Elevated GFAP Protein in Anterior Cingulate Cortical White Matter in Males With Autism Spectrum Disorder / Jessica D. CRAWFORD in Autism Research, 8-6 (December 2015)  

Public ISBD [article]  inAutism Research > 8-6 (December 2015) . - p.649-657 Titre : Elevated GFAP Protein in Anterior Cingulate Cortical White Matter in Males With Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Jessica D. CRAWFORD, Auteur ; Michelle J. CHANDLEY, Auteur ; Katalin SZEBENI, Auteur ; Attila SZEBENI, Auteur ; Brandon WATERS, Auteur ; Gregory A. ORDWAY, Auteur Article en page(s) : p.649-657 Langues : Anglais (eng) Mots-clés : cellular neurophysiology  neuroanatomy  neuropathology Index. décimale : PER Périodiques Résumé : Based on evidence of abnormalities in axon thickness and neuronal disorganization, autism spectrum disorder (ASD) is commonly considered to be a condition resulting from neuronal dysfunction. Yet, recent findings suggest that non-neuronal cell types also contribute to ASD pathology. To investigate the role of glial cells in ASD, a combination of protein and gene expression analyses were used to determine levels of two glial markers, glial fibrillary acidic protein (GFAP) and myelin oligodendrocyte glycoprotein (MOG), in the postmortem brain tissue from control and ASD donors. Levels of GFAP immunoreactivity (ir) were significantly elevated (P?=?0.008) in anterior cingulate cortex (Brodmann area 24; BA24) white matter of ASD donors compared to control donors. In contrast, GFAP-ir levels were similar in BA24 gray matter from ASD and control donors. MOG-ir was also similar in both BA24 white and gray matter from ASD and control donors. In anterior prefrontal cortex (BA10), there were no significant differences in GFAP-ir or MOG-ir in either white or gray matter comparing ASD to control donors. Levels of expression of the genes GFAP and MOG also showed no differences between control and ASD donors in BA24 and BA10 white and gray matter. Collectively, these data imply that ASD is associated with an activation of white matter astrocytes in the anterior cingulate cortex as a result of a yet undefined cellular insult. Research is needed to investigate the molecular pathways that underlie this astrocyte reaction and such research may yield important clues regarding the etiology of ASD. Autism Res 2015, 8: 649–657. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1480 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=278 [article] Elevated GFAP Protein in Anterior Cingulate Cortical White Matter in Males With Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Jessica D. CRAWFORD, Auteur ; Michelle J. CHANDLEY, Auteur ; Katalin SZEBENI, Auteur ; Attila SZEBENI, Auteur ; Brandon WATERS, Auteur ; Gregory A. ORDWAY, Auteur . - p.649-657. Langues : Anglais (eng) in Autism Research > 8-6 (December 2015) . - p.649-657 Mots-clés : cellular neurophysiology  neuroanatomy  neuropathology Index. décimale : PER Périodiques Résumé : Based on evidence of abnormalities in axon thickness and neuronal disorganization, autism spectrum disorder (ASD) is commonly considered to be a condition resulting from neuronal dysfunction. Yet, recent findings suggest that non-neuronal cell types also contribute to ASD pathology. To investigate the role of glial cells in ASD, a combination of protein and gene expression analyses were used to determine levels of two glial markers, glial fibrillary acidic protein (GFAP) and myelin oligodendrocyte glycoprotein (MOG), in the postmortem brain tissue from control and ASD donors. Levels of GFAP immunoreactivity (ir) were significantly elevated (P?=?0.008) in anterior cingulate cortex (Brodmann area 24; BA24) white matter of ASD donors compared to control donors. In contrast, GFAP-ir levels were similar in BA24 gray matter from ASD and control donors. MOG-ir was also similar in both BA24 white and gray matter from ASD and control donors. In anterior prefrontal cortex (BA10), there were no significant differences in GFAP-ir or MOG-ir in either white or gray matter comparing ASD to control donors. Levels of expression of the genes GFAP and MOG also showed no differences between control and ASD donors in BA24 and BA10 white and gray matter. Collectively, these data imply that ASD is associated with an activation of white matter astrocytes in the anterior cingulate cortex as a result of a yet undefined cellular insult. Research is needed to investigate the molecular pathways that underlie this astrocyte reaction and such research may yield important clues regarding the etiology of ASD. Autism Res 2015, 8: 649–657. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1480 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=278

Erratum to: NTRK2 expression levels are reduced in laser captured pyramidal neurons from the anterior cingulate cortex in males with autism spectrum disorder / Michelle J. CHANDLEY in Molecular Autism, (June 2015)  

Public ISBD [article]  inMolecular Autism > (June 2015) . - p.1-1 Titre : Erratum to: NTRK2 expression levels are reduced in laser captured pyramidal neurons from the anterior cingulate cortex in males with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Michelle J. CHANDLEY, Auteur ; Jessica D. CRAWFORD, Auteur ; Attila SZEBENI, Auteur ; Katalin SZEBENI, Auteur ; Gregory A. ORDWAY, Auteur Article en page(s) : p.1-1 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1186/s13229-015-0033-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277 [article] Erratum to: NTRK2 expression levels are reduced in laser captured pyramidal neurons from the anterior cingulate cortex in males with autism spectrum disorder [Texte imprimé et/ou numérique] / Michelle J. CHANDLEY, Auteur ; Jessica D. CRAWFORD, Auteur ; Attila SZEBENI, Auteur ; Katalin SZEBENI, Auteur ; Gregory A. ORDWAY, Auteur . - p.1-1. Langues : Anglais (eng) in Molecular Autism > (June 2015) . - p.1-1 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1186/s13229-015-0033-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277

NTRK2 expression levels are reduced in laser captured pyramidal neurons from the anterior cingulate cortex in males with autism spectrum disorder / Michelle J. CHANDLEY in Molecular Autism, (May 2015)  

Public ISBD [article]  inMolecular Autism > (May 2015) . - p.1-12 Titre : NTRK2 expression levels are reduced in laser captured pyramidal neurons from the anterior cingulate cortex in males with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Michelle J. CHANDLEY, Auteur ; Jessica D. CRAWFORD, Auteur ; Attila SZEBENI, Auteur ; Katalin SZEBENI, Auteur ; Gregory A. ORDWAY, Auteur Article en page(s) : p.1-12 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The anterior cingulate cortex (ACC) is a brain area involved in modulating behavior associated with social interaction, disruption of which is a core feature of autism spectrum disorder (ASD). Functional brain imaging studies demonstrate abnormalities of the ACC in ASD as compared to typically developing control patients. However, little is known regarding the cellular basis of these functional deficits in ASD. Pyramidal neurons in the ACC are excitatory glutamatergic neurons and key cellular mediators of the neural output of the ACC. This study was designed to investigate the potential role of ACC pyramidal neurons in ASD brain pathology. En ligne : http://dx.doi.org/10.1186/s13229-015-0023-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277 [article] NTRK2 expression levels are reduced in laser captured pyramidal neurons from the anterior cingulate cortex in males with autism spectrum disorder [Texte imprimé et/ou numérique] / Michelle J. CHANDLEY, Auteur ; Jessica D. CRAWFORD, Auteur ; Attila SZEBENI, Auteur ; Katalin SZEBENI, Auteur ; Gregory A. ORDWAY, Auteur . - p.1-12. Langues : Anglais (eng) in Molecular Autism > (May 2015) . - p.1-12 Index. décimale : PER Périodiques Résumé : The anterior cingulate cortex (ACC) is a brain area involved in modulating behavior associated with social interaction, disruption of which is a core feature of autism spectrum disorder (ASD). Functional brain imaging studies demonstrate abnormalities of the ACC in ASD as compared to typically developing control patients. However, little is known regarding the cellular basis of these functional deficits in ASD. Pyramidal neurons in the ACC are excitatory glutamatergic neurons and key cellular mediators of the neural output of the ACC. This study was designed to investigate the potential role of ACC pyramidal neurons in ASD brain pathology. En ligne : http://dx.doi.org/10.1186/s13229-015-0023-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277

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