Résumé : Internationally adopted adolescents who are adopted as young children from conditions of poverty and deprivation have poorer physical and mental health outcomes than do adolescents conceived, born, and raised in the United States by families similar to those who adopt internationally. Using a sample of Russian and Eastern European adoptees to control for Caucasian race and US birth, and nonadopted offspring of well-educated and well-resourced parents to control for postadoption conditions, we hypothesized that the important differences in environments, conception to adoption, might be reflected in epigenetic patterns between groups, specifically in DNA methylation. Thus, we conducted an epigenome-wide association study to compare DNA methylation profiles at approximately 416,000 individual CpG loci from peripheral blood mononuclear cells of 50 adopted youth and 33 nonadopted youth. Adopted youth averaged 22 months at adoption, and both groups averaged 15 years at testing; thus, roughly 80% of their lives were lived in similar circumstances. Although concurrent physical health did not differ, cell-type composition predicted using the DNA methylation data revealed a striking difference in the white blood cell-type composition of the adopted and nonadopted youth. After correcting for cell type and removing invariant probes, 30 CpG sites in 19 genes were more methylated in the adopted group. We also used an exploratory functional analysis that revealed that 223 gene ontology terms, clustered in neural and developmental categories, were significantly enriched between groups. En ligne : http://dx.doi.org/10.1017/s0954579416000055 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 Associations among child abuse, mental health, and epigenetic modifications in the proopiomelanocortin gene (POMC): A study with children in Tanzania / Tobias HECKER in Development and Psychopathology, 28-4 pt2 (November 2016)
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Titre : Associations among child abuse, mental health, and epigenetic modifications in the proopiomelanocortin gene (POMC): A study with children in Tanzania Type de document : Texte imprimé et/ou numérique Auteurs : Tobias HECKER, Auteur ; Karl M. RADTKE, Auteur ; Katharin HERMENAU, Auteur ; Andreas PAPASSOTIROPOULOS, Auteur ; Thomas ELBERT, Auteur Article en page(s) : p.1401-1412 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Child abuse is associated with a number of emotional and behavioral problems. Nevertheless, it has been argued that these adverse consequences may not hold for societies in which many of the specific acts of abuse are culturally normed. Epigenetic modifications in the genes of the hypothalamus–pituitary–adrenal axis may provide a potential mechanism translating abuse into altered gene expression, which subsequently results in behavioral changes. Our investigation took place in Tanzania, a society in which many forms of abuse are commonly employed as disciplinary methods. We included 35 children with high exposure and compared them to 25 children with low exposure. Extreme group comparisons revealed that children with high exposure reported more mental health problems. Child abuse was associated with differential methylation in the proopiomelanocortin gene (POMC), measured both in saliva and in blood. Hierarchical clustering based on the methylation of the POMC gene found two distinct clusters. These corresponded with children's self-reported abuse, with two-thirds of the children allocated into their respective group. Our results emphasize the consequences of child abuse based on both molecular and behavioral grounds, providing further evidence that acts of abuse affect children, even when culturally acceptable. Furthermore, on a molecular level, our findings strengthen the credibility of children's self-reports. En ligne : http://dx.doi.org/10.1017/s0954579415001248 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294
in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1401-1412[article] Associations among child abuse, mental health, and epigenetic modifications in the proopiomelanocortin gene (POMC): A study with children in Tanzania [Texte imprimé et/ou numérique] / Tobias HECKER, Auteur ; Karl M. RADTKE, Auteur ; Katharin HERMENAU, Auteur ; Andreas PAPASSOTIROPOULOS, Auteur ; Thomas ELBERT, Auteur . - p.1401-1412.
Langues : Anglais (eng)
in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1401-1412
Index. décimale : PER Périodiques Résumé : Child abuse is associated with a number of emotional and behavioral problems. Nevertheless, it has been argued that these adverse consequences may not hold for societies in which many of the specific acts of abuse are culturally normed. Epigenetic modifications in the genes of the hypothalamus–pituitary–adrenal axis may provide a potential mechanism translating abuse into altered gene expression, which subsequently results in behavioral changes. Our investigation took place in Tanzania, a society in which many forms of abuse are commonly employed as disciplinary methods. We included 35 children with high exposure and compared them to 25 children with low exposure. Extreme group comparisons revealed that children with high exposure reported more mental health problems. Child abuse was associated with differential methylation in the proopiomelanocortin gene (POMC), measured both in saliva and in blood. Hierarchical clustering based on the methylation of the POMC gene found two distinct clusters. These corresponded with children's self-reported abuse, with two-thirds of the children allocated into their respective group. Our results emphasize the consequences of child abuse based on both molecular and behavioral grounds, providing further evidence that acts of abuse affect children, even when culturally acceptable. Furthermore, on a molecular level, our findings strengthen the credibility of children's self-reports. En ligne : http://dx.doi.org/10.1017/s0954579415001248 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 Genome-wide DNA methylation in 1-year-old infants of mothers with major depressive disorder / Dante CICCHETTI in Development and Psychopathology, 28-4 pt2 (November 2016)
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[article]
Titre : Genome-wide DNA methylation in 1-year-old infants of mothers with major depressive disorder Type de document : Texte imprimé et/ou numérique Auteurs : Dante CICCHETTI, Auteur ; Susan HETZEL, Auteur ; Fred A. ROGOSCH, Auteur ; Elizabeth D. HANDLEY, Auteur ; Sheree L. TOTH, Auteur Article en page(s) : p.1413-1419 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : A genome-wide methylation study was conducted among a sample of 114 infants (M age = 13.2 months, SD = 1.08) of low-income urban women with (n = 73) and without (n = 41) major depressive disorder. The Illumina HumanMethylation450 BeadChip array with a GenomeStudio Methylation Module and Illumina Custom model were used to conduct differential methylation analyses. Using the 5.0 × 10–7p value, 2,119 loci were found to be significantly different between infants of depressed and nondepressed mothers. Infants of depressed mothers had greater methylation at low methylation sites (0%–29%) compared to infants of nondepressed mothers. At high levels of methylation (70%–100%), the infants of depressed mothers were predominantly hypomethylated. The mean difference in methylation between the infants of depressed and infants of nondepressed mothers was 5.23%. Disease by biomarker analyses were also conducted using GeneGo MetaCore Software. The results indicated significant cancer-related differences in biomarker networks such as prostatic neoplasms, ovarian and breast neoplasms, and colonic neoplasms. The results of a process networks analysis indicated significant differences in process networks associated with neuronal development and central nervous system functioning, as well as cardiac development between infants of depressed and nondepressed mothers. These findings indicate that early in development, infants of mothers with major depressive disorder evince epigenetic differences relative to infants of well mothers that suggest risk for later adverse health outcomes. En ligne : http://dx.doi.org/10.1017/s0954579416000912 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294
in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1413-1419[article] Genome-wide DNA methylation in 1-year-old infants of mothers with major depressive disorder [Texte imprimé et/ou numérique] / Dante CICCHETTI, Auteur ; Susan HETZEL, Auteur ; Fred A. ROGOSCH, Auteur ; Elizabeth D. HANDLEY, Auteur ; Sheree L. TOTH, Auteur . - p.1413-1419.
Langues : Anglais (eng)
in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1413-1419
Index. décimale : PER Périodiques Résumé : A genome-wide methylation study was conducted among a sample of 114 infants (M age = 13.2 months, SD = 1.08) of low-income urban women with (n = 73) and without (n = 41) major depressive disorder. The Illumina HumanMethylation450 BeadChip array with a GenomeStudio Methylation Module and Illumina Custom model were used to conduct differential methylation analyses. Using the 5.0 × 10–7p value, 2,119 loci were found to be significantly different between infants of depressed and nondepressed mothers. Infants of depressed mothers had greater methylation at low methylation sites (0%–29%) compared to infants of nondepressed mothers. At high levels of methylation (70%–100%), the infants of depressed mothers were predominantly hypomethylated. The mean difference in methylation between the infants of depressed and infants of nondepressed mothers was 5.23%. Disease by biomarker analyses were also conducted using GeneGo MetaCore Software. The results indicated significant cancer-related differences in biomarker networks such as prostatic neoplasms, ovarian and breast neoplasms, and colonic neoplasms. The results of a process networks analysis indicated significant differences in process networks associated with neuronal development and central nervous system functioning, as well as cardiac development between infants of depressed and nondepressed mothers. These findings indicate that early in development, infants of mothers with major depressive disorder evince epigenetic differences relative to infants of well mothers that suggest risk for later adverse health outcomes. En ligne : http://dx.doi.org/10.1017/s0954579416000912 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 Maternal mental well-being during pregnancy and glucocorticoid receptor gene promoter methylation in the neonate / Toby MANSELL in Development and Psychopathology, 28-4 pt2 (November 2016)
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[article]
Titre : Maternal mental well-being during pregnancy and glucocorticoid receptor gene promoter methylation in the neonate Type de document : Texte imprimé et/ou numérique Auteurs : Toby MANSELL, Auteur ; Peter VUILLERMIN, Auteur ; Anne-Louise PONSONBY, Auteur ; Fiona COLLIER, Auteur ; Richard SAFFERY, Auteur ; Joanne RYAN, Auteur Article en page(s) : p.1421-1430 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Maternal mental health during pregnancy has been linked to health outcomes in progeny. Mounting evidence implicates fetal “programming” in this process, possibly via epigenetic disruption. Maternal mental health has been associated with glucocorticoid receptor methylation (nuclear receptor subfamily 3, group C, member 1 [NR3C1]) in the neonate; however, most studies have been small (n < 100) and have failed to control for multiple testing in the statistical analysis. The Barwon Infant Study is a population-derived birth cohort with antenatal recruitment. Maternal depression and anxiety were assessed using the Edinburgh Postnatal Depression Scale and psychological distress using the Perceived Stress Scale. NR3C1 cord blood methylation levels were determined using Sequenom MassArray for 481 participants. Maternal psychological distress and anxiety were associated with a small increase in neonate NR3C1 methylation at specific CpG sites, thus replicating some previous findings. However, associations were only nominally significant and did not remain after correction for the number of CpG sites and exposures investigated. As the largest study to explore the relationship between maternal well-being and offspring NR3C1 cord blood methylation, our results highlight the need for caution when interpreting previous findings in this area. Future studies must ensure they are adequately powered to detect the likely small effect sizes while controlling for multiple testing. En ligne : http://dx.doi.org/10.1017/s0954579416000183 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294
in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1421-1430[article] Maternal mental well-being during pregnancy and glucocorticoid receptor gene promoter methylation in the neonate [Texte imprimé et/ou numérique] / Toby MANSELL, Auteur ; Peter VUILLERMIN, Auteur ; Anne-Louise PONSONBY, Auteur ; Fiona COLLIER, Auteur ; Richard SAFFERY, Auteur ; Joanne RYAN, Auteur . - p.1421-1430.
Langues : Anglais (eng)
in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1421-1430
Index. décimale : PER Périodiques Résumé : Maternal mental health during pregnancy has been linked to health outcomes in progeny. Mounting evidence implicates fetal “programming” in this process, possibly via epigenetic disruption. Maternal mental health has been associated with glucocorticoid receptor methylation (nuclear receptor subfamily 3, group C, member 1 [NR3C1]) in the neonate; however, most studies have been small (n < 100) and have failed to control for multiple testing in the statistical analysis. The Barwon Infant Study is a population-derived birth cohort with antenatal recruitment. Maternal depression and anxiety were assessed using the Edinburgh Postnatal Depression Scale and psychological distress using the Perceived Stress Scale. NR3C1 cord blood methylation levels were determined using Sequenom MassArray for 481 participants. Maternal psychological distress and anxiety were associated with a small increase in neonate NR3C1 methylation at specific CpG sites, thus replicating some previous findings. However, associations were only nominally significant and did not remain after correction for the number of CpG sites and exposures investigated. As the largest study to explore the relationship between maternal well-being and offspring NR3C1 cord blood methylation, our results highlight the need for caution when interpreting previous findings in this area. Future studies must ensure they are adequately powered to detect the likely small effect sizes while controlling for multiple testing. En ligne : http://dx.doi.org/10.1017/s0954579416000183 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 Understanding the unfolding of stress regulation in infants / Heidemarie K. LAURENT in Development and Psychopathology, 28-4 pt2 (November 2016)
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Titre : Understanding the unfolding of stress regulation in infants Type de document : Texte imprimé et/ou numérique Auteurs : Heidemarie K. LAURENT, Auteur ; Gordon T. HAROLD, Auteur ; Leslie LEVE, Auteur ; Katherine H. SHELTON, Auteur ; Stephanie H. M. VAN GOOZEN, Auteur Article en page(s) : p.1431-1440 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Early identification of problems with psychosocial stress regulation is important for supporting mental and physical health. However, we currently lack knowledge about when reliable individual differences in stress-responsive physiology emerge and which aspects of maternal behavior determine the unfolding of infants' stress responses. Knowledge of these processes is further limited by analytic approaches that do not account for multiple levels of within- and between-family effects. In a low-risk sample (n = 100 dyads), we observed infant cortisol and mother/infant behavior during regular play and stress sessions longitudinally from age 1 to 3, and used a three-level model to separately examine variability in infant cortisol trajectories within sessions, across years, and across infants. Stable individual differences in hypothalamus–pituitary–adrenal axis regulation were observed in the first 3 years of life. Infants of less sensitive and more intrusive mothers manifested stress sensitization, that is, elevated cortisol levels during and following stress exposure, a profile related to behavioral distress. These findings have important practical implications, suggesting that children at risk for long-term stress dysregulation may be identified in the earliest years of life. En ligne : http://dx.doi.org/10.1017/s0954579416000171 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294
in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1431-1440[article] Understanding the unfolding of stress regulation in infants [Texte imprimé et/ou numérique] / Heidemarie K. LAURENT, Auteur ; Gordon T. HAROLD, Auteur ; Leslie LEVE, Auteur ; Katherine H. SHELTON, Auteur ; Stephanie H. M. VAN GOOZEN, Auteur . - p.1431-1440.
Langues : Anglais (eng)
in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1431-1440
Index. décimale : PER Périodiques Résumé : Early identification of problems with psychosocial stress regulation is important for supporting mental and physical health. However, we currently lack knowledge about when reliable individual differences in stress-responsive physiology emerge and which aspects of maternal behavior determine the unfolding of infants' stress responses. Knowledge of these processes is further limited by analytic approaches that do not account for multiple levels of within- and between-family effects. In a low-risk sample (n = 100 dyads), we observed infant cortisol and mother/infant behavior during regular play and stress sessions longitudinally from age 1 to 3, and used a three-level model to separately examine variability in infant cortisol trajectories within sessions, across years, and across infants. Stable individual differences in hypothalamus–pituitary–adrenal axis regulation were observed in the first 3 years of life. Infants of less sensitive and more intrusive mothers manifested stress sensitization, that is, elevated cortisol levels during and following stress exposure, a profile related to behavioral distress. These findings have important practical implications, suggesting that children at risk for long-term stress dysregulation may be identified in the earliest years of life. En ligne : http://dx.doi.org/10.1017/s0954579416000171 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 Witnessing substance use increases same-day antisocial behavior among at-risk adolescents: Gene–environment interaction in a 30-day ecological momentary assessment study / Michael A. RUSSELL in Development and Psychopathology, 28-4 pt2 (November 2016)
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Titre : Witnessing substance use increases same-day antisocial behavior among at-risk adolescents: Gene–environment interaction in a 30-day ecological momentary assessment study Type de document : Texte imprimé et/ou numérique Auteurs : Michael A. RUSSELL, Auteur ; Lin WANG, Auteur ; Candice L. ODGERS, Auteur Article en page(s) : p.1441-1456 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Many young adolescents are embedded in neighborhoods, schools, and homes where alcohol and drugs are frequently used. However, little is known about (a) how witnessing others' substance use affects adolescents in their daily lives and (b) which adolescents will be most affected. The current study used ecological momentary assessment with 151 young adolescents (ages 11–15) to examine the daily association between witnessing substance use and antisocial behavior across 38 consecutive days. Results from multilevel logistic regression models indicated that adolescents were more likely to engage in antisocial behavior on days when they witnessed others using substances, an association that held when substance use was witnessed inside the home as well as outside the home (e.g., at school or in their neighborhoods). A significant Gene × Environment interaction suggested that the same-day association between witnessing substance use and antisocial behavior was significantly stronger among adolescents with, versus without, the dopamine receptor D4 seven repeat (DRD4-7R) allele. The implications of the findings for theory and research related to adolescent antisocial behavior are discussed. En ligne : http://dx.doi.org/10.1017/s0954579415001182 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294
in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1441-1456[article] Witnessing substance use increases same-day antisocial behavior among at-risk adolescents: Gene–environment interaction in a 30-day ecological momentary assessment study [Texte imprimé et/ou numérique] / Michael A. RUSSELL, Auteur ; Lin WANG, Auteur ; Candice L. ODGERS, Auteur . - p.1441-1456.
Langues : Anglais (eng)
in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1441-1456
Index. décimale : PER Périodiques Résumé : Many young adolescents are embedded in neighborhoods, schools, and homes where alcohol and drugs are frequently used. However, little is known about (a) how witnessing others' substance use affects adolescents in their daily lives and (b) which adolescents will be most affected. The current study used ecological momentary assessment with 151 young adolescents (ages 11–15) to examine the daily association between witnessing substance use and antisocial behavior across 38 consecutive days. Results from multilevel logistic regression models indicated that adolescents were more likely to engage in antisocial behavior on days when they witnessed others using substances, an association that held when substance use was witnessed inside the home as well as outside the home (e.g., at school or in their neighborhoods). A significant Gene × Environment interaction suggested that the same-day association between witnessing substance use and antisocial behavior was significantly stronger among adolescents with, versus without, the dopamine receptor D4 seven repeat (DRD4-7R) allele. The implications of the findings for theory and research related to adolescent antisocial behavior are discussed. En ligne : http://dx.doi.org/10.1017/s0954579415001182 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 The cognitive developmental profile associated with fragile X syndrome: A longitudinal investigation of cognitive strengths and weaknesses through childhood and adolescence / Eve-Marie QUINTIN in Development and Psychopathology, 28-4 pt2 (November 2016)
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[article]
Titre : The cognitive developmental profile associated with fragile X syndrome: A longitudinal investigation of cognitive strengths and weaknesses through childhood and adolescence Type de document : Texte imprimé et/ou numérique Auteurs : Eve-Marie QUINTIN, Auteur ; Booil JO, Auteur ; Scott S. HALL, Auteur ; Jennifer L. BRUNO, Auteur ; Lindsay C. CHROMIK, Auteur ; Mira M. RAMAN, Auteur ; Amy A. LIGHTBODY, Auteur ; Arianna MARTIN, Auteur ; Allan L. REISS, Auteur Article en page(s) : p.1457-1469 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Few studies have investigated developmental strengths and weaknesses within the cognitive profile of children and adolescents with fragile X syndrome (FXS), a single-gene cause of inherited intellectual impairment. With a prospective longitudinal design and using normalized raw scores (Z scores) to circumvent floor effects, we measured cognitive functioning of 184 children and adolescents with FXS (ages 6 to 16) using the Wechsler Scale of Intelligence for Children on one to three occasions for each participant. Participants with FXS received lower raw scores relative to the Wechsler Scale of Intelligence for Children normative sample across the developmental period. Verbal comprehension, perceptual organization, and processing speed Z scores were marked by a widening gap from the normative sample, while freedom from distractibility Z scores showed a narrowing gap. Key findings include a relative strength for verbal skills in comparison with visuospatial–constructive skills arising in adolescence and a discrepancy between working memory (weakness) and processing speed (strength) in childhood that diminishes in adolescence. Results suggest that the cognitive profile associated with FXS develops dynamically from childhood to adolescence. Findings are discussed within the context of aberrant brain morphology in childhood and maturation in adolescence. We argue that assessing disorder-specific cognitive developmental profiles will benefit future disorder-specific treatment research. En ligne : http://dx.doi.org/10.1017/s0954579415001200 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294
in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1457-1469[article] The cognitive developmental profile associated with fragile X syndrome: A longitudinal investigation of cognitive strengths and weaknesses through childhood and adolescence [Texte imprimé et/ou numérique] / Eve-Marie QUINTIN, Auteur ; Booil JO, Auteur ; Scott S. HALL, Auteur ; Jennifer L. BRUNO, Auteur ; Lindsay C. CHROMIK, Auteur ; Mira M. RAMAN, Auteur ; Amy A. LIGHTBODY, Auteur ; Arianna MARTIN, Auteur ; Allan L. REISS, Auteur . - p.1457-1469.
Langues : Anglais (eng)
in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1457-1469
Index. décimale : PER Périodiques Résumé : Few studies have investigated developmental strengths and weaknesses within the cognitive profile of children and adolescents with fragile X syndrome (FXS), a single-gene cause of inherited intellectual impairment. With a prospective longitudinal design and using normalized raw scores (Z scores) to circumvent floor effects, we measured cognitive functioning of 184 children and adolescents with FXS (ages 6 to 16) using the Wechsler Scale of Intelligence for Children on one to three occasions for each participant. Participants with FXS received lower raw scores relative to the Wechsler Scale of Intelligence for Children normative sample across the developmental period. Verbal comprehension, perceptual organization, and processing speed Z scores were marked by a widening gap from the normative sample, while freedom from distractibility Z scores showed a narrowing gap. Key findings include a relative strength for verbal skills in comparison with visuospatial–constructive skills arising in adolescence and a discrepancy between working memory (weakness) and processing speed (strength) in childhood that diminishes in adolescence. Results suggest that the cognitive profile associated with FXS develops dynamically from childhood to adolescence. Findings are discussed within the context of aberrant brain morphology in childhood and maturation in adolescence. We argue that assessing disorder-specific cognitive developmental profiles will benefit future disorder-specific treatment research. En ligne : http://dx.doi.org/10.1017/s0954579415001200 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 The long-term effectiveness of the Family Check-Up on school-age conduct problems: Moderation by neighborhood deprivation / Daniel S. SHAW in Development and Psychopathology, 28-4 pt2 (November 2016)
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[article]
Titre : The long-term effectiveness of the Family Check-Up on school-age conduct problems: Moderation by neighborhood deprivation Type de document : Texte imprimé et/ou numérique Auteurs : Daniel S. SHAW, Auteur ; Stephanie L. SITNICK, Auteur ; Lauretta M. BRENNAN, Auteur ; Daniel Ewon CHOE, Auteur ; Thomas J. DISHION, Auteur ; Melvin N. WILSON, Auteur ; Frances GARDNER, Auteur Article en page(s) : p.1471-1486 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Several studies suggest that neighborhood deprivation is a unique risk factor in child and adolescent development of problem behavior. We sought to examine whether previously established intervention effects of the Family Check-Up (FCU) on child conduct problems at age 7.5 would persist through age 9.5, and whether neighborhood deprivation would moderate these effects. In addition, we examined whether improvements in parent–child interaction during early childhood associated with the FCU would be related to later reductions in child aggression among families living in the highest risk neighborhoods. Using a multisite cohort of at-risk children identified on the basis of family, child, and socioeconomic risk and randomly assigned to the FCU, intervention effects were found to be moderated by neighborhood deprivation, such that they were only directly present for those living at moderate versus extreme levels of neighborhood deprivation. In addition, improvements in child aggression were evident for children living in extreme neighborhood deprivation when parents improved the quality of their parent–child interaction during the toddler period (i.e., moderated mediation). Implications of the findings are discussed in relation to the possibilities and possible limitations in prevention of early problem behavior for those children living in extreme and moderate levels of poverty. En ligne : http://dx.doi.org/10.1017/s0954579415001212 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294
in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1471-1486[article] The long-term effectiveness of the Family Check-Up on school-age conduct problems: Moderation by neighborhood deprivation [Texte imprimé et/ou numérique] / Daniel S. SHAW, Auteur ; Stephanie L. SITNICK, Auteur ; Lauretta M. BRENNAN, Auteur ; Daniel Ewon CHOE, Auteur ; Thomas J. DISHION, Auteur ; Melvin N. WILSON, Auteur ; Frances GARDNER, Auteur . - p.1471-1486.
Langues : Anglais (eng)
in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1471-1486
Index. décimale : PER Périodiques Résumé : Several studies suggest that neighborhood deprivation is a unique risk factor in child and adolescent development of problem behavior. We sought to examine whether previously established intervention effects of the Family Check-Up (FCU) on child conduct problems at age 7.5 would persist through age 9.5, and whether neighborhood deprivation would moderate these effects. In addition, we examined whether improvements in parent–child interaction during early childhood associated with the FCU would be related to later reductions in child aggression among families living in the highest risk neighborhoods. Using a multisite cohort of at-risk children identified on the basis of family, child, and socioeconomic risk and randomly assigned to the FCU, intervention effects were found to be moderated by neighborhood deprivation, such that they were only directly present for those living at moderate versus extreme levels of neighborhood deprivation. In addition, improvements in child aggression were evident for children living in extreme neighborhood deprivation when parents improved the quality of their parent–child interaction during the toddler period (i.e., moderated mediation). Implications of the findings are discussed in relation to the possibilities and possible limitations in prevention of early problem behavior for those children living in extreme and moderate levels of poverty. En ligne : http://dx.doi.org/10.1017/s0954579415001212 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 Role of temperament in early adolescent pure and co-occurring internalizing and externalizing problems using a bifactor model: Moderation by parenting and gender / Frances L. WANG in Development and Psychopathology, 28-4 pt2 (November 2016)
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[article]
Titre : Role of temperament in early adolescent pure and co-occurring internalizing and externalizing problems using a bifactor model: Moderation by parenting and gender Type de document : Texte imprimé et/ou numérique Auteurs : Frances L. WANG, Auteur ; Nancy EISENBERG, Auteur ; Carlos VALIENTE, Auteur ; Tracy L. SPINRAD, Auteur Article en page(s) : p.1487-1504 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : We contribute to the literature on the relations of temperament to externalizing and internalizing problems by considering parental emotional expressivity and child gender as moderators of such relations and examining prediction of pure and co-occurring problem behaviors during early to middle adolescence using bifactor models (which provide unique and continuous factors for pure and co-occurring internalizing and externalizing problems). Parents and teachers reported on children's (4.5- to 8-year-olds; N = 214) and early adolescents’ (6 years later; N = 168) effortful control, impulsivity, anger, sadness, and problem behaviors. Parental emotional expressivity was measured observationally and with parents’ self-reports. Early-adolescents’ pure externalizing and co-occurring problems shared childhood and/or early-adolescent risk factors of low effortful control, high impulsivity, and high anger. Lower childhood and early-adolescent impulsivity and higher early-adolescent sadness predicted early-adolescents’ pure internalizing. Childhood positive parental emotional expressivity more consistently related to early-adolescents’ lower pure externalizing compared to co-occurring problems and pure internalizing. Lower effortful control predicted changes in externalizing (pure and co-occurring) over 6 years, but only when parental positive expressivity was low. Higher impulsivity predicted co-occurring problems only for boys. Findings highlight the probable complex developmental pathways to adolescent pure and co-occurring externalizing and internalizing problems. En ligne : http://dx.doi.org/10.1017/s0954579415001224 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294
in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1487-1504[article] Role of temperament in early adolescent pure and co-occurring internalizing and externalizing problems using a bifactor model: Moderation by parenting and gender [Texte imprimé et/ou numérique] / Frances L. WANG, Auteur ; Nancy EISENBERG, Auteur ; Carlos VALIENTE, Auteur ; Tracy L. SPINRAD, Auteur . - p.1487-1504.
Langues : Anglais (eng)
in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1487-1504
Index. décimale : PER Périodiques Résumé : We contribute to the literature on the relations of temperament to externalizing and internalizing problems by considering parental emotional expressivity and child gender as moderators of such relations and examining prediction of pure and co-occurring problem behaviors during early to middle adolescence using bifactor models (which provide unique and continuous factors for pure and co-occurring internalizing and externalizing problems). Parents and teachers reported on children's (4.5- to 8-year-olds; N = 214) and early adolescents’ (6 years later; N = 168) effortful control, impulsivity, anger, sadness, and problem behaviors. Parental emotional expressivity was measured observationally and with parents’ self-reports. Early-adolescents’ pure externalizing and co-occurring problems shared childhood and/or early-adolescent risk factors of low effortful control, high impulsivity, and high anger. Lower childhood and early-adolescent impulsivity and higher early-adolescent sadness predicted early-adolescents’ pure internalizing. Childhood positive parental emotional expressivity more consistently related to early-adolescents’ lower pure externalizing compared to co-occurring problems and pure internalizing. Lower effortful control predicted changes in externalizing (pure and co-occurring) over 6 years, but only when parental positive expressivity was low. Higher impulsivity predicted co-occurring problems only for boys. Findings highlight the probable complex developmental pathways to adolescent pure and co-occurring externalizing and internalizing problems. En ligne : http://dx.doi.org/10.1017/s0954579415001224 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 Early unpredictability predicts increased adolescent externalizing behaviors and substance use: A life history perspective / Jenalee R. DOOM in Development and Psychopathology, 28-4 pt2 (November 2016)
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[article]
Titre : Early unpredictability predicts increased adolescent externalizing behaviors and substance use: A life history perspective Type de document : Texte imprimé et/ou numérique Auteurs : Jenalee R. DOOM, Auteur ; Adrienne A. VANZOMEREN-DOHM, Auteur ; Jeffry A. SIMPSON, Auteur Article en page(s) : p.1505-1516 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : According to evolutionary life history models, environmental harshness and unpredictability can both promote a fast life history strategy characterized by increased risk taking and enacting short-term, opportunistic behaviors. The current longitudinal study tests whether environmental unpredictability during childhood has stronger effects on risky behavior during adolescence than harshness, and whether there may be an early “sensitive period” during which unpredictability has particularly strong and unique effects on these outcomes. Using data from the Minnesota Longitudinal Study of Risk and Adaptation, prospective assessments of environmental unpredictability (changes in residence, cohabitation, and parental occupation) and harshness (mean socioeconomic status) from birth into adolescence were used to predict self-reported externalizing behaviors and substance use at age 16 (N = 220). Exposure to greater early unpredictability (between ages 0 and 5) predicted more externalizing behaviors as well as more alcohol and marijuana use at age 16, controlling for harshness and later unpredictability (between ages 6 and 16). Harshness predicted adolescent substance use, and later unpredictability predicted adolescent externalizing behaviors at the trend level. Early unpredictability and harshness also interacted, such that the highest levels of risk taking occurred in individuals who experienced more early unpredictability and lived in harsher environments. Age 16 externalizing behaviors, but not substance use, mediated the association between early unpredictability and externalizing/criminal behaviors at age 23. We discuss how exposure to early environmental unpredictability may alter biological and social–cognitive functioning from a life history perspective. En ligne : http://dx.doi.org/10.1017/s0954579415001169 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294
in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1505-1516[article] Early unpredictability predicts increased adolescent externalizing behaviors and substance use: A life history perspective [Texte imprimé et/ou numérique] / Jenalee R. DOOM, Auteur ; Adrienne A. VANZOMEREN-DOHM, Auteur ; Jeffry A. SIMPSON, Auteur . - p.1505-1516.
Langues : Anglais (eng)
in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1505-1516
Index. décimale : PER Périodiques Résumé : According to evolutionary life history models, environmental harshness and unpredictability can both promote a fast life history strategy characterized by increased risk taking and enacting short-term, opportunistic behaviors. The current longitudinal study tests whether environmental unpredictability during childhood has stronger effects on risky behavior during adolescence than harshness, and whether there may be an early “sensitive period” during which unpredictability has particularly strong and unique effects on these outcomes. Using data from the Minnesota Longitudinal Study of Risk and Adaptation, prospective assessments of environmental unpredictability (changes in residence, cohabitation, and parental occupation) and harshness (mean socioeconomic status) from birth into adolescence were used to predict self-reported externalizing behaviors and substance use at age 16 (N = 220). Exposure to greater early unpredictability (between ages 0 and 5) predicted more externalizing behaviors as well as more alcohol and marijuana use at age 16, controlling for harshness and later unpredictability (between ages 6 and 16). Harshness predicted adolescent substance use, and later unpredictability predicted adolescent externalizing behaviors at the trend level. Early unpredictability and harshness also interacted, such that the highest levels of risk taking occurred in individuals who experienced more early unpredictability and lived in harsher environments. Age 16 externalizing behaviors, but not substance use, mediated the association between early unpredictability and externalizing/criminal behaviors at age 23. We discuss how exposure to early environmental unpredictability may alter biological and social–cognitive functioning from a life history perspective. En ligne : http://dx.doi.org/10.1017/s0954579415001169 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 Predictors of change in depressive symptoms from preschool to first grade / Trude REINFJELL in Development and Psychopathology, 28-4 pt2 (November 2016)
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[article]
Titre : Predictors of change in depressive symptoms from preschool to first grade Type de document : Texte imprimé et/ou numérique Auteurs : Trude REINFJELL, Auteur ; Silja Berg KÅRSTAD, Auteur ; Turid Suzanne BERG-NIELSEN, Auteur ; Joan L. LUBY, Auteur ; Lars WICHSTRØM, Auteur Article en page(s) : p.1517-1530 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Children's depressive symptoms in the transition from preschool to school are rarely investigated. We therefore tested whether children's temperament (effortful control and negative affect), social skills, child psychopathology, environmental stressors (life events), parental accuracy of predicting their child's emotion understanding (parental accuracy), parental emotional availability, and parental depression predict changes in depressive symptoms from preschool to first grade. Parents of a community sample of 995 4-year-olds were interviewed using the Preschool Age Psychiatric Assessment. The children and parents were reassessed when the children started first grade (n = 795). The results showed that DSM-5 defined depressive symptoms increased. Child temperamental negative affect and parental depression predicted increased, whereas social skills predicted decreased, depressive symptoms. However, such social skills were only protective among children with low and medium effortful control. Further, high parental accuracy proved protective among children with low effortful control and high negative affect. Thus, interventions that treat parental depression may be important for young children. Children with low effortful control and high negative affect may especially benefit from having parents who accurately perceive their emotional understanding. Efforts to enhance social skills may prove particularly important for children with low or medium effortful control. En ligne : http://dx.doi.org/10.1017/s0954579415001170 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294
in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1517-1530[article] Predictors of change in depressive symptoms from preschool to first grade [Texte imprimé et/ou numérique] / Trude REINFJELL, Auteur ; Silja Berg KÅRSTAD, Auteur ; Turid Suzanne BERG-NIELSEN, Auteur ; Joan L. LUBY, Auteur ; Lars WICHSTRØM, Auteur . - p.1517-1530.
Langues : Anglais (eng)
in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1517-1530
Index. décimale : PER Périodiques Résumé : Children's depressive symptoms in the transition from preschool to school are rarely investigated. We therefore tested whether children's temperament (effortful control and negative affect), social skills, child psychopathology, environmental stressors (life events), parental accuracy of predicting their child's emotion understanding (parental accuracy), parental emotional availability, and parental depression predict changes in depressive symptoms from preschool to first grade. Parents of a community sample of 995 4-year-olds were interviewed using the Preschool Age Psychiatric Assessment. The children and parents were reassessed when the children started first grade (n = 795). The results showed that DSM-5 defined depressive symptoms increased. Child temperamental negative affect and parental depression predicted increased, whereas social skills predicted decreased, depressive symptoms. However, such social skills were only protective among children with low and medium effortful control. Further, high parental accuracy proved protective among children with low effortful control and high negative affect. Thus, interventions that treat parental depression may be important for young children. Children with low effortful control and high negative affect may especially benefit from having parents who accurately perceive their emotional understanding. Efforts to enhance social skills may prove particularly important for children with low or medium effortful control. En ligne : http://dx.doi.org/10.1017/s0954579415001170 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 Longitudinal phenotypes for alcoholism: Heterogeneity of course, early identifiers, and life course correlates / Jennifer M. JESTER in Development and Psychopathology, 28-4 pt2 (November 2016)
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[article]
Titre : Longitudinal phenotypes for alcoholism: Heterogeneity of course, early identifiers, and life course correlates Type de document : Texte imprimé et/ou numérique Auteurs : Jennifer M. JESTER, Auteur ; Anne BUU, Auteur ; Robert A. ZUCKER, Auteur Article en page(s) : p.1531-1546 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Alcoholism is a heterogeneous disorder; however, characterization of life-course variations in symptomatology is almost nonexistent, and developmentally early predictors of variations are very poorly characterized. In this study, the course of alcoholic symptomatology over 32 years is differentiated, and predictors and covariates of trajectory class membership are identified. A community sample of alcoholic and neighborhood matched control families, 332 men and 336 women, was recruited based on alcoholism in the men. Symptoms were assessed retrospectively at baseline (mean age = 32) back to age 15 and prospectively from baseline every 3 years for 15 years. Trajectory classes were established using growth mixture modeling. Men and women had very similarly shaped trajectory classes: developmentally limited (men: 29%, women: 42%), developmentally cumulative (men: 26%, women: 38%), young adult onset (men: 31%, women: 21%), and early onset severe (men: 13%). Three factors at age 15 predicted class membership: family history of alcoholism, age 15 symptoms, and level of childhood antisocial behavior. Numerous measures of drinking and other psychopathology were also associated with class membership. The findings suggest that clinical assessments can be crafted where the profile of current and historical information can predict not only severity of prognosis but also future moderation of symptoms and/or remission over intervals as long as decades. En ligne : http://dx.doi.org/10.1017/s0954579415001157 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294
in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1531-1546[article] Longitudinal phenotypes for alcoholism: Heterogeneity of course, early identifiers, and life course correlates [Texte imprimé et/ou numérique] / Jennifer M. JESTER, Auteur ; Anne BUU, Auteur ; Robert A. ZUCKER, Auteur . - p.1531-1546.
Langues : Anglais (eng)
in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1531-1546
Index. décimale : PER Périodiques Résumé : Alcoholism is a heterogeneous disorder; however, characterization of life-course variations in symptomatology is almost nonexistent, and developmentally early predictors of variations are very poorly characterized. In this study, the course of alcoholic symptomatology over 32 years is differentiated, and predictors and covariates of trajectory class membership are identified. A community sample of alcoholic and neighborhood matched control families, 332 men and 336 women, was recruited based on alcoholism in the men. Symptoms were assessed retrospectively at baseline (mean age = 32) back to age 15 and prospectively from baseline every 3 years for 15 years. Trajectory classes were established using growth mixture modeling. Men and women had very similarly shaped trajectory classes: developmentally limited (men: 29%, women: 42%), developmentally cumulative (men: 26%, women: 38%), young adult onset (men: 31%, women: 21%), and early onset severe (men: 13%). Three factors at age 15 predicted class membership: family history of alcoholism, age 15 symptoms, and level of childhood antisocial behavior. Numerous measures of drinking and other psychopathology were also associated with class membership. The findings suggest that clinical assessments can be crafted where the profile of current and historical information can predict not only severity of prognosis but also future moderation of symptoms and/or remission over intervals as long as decades. En ligne : http://dx.doi.org/10.1017/s0954579415001157 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 A multidomain cascade model of early childhood risk factors associated with oppositional defiant disorder symptoms in a community sample of 6-year-olds / John V. LAVIGNE in Development and Psychopathology, 28-4 pt2 (November 2016)
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[article]
Titre : A multidomain cascade model of early childhood risk factors associated with oppositional defiant disorder symptoms in a community sample of 6-year-olds Type de document : Texte imprimé et/ou numérique Auteurs : John V. LAVIGNE, Auteur ; Karen R. GOUZE, Auteur ; Joyce HOPKINS, Auteur ; Fred B. BRYANT, Auteur Article en page(s) : p.1547-1562 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The present study examined a cascade model of age 4 and 5 contextual, parent, parenting, and child factors on symptoms of oppositional defiant disorder (ODD) at age 6 in a diverse community sample of 796 children. Contextual factors include socioeconomic status, family stress, and conflict; parent factors included parental depression; parenting factors included parental hostility, support, and scaffolding skills; child factors included child effortful control (EC), negative affect (NA), and sensory regulation. Direct effects of age 5 conflict, hostility, scaffolding, EC, and NA were found. Significant indirect, cascading effects on age 6 ODD symptom levels were noted for age 4 socioeconomic status via age 5 conflict and scaffolding skills; age 4 parental depression via age 5 child NA; age 4 parental hostility and support via age 5 EC; age 4 support via age 5 EC; and age 4 attachment via age 5 EC. Parenting contributed to EC, and the age 5 EC effects on subsequent ODD symptom levels were distinct from age 5 parental contributions. Scaffolding and ODD symptoms may have a reciprocal relationship. These results highlight the importance of using a multidomain model to examine factors associated with ODD symptoms early in the child's grammar school years. En ligne : http://dx.doi.org/10.1017/s0954579415001194 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294
in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1547-1562[article] A multidomain cascade model of early childhood risk factors associated with oppositional defiant disorder symptoms in a community sample of 6-year-olds [Texte imprimé et/ou numérique] / John V. LAVIGNE, Auteur ; Karen R. GOUZE, Auteur ; Joyce HOPKINS, Auteur ; Fred B. BRYANT, Auteur . - p.1547-1562.
Langues : Anglais (eng)
in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1547-1562
Index. décimale : PER Périodiques Résumé : The present study examined a cascade model of age 4 and 5 contextual, parent, parenting, and child factors on symptoms of oppositional defiant disorder (ODD) at age 6 in a diverse community sample of 796 children. Contextual factors include socioeconomic status, family stress, and conflict; parent factors included parental depression; parenting factors included parental hostility, support, and scaffolding skills; child factors included child effortful control (EC), negative affect (NA), and sensory regulation. Direct effects of age 5 conflict, hostility, scaffolding, EC, and NA were found. Significant indirect, cascading effects on age 6 ODD symptom levels were noted for age 4 socioeconomic status via age 5 conflict and scaffolding skills; age 4 parental depression via age 5 child NA; age 4 parental hostility and support via age 5 EC; age 4 support via age 5 EC; and age 4 attachment via age 5 EC. Parenting contributed to EC, and the age 5 EC effects on subsequent ODD symptom levels were distinct from age 5 parental contributions. Scaffolding and ODD symptoms may have a reciprocal relationship. These results highlight the importance of using a multidomain model to examine factors associated with ODD symptoms early in the child's grammar school years. En ligne : http://dx.doi.org/10.1017/s0954579415001194 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 Cortisol profiles: A test for adaptive calibration of the stress response system in maltreated and nonmaltreated youth—CORRIGENDUM / Melissa K. PECKINS in Development and Psychopathology, 28-4 pt2 (November 2016)
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Titre : Cortisol profiles: A test for adaptive calibration of the stress response system in maltreated and nonmaltreated youth—CORRIGENDUM Type de document : Texte imprimé et/ou numérique Auteurs : Melissa K. PECKINS, Auteur ; Elizabeth J. SUSMAN, Auteur ; Sonya NEGRIFF, Auteur ; Jennie G. NOLL, Auteur ; Penelope K. TRICKETT, Auteur Article en page(s) : p.1563-1564 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1017/s0954579415001273 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294
in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1563-1564[article] Cortisol profiles: A test for adaptive calibration of the stress response system in maltreated and nonmaltreated youth—CORRIGENDUM [Texte imprimé et/ou numérique] / Melissa K. PECKINS, Auteur ; Elizabeth J. SUSMAN, Auteur ; Sonya NEGRIFF, Auteur ; Jennie G. NOLL, Auteur ; Penelope K. TRICKETT, Auteur . - p.1563-1564.
Langues : Anglais (eng)
in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1563-1564
Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1017/s0954579415001273 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 Putting theory to the test: Examining family context, caregiver motivation, and conflict in the Family Check-Up model—CORRIGENDUM / Gregory M. FOSCO in Development and Psychopathology, 28-4 pt2 (November 2016)
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Titre : Putting theory to the test: Examining family context, caregiver motivation, and conflict in the Family Check-Up model—CORRIGENDUM Type de document : Texte imprimé et/ou numérique Auteurs : Gregory M. FOSCO, Auteur ; Mark J. VAN RYZIN, Auteur ; Elizabeth A. STORMSHAK, Auteur ; Thomas J. DISHION, Auteur Article en page(s) : p.1565-1565 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1017/s0954579415001261 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294
in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1565-1565[article] Putting theory to the test: Examining family context, caregiver motivation, and conflict in the Family Check-Up model—CORRIGENDUM [Texte imprimé et/ou numérique] / Gregory M. FOSCO, Auteur ; Mark J. VAN RYZIN, Auteur ; Elizabeth A. STORMSHAK, Auteur ; Thomas J. DISHION, Auteur . - p.1565-1565.
Langues : Anglais (eng)
in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1565-1565
Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1017/s0954579415001261 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 Empathy as a “risky strength”: A multilevel examination of empathy and risk for internalizing disorders—CORRIGENDUM / Erin B. TONE in Development and Psychopathology, 28-4 pt2 (November 2016)
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Titre : Empathy as a “risky strength”: A multilevel examination of empathy and risk for internalizing disorders—CORRIGENDUM Type de document : Texte imprimé et/ou numérique Auteurs : Erin B. TONE, Auteur ; Erin C. TULLY, Auteur Article en page(s) : p.1567-1567 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1017/s0954579415000231 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294
in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1567-1567[article] Empathy as a “risky strength”: A multilevel examination of empathy and risk for internalizing disorders—CORRIGENDUM [Texte imprimé et/ou numérique] / Erin B. TONE, Auteur ; Erin C. TULLY, Auteur . - p.1567-1567.
Langues : Anglais (eng)
in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1567-1567
Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1017/s0954579415000231 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 Differential susceptibility to effects of maternal sensitivity? A study of candidate plasticity genes—CORRIGENDUM / Jay BELSKY in Development and Psychopathology, 28-4 pt2 (November 2016)
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Titre : Differential susceptibility to effects of maternal sensitivity? A study of candidate plasticity genes—CORRIGENDUM Type de document : Texte imprimé et/ou numérique Auteurs : Jay BELSKY, Auteur ; Daniel A. NEWMAN, Auteur ; Keith F. WIDAMAN, Auteur ; Phil RODKIN, Auteur ; Michael PLUESS, Auteur ; R. Chris FRALEY, Auteur ; Daniel BERRY, Auteur ; Jonathan L. HELM, Auteur ; Glenn I. ROISMAN, Auteur Article en page(s) : p.1569-1570 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1017/s0954579414001497 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294
in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1569-1570[article] Differential susceptibility to effects of maternal sensitivity? A study of candidate plasticity genes—CORRIGENDUM [Texte imprimé et/ou numérique] / Jay BELSKY, Auteur ; Daniel A. NEWMAN, Auteur ; Keith F. WIDAMAN, Auteur ; Phil RODKIN, Auteur ; Michael PLUESS, Auteur ; R. Chris FRALEY, Auteur ; Daniel BERRY, Auteur ; Jonathan L. HELM, Auteur ; Glenn I. ROISMAN, Auteur . - p.1569-1570.
Langues : Anglais (eng)
in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1569-1570
Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1017/s0954579414001497 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 Early unpredictability predicts increased adolescent externalizing behaviors and substance use: A life history perspective—CORRIGENDUM / Jenalee R. DOOM in Development and Psychopathology, 28-4 pt2 (November 2016)
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Titre : Early unpredictability predicts increased adolescent externalizing behaviors and substance use: A life history perspective—CORRIGENDUM Type de document : Texte imprimé et/ou numérique Auteurs : Jenalee R. DOOM, Auteur ; Adrienne A. VANZOMEREN-DOHM, Auteur ; Jeffry A. SIMPSON, Auteur Article en page(s) : p.1571-1571 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1017/s0954579416000948 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294
in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1571-1571[article] Early unpredictability predicts increased adolescent externalizing behaviors and substance use: A life history perspective—CORRIGENDUM [Texte imprimé et/ou numérique] / Jenalee R. DOOM, Auteur ; Adrienne A. VANZOMEREN-DOHM, Auteur ; Jeffry A. SIMPSON, Auteur . - p.1571-1571.
Langues : Anglais (eng)
in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1571-1571
Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1017/s0954579416000948 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294