Role of the cytoplasmic isoform of RBFOX1/A2BP1 in establishing the architecture of the developing cerebral cortex / Nanako HAMADA in Molecular Autism, (October 2015)  

Public ISBD [article]  inMolecular Autism > (October 2015) . - p.1-13 Titre : Role of the cytoplasmic isoform of RBFOX1/A2BP1 in establishing the architecture of the developing cerebral cortex Type de document : Texte imprimé et/ou numérique Auteurs : Nanako HAMADA, Auteur ; Hidenori ITO, Auteur ; Ikuko IWAMOTO, Auteur ; Rika MORISHITA, Auteur ; Hidenori TABATA, Auteur ; Koh-ichi NAGATA, Auteur Article en page(s) : p.1-13 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : RBFOX1 (also known as FOX1 or A2BP1) regulates alternative splicing of a variety of transcripts crucial for neuronal functions. Physiological significance of RBFOX1 during brain development is seemingly essential since abnormalities in the gene cause autism spectrum disorder (ASD) and other neurodevelopmental and neuropsychiatric disorders such as intellectual disability, epilepsy, attention deficit hyperactivity disorder, and schizophrenia. RBFOX1 was also shown to serve as a “hub” in ASD gene transcriptome network. However, the pathophysiological significance of RBFOX1 gene abnormalities remains to be clarified. En ligne : http://dx.doi.org/10.1186/s13229-015-0049-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277 [article] Role of the cytoplasmic isoform of RBFOX1/A2BP1 in establishing the architecture of the developing cerebral cortex [Texte imprimé et/ou numérique] / Nanako HAMADA, Auteur ; Hidenori ITO, Auteur ; Ikuko IWAMOTO, Auteur ; Rika MORISHITA, Auteur ; Hidenori TABATA, Auteur ; Koh-ichi NAGATA, Auteur . - p.1-13. Langues : Anglais (eng) in Molecular Autism > (October 2015) . - p.1-13 Index. décimale : PER Périodiques Résumé : RBFOX1 (also known as FOX1 or A2BP1) regulates alternative splicing of a variety of transcripts crucial for neuronal functions. Physiological significance of RBFOX1 during brain development is seemingly essential since abnormalities in the gene cause autism spectrum disorder (ASD) and other neurodevelopmental and neuropsychiatric disorders such as intellectual disability, epilepsy, attention deficit hyperactivity disorder, and schizophrenia. RBFOX1 was also shown to serve as a “hub” in ASD gene transcriptome network. However, the pathophysiological significance of RBFOX1 gene abnormalities remains to be clarified. En ligne : http://dx.doi.org/10.1186/s13229-015-0049-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277

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