[article] 
inJournal of Autism and Developmental Disorders > 38-2 (February 2008) . - p.333-341

Titre :	How Relevant are GFAP Autoantibodies in Autism and Tourette Syndrome?
Type de document :	Texte imprimé et/ou numérique
Auteurs :	Nikki J. KIRKMAN, Auteur ; William M. MCMAHON, Auteur ; Janet E. LAINHART, Auteur ; Jane E. LIBBEY, Auteur ; Hilary H. COON, Auteur ; Thayne L. SWEETEN, Auteur ; Judith N. MILLER, Auteur ; Edward K. STEVENSON, Auteur ; Robert S. FUJINAMI, Auteur
Année de publication :	2008
Article en page(s) :	p.333-341
Langues :	Anglais (eng)
Mots-clés :	Autism Tourette-Syndrome Autoantibody Glial-fibrillary-acidic-protein Immunoglobulin
Index. décimale :	PER Périodiques
Résumé :	Controversy exists over the role of autoantibodies to central nervous system antigens in autism and Tourette Syndrome. We investigated plasma autoantibody titers to glial fibrillary acidic protein (GFAP) in children with classic onset (33) and regressive onset (26) autism, controls (25, healthy age- and gender-matched) and individuals with Tourette Syndrome (24) by enzyme-linked immunosorbent assays. We found a significant difference in autoantibody titers to GFAP, not accounted for by age, between the Tourette (significantly lower) and regressive autism groups. However, no differences were found between: classic/regressive; classic/controls; classic/Tourette; regressive/controls; or controls/Tourette. Autoantibody responses against GFAP are unlikely to play a pathogenic role in autism or Tourette Syndrome.
En ligne :	http://dx.doi.org/10.1007/s10803-007-0398-9
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=318

[article] How Relevant are GFAP Autoantibodies in Autism and Tourette Syndrome? [Texte imprimé et/ou numérique] / Nikki J. KIRKMAN, Auteur ; William M. MCMAHON, Auteur ; Janet E. LAINHART, Auteur ; Jane E. LIBBEY, Auteur ; Hilary H. COON, Auteur ; Thayne L. SWEETEN, Auteur ; Judith N. MILLER, Auteur ; Edward K. STEVENSON, Auteur ; Robert S. FUJINAMI, Auteur . - 2008 . - p.333-341.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 38-2 (February 2008) . - p.333-341

Mots-clés :	Autism Tourette-Syndrome Autoantibody Glial-fibrillary-acidic-protein Immunoglobulin
Index. décimale :	PER Périodiques
Résumé :	Controversy exists over the role of autoantibodies to central nervous system antigens in autism and Tourette Syndrome. We investigated plasma autoantibody titers to glial fibrillary acidic protein (GFAP) in children with classic onset (33) and regressive onset (26) autism, controls (25, healthy age- and gender-matched) and individuals with Tourette Syndrome (24) by enzyme-linked immunosorbent assays. We found a significant difference in autoantibody titers to GFAP, not accounted for by age, between the Tourette (significantly lower) and regressive autism groups. However, no differences were found between: classic/regressive; classic/controls; classic/Tourette; regressive/controls; or controls/Tourette. Autoantibody responses against GFAP are unlikely to play a pathogenic role in autism or Tourette Syndrome.
En ligne :	http://dx.doi.org/10.1007/s10803-007-0398-9
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=318