Inactivation of the Catalytic Phosphatase Domain of PTPRT/RPTP? Increases Social Interaction in Mice / Keerthi THIRTAMARA RAJAMANI in Autism Research, 8-1 (February 2015)  

Public ISBD [article]  inAutism Research > 8-1 (February 2015) . - p.19-28 Titre : Inactivation of the Catalytic Phosphatase Domain of PTPRT/RPTP? Increases Social Interaction in Mice Type de document : Texte imprimé et/ou numérique Auteurs : Keerthi THIRTAMARA RAJAMANI, Auteur ; Brian O'NEILL, Auteur ; Dawn D. HAN, Auteur ; Adrienne FROSTHOLM, Auteur ; Andrej ROTTER, Auteur ; Howard H. GU, Auteur Article en page(s) : p.19-28 Langues : Anglais (eng) Mots-clés : PTPRT  RPTP?  social interaction  animal model Index. décimale : PER Périodiques Résumé : Receptor protein tyrosine phosphatase rho (RPTP?, gene symbol PTPRT) is a transmembrane protein expressed at high levels in the developing hippocampus, olfactory bulb, cortex, and cerebellum. It has an extracellular domain that interacts with other cell adhesion molecules, and it has two intracellular phosphatase domains, one of which is catalytically active. In a recent genome-wide association study, PTPRT was identified as a potential candidate gene for autism spectrum disorder (ASD) susceptibility. Mutation of a critical aspartate to alanine (D1046A) in the PTPRT catalytic domain inactivates phosphatase function but retains substrate binding. We have generated a knockin mouse line carrying the PTPRT D1046A mutation. The D1046A mutation in homozygous knockin mice did not significantly change locomotor activities or anxiety-related behaviors. In contrast, male homozygous mice had significantly higher social approach scores than wild-type animals. Our results suggest that PTPRT phosphatase function is important in modulating neural pathways involved in mouse social behaviors relevant to the symptoms in human ASD patients. Autism Res 2015, 8: 19–28. En ligne : http://dx.doi.org/10.1002/aur.1390 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256 [article] Inactivation of the Catalytic Phosphatase Domain of PTPRT/RPTP? Increases Social Interaction in Mice [Texte imprimé et/ou numérique] / Keerthi THIRTAMARA RAJAMANI, Auteur ; Brian O'NEILL, Auteur ; Dawn D. HAN, Auteur ; Adrienne FROSTHOLM, Auteur ; Andrej ROTTER, Auteur ; Howard H. GU, Auteur . - p.19-28. Langues : Anglais (eng) in Autism Research > 8-1 (February 2015) . - p.19-28 Mots-clés : PTPRT  RPTP?  social interaction  animal model Index. décimale : PER Périodiques Résumé : Receptor protein tyrosine phosphatase rho (RPTP?, gene symbol PTPRT) is a transmembrane protein expressed at high levels in the developing hippocampus, olfactory bulb, cortex, and cerebellum. It has an extracellular domain that interacts with other cell adhesion molecules, and it has two intracellular phosphatase domains, one of which is catalytically active. In a recent genome-wide association study, PTPRT was identified as a potential candidate gene for autism spectrum disorder (ASD) susceptibility. Mutation of a critical aspartate to alanine (D1046A) in the PTPRT catalytic domain inactivates phosphatase function but retains substrate binding. We have generated a knockin mouse line carrying the PTPRT D1046A mutation. The D1046A mutation in homozygous knockin mice did not significantly change locomotor activities or anxiety-related behaviors. In contrast, male homozygous mice had significantly higher social approach scores than wild-type animals. Our results suggest that PTPRT phosphatase function is important in modulating neural pathways involved in mouse social behaviors relevant to the symptoms in human ASD patients. Autism Res 2015, 8: 19–28. En ligne : http://dx.doi.org/10.1002/aur.1390 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256

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