[article]
Titre : |
Ultrastructural analyses in the hippocampus CA1 field in Shank3-deficient mice |
Type de document : |
Texte imprimé et/ou numérique |
Auteurs : |
Neha UPPAL, Auteur ; Rishi PURI, Auteur ; Frank YUK, Auteur ; William G. M. JANSSEN, Auteur ; Ozlem BOZDAGI-GUNAL, Auteur ; Hala HARONY-NICOLAS, Auteur ; Dara L. DICKSTEIN, Auteur ; Joseph D. BUXBAUM, Auteur ; Patrick R. HOF, Auteur |
Article en page(s) : |
p.1-10 |
Langues : |
Anglais (eng) |
Index. décimale : |
PER Périodiques |
Résumé : |
The genetics of autism spectrum disorder (hereafter referred to as “autism”) are rapidly unfolding, with a significant increase in the identification of genes implicated in the disorder. Many of these genes are part of a complex landscape of genetic variants that are thought to act together to cause the behavioral phenotype associated with autism. One of the few single-locus causes of autism involves a mutation in the SH3 and multiple ankyrin repeat domains 3 (SHANK3) gene. Previous electrophysiological studies in mice with Shank3 mutations demonstrated impairment in synaptic long-term potentiation, suggesting a potential disruption at the synapse. |
En ligne : |
http://dx.doi.org/10.1186/s13229-015-0036-x |
Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277 |
in Molecular Autism > (June 2015) . - p.1-10
[article] Ultrastructural analyses in the hippocampus CA1 field in Shank3-deficient mice [Texte imprimé et/ou numérique] / Neha UPPAL, Auteur ; Rishi PURI, Auteur ; Frank YUK, Auteur ; William G. M. JANSSEN, Auteur ; Ozlem BOZDAGI-GUNAL, Auteur ; Hala HARONY-NICOLAS, Auteur ; Dara L. DICKSTEIN, Auteur ; Joseph D. BUXBAUM, Auteur ; Patrick R. HOF, Auteur . - p.1-10. Langues : Anglais ( eng) in Molecular Autism > (June 2015) . - p.1-10
Index. décimale : |
PER Périodiques |
Résumé : |
The genetics of autism spectrum disorder (hereafter referred to as “autism”) are rapidly unfolding, with a significant increase in the identification of genes implicated in the disorder. Many of these genes are part of a complex landscape of genetic variants that are thought to act together to cause the behavioral phenotype associated with autism. One of the few single-locus causes of autism involves a mutation in the SH3 and multiple ankyrin repeat domains 3 (SHANK3) gene. Previous electrophysiological studies in mice with Shank3 mutations demonstrated impairment in synaptic long-term potentiation, suggesting a potential disruption at the synapse. |
En ligne : |
http://dx.doi.org/10.1186/s13229-015-0036-x |
Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277 |
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