[article]
| Titre : |
Omega 3/6 fatty acids for reading in children: a randomized, double-blind, placebo-controlled trial in 9-year-old mainstream schoolchildren in Sweden |
| Type de document : |
Texte imprimé et/ou numérique |
| Auteurs : |
Mats JOHNSON, Auteur ; Gunnar FRANSSON, Auteur ; Sven ÖSTLUND, Auteur ; Björn ARESKOUG, Auteur ; Christopher GILLBERG, Auteur |
| Article en page(s) : |
p.83-93 |
| Langues : |
Anglais (eng) |
| Mots-clés : |
Omega 3/6 Logos test reading mainstream schoolchildren attention problems |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Background Previous research has shown positive effects of Omega 3/6 fatty acids in children with inattention and reading difficulties. We aimed to investigate if Omega 3/6 improved reading ability in mainstream schoolchildren. Methods We performed a 3-month parallel, randomized, double-blind, placebo-controlled trial followed by 3-month active treatment for all subjects. Mainstream schoolchildren aged 9–10 years were randomized 1:1 to receive three Omega 3/6 capsules twice daily or identical placebo. Assessments were made at baseline, 3 months, and 6 months. The primary outcome measure was the Logos test battery for evaluating reading abilities. The trial is registered with ClinicalTrials.gov, number NCT02557477. Results The study enrolled 154 children (active n = 78; placebo n = 76), of whom 122 completed the first 3 months (active n = 64; placebo n = 58) and 105 completed the whole study (active/active n = 55; placebo/active n = 50). Outcomes were assessed by per protocol (PP) and intention-to-treat (ITT) analyses. Active treatment was superior to placebo at 3 months for improvement in phonologic decoding time (PP active/placebo difference ?0.16; 95% CI ?0.03, ?0.29; effect size (ES) .44; p = .005; and ITT ES .37; p = .036), in visual analysis time (PP active/placebo difference ?0.19; 95% CI ?0.05, ?0.33; ES .49; p = .013; and ITT ES .40; p = .01), and for boys in phonologic decoding time (PP ?0.22; 95% CI ?0.03, ?0.41; ES .62; p = .004). Children with ADHD-RS scores above the median showed treatment benefits in visual analysis time (PP ES .8, p = .009), reading speed per word (PP ES .61, p = .008), and phonologic decoding time per word (PP ES .85, p = .006). Adverse events were rare and mild, mainly stomach pain/diarrhea (active n = 9, placebo n = 2). Conclusions Compared with placebo, 3 months of Omega 3/6 treatment improved reading ability – specifically the clinically relevant ‘phonologic decoding time’ and ‘visual analysis time’ – in mainstream schoolchildren. In particular, children with attention problems showed treatment benefits. |
| En ligne : |
http://dx.doi.org/10.1111/jcpp.12614 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298 |
in Journal of Child Psychology and Psychiatry > 58-1 (January 2017) . - p.83-93
[article] Omega 3/6 fatty acids for reading in children: a randomized, double-blind, placebo-controlled trial in 9-year-old mainstream schoolchildren in Sweden [Texte imprimé et/ou numérique] / Mats JOHNSON, Auteur ; Gunnar FRANSSON, Auteur ; Sven ÖSTLUND, Auteur ; Björn ARESKOUG, Auteur ; Christopher GILLBERG, Auteur . - p.83-93. Langues : Anglais ( eng) in Journal of Child Psychology and Psychiatry > 58-1 (January 2017) . - p.83-93
| Mots-clés : |
Omega 3/6 Logos test reading mainstream schoolchildren attention problems |
| Index. décimale : |
PER Périodiques |
| Résumé : |
Background Previous research has shown positive effects of Omega 3/6 fatty acids in children with inattention and reading difficulties. We aimed to investigate if Omega 3/6 improved reading ability in mainstream schoolchildren. Methods We performed a 3-month parallel, randomized, double-blind, placebo-controlled trial followed by 3-month active treatment for all subjects. Mainstream schoolchildren aged 9–10 years were randomized 1:1 to receive three Omega 3/6 capsules twice daily or identical placebo. Assessments were made at baseline, 3 months, and 6 months. The primary outcome measure was the Logos test battery for evaluating reading abilities. The trial is registered with ClinicalTrials.gov, number NCT02557477. Results The study enrolled 154 children (active n = 78; placebo n = 76), of whom 122 completed the first 3 months (active n = 64; placebo n = 58) and 105 completed the whole study (active/active n = 55; placebo/active n = 50). Outcomes were assessed by per protocol (PP) and intention-to-treat (ITT) analyses. Active treatment was superior to placebo at 3 months for improvement in phonologic decoding time (PP active/placebo difference ?0.16; 95% CI ?0.03, ?0.29; effect size (ES) .44; p = .005; and ITT ES .37; p = .036), in visual analysis time (PP active/placebo difference ?0.19; 95% CI ?0.05, ?0.33; ES .49; p = .013; and ITT ES .40; p = .01), and for boys in phonologic decoding time (PP ?0.22; 95% CI ?0.03, ?0.41; ES .62; p = .004). Children with ADHD-RS scores above the median showed treatment benefits in visual analysis time (PP ES .8, p = .009), reading speed per word (PP ES .61, p = .008), and phonologic decoding time per word (PP ES .85, p = .006). Adverse events were rare and mild, mainly stomach pain/diarrhea (active n = 9, placebo n = 2). Conclusions Compared with placebo, 3 months of Omega 3/6 treatment improved reading ability – specifically the clinically relevant ‘phonologic decoding time’ and ‘visual analysis time’ – in mainstream schoolchildren. In particular, children with attention problems showed treatment benefits. |
| En ligne : |
http://dx.doi.org/10.1111/jcpp.12614 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298 |
|
Omega 3/6 fatty acids for reading in children: a randomized, double-blind, placebo-controlled trial in 9-year-old mainstream schoolchildren in Sweden in Journal of Child Psychology and Psychiatry, 58-1 (January 2017)
