Epigenetic regulation of cognition: A circumscribed review of the field / Elena L. GRIGORENKO in Development and Psychopathology, 28-4 pt2 (November 2016)  

Public ISBD [article]  inDevelopment and Psychopathology > 28-4 pt2 (November 2016) . - p.1285-1304 Titre : Epigenetic regulation of cognition: A circumscribed review of the field Type de document : Texte imprimé et/ou numérique Auteurs : Elena L. GRIGORENKO, Auteur ; Sergey A. KORNILOV, Auteur ; Oksana Yu NAUMOVA, Auteur Article en page(s) : p.1285-1304 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The last decade has been marked by an increased interest in relating epigenetic mechanisms to complex human behaviors, although this interest has not been balanced, accentuating various types of affective and primarily ignoring cognitive functioning. Recent animal model data support the view that epigenetic processes play a role in learning and memory consolidation and help transmit acquired memories even across generations. In this review, we provide an overview of various types of epigenetic mechanisms in the brain (DNA methylation, histone modification, and noncoding RNA action) and discuss their impact proximally on gene transcription, protein synthesis, and synaptic plasticity and distally on learning, memory, and other cognitive functions. Of particular importance are observations that neuronal activation regulates the dynamics of the epigenome's functioning under precise timing, with subsequent alterations in the gene expression profile. In turn, epigenetic regulation impacts neuronal action, closing the circle and substantiating the signaling pathways that underlie, at least partially, learning, memory, and other cognitive processes. En ligne : http://dx.doi.org/10.1017/s0954579416000857 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 [article] Epigenetic regulation of cognition: A circumscribed review of the field [Texte imprimé et/ou numérique] / Elena L. GRIGORENKO, Auteur ; Sergey A. KORNILOV, Auteur ; Oksana Yu NAUMOVA, Auteur . - p.1285-1304. Langues : Anglais (eng) in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1285-1304 Index. décimale : PER Périodiques Résumé : The last decade has been marked by an increased interest in relating epigenetic mechanisms to complex human behaviors, although this interest has not been balanced, accentuating various types of affective and primarily ignoring cognitive functioning. Recent animal model data support the view that epigenetic processes play a role in learning and memory consolidation and help transmit acquired memories even across generations. In this review, we provide an overview of various types of epigenetic mechanisms in the brain (DNA methylation, histone modification, and noncoding RNA action) and discuss their impact proximally on gene transcription, protein synthesis, and synaptic plasticity and distally on learning, memory, and other cognitive functions. Of particular importance are observations that neuronal activation regulates the dynamics of the epigenome's functioning under precise timing, with subsequent alterations in the gene expression profile. In turn, epigenetic regulation impacts neuronal action, closing the circle and substantiating the signaling pathways that underlie, at least partially, learning, memory, and other cognitive processes. En ligne : http://dx.doi.org/10.1017/s0954579416000857 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294

Lexical processing deficits in children with developmental language disorder: An event-related potentials study / Sergey A. KORNILOV in Development and Psychopathology, 27-2 (May 2015)  

Public ISBD [article]  inDevelopment and Psychopathology > 27-2 (May 2015) . - p.459-476 Titre : Lexical processing deficits in children with developmental language disorder: An event-related potentials study Type de document : Texte imprimé et/ou numérique Auteurs : Sergey A. KORNILOV, Auteur ; James S. MAGNUSON, Auteur ; Natalia RAKHLIN, Auteur ; Nicole LANDI, Auteur ; Elena L. GRIGORENKO, Auteur Article en page(s) : p.459-476 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Lexical processing deficits in children with developmental language disorder (DLD) have been postulated to arise as sequelae of their grammatical deficits (either directly or via compensatory mechanisms) and vice versa. We examined event-related potential indices of lexical processing in children with DLD (n = 23) and their typically developing peers (n = 16) using a picture–word matching paradigm. We found that children with DLD showed markedly reduced N400 amplitudes in response both to auditorily presented words that had initial phonological overlap with the name of the pictured object and to words that were not semantically or phonologically related to the pictured object. Moreover, this reduction was related to behavioral indices of phonological and lexical but not grammatical development. We also found that children with DLD showed a depressed phonological mapping negativity component in the early time window, suggesting deficits in phonological processing or early lexical access. The results are partially consistent with the overactivation account of lexical processing deficits in DLD and point to the relative functional independence of lexical/phonological and grammatical deficits in DLD, supporting a multidimensional view of the disorder. The results also, although indirectly, support the neuroplasticity account of DLD, according to which language impairment affects brain development and shapes the specific patterns of brain responses to language stimuli. En ligne : http://dx.doi.org/10.1017/S0954579415000097 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=257 [article] Lexical processing deficits in children with developmental language disorder: An event-related potentials study [Texte imprimé et/ou numérique] / Sergey A. KORNILOV, Auteur ; James S. MAGNUSON, Auteur ; Natalia RAKHLIN, Auteur ; Nicole LANDI, Auteur ; Elena L. GRIGORENKO, Auteur . - p.459-476. Langues : Anglais (eng) in Development and Psychopathology > 27-2 (May 2015) . - p.459-476 Index. décimale : PER Périodiques Résumé : Lexical processing deficits in children with developmental language disorder (DLD) have been postulated to arise as sequelae of their grammatical deficits (either directly or via compensatory mechanisms) and vice versa. We examined event-related potential indices of lexical processing in children with DLD (n = 23) and their typically developing peers (n = 16) using a picture–word matching paradigm. We found that children with DLD showed markedly reduced N400 amplitudes in response both to auditorily presented words that had initial phonological overlap with the name of the pictured object and to words that were not semantically or phonologically related to the pictured object. Moreover, this reduction was related to behavioral indices of phonological and lexical but not grammatical development. We also found that children with DLD showed a depressed phonological mapping negativity component in the early time window, suggesting deficits in phonological processing or early lexical access. The results are partially consistent with the overactivation account of lexical processing deficits in DLD and point to the relative functional independence of lexical/phonological and grammatical deficits in DLD, supporting a multidimensional view of the disorder. The results also, although indirectly, support the neuroplasticity account of DLD, according to which language impairment affects brain development and shapes the specific patterns of brain responses to language stimuli. En ligne : http://dx.doi.org/10.1017/S0954579415000097 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=257

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