[article] 
inAutism Research > 10-9 (September 2017) . - p.1544-1546

Titre :	Maternal hirsutism and autism spectrum disorders in offspring
Type de document :	Texte imprimé et/ou numérique
Auteurs :	Brian K. LEE, Auteur ; Stefan ARVER, Auteur ; Linnea WIDMAN, Auteur ; Renee M. GARDNER, Auteur ; Cecilia MAGNUSSON, Auteur ; Christina DALMAN, Auteur ; Kyriaki KOSIDOU, Auteur
Article en page(s) :	p.1544-1546
Langues :	Anglais (eng)
Mots-clés :	epidemiology - analytic (risk factors)  pre- and perinatal risk factors  environmental risk factors
Index. décimale :	PER Périodiques
Résumé :	Because animal and human studies indicate that androgen exposure can influence neurodevelopment, it has been hypothesized that prenatal exposure to excess androgens may predispose to disorders with male-skewed ratio such as autism spectrum disorders (ASD). Therefore, maternal conditions characterized by hyperandrogenism such as polycystic ovary syndrome (PCOS) or hirsutism may be relevant to child ASD. We previously found in a large Swedish case-control study of 23,748 ASD cases and 208,796 matched controls that PCOS in mothers is associated with increased offspring risk of ASD. In the same sample, we have now examined whether maternal diagnoses of hirsutism were associated with ASD. In both unadjusted logistic regression models and models adjusted for a variety of covariates, hirsutism was associated with higher odds of ASD. The most adjusted odds ratios for associations with ASD for hirsutism diagnosis before birth and lifetime diagnosis of hirsutism were 1.64 (95% CI: 0.94, 2.83) and 1.26 (95% CI: 1.01, 1.57), respectively. The presence of an association of maternal hirsutism with child ASD is consistent with the hypothesis that androgens may be involved in the etiology of ASD.
En ligne :	http://dx.doi.org/10.1002/aur.1797
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=320

[article] Maternal hirsutism and autism spectrum disorders in offspring [Texte imprimé et/ou numérique] / Brian K. LEE, Auteur ; Stefan ARVER, Auteur ; Linnea WIDMAN, Auteur ; Renee M. GARDNER, Auteur ; Cecilia MAGNUSSON, Auteur ; Christina DALMAN, Auteur ; Kyriaki KOSIDOU, Auteur . - p.1544-1546.
Langues : Anglais (eng)
in Autism Research > 10-9 (September 2017) . - p.1544-1546

Mots-clés :	epidemiology - analytic (risk factors)  pre- and perinatal risk factors  environmental risk factors
Index. décimale :	PER Périodiques
Résumé :	Because animal and human studies indicate that androgen exposure can influence neurodevelopment, it has been hypothesized that prenatal exposure to excess androgens may predispose to disorders with male-skewed ratio such as autism spectrum disorders (ASD). Therefore, maternal conditions characterized by hyperandrogenism such as polycystic ovary syndrome (PCOS) or hirsutism may be relevant to child ASD. We previously found in a large Swedish case-control study of 23,748 ASD cases and 208,796 matched controls that PCOS in mothers is associated with increased offspring risk of ASD. In the same sample, we have now examined whether maternal diagnoses of hirsutism were associated with ASD. In both unadjusted logistic regression models and models adjusted for a variety of covariates, hirsutism was associated with higher odds of ASD. The most adjusted odds ratios for associations with ASD for hirsutism diagnosis before birth and lifetime diagnosis of hirsutism were 1.64 (95% CI: 0.94, 2.83) and 1.26 (95% CI: 1.01, 1.57), respectively. The presence of an association of maternal hirsutism with child ASD is consistent with the hypothesis that androgens may be involved in the etiology of ASD.
En ligne :	http://dx.doi.org/10.1002/aur.1797
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=320