| Titre : |
Immune Dysfunction in Autism Spectrum Disorder |
| Type de document : |
Texte imprimé et/ou numérique |
| Auteurs : |
Natalia V. MALKOVA, Auteur ; Elaine Y. HSIAO, Auteur |
| Année de publication : |
2016 |
| Importance : |
p.65-82 |
| Langues : |
Anglais (eng) |
| Mots-clés : |
Autoimmunity Maternal immune activation Microglia Neuroimmunology Neuroinflammation |
| Index. décimale : |
SCI-D SCI-D - Neurosciences |
| Résumé : |
Autism spectrum disorder (ASD) is diagnosed based on abnormalities in social, communicative, and stereotyped behaviors, but a preponderance of evidence indicates that immune dysfunction is a key feature of ASD. In this chapter, we review the several cellular and functional immune alterations observed in the brains, periphery, and gastrointestinal tracts of ASD individuals. In addition, we highlight pathways for neuroimmune interactions and novel roles for immune factors in neurodevelopment. We further discuss immune-related environmental and genetic risk factors for ASD, along with findings from animal models that support a role for early life immune dysregulation in the etiopathogenesis of ASD symptoms. Finally, we outline results from clinical trials of immune-based therapies for ASD and consider future directions for investigating potential immune contributions to ASD diagnosis and treatment. |
| En ligne : |
http://dx.doi.org/10.1016/B978-0-12-800109-7.00005-4 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=301 |
Immune Dysfunction in Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Natalia V. MALKOVA, Auteur ; Elaine Y. HSIAO, Auteur . - 2016 . - p.65-82. Langues : Anglais ( eng)
| Mots-clés : |
Autoimmunity Maternal immune activation Microglia Neuroimmunology Neuroinflammation |
| Index. décimale : |
SCI-D SCI-D - Neurosciences |
| Résumé : |
Autism spectrum disorder (ASD) is diagnosed based on abnormalities in social, communicative, and stereotyped behaviors, but a preponderance of evidence indicates that immune dysfunction is a key feature of ASD. In this chapter, we review the several cellular and functional immune alterations observed in the brains, periphery, and gastrointestinal tracts of ASD individuals. In addition, we highlight pathways for neuroimmune interactions and novel roles for immune factors in neurodevelopment. We further discuss immune-related environmental and genetic risk factors for ASD, along with findings from animal models that support a role for early life immune dysregulation in the etiopathogenesis of ASD symptoms. Finally, we outline results from clinical trials of immune-based therapies for ASD and consider future directions for investigating potential immune contributions to ASD diagnosis and treatment. |
| En ligne : |
http://dx.doi.org/10.1016/B978-0-12-800109-7.00005-4 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=301 |
|
Immune Dysfunction in Autism Spectrum Disorder
