Personality disorder diagnoses in UK Autistic people: Evidence from a matched cohort study / Elizabeth O’NIONS in Autism, 30-4 (April 2026)  

Public ISBD [article]  inAutism > 30-4 (April 2026) . - p.901-913 Titre : Personality disorder diagnoses in UK Autistic people: Evidence from a matched cohort study Type de document : texte imprimé Auteurs : Elizabeth O’NIONS, Auteur ; Jude BROWN, Auteur ; Joshua E.J. BUCKMAN, Auteur ; Rebecca CHARLTON, Auteur ; Claudia COOPER, Auteur ; Céline EL BAOU, Auteur ; Francesca HAPPE, Auteur ; Sarah HOARE, Auteur ; Dan LEWER, Auteur ; Cathie LONG, Auteur ; Jill MANTHORPE, Auteur ; Douglas G.J. MCKECHNIE, Auteur ; Marcus RICHARDS, Auteur ; Rob SAUNDERS, Auteur ; Will MANDY, Auteur ; Joshua STOTT, Auteur Article en page(s) : p.901-913 Langues : Anglais (eng) Mots-clés : autism  borderline personality disorder  emotionally unstable personality disorder  personality disorder  primary care Index. décimale : PER Périodiques Résumé : Clinical accounts and cohort studies suggest that Autistic people are disproportionately likely to be diagnosed with personality disorder. We conducted a cohort study of adults diagnosed Autistic drawn from the IQVIA Medical Research Database, with follow-up from 1 January 2000 to 16 January 2019. We included a comparison group without diagnosed autism, matched (1:10) by age, sex and primary care practice. We included 22,112 Autistic adults, of whom 6437 (29.1%) had a diagnosis of intellectual disability. Median age was 20.36 (interquartile range: 18.0–28.5), and 16,881 (76.3%) were men. The rate of new personality disorder diagnosis in Autistic people without intellectual disability was 4.8 (3.5–6.7) times higher for Autistic versus comparison men, and 4.6 (3.1–6.8) times higher for Autistic versus comparison women. For Autistic participants with intellectual disability, the rate was 2.0 (1.0–3.7) times higher for Autistic versus comparison men and 8.3 (4.0–17.2) times higher for Autistic versus comparison women. The estimated rate of new personality disorder diagnosis for Autistic people aged 20 increased from 14.67 (95% confidence interval: 10.4–20.8) per 10,000 person-years in 2009 to 22.43 (95% confidence interval: 13.9–36.3) in 2019. The findings indicate that personality disorder diagnoses are more common in Autistic people and increased overall in women from 2000 to 2019.Lay abstract Several research studies have suggested that Autistic people are more likely to be diagnosed with personality disorder than people who are not Autistic. We compared rates of personality disorder diagnoses between Autistic people and a comparison group of people not diagnosed Autistic using anonymised data collected by UK primary care practitioners for participants registered at a primary care (general practitioner) practice sometime between 1 January 2000 to 16 January 2019. The comparison group of people in the community who did not have an autism diagnosis were of the same age, sex and registered at the same primary care practice as their matched Autistic participant, with 10 times as many matched participants as Autistic participants. We included 22,112 Autistic adults, of whom 6437 (29.1%) had a diagnosis of intellectual disability. Median age was 20.36 years, and most, 16,881 (76.3%), were men. We included 221,120 comparison adults. New personality disorder diagnoses were more than four times as common for Autistic men and women without an intellectual disability compared to men and women in the comparison group. For Autistic participants with an intellectual disability, the rate was twice as high for Autistic versus comparison men and 8 times higher for Autistic versus comparison women. Between 2000 and 2019, there was an increase in the rate of new personality disorder diagnoses among Autistic people, and in women. The findings highlight the need for further investigation into reasons for this increase. En ligne : https://dx.doi.org/10.1177/13623613251414911 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=584 [article] Personality disorder diagnoses in UK Autistic people: Evidence from a matched cohort study [texte imprimé] / Elizabeth O’NIONS, Auteur ; Jude BROWN, Auteur ; Joshua E.J. BUCKMAN, Auteur ; Rebecca CHARLTON, Auteur ; Claudia COOPER, Auteur ; Céline EL BAOU, Auteur ; Francesca HAPPE, Auteur ; Sarah HOARE, Auteur ; Dan LEWER, Auteur ; Cathie LONG, Auteur ; Jill MANTHORPE, Auteur ; Douglas G.J. MCKECHNIE, Auteur ; Marcus RICHARDS, Auteur ; Rob SAUNDERS, Auteur ; Will MANDY, Auteur ; Joshua STOTT, Auteur . - p.901-913. Langues : Anglais (eng) in Autism > 30-4 (April 2026) . - p.901-913 Mots-clés : autism  borderline personality disorder  emotionally unstable personality disorder  personality disorder  primary care Index. décimale : PER Périodiques Résumé : Clinical accounts and cohort studies suggest that Autistic people are disproportionately likely to be diagnosed with personality disorder. We conducted a cohort study of adults diagnosed Autistic drawn from the IQVIA Medical Research Database, with follow-up from 1 January 2000 to 16 January 2019. We included a comparison group without diagnosed autism, matched (1:10) by age, sex and primary care practice. We included 22,112 Autistic adults, of whom 6437 (29.1%) had a diagnosis of intellectual disability. Median age was 20.36 (interquartile range: 18.0–28.5), and 16,881 (76.3%) were men. The rate of new personality disorder diagnosis in Autistic people without intellectual disability was 4.8 (3.5–6.7) times higher for Autistic versus comparison men, and 4.6 (3.1–6.8) times higher for Autistic versus comparison women. For Autistic participants with intellectual disability, the rate was 2.0 (1.0–3.7) times higher for Autistic versus comparison men and 8.3 (4.0–17.2) times higher for Autistic versus comparison women. The estimated rate of new personality disorder diagnosis for Autistic people aged 20 increased from 14.67 (95% confidence interval: 10.4–20.8) per 10,000 person-years in 2009 to 22.43 (95% confidence interval: 13.9–36.3) in 2019. The findings indicate that personality disorder diagnoses are more common in Autistic people and increased overall in women from 2000 to 2019.Lay abstract Several research studies have suggested that Autistic people are more likely to be diagnosed with personality disorder than people who are not Autistic. We compared rates of personality disorder diagnoses between Autistic people and a comparison group of people not diagnosed Autistic using anonymised data collected by UK primary care practitioners for participants registered at a primary care (general practitioner) practice sometime between 1 January 2000 to 16 January 2019. The comparison group of people in the community who did not have an autism diagnosis were of the same age, sex and registered at the same primary care practice as their matched Autistic participant, with 10 times as many matched participants as Autistic participants. We included 22,112 Autistic adults, of whom 6437 (29.1%) had a diagnosis of intellectual disability. Median age was 20.36 years, and most, 16,881 (76.3%), were men. We included 221,120 comparison adults. New personality disorder diagnoses were more than four times as common for Autistic men and women without an intellectual disability compared to men and women in the comparison group. For Autistic participants with an intellectual disability, the rate was twice as high for Autistic versus comparison men and 8 times higher for Autistic versus comparison women. Between 2000 and 2019, there was an increase in the rate of new personality disorder diagnoses among Autistic people, and in women. The findings highlight the need for further investigation into reasons for this increase. En ligne : https://dx.doi.org/10.1177/13623613251414911 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=584

Pubertal maturation and affective symptoms in adolescence and adulthood: Evidence from a prospective birth cohort / Darya GAYSINA in Development and Psychopathology, 27-4 (Part 1) (November 2015)  

Public ISBD [article]  inDevelopment and Psychopathology > 27-4 (Part 1) (November 2015) . - p.1331-1340 Titre : Pubertal maturation and affective symptoms in adolescence and adulthood: Evidence from a prospective birth cohort Type de document : texte imprimé Auteurs : Darya GAYSINA, Auteur ; Marcus RICHARDS, Auteur ; Diana KUH, Auteur ; Rebecca HARDY, Auteur Année de publication : 2015 Article en page(s) : p.1331-1340 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The higher prevalence of affective symptoms among women compared to men emerges in adolescence, and it has been associated with pubertal maturation. However, it remains unclear whether pubertal timing has long-term influences on affective symptoms. Using data from the British 1946 birth cohort, we investigated whether pubertal timing was associated with affective symptoms over the life course, distinguishing those with symptoms in adolescence only, symptoms in adulthood only, and symptoms in both adolescence and adulthood. In females, there was no evidence that early pubertal maturation was a risk factor for affective symptoms. However, those with particularly late menarche (≥15 years) showed a lower risk of adult-onset affective symptoms (odds ratio = 0.54, 95% confidence interval = 0.31, 0.95). This effect of late pubertal timing was not explained by a range of sociobehavioral factors. In contrast, in males, late pubertal timing was associated with increased risk of adolescent-onset affective symptoms that tracked into adulthood (odds ratio = 2.10, 95% confidence interval = 1.44, 3.06). This effect was partly explained by low prepubertal body mass index. Sex-specific effects of pubertal timing on the long-term risk of affective symptoms might be due to different effects of gonadal hormonal on the central nervous system, as well as different social experiences during puberty. En ligne : http://dx.doi.org/10.1017/S0954579414001448 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=268 [article] Pubertal maturation and affective symptoms in adolescence and adulthood: Evidence from a prospective birth cohort [texte imprimé] / Darya GAYSINA, Auteur ; Marcus RICHARDS, Auteur ; Diana KUH, Auteur ; Rebecca HARDY, Auteur . - 2015 . - p.1331-1340. Langues : Anglais (eng) in Development and Psychopathology > 27-4 (Part 1) (November 2015) . - p.1331-1340 Index. décimale : PER Périodiques Résumé : The higher prevalence of affective symptoms among women compared to men emerges in adolescence, and it has been associated with pubertal maturation. However, it remains unclear whether pubertal timing has long-term influences on affective symptoms. Using data from the British 1946 birth cohort, we investigated whether pubertal timing was associated with affective symptoms over the life course, distinguishing those with symptoms in adolescence only, symptoms in adulthood only, and symptoms in both adolescence and adulthood. In females, there was no evidence that early pubertal maturation was a risk factor for affective symptoms. However, those with particularly late menarche (≥15 years) showed a lower risk of adult-onset affective symptoms (odds ratio = 0.54, 95% confidence interval = 0.31, 0.95). This effect of late pubertal timing was not explained by a range of sociobehavioral factors. In contrast, in males, late pubertal timing was associated with increased risk of adolescent-onset affective symptoms that tracked into adulthood (odds ratio = 2.10, 95% confidence interval = 1.44, 3.06). This effect was partly explained by low prepubertal body mass index. Sex-specific effects of pubertal timing on the long-term risk of affective symptoms might be due to different effects of gonadal hormonal on the central nervous system, as well as different social experiences during puberty. En ligne : http://dx.doi.org/10.1017/S0954579414001448 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=268

Research Review: Childhood chronic physical illness and adult emotional health – a systematic review and meta-analysis / Ekin SECINTI in Journal of Child Psychology and Psychiatry, 58-7 (July 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-7 (July 2017) . - p.753-769 Titre : Research Review: Childhood chronic physical illness and adult emotional health – a systematic review and meta-analysis Type de document : texte imprimé Auteurs : Ekin SECINTI, Auteur ; Ellen J. THOMPSON, Auteur ; Marcus RICHARDS, Auteur ; Darya GAYSINA, Auteur Article en page(s) : p.753-769 Langues : Anglais (eng) Mots-clés : Depression  anxiety  chronic disorders  meta-analysis  paediatrics Index. décimale : PER Périodiques Résumé : Background Childhood chronic physical illness is associated with a greater vulnerability for emotional problems (i.e. depression and anxiety) in childhood. However, little is known about life-long effects of childhood chronic physical illness on mental health. The present study aims to systematically review evidence for associations between eight chronic physical illnesses with childhood onset (arthritis, asthma, cancer, chronic renal failure, congenital heart disease, cystic fibrosis, type 1 diabetes, and epilepsy) and adult emotional problems. Methods A database search of MEDLINE, PsycARTICLES, PsycINFO, and ScienceDirect was undertaken, and random effects meta-analyses were used to synthesise evidence from eligible studies. Results In total, 37 studies were eligible for the systematic review (n = 45,733) and of these, 34 studies were included in the meta-analyses (n = 45,358). There were overall associations between childhood chronic physical illness and adult depression (OR = 1.31; 95% CI [1.12, 1.54]) and anxiety (OR = 1.47; 95% CI [1.13, 1.92]). Separate meta-analyses for childhood asthma, type 1 diabetes and cancer were also conducted, with cancer being significantly associated with adult depression (OR = 1.19; 95% CI [1.00, 1.42]). Conclusions The effects of childhood chronic physical illness on the risk of emotional problems persist beyond childhood and adolescence. Mental health prevention and intervention strategies targeting children with chronic physical illnesses can have long-term benefits. En ligne : http://dx.doi.org/10.1111/jcpp.12727 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=316 [article] Research Review: Childhood chronic physical illness and adult emotional health – a systematic review and meta-analysis [texte imprimé] / Ekin SECINTI, Auteur ; Ellen J. THOMPSON, Auteur ; Marcus RICHARDS, Auteur ; Darya GAYSINA, Auteur . - p.753-769. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-7 (July 2017) . - p.753-769 Mots-clés : Depression  anxiety  chronic disorders  meta-analysis  paediatrics Index. décimale : PER Périodiques Résumé : Background Childhood chronic physical illness is associated with a greater vulnerability for emotional problems (i.e. depression and anxiety) in childhood. However, little is known about life-long effects of childhood chronic physical illness on mental health. The present study aims to systematically review evidence for associations between eight chronic physical illnesses with childhood onset (arthritis, asthma, cancer, chronic renal failure, congenital heart disease, cystic fibrosis, type 1 diabetes, and epilepsy) and adult emotional problems. Methods A database search of MEDLINE, PsycARTICLES, PsycINFO, and ScienceDirect was undertaken, and random effects meta-analyses were used to synthesise evidence from eligible studies. Results In total, 37 studies were eligible for the systematic review (n = 45,733) and of these, 34 studies were included in the meta-analyses (n = 45,358). There were overall associations between childhood chronic physical illness and adult depression (OR = 1.31; 95% CI [1.12, 1.54]) and anxiety (OR = 1.47; 95% CI [1.13, 1.92]). Separate meta-analyses for childhood asthma, type 1 diabetes and cancer were also conducted, with cancer being significantly associated with adult depression (OR = 1.19; 95% CI [1.00, 1.42]). Conclusions The effects of childhood chronic physical illness on the risk of emotional problems persist beyond childhood and adolescence. Mental health prevention and intervention strategies targeting children with chronic physical illnesses can have long-term benefits. En ligne : http://dx.doi.org/10.1111/jcpp.12727 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=316

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