Aggressive behaviors and treatable risk factors of preschool children with autism spectrum disorder / Chen CHEN in Autism Research, 10-6 (June 2017)  

Public ISBD [article]  inAutism Research > 10-6 (June 2017) . - p.1155-1162 Titre : Aggressive behaviors and treatable risk factors of preschool children with autism spectrum disorder Type de document : texte imprimé Auteurs : Chen CHEN, Auteur ; Yi-Dong SHEN, Auteur ; Guang-Lei XUN, Auteur ; Wei-Xiong CAI, Auteur ; Li-Juan SHI, Auteur ; Lu XIAO, Auteur ; Ren-Rong WU, Auteur ; Jing-Ping ZHAO, Auteur ; Jian-Jun OU, Auteur Article en page(s) : p.1155-1162 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  aggressive behaviors  treatable risk factors  sleep problems  ADHD symptoms Index. décimale : PER Périodiques Résumé : Aggressive behaviors of children with autism spectrum disorder (ASD) are common. We conducted this study to describe the aggressive mode of preschool children with ASD and examine the associations between specific aggressive behaviors and two treatable factors: sleep problems and attention deficit hyperactivity disorder (ADHD) symptoms. In total, 577 typically developing (TD) children and 490 children with ASD were investigated in this study. The Institute for Basic Research – Modified Overt Aggression Scale (IBR-MOAS) was used to assess aggressive behaviors. Children's social impairments, sleep problems and ADHD symptoms were also measured with specific scales. The total IBR-MOAS score was significantly higher (worse) in the TD group [4.47 (5.36)] than in the ASD group [3.47 (5.63), P = 0.004]. The aggressive modes differed between groups: when compared with each other, the TD group received higher scores on Verbal and Physical Aggression Toward Others (all P < 0.01), while the ASD group had higher scores on Physical Aggression Against Self (P = 0.006). The linear regression model demonstrated that the aggressive behaviors of children with ASD were significantly associated with two treatable factors: sleep problems and ADHD symptoms. These findings have substantial clinical implications: treatment of these two risk factors may be helpful in managing aggressive behavior in children with ASD. En ligne : http://dx.doi.org/10.1002/aur.1751 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=309 [article] Aggressive behaviors and treatable risk factors of preschool children with autism spectrum disorder [texte imprimé] / Chen CHEN, Auteur ; Yi-Dong SHEN, Auteur ; Guang-Lei XUN, Auteur ; Wei-Xiong CAI, Auteur ; Li-Juan SHI, Auteur ; Lu XIAO, Auteur ; Ren-Rong WU, Auteur ; Jing-Ping ZHAO, Auteur ; Jian-Jun OU, Auteur . - p.1155-1162. Langues : Anglais (eng) in Autism Research > 10-6 (June 2017) . - p.1155-1162 Mots-clés : autism spectrum disorder  aggressive behaviors  treatable risk factors  sleep problems  ADHD symptoms Index. décimale : PER Périodiques Résumé : Aggressive behaviors of children with autism spectrum disorder (ASD) are common. We conducted this study to describe the aggressive mode of preschool children with ASD and examine the associations between specific aggressive behaviors and two treatable factors: sleep problems and attention deficit hyperactivity disorder (ADHD) symptoms. In total, 577 typically developing (TD) children and 490 children with ASD were investigated in this study. The Institute for Basic Research – Modified Overt Aggression Scale (IBR-MOAS) was used to assess aggressive behaviors. Children's social impairments, sleep problems and ADHD symptoms were also measured with specific scales. The total IBR-MOAS score was significantly higher (worse) in the TD group [4.47 (5.36)] than in the ASD group [3.47 (5.63), P = 0.004]. The aggressive modes differed between groups: when compared with each other, the TD group received higher scores on Verbal and Physical Aggression Toward Others (all P < 0.01), while the ASD group had higher scores on Physical Aggression Against Self (P = 0.006). The linear regression model demonstrated that the aggressive behaviors of children with ASD were significantly associated with two treatable factors: sleep problems and ADHD symptoms. These findings have substantial clinical implications: treatment of these two risk factors may be helpful in managing aggressive behavior in children with ASD. En ligne : http://dx.doi.org/10.1002/aur.1751 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=309

Association and gene–gene interactions study of reelin signaling pathway related genes with autism in the Han Chinese population / Yidong SHEN in Autism Research, 9-4 (April 2016)  

Public ISBD [article]  inAutism Research > 9-4 (April 2016) . - p.436-442 Titre : Association and gene–gene interactions study of reelin signaling pathway related genes with autism in the Han Chinese population Type de document : texte imprimé Auteurs : Yidong SHEN, Auteur ; Guanglei XUN, Auteur ; Hui GUO, Auteur ; Yiqun HE, Auteur ; Jianjun OU, Auteur ; Huixi DONG, Auteur ; Kun XIA, Auteur ; Jingping ZHAO, Auteur Article en page(s) : p.436-442 Langues : Anglais (eng) Mots-clés : autism  reelin  signaling pathway  interaction  polymorphism Index. décimale : PER Périodiques Résumé : Autism is a neurodevelopmental disorder with unclear etiology. Reelin had been proposed to participate in the etiology of autism due to its important role in brain development. The goal of this study was to explore the association and gene–gene interactions of reelin signaling pathway related genes (RELN, VLDLR, LRP8, DAB1, FYN, and CDK5) with autism in Han Chinese population. Genotyping data of the six genes were obtained from a recent genome-wide association study performed in 430 autistic children who fulfilled the DSM-IV-TR criteria for autistic disorder, and 1,074 healthy controls. Single marker case-control association analysis and haplotype case-control association analysis were conducted after the data was screened. Multifactor dimensionality reduction (MDR) was applied to further test gene–gene interactions. Neither the single marker nor the haplotype association tests found any significant difference between the autistic group and the control group after permutation test of 1,000 rounds. The 4-locus MDR model (comprising rs6143734, rs1858782, rs634500, and rs1924267 which belong to RELN and DAB1) was determined to be the model with the highest cross-validation consistency (CVC) and testing balanced accuracy. The results indicate that an interaction between RELN and DAB1 may increase the risk of autism in the Han Chinese population. Furthermore, it can also be inferred that the involvement of RELN in the etiology of autism would occur through interaction with DAB1. Autism Res 2016, 9: 436–442. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1540 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=287 [article] Association and gene–gene interactions study of reelin signaling pathway related genes with autism in the Han Chinese population [texte imprimé] / Yidong SHEN, Auteur ; Guanglei XUN, Auteur ; Hui GUO, Auteur ; Yiqun HE, Auteur ; Jianjun OU, Auteur ; Huixi DONG, Auteur ; Kun XIA, Auteur ; Jingping ZHAO, Auteur . - p.436-442. Langues : Anglais (eng) in Autism Research > 9-4 (April 2016) . - p.436-442 Mots-clés : autism  reelin  signaling pathway  interaction  polymorphism Index. décimale : PER Périodiques Résumé : Autism is a neurodevelopmental disorder with unclear etiology. Reelin had been proposed to participate in the etiology of autism due to its important role in brain development. The goal of this study was to explore the association and gene–gene interactions of reelin signaling pathway related genes (RELN, VLDLR, LRP8, DAB1, FYN, and CDK5) with autism in Han Chinese population. Genotyping data of the six genes were obtained from a recent genome-wide association study performed in 430 autistic children who fulfilled the DSM-IV-TR criteria for autistic disorder, and 1,074 healthy controls. Single marker case-control association analysis and haplotype case-control association analysis were conducted after the data was screened. Multifactor dimensionality reduction (MDR) was applied to further test gene–gene interactions. Neither the single marker nor the haplotype association tests found any significant difference between the autistic group and the control group after permutation test of 1,000 rounds. The 4-locus MDR model (comprising rs6143734, rs1858782, rs634500, and rs1924267 which belong to RELN and DAB1) was determined to be the model with the highest cross-validation consistency (CVC) and testing balanced accuracy. The results indicate that an interaction between RELN and DAB1 may increase the risk of autism in the Han Chinese population. Furthermore, it can also be inferred that the involvement of RELN in the etiology of autism would occur through interaction with DAB1. Autism Res 2016, 9: 436–442. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1540 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=287

Association between maternal antidepressant use during pregnancy and autism spectrum disorder: an updated meta-analysis / Xi-Hong ZHOU in Molecular Autism, 9 (2018)  

Public ISBD [article]  inMolecular Autism > 9 (2018) . - 21p. Titre : Association between maternal antidepressant use during pregnancy and autism spectrum disorder: an updated meta-analysis Type de document : texte imprimé Auteurs : Xi-Hong ZHOU, Auteur ; Yong-Jiang LI, Auteur ; Jian-Jun OU, Auteur ; Ya-Min LI, Auteur Article en page(s) : 21p. Langues : Anglais (eng) Mots-clés : Antidepressant exposure  Autism spectrum disorder  Meta-analysis  Offspring Index. décimale : PER Périodiques Résumé : Studies have investigated the risk of autism spectrum disorder (ASD) in children exposed in utero to antidepressant, with inconsistent results. Given the substantial public health implications on this topic, here, we presented an updated meta-analysis of the association between maternal antidepressant use during pregnancy and ASD. Cochrane Library, EMBASE, PsycINFO, and PubMed databases were systematically searched. A random effects model was used to pool the adjusted relative risk (RR) for cohort studies and the adjusted odds ratio (OR) for case-control studies as well as their corresponding 95% confidence intervals (CIs). Meta-analysis restricted to sibling studies was also conducted. Publication bias was systematically assessed. Fourteen studies were identified (eight cohort studies and six case-control studies). Pooled adjusted RR for cohort studies (n = 2,839,980) was 1.13 (0.93-1.39) showed a non-significant association; while two studies were potentially missing from the test of publication bias, filled estimates also showed a non-significant association (filled RR 0.97, 95% CI 0.79-1.19). Pooled OR was 1.51 (1.15-1.99) for case-control studies (n = 117,737) showed a significant association; two studies were potentially missing; however, the filled estimates suggested a non-significant association (filled OR 1.26, 95% CI 0.98-1.62). Analyses restricted to sibling studies also showed a non-significant association (RR 0.99, 95% CI 0.81-1.22). In summary, we did not evidence a significant association between maternal antidepressant use during pregnancy and ASD. En ligne : http://dx.doi.org/10.1186/s13229-018-0207-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=354 [article] Association between maternal antidepressant use during pregnancy and autism spectrum disorder: an updated meta-analysis [texte imprimé] / Xi-Hong ZHOU, Auteur ; Yong-Jiang LI, Auteur ; Jian-Jun OU, Auteur ; Ya-Min LI, Auteur . - 21p. Langues : Anglais (eng) in Molecular Autism > 9 (2018) . - 21p. Mots-clés : Antidepressant exposure  Autism spectrum disorder  Meta-analysis  Offspring Index. décimale : PER Périodiques Résumé : Studies have investigated the risk of autism spectrum disorder (ASD) in children exposed in utero to antidepressant, with inconsistent results. Given the substantial public health implications on this topic, here, we presented an updated meta-analysis of the association between maternal antidepressant use during pregnancy and ASD. Cochrane Library, EMBASE, PsycINFO, and PubMed databases were systematically searched. A random effects model was used to pool the adjusted relative risk (RR) for cohort studies and the adjusted odds ratio (OR) for case-control studies as well as their corresponding 95% confidence intervals (CIs). Meta-analysis restricted to sibling studies was also conducted. Publication bias was systematically assessed. Fourteen studies were identified (eight cohort studies and six case-control studies). Pooled adjusted RR for cohort studies (n = 2,839,980) was 1.13 (0.93-1.39) showed a non-significant association; while two studies were potentially missing from the test of publication bias, filled estimates also showed a non-significant association (filled RR 0.97, 95% CI 0.79-1.19). Pooled OR was 1.51 (1.15-1.99) for case-control studies (n = 117,737) showed a significant association; two studies were potentially missing; however, the filled estimates suggested a non-significant association (filled OR 1.26, 95% CI 0.98-1.62). Analyses restricted to sibling studies also showed a non-significant association (RR 0.99, 95% CI 0.81-1.22). In summary, we did not evidence a significant association between maternal antidepressant use during pregnancy and ASD. En ligne : http://dx.doi.org/10.1186/s13229-018-0207-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=354

Association Between Maternal Obesity and Autism Spectrum Disorder in Offspring: A Meta-analysis / Ya-Min LI in Journal of Autism and Developmental Disorders, 46-1 (January 2016)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 46-1 (January 2016) . - p.95-102 Titre : Association Between Maternal Obesity and Autism Spectrum Disorder in Offspring: A Meta-analysis Type de document : texte imprimé Auteurs : Ya-Min LI, Auteur ; Jian-Jun OU, Auteur ; Li LIU, Auteur ; Dan ZHANG, Auteur ; Jing-Ping ZHAO, Auteur ; Si-Yuan TANG, Auteur Année de publication : 2016 Article en page(s) : p.95-102 Langues : Anglais (eng) Mots-clés : Obésité maternelle  Maternal obesity  Autism spectrum disorder  Offspring  Meta-analysis Index. décimale : PER Périodiques Résumé : As the link between maternal obesity and risk of autism among offspring is unclear, the present study assessed this association. A systematic search of an electronic database was performed to identify observational studies that examined the association between maternal obesity and autism. The outcome measures were odds ratios comparing offspring autism risk between obese and normal-weight mothers. Five observational studies were included in the meta-analysis. A fixed-effects model was used since low heterogeneity was observed between studies. The pooled adjusted odds ratio was 1.47 (95 % CI 1.24–1.74). The meta-analysis results support an increased risk of autism spectrum disorder in children of women who were obese during pregnancy. However, further study is warranted to confirm these results. En ligne : http://dx.doi.org/10.1007/s10803-015-2549-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=278 [article] Association Between Maternal Obesity and Autism Spectrum Disorder in Offspring: A Meta-analysis [texte imprimé] / Ya-Min LI, Auteur ; Jian-Jun OU, Auteur ; Li LIU, Auteur ; Dan ZHANG, Auteur ; Jing-Ping ZHAO, Auteur ; Si-Yuan TANG, Auteur . - 2016 . - p.95-102. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 46-1 (January 2016) . - p.95-102 Mots-clés : Obésité maternelle  Maternal obesity  Autism spectrum disorder  Offspring  Meta-analysis Index. décimale : PER Périodiques Résumé : As the link between maternal obesity and risk of autism among offspring is unclear, the present study assessed this association. A systematic search of an electronic database was performed to identify observational studies that examined the association between maternal obesity and autism. The outcome measures were odds ratios comparing offspring autism risk between obese and normal-weight mothers. Five observational studies were included in the meta-analysis. A fixed-effects model was used since low heterogeneity was observed between studies. The pooled adjusted odds ratio was 1.47 (95 % CI 1.24–1.74). The meta-analysis results support an increased risk of autism spectrum disorder in children of women who were obese during pregnancy. However, further study is warranted to confirm these results. En ligne : http://dx.doi.org/10.1007/s10803-015-2549-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=278

Differential profiles of response inhibition deficit between male children with autism spectrum disorders and schizophrenia / Li-Juan SHI in Autism Research, 13-4 (April 2020)  

Public ISBD [article]  inAutism Research > 13-4 (April 2020) . - p.591-602 Titre : Differential profiles of response inhibition deficit between male children with autism spectrum disorders and schizophrenia Type de document : texte imprimé Auteurs : Li-Juan SHI, Auteur ; Han-Yu ZHOU, Auteur ; Yan-Mei SHEN, Auteur ; Ya WANG, Auteur ; Yu-Min FANG, Auteur ; Yu-Qiong HE, Auteur ; Jian-Jun OU, Auteur ; Xue-Rong LUO, Auteur ; Eric F.C. CHEUNG, Auteur ; Raymond C.K. CHAN, Auteur Article en page(s) : p.591-602 Langues : Anglais (eng) Mots-clés : auditory  autism spectrum disorder  response inhibition  schizophrenia  verbal  visual Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) and schizophrenia (SZ) are both associated with response inhibition impairment. However, the relative pattern of deficits in these two disorders remains unclear. Twenty-three male children with ASD, 23 male children with SZ, and 32 typically developing male controls were recruited to complete a set of tasks measuring response inhibition in the visual, auditory, and verbal domains. We found that visual, auditory, and verbal response inhibitions were impaired in both children with ASD and children with SZ. Compared with typically developing controls, children with ASD made more commission errors whereas children with SZ responded much slower in the visual response inhibition task. Both clinical groups showed comparable impairment in verbal response inhibition, but children with SZ were more impaired in auditory response inhibition than children with ASD. These different patterns of response inhibition deficit between male children with ASD and SZ may help to differentiate between these two disorders and may be potential targets for intervention. Autism Res 2020, 13: 591-602. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: In this study, we found that male children with autism spectrum disorder (ASD) made more commission errors whereas male children with schizophrenia (SZ) responded much slower in the visual response inhibition task. Both clinical groups exhibited comparable impairments in verbal response inhibition, but male children with SZ were more impaired in auditory response inhibition than male children with ASD. Our findings provide potential targets for intervention. En ligne : http://dx.doi.org/10.1002/aur.2231 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=421 [article] Differential profiles of response inhibition deficit between male children with autism spectrum disorders and schizophrenia [texte imprimé] / Li-Juan SHI, Auteur ; Han-Yu ZHOU, Auteur ; Yan-Mei SHEN, Auteur ; Ya WANG, Auteur ; Yu-Min FANG, Auteur ; Yu-Qiong HE, Auteur ; Jian-Jun OU, Auteur ; Xue-Rong LUO, Auteur ; Eric F.C. CHEUNG, Auteur ; Raymond C.K. CHAN, Auteur . - p.591-602. Langues : Anglais (eng) in Autism Research > 13-4 (April 2020) . - p.591-602 Mots-clés : auditory  autism spectrum disorder  response inhibition  schizophrenia  verbal  visual Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) and schizophrenia (SZ) are both associated with response inhibition impairment. However, the relative pattern of deficits in these two disorders remains unclear. Twenty-three male children with ASD, 23 male children with SZ, and 32 typically developing male controls were recruited to complete a set of tasks measuring response inhibition in the visual, auditory, and verbal domains. We found that visual, auditory, and verbal response inhibitions were impaired in both children with ASD and children with SZ. Compared with typically developing controls, children with ASD made more commission errors whereas children with SZ responded much slower in the visual response inhibition task. Both clinical groups showed comparable impairment in verbal response inhibition, but children with SZ were more impaired in auditory response inhibition than children with ASD. These different patterns of response inhibition deficit between male children with ASD and SZ may help to differentiate between these two disorders and may be potential targets for intervention. Autism Res 2020, 13: 591-602. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: In this study, we found that male children with autism spectrum disorder (ASD) made more commission errors whereas male children with schizophrenia (SZ) responded much slower in the visual response inhibition task. Both clinical groups exhibited comparable impairments in verbal response inhibition, but male children with SZ were more impaired in auditory response inhibition than male children with ASD. Our findings provide potential targets for intervention. En ligne : http://dx.doi.org/10.1002/aur.2231 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=421

Genome-wide association analysis of autism identified multiple loci that have been reported as strong signals for neuropsychiatric disorders / Lu XIA in Autism Research, 13-3 (March 2020)  

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