Centre d'Information et de documentation du CRA Rhône-Alpes
CRA
Informations pratiques
-
Adresse
Centre d'information et de documentation
du CRA Rhône-Alpes
Centre Hospitalier le Vinatier
bât 211
95, Bd Pinel
69678 Bron CedexHoraires
Lundi au Vendredi
9h00-12h00 13h30-16h00Contact
Tél: +33(0)4 37 91 54 65
Mail
Fax: +33(0)4 37 91 54 37
-
Détail de l'auteur
Auteur Elaine Y. HSIAO |
Documents disponibles écrits par cet auteur (2)
Faire une suggestion Affiner la recherche
in Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability / Carlo SALA
Titre : Immune Dysfunction in Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Natalia V. MALKOVA, Auteur ; Elaine Y. HSIAO, Auteur Année de publication : 2016 Importance : p.65-82 Langues : Anglais (eng) Mots-clés : Autoimmunity Maternal immune activation Microglia Neuroimmunology Neuroinflammation Index. décimale : SCI-D SCI-D - Neurosciences Résumé : Autism spectrum disorder (ASD) is diagnosed based on abnormalities in social, communicative, and stereotyped behaviors, but a preponderance of evidence indicates that immune dysfunction is a key feature of ASD. In this chapter, we review the several cellular and functional immune alterations observed in the brains, periphery, and gastrointestinal tracts of ASD individuals. In addition, we highlight pathways for neuroimmune interactions and novel roles for immune factors in neurodevelopment. We further discuss immune-related environmental and genetic risk factors for ASD, along with findings from animal models that support a role for early life immune dysregulation in the etiopathogenesis of ASD symptoms. Finally, we outline results from clinical trials of immune-based therapies for ASD and consider future directions for investigating potential immune contributions to ASD diagnosis and treatment. En ligne : http://dx.doi.org/10.1016/B978-0-12-800109-7.00005-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=301 Immune Dysfunction in Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Natalia V. MALKOVA, Auteur ; Elaine Y. HSIAO, Auteur . - 2016 . - p.65-82.
in Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability / Carlo SALA
Langues : Anglais (eng)
Mots-clés : Autoimmunity Maternal immune activation Microglia Neuroimmunology Neuroinflammation Index. décimale : SCI-D SCI-D - Neurosciences Résumé : Autism spectrum disorder (ASD) is diagnosed based on abnormalities in social, communicative, and stereotyped behaviors, but a preponderance of evidence indicates that immune dysfunction is a key feature of ASD. In this chapter, we review the several cellular and functional immune alterations observed in the brains, periphery, and gastrointestinal tracts of ASD individuals. In addition, we highlight pathways for neuroimmune interactions and novel roles for immune factors in neurodevelopment. We further discuss immune-related environmental and genetic risk factors for ASD, along with findings from animal models that support a role for early life immune dysregulation in the etiopathogenesis of ASD symptoms. Finally, we outline results from clinical trials of immune-based therapies for ASD and consider future directions for investigating potential immune contributions to ASD diagnosis and treatment. En ligne : http://dx.doi.org/10.1016/B978-0-12-800109-7.00005-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=301 Exemplaires
Code-barres Cote Support Localisation Section Disponibilité aucun exemplaire Immune Involvement in Autism Spectrum Disorder as a Basis for Animal Models / Elaine Y. HSIAO in Autism - Open Access, 2-S ([01/12/2012])
[article]
Titre : Immune Involvement in Autism Spectrum Disorder as a Basis for Animal Models Type de document : Texte imprimé et/ou numérique Auteurs : Elaine Y. HSIAO, Auteur ; Paul H. PATTERSON, Auteur Article en page(s) : 6 p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Several of the environmental stimuli suggested to play a role in the pathogenesis of ASD involve altered immune responses during gestation. In this review, we discuss maternal immune activation as a primary risk factor for ASD, with an emphasis on recent findings from animal models of prenatal immune challenges. We further address the presence of autoantibodies as an additional immune-related autism risk factor, drawing upon work done in rodent and monkey models. We then explore the intersection between genetic and environmental susceptibility, with a focus on gene-environment interactions and immune involvement, in genetic risk factors for autism. Finally, we provide emerging evidence for the role of immune dysregulation in the pathogenesis of ASD. En ligne : https://dx.doi.org/10.4172/2165-7890.S1-003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409
in Autism - Open Access > 2-S [01/12/2012] . - 6 p.[article] Immune Involvement in Autism Spectrum Disorder as a Basis for Animal Models [Texte imprimé et/ou numérique] / Elaine Y. HSIAO, Auteur ; Paul H. PATTERSON, Auteur . - 6 p.
Langues : Anglais (eng)
in Autism - Open Access > 2-S [01/12/2012] . - 6 p.
Index. décimale : PER Périodiques Résumé : Several of the environmental stimuli suggested to play a role in the pathogenesis of ASD involve altered immune responses during gestation. In this review, we discuss maternal immune activation as a primary risk factor for ASD, with an emphasis on recent findings from animal models of prenatal immune challenges. We further address the presence of autoantibodies as an additional immune-related autism risk factor, drawing upon work done in rodent and monkey models. We then explore the intersection between genetic and environmental susceptibility, with a focus on gene-environment interactions and immune involvement, in genetic risk factors for autism. Finally, we provide emerging evidence for the role of immune dysregulation in the pathogenesis of ASD. En ligne : https://dx.doi.org/10.4172/2165-7890.S1-003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409