[article]
Titre : |
Platelet studies in autism spectrum disorder patients and first-degree relatives |
Type de document : |
Texte imprimé et/ou numérique |
Auteurs : |
Nora BIJL, Auteur ; Chantal THYS, Auteur ; Christine WITTEVRONGEL, Auteur ; Wouter DE LA MARCHE, Auteur ; Koenraad DEVRIENDT, Auteur ; Hilde PEETERS, Auteur ; Chris VAN GEET, Auteur ; Kathleen FRESON, Auteur |
Article en page(s) : |
p.1-10 |
Langues : |
Anglais (eng) |
Index. décimale : |
PER Périodiques |
Résumé : |
Platelets have been proven to be a useful cellular model to study some neuropathologies, due to the overlapping biological features between neurons and platelets as granule secreting cells. Altered platelet dense granule morphology was previously reported in three autism spectrum disorder (ASD) patients with chromosomal translocations that disrupted ASD candidate genes NBEA, SCAMP5, and AMYSIN, but a systematic analysis of platelet function in ASD is lacking in contrast to numerous reports of elevated serotonin levels in platelets and blood as potential biomarker for ASD. |
En ligne : |
http://dx.doi.org/10.1186/s13229-015-0051-y |
Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277 |
in Molecular Autism > (October 2015) . - p.1-10
[article] Platelet studies in autism spectrum disorder patients and first-degree relatives [Texte imprimé et/ou numérique] / Nora BIJL, Auteur ; Chantal THYS, Auteur ; Christine WITTEVRONGEL, Auteur ; Wouter DE LA MARCHE, Auteur ; Koenraad DEVRIENDT, Auteur ; Hilde PEETERS, Auteur ; Chris VAN GEET, Auteur ; Kathleen FRESON, Auteur . - p.1-10. Langues : Anglais ( eng) in Molecular Autism > (October 2015) . - p.1-10
Index. décimale : |
PER Périodiques |
Résumé : |
Platelets have been proven to be a useful cellular model to study some neuropathologies, due to the overlapping biological features between neurons and platelets as granule secreting cells. Altered platelet dense granule morphology was previously reported in three autism spectrum disorder (ASD) patients with chromosomal translocations that disrupted ASD candidate genes NBEA, SCAMP5, and AMYSIN, but a systematic analysis of platelet function in ASD is lacking in contrast to numerous reports of elevated serotonin levels in platelets and blood as potential biomarker for ASD. |
En ligne : |
http://dx.doi.org/10.1186/s13229-015-0051-y |
Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277 |
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