Abnormal lateralization of functional connectivity between language and default mode regions in autism / Jared NIELSEN in Molecular Autism, (February 2014)  

Public ISBD [article]  inMolecular Autism > (February 2014) Titre : Abnormal lateralization of functional connectivity between language and default mode regions in autism Type de document : Texte imprimé et/ou numérique Auteurs : Jared NIELSEN, Auteur ; Brandon ZIELINSKI, Auteur ; P FLETCHER, Auteur ; Andrew A. ALEXANDER, Auteur ; Nicholas LANGE, Auteur ; Erin D. BIGLER, Auteur ; Janet E. LAINHART, Auteur ; Jeffrey S. ANDERSON, Auteur Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Lateralization of brain structure and function occurs in typical development, and abnormal lateralization is present in various neuropsychiatric disorders. Autism is characterized by a lack of left lateralization in structure and function of regions involved in language, such as Broca and Wernicke areas. Using functional connectivity magnetic resonance imaging from a large publicly available sample (n=964), we tested whether abnormal functional lateralization in autism exists preferentially in language regions or in a more diffuse pattern across networks of lateralized brain regions. The autism group exhibited significantly reduced left lateralization in a few connections involving language regions and regions from the default mode network, but results were not significant throughout left- and right-lateralized networks. There is a trend that suggests the lack of left lateralization in a connection involving Wernicke area and the posterior cingulate cortex associates with more severe autism. Abnormal language lateralization in autism may be due to abnormal language development rather than to a deficit in hemispheric specialization of the entire brain. En ligne : http://dx.doi.org/10.1186/2040-2392-5-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=227 [article] Abnormal lateralization of functional connectivity between language and default mode regions in autism [Texte imprimé et/ou numérique] / Jared NIELSEN, Auteur ; Brandon ZIELINSKI, Auteur ; P FLETCHER, Auteur ; Andrew A. ALEXANDER, Auteur ; Nicholas LANGE, Auteur ; Erin D. BIGLER, Auteur ; Janet E. LAINHART, Auteur ; Jeffrey S. ANDERSON, Auteur. Langues : Anglais (eng) in Molecular Autism > (February 2014) Index. décimale : PER Périodiques Résumé : Lateralization of brain structure and function occurs in typical development, and abnormal lateralization is present in various neuropsychiatric disorders. Autism is characterized by a lack of left lateralization in structure and function of regions involved in language, such as Broca and Wernicke areas. Using functional connectivity magnetic resonance imaging from a large publicly available sample (n=964), we tested whether abnormal functional lateralization in autism exists preferentially in language regions or in a more diffuse pattern across networks of lateralized brain regions. The autism group exhibited significantly reduced left lateralization in a few connections involving language regions and regions from the default mode network, but results were not significant throughout left- and right-lateralized networks. There is a trend that suggests the lack of left lateralization in a connection involving Wernicke area and the posterior cingulate cortex associates with more severe autism. Abnormal language lateralization in autism may be due to abnormal language development rather than to a deficit in hemispheric specialization of the entire brain. En ligne : http://dx.doi.org/10.1186/2040-2392-5-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=227

Are There Enhanced MBP Autoantibodies in Autism? / Jane E. LIBBEY in Journal of Autism and Developmental Disorders, 38-2 (February 2008)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 38-2 (February 2008) . - p.324-332 Titre : Are There Enhanced MBP Autoantibodies in Autism? Type de document : Texte imprimé et/ou numérique Auteurs : Jane E. LIBBEY, Auteur ; William M. MCMAHON, Auteur ; Janet E. LAINHART, Auteur ; Hilary H. COON, Auteur ; Nikki J. KIRKMAN, Auteur ; Thayne L. SWEETEN, Auteur ; Judith N. MILLER, Auteur ; Edward K. STEVENSON, Auteur ; Robert S. FUJINAMI, Auteur Année de publication : 2008 Article en page(s) : p.324-332 Langues : Anglais (eng) Mots-clés : Autism Tourette-syndrome Autoantibody Myelin-basic-protein Immunoglobulin Index. décimale : PER Périodiques Résumé : Autoantibodies to central nervous system antigens, such as myelin basic protein (MBP), may play a role in autism. We measured autoantibody titers to MBP in children with autism, both classic onset and regressive onset forms, controls (healthy age- and gender-matched) and individuals with Tourette syndrome via enzyme-linked immunosorbent assays. We found a significant difference in autoantibody titers to MBP, not accounted for by age or medication, between Tourette and classic autism (both significantly lower) when compared to regressive autism, but not when compared to controls. Autoantibody responses against MBP are unlikely to play a pathogenic role in autism. En ligne : http://dx.doi.org/10.1007/s10803-007-0400-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=318 [article] Are There Enhanced MBP Autoantibodies in Autism? [Texte imprimé et/ou numérique] / Jane E. LIBBEY, Auteur ; William M. MCMAHON, Auteur ; Janet E. LAINHART, Auteur ; Hilary H. COON, Auteur ; Nikki J. KIRKMAN, Auteur ; Thayne L. SWEETEN, Auteur ; Judith N. MILLER, Auteur ; Edward K. STEVENSON, Auteur ; Robert S. FUJINAMI, Auteur . - 2008 . - p.324-332. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 38-2 (February 2008) . - p.324-332 Mots-clés : Autism Tourette-syndrome Autoantibody Myelin-basic-protein Immunoglobulin Index. décimale : PER Périodiques Résumé : Autoantibodies to central nervous system antigens, such as myelin basic protein (MBP), may play a role in autism. We measured autoantibody titers to MBP in children with autism, both classic onset and regressive onset forms, controls (healthy age- and gender-matched) and individuals with Tourette syndrome via enzyme-linked immunosorbent assays. We found a significant difference in autoantibody titers to MBP, not accounted for by age or medication, between Tourette and classic autism (both significantly lower) when compared to regressive autism, but not when compared to controls. Autoantibody responses against MBP are unlikely to play a pathogenic role in autism. En ligne : http://dx.doi.org/10.1007/s10803-007-0400-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=318

Atypical development of white matter microstructure of the corpus callosum in males with autism: a longitudinal investigation / Brittany G. TRAVERS in Molecular Autism, (March 2015)  

Public ISBD [article]  inMolecular Autism > (March 2015) . - p.1-15 Titre : Atypical development of white matter microstructure of the corpus callosum in males with autism: a longitudinal investigation Type de document : Texte imprimé et/ou numérique Auteurs : Brittany G. TRAVERS, Auteur ; Do P. M. TROMP, Auteur ; Nagesh ADLURU, Auteur ; Nicholas LANGE, Auteur ; Dan DESTICHE, Auteur ; Chad ENNIS, Auteur ; Jared A. NIELSEN, Auteur ; Alyson L. FROEHLICH, Auteur ; Molly B. D. PRIGGE, Auteur ; P. Thomas FLETCHER, Auteur ; Jeffrey S. ANDERSON, Auteur ; Brandon A. ZIELINSKI, Auteur ; Erin D. BIGLER, Auteur ; Janet E. LAINHART, Auteur ; Andrew L. ALEXANDER, Auteur Article en page(s) : p.1-15 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The corpus callosum is the largest white matter structure in the brain, and it is the most consistently reported to be atypical in diffusion tensor imaging studies of autism spectrum disorder. In individuals with typical development, the corpus callosum is known to undergo a protracted development from childhood through young adulthood. However, no study has longitudinally examined the developmental trajectory of corpus callosum in autism past early childhood. En ligne : http://dx.doi.org/10.1186/s13229-015-0001-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277 [article] Atypical development of white matter microstructure of the corpus callosum in males with autism: a longitudinal investigation [Texte imprimé et/ou numérique] / Brittany G. TRAVERS, Auteur ; Do P. M. TROMP, Auteur ; Nagesh ADLURU, Auteur ; Nicholas LANGE, Auteur ; Dan DESTICHE, Auteur ; Chad ENNIS, Auteur ; Jared A. NIELSEN, Auteur ; Alyson L. FROEHLICH, Auteur ; Molly B. D. PRIGGE, Auteur ; P. Thomas FLETCHER, Auteur ; Jeffrey S. ANDERSON, Auteur ; Brandon A. ZIELINSKI, Auteur ; Erin D. BIGLER, Auteur ; Janet E. LAINHART, Auteur ; Andrew L. ALEXANDER, Auteur . - p.1-15. Langues : Anglais (eng) in Molecular Autism > (March 2015) . - p.1-15 Index. décimale : PER Périodiques Résumé : The corpus callosum is the largest white matter structure in the brain, and it is the most consistently reported to be atypical in diffusion tensor imaging studies of autism spectrum disorder. In individuals with typical development, the corpus callosum is known to undergo a protracted development from childhood through young adulthood. However, no study has longitudinally examined the developmental trajectory of corpus callosum in autism past early childhood. En ligne : http://dx.doi.org/10.1186/s13229-015-0001-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277

Atypical diffusion tensor hemispheric asymmetry in autism / Nicholas LANGE in Autism Research, 3-6 (December 2010)  

Public ISBD [article]  inAutism Research > 3-6 (December 2010) . - p.350-358 Titre : Atypical diffusion tensor hemispheric asymmetry in autism Type de document : Texte imprimé et/ou numérique Auteurs : Nicholas LANGE, Auteur ; Molly B. DUBRAY, Auteur ; Jee Eun LEE, Auteur ; Michael P. FROIMOWITZ, Auteur ; Alyson L. FROEHLICH, Auteur ; Nagesh ADLURU, Auteur ; Brad WRIGHT, Auteur ; Caitlin RAVICHANDRAN, Auteur ; P. Thomas FLETCHER, Auteur ; Erin D. BIGLER, Auteur ; Andrew A. ALEXANDER, Auteur ; Janet E. LAINHART, Auteur Année de publication : 2010 Article en page(s) : p.350-358 Langues : Anglais (eng) Mots-clés : adaptive functioning  classification  diffusion tensor imaging  hemispheric asymmetry  language functioning Index. décimale : PER Périodiques Résumé : Background: Biological measurements that distinguish individuals with autism from typically developing individuals and those with other developmental and neuropsychiatric disorders must demonstrate very high performance to have clinical value as potential imaging biomarkers. We hypothesized that further study of white matter microstructure (WMM) in the superior temporal gyrus (STG) and temporal stem (TS), two brain regions in the temporal lobe containing circuitry central to language, emotion, and social cognition, would identify a useful combination of classification features and further understand autism neuropathology. Methods: WMM measurements from the STG and TS were examined from 30 high-functioning males satisfying full criteria for idiopathic autism aged 7–28 years and 30 matched controls and a replication sample of 12 males with idiopathic autism and 7 matched controls who participated in a previous case–control diffusion tensor imaging (DTI) study. Language functioning, adaptive functioning, and psychotropic medication usage were also examined. Results: In the STG, we find reversed hemispheric asymmetry of two separable measures of directional diffusion coherence, tensor skewness, and fractional anisotropy. In autism, tensor skewness is greater on the right and fractional anisotropy is decreased on the left. We also find increased diffusion parallel to white matter fibers bilaterally. In the right not left TS, we find increased omnidirectional, parallel, and perpendicular diffusion. These six multivariate measurements possess very high ability to discriminate individuals with autism from individuals without autism with 94% sensitivity, 90% specificity, and 92% accuracy in our original and replication samples. We also report a near-significant association between the classifier and a quantitative trait index of autism and significant correlations between two classifier components and measures of language, IQ, and adaptive functioning in autism. En ligne : http://dx.doi.org/10.1002/aur.162 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=115 [article] Atypical diffusion tensor hemispheric asymmetry in autism [Texte imprimé et/ou numérique] / Nicholas LANGE, Auteur ; Molly B. DUBRAY, Auteur ; Jee Eun LEE, Auteur ; Michael P. FROIMOWITZ, Auteur ; Alyson L. FROEHLICH, Auteur ; Nagesh ADLURU, Auteur ; Brad WRIGHT, Auteur ; Caitlin RAVICHANDRAN, Auteur ; P. Thomas FLETCHER, Auteur ; Erin D. BIGLER, Auteur ; Andrew A. ALEXANDER, Auteur ; Janet E. LAINHART, Auteur . - 2010 . - p.350-358. Langues : Anglais (eng) in Autism Research > 3-6 (December 2010) . - p.350-358 Mots-clés : adaptive functioning  classification  diffusion tensor imaging  hemispheric asymmetry  language functioning Index. décimale : PER Périodiques Résumé : Background: Biological measurements that distinguish individuals with autism from typically developing individuals and those with other developmental and neuropsychiatric disorders must demonstrate very high performance to have clinical value as potential imaging biomarkers. We hypothesized that further study of white matter microstructure (WMM) in the superior temporal gyrus (STG) and temporal stem (TS), two brain regions in the temporal lobe containing circuitry central to language, emotion, and social cognition, would identify a useful combination of classification features and further understand autism neuropathology. Methods: WMM measurements from the STG and TS were examined from 30 high-functioning males satisfying full criteria for idiopathic autism aged 7–28 years and 30 matched controls and a replication sample of 12 males with idiopathic autism and 7 matched controls who participated in a previous case–control diffusion tensor imaging (DTI) study. Language functioning, adaptive functioning, and psychotropic medication usage were also examined. Results: In the STG, we find reversed hemispheric asymmetry of two separable measures of directional diffusion coherence, tensor skewness, and fractional anisotropy. In autism, tensor skewness is greater on the right and fractional anisotropy is decreased on the left. We also find increased diffusion parallel to white matter fibers bilaterally. In the right not left TS, we find increased omnidirectional, parallel, and perpendicular diffusion. These six multivariate measurements possess very high ability to discriminate individuals with autism from individuals without autism with 94% sensitivity, 90% specificity, and 92% accuracy in our original and replication samples. We also report a near-significant association between the classifier and a quantitative trait index of autism and significant correlations between two classifier components and measures of language, IQ, and adaptive functioning in autism. En ligne : http://dx.doi.org/10.1002/aur.162 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=115

Brainstem White Matter Predicts Individual Differences in Manual Motor Difficulties and Symptom Severity in Autism / Brittany G. TRAVERS in Journal of Autism and Developmental Disorders, 45-9 (September 2015)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 45-9 (September 2015) . - p.3030-3040 Titre : Brainstem White Matter Predicts Individual Differences in Manual Motor Difficulties and Symptom Severity in Autism Type de document : Texte imprimé et/ou numérique Auteurs : Brittany G. TRAVERS, Auteur ; Erin D. BIGLER, Auteur ; Do P. M. TROMP, Auteur ; Nagesh ADLURU, Auteur ; Dan DESTICHE, Auteur ; Danica SAMSIN, Auteur ; Alyson FROEHLICH, Auteur ; Molly D. B. PRIGGE, Auteur ; Tyler C. DUFFIELD, Auteur ; Nicholas LANGE, Auteur ; Andrew L. ALEXANDER, Auteur ; Janet E. LAINHART, Auteur Article en page(s) : p.3030-3040 Langues : Anglais (eng) Mots-clés : Autism  Motor  Diffusion tensor imaging  Brainstem  Grip strength  Finger tapping Index. décimale : PER Périodiques Résumé : Mounting evidence suggests that poorer motor skills may be related to more severe autism symptoms. This study investigated if atypical white matter microstructure in the brain mediated the relationship between motor skills and ASD symptom severity. Sixty-seven males with ASD and 42 males with typical development (5–33 years old) completed a diffusion tensor imaging scan and measures of grip strength, finger tapping, and autism symptom severity. Within the ASD group, weaker grip strength predicted more severe autism symptoms. Fractional anisotropy of the brainstem’s corticospinal tract predicted both grip strength and autism symptom severity and mediated the relationship between the two. These findings suggest that brainstem white matter may contribute to autism symptoms and grip strength in ASD. En ligne : http://dx.doi.org/10.1007/s10803-015-2467-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=267 [article] Brainstem White Matter Predicts Individual Differences in Manual Motor Difficulties and Symptom Severity in Autism [Texte imprimé et/ou numérique] / Brittany G. TRAVERS, Auteur ; Erin D. BIGLER, Auteur ; Do P. M. TROMP, Auteur ; Nagesh ADLURU, Auteur ; Dan DESTICHE, Auteur ; Danica SAMSIN, Auteur ; Alyson FROEHLICH, Auteur ; Molly D. B. PRIGGE, Auteur ; Tyler C. DUFFIELD, Auteur ; Nicholas LANGE, Auteur ; Andrew L. ALEXANDER, Auteur ; Janet E. LAINHART, Auteur . - p.3030-3040. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 45-9 (September 2015) . - p.3030-3040 Mots-clés : Autism  Motor  Diffusion tensor imaging  Brainstem  Grip strength  Finger tapping Index. décimale : PER Périodiques Résumé : Mounting evidence suggests that poorer motor skills may be related to more severe autism symptoms. This study investigated if atypical white matter microstructure in the brain mediated the relationship between motor skills and ASD symptom severity. Sixty-seven males with ASD and 42 males with typical development (5–33 years old) completed a diffusion tensor imaging scan and measures of grip strength, finger tapping, and autism symptom severity. Within the ASD group, weaker grip strength predicted more severe autism symptoms. Fractional anisotropy of the brainstem’s corticospinal tract predicted both grip strength and autism symptom severity and mediated the relationship between the two. These findings suggest that brainstem white matter may contribute to autism symptoms and grip strength in ASD. En ligne : http://dx.doi.org/10.1007/s10803-015-2467-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=267

Corpus callosum area in children and adults with autism / Molly B. D. PRIGGE in Research in Autism Spectrum Disorders, 7-2 (February 2013)  

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Diffusion Tensor Imaging in Autism Spectrum Disorder: A Review / Brittany G. TRAVERS in Autism Research, 5-5 (October 2012)  

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How Relevant are GFAP Autoantibodies in Autism and Tourette Syndrome? / Nikki J. KIRKMAN in Journal of Autism and Developmental Disorders, 38-2 (February 2008)  

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Intact prototype formation but impaired generalization in autism / A.H. FROEHLICH in Research in Autism Spectrum Disorders, 6-2 (April-June 2012)  

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Longitudinal Heschl's Gyrus Growth During Childhood and Adolescence in Typical Development and Autism / Molly B. D. PRIGGE in Autism Research, 6-2 (April 2013)  

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Longitudinal Stability of Intellectual Functioning in Autism Spectrum Disorder: From Age 3 Through Mid-adulthood / Molly B. D. PRIGGE in Journal of Autism and Developmental Disorders, 52-10 (October 2022)  

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Longitudinal Volumetric Brain Changes in Autism Spectrum Disorder Ages 6–35 Years / Nicholas LANGE in Autism Research, 8-1 (February 2015)  

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Offering to Share: How to Put Heads Together in Autism Neuroimaging / Matthew K. BELMONTE in Journal of Autism and Developmental Disorders, 38-1 (January 2008)  

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Overrepresentation of mood and anxiety disorders in adults with autism and their first-degree relatives: what does it mean? / Carla A. MAZEFSKY in Autism Research, 1-3 (June 2008)  

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Predictors of Cognitive Test Patterns in Autism Families / S. E. FOLSTEIN in Journal of Child Psychology and Psychiatry, 40-7 (October 1999)

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