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Oral probiotic administration during pregnancy prevents autism-related behaviors in offspring induced by maternal immune activation via anti-inflammation in mice / X. WANG in Autism Research, 12-4 (April 2019)
[article]
Titre : Oral probiotic administration during pregnancy prevents autism-related behaviors in offspring induced by maternal immune activation via anti-inflammation in mice Type de document : Texte imprimé et/ou numérique Auteurs : X. WANG, Auteur ; J. YANG, Auteur ; H. ZHANG, Auteur ; J. YU, Auteur ; Z. YAO, Auteur Article en page(s) : p.576-588 Langues : Anglais (eng) Mots-clés : anti-inflammation autism spectrum disorders interleukin 17a interleukin 6 maternal immune activation probiotics Index. décimale : PER Périodiques Résumé : Maternal immune activation (MIA) is associated with an increased risk for autism spectrum disorders (ASD) in offspring. Animal experiments have found that interleukin 6 (IL-6) and IL-17a are key cytokines in the induction of ASD by MIA. Moreover, probiotics were verified to inhibit the production of proinflammatory cytokines. Therefore, we investigated whether the administration of oral probiotics during pregnancy might protect the offspring that have suffered MIA from developing ASD. Probiotics were orally administered to pregnant mice with/without the simultaneous administration of Poly(I:C). We found that oral probiotics prevented the ASD-like behaviors induced by MIA in offspring. Furthermore, oral probiotics prevented the MIA-induced increases in the IL-6 and IL-17a levels in both maternal serum and fetal brains, parvalbumin positive (PV(+) ) neuron loss, and the decrease in the gamma-aminobutyric acid levels in the prefrontal cortex of adult offspring. This work suggests that administering oral probiotics during pregnancy may help decrease the risk of ASD following MIA during pregnancy. Autism Res 2019, 12: 576-588. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Interleukin 6 (IL-6) and IL-17a are key cytokines in the maternal immune activation (MIA)-induced autism spectrum disorders (ASD). Based on emerging evidence that probiotics can inhibit the production of proinflammatory cytokines, we found that oral probiotics prevented MIA-induced ASD-like behaviors in offspring. This work suggested that oral probiotics during pregnancy may be an effective means for decreasing the incidence of ASD in offspring. En ligne : https://dx.doi.org/10.1002/aur.2079 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=388
in Autism Research > 12-4 (April 2019) . - p.576-588[article] Oral probiotic administration during pregnancy prevents autism-related behaviors in offspring induced by maternal immune activation via anti-inflammation in mice [Texte imprimé et/ou numérique] / X. WANG, Auteur ; J. YANG, Auteur ; H. ZHANG, Auteur ; J. YU, Auteur ; Z. YAO, Auteur . - p.576-588.
Langues : Anglais (eng)
in Autism Research > 12-4 (April 2019) . - p.576-588
Mots-clés : anti-inflammation autism spectrum disorders interleukin 17a interleukin 6 maternal immune activation probiotics Index. décimale : PER Périodiques Résumé : Maternal immune activation (MIA) is associated with an increased risk for autism spectrum disorders (ASD) in offspring. Animal experiments have found that interleukin 6 (IL-6) and IL-17a are key cytokines in the induction of ASD by MIA. Moreover, probiotics were verified to inhibit the production of proinflammatory cytokines. Therefore, we investigated whether the administration of oral probiotics during pregnancy might protect the offspring that have suffered MIA from developing ASD. Probiotics were orally administered to pregnant mice with/without the simultaneous administration of Poly(I:C). We found that oral probiotics prevented the ASD-like behaviors induced by MIA in offspring. Furthermore, oral probiotics prevented the MIA-induced increases in the IL-6 and IL-17a levels in both maternal serum and fetal brains, parvalbumin positive (PV(+) ) neuron loss, and the decrease in the gamma-aminobutyric acid levels in the prefrontal cortex of adult offspring. This work suggests that administering oral probiotics during pregnancy may help decrease the risk of ASD following MIA during pregnancy. Autism Res 2019, 12: 576-588. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Interleukin 6 (IL-6) and IL-17a are key cytokines in the maternal immune activation (MIA)-induced autism spectrum disorders (ASD). Based on emerging evidence that probiotics can inhibit the production of proinflammatory cytokines, we found that oral probiotics prevented MIA-induced ASD-like behaviors in offspring. This work suggested that oral probiotics during pregnancy may be an effective means for decreasing the incidence of ASD in offspring. En ligne : https://dx.doi.org/10.1002/aur.2079 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=388 Maternal Mid-Gestation Cytokine Dysregulation in Mothers of Children with Autism Spectrum Disorder / S. CASEY in Journal of Autism and Developmental Disorders, 52-9 (September 2022)
[article]
Titre : Maternal Mid-Gestation Cytokine Dysregulation in Mothers of Children with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : S. CASEY, Auteur ; M. CARTER, Auteur ; A. M. LOONEY, Auteur ; V. LIVINGSTONE, Auteur ; G. MOLONEY, Auteur ; G. W. O'KEEFFE, Auteur ; Rebecca S. TAYLOR, Auteur ; L. C. KENNY, Auteur ; F. P. MCCARTHY, Auteur ; L. M. E. MCCOWAN, Auteur ; J. M. D. THOMPSON, Auteur ; D. M. MURRAY, Auteur ; SCOPE CONSORTIUM, Auteur Article en page(s) : p.3919-3932 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder Child Cytokines Female Humans Mothers Pregnancy Autism spectrum disorder Cytokine Il-17a Inflammation Maternal immune activation Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a developmental disorder characterised by deficits in social interactions and communication, with stereotypical and repetitive behaviours. Recent evidence suggests that maternal immune dysregulation may predispose offspring to ASD. Independent samples t-tests revealed downregulation of IL-17A concentrations in cases, when compared to controls, at both 15 weeks (p=0.02), and 20 weeks (p=0.02), which persisted at 20 weeks following adjustment for confounding variables. This adds to the growing body of evidence that maternal immune regulation may play a role in foetal neurodevelopment. En ligne : http://dx.doi.org/10.1007/s10803-021-05271-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=485
in Journal of Autism and Developmental Disorders > 52-9 (September 2022) . - p.3919-3932[article] Maternal Mid-Gestation Cytokine Dysregulation in Mothers of Children with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / S. CASEY, Auteur ; M. CARTER, Auteur ; A. M. LOONEY, Auteur ; V. LIVINGSTONE, Auteur ; G. MOLONEY, Auteur ; G. W. O'KEEFFE, Auteur ; Rebecca S. TAYLOR, Auteur ; L. C. KENNY, Auteur ; F. P. MCCARTHY, Auteur ; L. M. E. MCCOWAN, Auteur ; J. M. D. THOMPSON, Auteur ; D. M. MURRAY, Auteur ; SCOPE CONSORTIUM, Auteur . - p.3919-3932.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 52-9 (September 2022) . - p.3919-3932
Mots-clés : Autism Spectrum Disorder Child Cytokines Female Humans Mothers Pregnancy Autism spectrum disorder Cytokine Il-17a Inflammation Maternal immune activation Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a developmental disorder characterised by deficits in social interactions and communication, with stereotypical and repetitive behaviours. Recent evidence suggests that maternal immune dysregulation may predispose offspring to ASD. Independent samples t-tests revealed downregulation of IL-17A concentrations in cases, when compared to controls, at both 15 weeks (p=0.02), and 20 weeks (p=0.02), which persisted at 20 weeks following adjustment for confounding variables. This adds to the growing body of evidence that maternal immune regulation may play a role in foetal neurodevelopment. En ligne : http://dx.doi.org/10.1007/s10803-021-05271-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=485
in Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability / Carlo SALA
Titre : Immune Dysfunction in Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Natalia V. MALKOVA, Auteur ; Elaine Y. HSIAO, Auteur Année de publication : 2016 Importance : p.65-82 Langues : Anglais (eng) Mots-clés : Autoimmunity Maternal immune activation Microglia Neuroimmunology Neuroinflammation Index. décimale : SCI-D SCI-D - Neurosciences Résumé : Autism spectrum disorder (ASD) is diagnosed based on abnormalities in social, communicative, and stereotyped behaviors, but a preponderance of evidence indicates that immune dysfunction is a key feature of ASD. In this chapter, we review the several cellular and functional immune alterations observed in the brains, periphery, and gastrointestinal tracts of ASD individuals. In addition, we highlight pathways for neuroimmune interactions and novel roles for immune factors in neurodevelopment. We further discuss immune-related environmental and genetic risk factors for ASD, along with findings from animal models that support a role for early life immune dysregulation in the etiopathogenesis of ASD symptoms. Finally, we outline results from clinical trials of immune-based therapies for ASD and consider future directions for investigating potential immune contributions to ASD diagnosis and treatment. En ligne : http://dx.doi.org/10.1016/B978-0-12-800109-7.00005-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=301 Immune Dysfunction in Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Natalia V. MALKOVA, Auteur ; Elaine Y. HSIAO, Auteur . - 2016 . - p.65-82.
in Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability / Carlo SALA
Langues : Anglais (eng)
Mots-clés : Autoimmunity Maternal immune activation Microglia Neuroimmunology Neuroinflammation Index. décimale : SCI-D SCI-D - Neurosciences Résumé : Autism spectrum disorder (ASD) is diagnosed based on abnormalities in social, communicative, and stereotyped behaviors, but a preponderance of evidence indicates that immune dysfunction is a key feature of ASD. In this chapter, we review the several cellular and functional immune alterations observed in the brains, periphery, and gastrointestinal tracts of ASD individuals. In addition, we highlight pathways for neuroimmune interactions and novel roles for immune factors in neurodevelopment. We further discuss immune-related environmental and genetic risk factors for ASD, along with findings from animal models that support a role for early life immune dysregulation in the etiopathogenesis of ASD symptoms. Finally, we outline results from clinical trials of immune-based therapies for ASD and consider future directions for investigating potential immune contributions to ASD diagnosis and treatment. En ligne : http://dx.doi.org/10.1016/B978-0-12-800109-7.00005-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=301 Exemplaires
Code-barres Cote Support Localisation Section Disponibilité aucun exemplaire Fever during pregnancy as a risk factor for neurodevelopmental disorders: results from a systematic review and meta-analysis / S. ANTOUN in Molecular Autism, 12 (2021)
[article]
Titre : Fever during pregnancy as a risk factor for neurodevelopmental disorders: results from a systematic review and meta-analysis Type de document : Texte imprimé et/ou numérique Auteurs : S. ANTOUN, Auteur ; P. ELLUL, Auteur ; H. PEYRE, Auteur ; M. ROSENZWAJG, Auteur ; P. GRESSENS, Auteur ; D. KLATZMANN, Auteur ; R. DELORME, Auteur Article en page(s) : 60 p. Langues : Anglais (eng) Mots-clés : Autism Children Immunology Maternal immune activation Index. décimale : PER Périodiques Résumé : BACKGROUND: Fever during pregnancy is a relatively common and most often trivial event. However, under specific conditions, it could affect significantly fetal brain development. Few studies, with inconsistent results, investigated whether fever, regardless the pathogen, could represent a risk factor for neurodevelopmental disorders (NDD) in the offspring. We aimed to explore further this question by performing a systematic review and meta-analysis. METHODS: Peer-reviewed studies exploring the occurrence of NDD in offspring after a fetal exposure to maternal fever were included. We specifically considered the impact of fever severity and duration, taking into consideration some confounding variables such as the use of antipyretic during pregnancy, the trimester in which the fever arose, the maternal age or smoking at time of gestation. MEDLINE, EMBASE, PsycINFO, Cochrane and Web of Science were searched without language restriction. PRISMA recommendations were followed. Odds ratio (OR) were pooled using random-effects meta-analysis. Heterogeneity in effect size across studies was studied using random-effects meta-regression analysis. (PROSPERO CRD42020182801). RESULTS: We finally considered ten studies gathering a total of 10,304 children with NDD. Among them, 1394 were exposed to fever during pregnancy. The selected studies were divided into 5 case-control studies and 5 cohort studies. Maternal exposure to fever during pregnancy increased the risk of NDD in offspring with an OR of 1.24 [95% CI: 1.12-1.38]. Secondary analysis revealed an increased risk for NDD when fever occurred during the first trimester of gestation [OR 1.13-95% CI: 1.02-1.26]. LIMITATIONS: We excluded studies that considered infections with no evidence of fever. Another potential limitation may be the possible heterogeneity between study designs (cohorts and case-control). CONCLUSION: Additional evidence supported the association between fever during pregnancy and increased risk for NDD in offspring. Careful monitoring should be considered for children born from mothers with a febrile episode during pregnancy (specifically during the first trimester). En ligne : http://dx.doi.org/10.1186/s13229-021-00464-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459
in Molecular Autism > 12 (2021) . - 60 p.[article] Fever during pregnancy as a risk factor for neurodevelopmental disorders: results from a systematic review and meta-analysis [Texte imprimé et/ou numérique] / S. ANTOUN, Auteur ; P. ELLUL, Auteur ; H. PEYRE, Auteur ; M. ROSENZWAJG, Auteur ; P. GRESSENS, Auteur ; D. KLATZMANN, Auteur ; R. DELORME, Auteur . - 60 p.
Langues : Anglais (eng)
in Molecular Autism > 12 (2021) . - 60 p.
Mots-clés : Autism Children Immunology Maternal immune activation Index. décimale : PER Périodiques Résumé : BACKGROUND: Fever during pregnancy is a relatively common and most often trivial event. However, under specific conditions, it could affect significantly fetal brain development. Few studies, with inconsistent results, investigated whether fever, regardless the pathogen, could represent a risk factor for neurodevelopmental disorders (NDD) in the offspring. We aimed to explore further this question by performing a systematic review and meta-analysis. METHODS: Peer-reviewed studies exploring the occurrence of NDD in offspring after a fetal exposure to maternal fever were included. We specifically considered the impact of fever severity and duration, taking into consideration some confounding variables such as the use of antipyretic during pregnancy, the trimester in which the fever arose, the maternal age or smoking at time of gestation. MEDLINE, EMBASE, PsycINFO, Cochrane and Web of Science were searched without language restriction. PRISMA recommendations were followed. Odds ratio (OR) were pooled using random-effects meta-analysis. Heterogeneity in effect size across studies was studied using random-effects meta-regression analysis. (PROSPERO CRD42020182801). RESULTS: We finally considered ten studies gathering a total of 10,304 children with NDD. Among them, 1394 were exposed to fever during pregnancy. The selected studies were divided into 5 case-control studies and 5 cohort studies. Maternal exposure to fever during pregnancy increased the risk of NDD in offspring with an OR of 1.24 [95% CI: 1.12-1.38]. Secondary analysis revealed an increased risk for NDD when fever occurred during the first trimester of gestation [OR 1.13-95% CI: 1.02-1.26]. LIMITATIONS: We excluded studies that considered infections with no evidence of fever. Another potential limitation may be the possible heterogeneity between study designs (cohorts and case-control). CONCLUSION: Additional evidence supported the association between fever during pregnancy and increased risk for NDD in offspring. Careful monitoring should be considered for children born from mothers with a febrile episode during pregnancy (specifically during the first trimester). En ligne : http://dx.doi.org/10.1186/s13229-021-00464-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459 Congenital Cytomegalovirus Infection in Children with Autism Spectrum Disorder: Systematic Review and Meta-Analysis / K. MAEYAMA in Journal of Autism and Developmental Disorders, 48-5 (May 2018)
[article]
Titre : Congenital Cytomegalovirus Infection in Children with Autism Spectrum Disorder: Systematic Review and Meta-Analysis Type de document : Texte imprimé et/ou numérique Auteurs : K. MAEYAMA, Auteur ; K. TOMIOKA, Auteur ; H. NAGASE, Auteur ; M. YOSHIOKA, Auteur ; Y. TAKAGI, Auteur ; T. KATO, Auteur ; M. MIZOBUCHI, Auteur ; S. KITAYAMA, Auteur ; S. TAKADA, Auteur ; M. NAGAI, Auteur ; N. SAKAKIBARA, Auteur ; M. NISHIYAMA, Auteur ; M. TANIGUCHI-IKEDA, Auteur ; I. MORIOKA, Auteur ; K. IIJIMA, Auteur ; N. NISHIMURA, Auteur Article en page(s) : p.1483-1491 Langues : Anglais (eng) Mots-clés : Asd Congenital CMV infection Maternal immune activation Neurodevelopmental disorder Prenatal environment Risk factor Index. décimale : PER Périodiques Résumé : Association of congenital cytomegalovirus (CMV) infection with autism spectral disorder (ASD) has been suggested since 1980s. Despite the observed association, its role as a risk factor for ASD remains to be defined. In the present review, we systematically evaluated the available evidence associating congenital CMV infection with ASD using PubMed, Web of Science, Cochrane Library, and Embase databases. Any studies on children with CMV infection and ASD were evaluated for eligibility and three observational studies were included in meta-analysis. Although a high prevalence of congenital CMV infection in ASD cases (OR 11.31, 95% CI 3.07-41.66) was indicated, too few events (0-2 events) in all included studies imposed serious limitations. There is urgent need for further studies to clarify this issue. En ligne : http://dx.doi.org/10.1007/s10803-017-3412-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=355
in Journal of Autism and Developmental Disorders > 48-5 (May 2018) . - p.1483-1491[article] Congenital Cytomegalovirus Infection in Children with Autism Spectrum Disorder: Systematic Review and Meta-Analysis [Texte imprimé et/ou numérique] / K. MAEYAMA, Auteur ; K. TOMIOKA, Auteur ; H. NAGASE, Auteur ; M. YOSHIOKA, Auteur ; Y. TAKAGI, Auteur ; T. KATO, Auteur ; M. MIZOBUCHI, Auteur ; S. KITAYAMA, Auteur ; S. TAKADA, Auteur ; M. NAGAI, Auteur ; N. SAKAKIBARA, Auteur ; M. NISHIYAMA, Auteur ; M. TANIGUCHI-IKEDA, Auteur ; I. MORIOKA, Auteur ; K. IIJIMA, Auteur ; N. NISHIMURA, Auteur . - p.1483-1491.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 48-5 (May 2018) . - p.1483-1491
Mots-clés : Asd Congenital CMV infection Maternal immune activation Neurodevelopmental disorder Prenatal environment Risk factor Index. décimale : PER Périodiques Résumé : Association of congenital cytomegalovirus (CMV) infection with autism spectral disorder (ASD) has been suggested since 1980s. Despite the observed association, its role as a risk factor for ASD remains to be defined. In the present review, we systematically evaluated the available evidence associating congenital CMV infection with ASD using PubMed, Web of Science, Cochrane Library, and Embase databases. Any studies on children with CMV infection and ASD were evaluated for eligibility and three observational studies were included in meta-analysis. Although a high prevalence of congenital CMV infection in ASD cases (OR 11.31, 95% CI 3.07-41.66) was indicated, too few events (0-2 events) in all included studies imposed serious limitations. There is urgent need for further studies to clarify this issue. En ligne : http://dx.doi.org/10.1007/s10803-017-3412-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=355