Amygdale et Autisme: apport des études chez le primate non humain / David G. AMARAL

Public ISBD contenu dans L'autisme / Alain BERTHOZ Titre : Amygdale et Autisme: apport des études chez le primate non humain Type de document : Texte imprimé et/ou numérique Auteurs : David G. AMARAL, Auteur ; Margaret L. BAUMAN, Auteur ; Cynthia MILLS-SCHUMANN, Auteur Année de publication : 2005 Importance : p.321-342 Langues : Français (fre) Mots-clés : Amygdales Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=193 contenu dans L'autisme / Alain BERTHOZ Amygdale et Autisme: apport des études chez le primate non humain [Texte imprimé et/ou numérique] / David G. AMARAL, Auteur ; Margaret L. BAUMAN, Auteur ; Cynthia MILLS-SCHUMANN, Auteur . - 2005 . - p.321-342. Langues : Français (fre) Mots-clés : Amygdales Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=193

Exemplaires

Code-barres	Cote	Support	Localisation	Section	Disponibilité
aucun exemplaire

Atypical miRNA expression in temporal cortex associated with dysregulation of immune, cell cycle, and other pathways in autism spectrum disorders / Bradley P. ANDER in Molecular Autism, (June 2015)  

Public ISBD [article]  inMolecular Autism > (June 2015) . - p.1-13 Titre : Atypical miRNA expression in temporal cortex associated with dysregulation of immune, cell cycle, and other pathways in autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Bradley P. ANDER, Auteur ; Nicole BARGER, Auteur ; Boryana STAMOVA, Auteur ; Frank R. SHARP, Auteur ; Cynthia M. SCHUMANN, Auteur Article en page(s) : p.1-13 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASDs) likely involve dysregulation of multiple genes related to brain function and development. Abnormalities in individual regulatory small non-coding RNA (sncRNA), including microRNA (miRNA), could have profound effects upon multiple functional pathways. We assessed whether a brain region associated with core social impairments in ASD, the superior temporal sulcus (STS), would evidence greater transcriptional dysregulation of sncRNA than adjacent, yet functionally distinct, primary auditory cortex (PAC). En ligne : http://dx.doi.org/10.1186/s13229-015-0029-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277 [article] Atypical miRNA expression in temporal cortex associated with dysregulation of immune, cell cycle, and other pathways in autism spectrum disorders [Texte imprimé et/ou numérique] / Bradley P. ANDER, Auteur ; Nicole BARGER, Auteur ; Boryana STAMOVA, Auteur ; Frank R. SHARP, Auteur ; Cynthia M. SCHUMANN, Auteur . - p.1-13. Langues : Anglais (eng) in Molecular Autism > (June 2015) . - p.1-13 Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASDs) likely involve dysregulation of multiple genes related to brain function and development. Abnormalities in individual regulatory small non-coding RNA (sncRNA), including microRNA (miRNA), could have profound effects upon multiple functional pathways. We assessed whether a brain region associated with core social impairments in ASD, the superior temporal sulcus (STS), would evidence greater transcriptional dysregulation of sncRNA than adjacent, yet functionally distinct, primary auditory cortex (PAC). En ligne : http://dx.doi.org/10.1186/s13229-015-0029-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277

A comprehensive volumetric analysis of the cerebellum in children and adolescents with autism spectrum disorder / Julia A. SCOTT in Autism Research, 2-5 (October 2009)  

Public ISBD [article]  inAutism Research > 2-5 (October 2009) . - p.246-257 Titre : A comprehensive volumetric analysis of the cerebellum in children and adolescents with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Julia A. SCOTT, Auteur ; David G. AMARAL, Auteur ; Cynthia MILLS-SCHUMANN, Auteur ; Beth GOODLIN-JONES, Auteur Année de publication : 2009 Article en page(s) : p.246-257 Langues : Anglais (eng) Mots-clés : Asperger MRI developmental-delays vermis neurodevelopmental-disorder Index. décimale : PER Périodiques Résumé : Magnetic resonance imaging (MRI) and postmortem neuropathological studies have implicated the cerebellum in the pathophysiology of autism. Controversy remains, however, concerning the nature and the consistency of cerebellar alterations. MRI studies of the cross-sectional area of the vermis have found both decreases and no difference in autism groups. Volumetric analysis of the vermis, which is less prone to plane of section artifacts may provide a more reliable assessment of size differences but few such studies exist in the literature. Here we present the results of a volumetric analysis of the structure of the whole cerebellum and its components in children and adolescents with autism spectrum disorders. Structural MRI's were acquired from 62 male participants (7.5 to 18.5 years-old) who met criteria for the following age-matched diagnostic groups: low functioning autism, high functioning autism (HFA), Asperger syndrome, and typically developing children. When compared to controls, the midsagittal area of the vermis, or of subgroups of lobules, was not reduced in any of the autism groups. However, we did find that total vermis volume was decreased in the combined autism group. When examined separately, the vermis of only the HFA group was significantly reduced compared to typically developing controls. Neither IQ nor age predicted the size of the vermis within the autism groups. There were no differences in the volume of individual vermal lobules or cerebellar hemispheres. These findings are discussed in relation to the pathology of autism and to the fairly common alterations of vermal morphology in various neurodevelopmental disorders. En ligne : http://dx.doi.org/10.1002/aur.97 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=938 [article] A comprehensive volumetric analysis of the cerebellum in children and adolescents with autism spectrum disorder [Texte imprimé et/ou numérique] / Julia A. SCOTT, Auteur ; David G. AMARAL, Auteur ; Cynthia MILLS-SCHUMANN, Auteur ; Beth GOODLIN-JONES, Auteur . - 2009 . - p.246-257. Langues : Anglais (eng) in Autism Research > 2-5 (October 2009) . - p.246-257 Mots-clés : Asperger MRI developmental-delays vermis neurodevelopmental-disorder Index. décimale : PER Périodiques Résumé : Magnetic resonance imaging (MRI) and postmortem neuropathological studies have implicated the cerebellum in the pathophysiology of autism. Controversy remains, however, concerning the nature and the consistency of cerebellar alterations. MRI studies of the cross-sectional area of the vermis have found both decreases and no difference in autism groups. Volumetric analysis of the vermis, which is less prone to plane of section artifacts may provide a more reliable assessment of size differences but few such studies exist in the literature. Here we present the results of a volumetric analysis of the structure of the whole cerebellum and its components in children and adolescents with autism spectrum disorders. Structural MRI's were acquired from 62 male participants (7.5 to 18.5 years-old) who met criteria for the following age-matched diagnostic groups: low functioning autism, high functioning autism (HFA), Asperger syndrome, and typically developing children. When compared to controls, the midsagittal area of the vermis, or of subgroups of lobules, was not reduced in any of the autism groups. However, we did find that total vermis volume was decreased in the combined autism group. When examined separately, the vermis of only the HFA group was significantly reduced compared to typically developing controls. Neither IQ nor age predicted the size of the vermis within the autism groups. There were no differences in the volume of individual vermal lobules or cerebellar hemispheres. These findings are discussed in relation to the pathology of autism and to the fairly common alterations of vermal morphology in various neurodevelopmental disorders. En ligne : http://dx.doi.org/10.1002/aur.97 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=938

From Toddlers to Adults: The Changing Landscape of the Brain in Autism / Eric COURCHESNE

Public ISBD in Autism Spectrum Disorders / David G. AMARAL Titre : From Toddlers to Adults: The Changing Landscape of the Brain in Autism Type de document : Texte imprimé et/ou numérique Auteurs : Eric COURCHESNE, Auteur ; Sara Jane WEBB, Auteur ; Cynthia M. SCHUMANN, Auteur Année de publication : 2011 Importance : p.611-631 Langues : Anglais (eng) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=139 in Autism Spectrum Disorders / David G. AMARAL From Toddlers to Adults: The Changing Landscape of the Brain in Autism [Texte imprimé et/ou numérique] / Eric COURCHESNE, Auteur ; Sara Jane WEBB, Auteur ; Cynthia M. SCHUMANN, Auteur . - 2011 . - p.611-631. Langues : Anglais (eng) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=139

Exemplaires

Code-barres	Cote	Support	Localisation	Section	Disponibilité
aucun exemplaire

Neuropathologic features in the hippocampus and cerebellum of three older men with fragile X syndrome / Claudia M. GRECO in Molecular Autism, (February 2011)  

Public ISBD [article]  inMolecular Autism > (February 2011) . - 13 p. Titre : Neuropathologic features in the hippocampus and cerebellum of three older men with fragile X syndrome Type de document : Texte imprimé et/ou numérique Auteurs : Claudia M. GRECO, Auteur ; Celestine S. NAVARRO, Auteur ; Michael R. HUNSAKER, Auteur ; Izumi MAEZAWA, Auteur ; John F. SHULER, Auteur ; Flora TASSONE, Auteur ; Mary DELANY, Auteur ; Jacky W. AU, Auteur ; Robert F. BERMAN, Auteur ; Lee-Way JIN, Auteur ; Cynthia M. SCHUMANN, Auteur ; Paul J. HAGERMAN, Auteur ; Randi J. HAGERMAN, Auteur Année de publication : 2011 Article en page(s) : 13 p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Fragile X syndrome (FXS) is the most common inherited form of intellectual disability, and is the most common single-gene disorder known to be associated with autism. Despite recent advances in functional neuroimaging and our understanding of the molecular pathogenesis, only limited neuropathologic information on FXS is available. Methods Neuropathologic examinations were performed on post-mortem brain tissue from three older men (aged 57, 64 and 78 years) who had received a clinical or genetic diagnosis of FXS. In each case, physical and cognitive features were typical of FXS, and one man was also diagnosed with autism. Guided by reports of clinical and neuroimaging abnormalities of the limbic system and cerebellum of individuals with FXS, the current analysis focused on neuropathologic features present in the hippocampus and the cerebellar vermis. Results Histologic and immunologic staining revealed abnormalities in both the hippocampus and cerebellar vermis. Focal thickening of hippocampal CA1 and irregularities in the appearance of the dentate gyrus were identified. All lobules of the cerebellar vermis and the lateral cortex of the posterior lobe of the cerebellum had decreased numbers of Purkinje cells, which were occasionally misplaced, and often lacked proper orientation. There were mild, albeit excessive, undulations of the internal granular cell layer, with patchy foliar white matter axonal and astrocytic abnormalities. Quantitative analysis documented panfoliar atrophy of both the anterior and posterior lobes of the vermis, with preferential atrophy of the posterior lobule (VI to VII) compared with age-matched normal controls. Conclusions Significant morphologic changes in the hippocampus and cerebellum in three adult men with FXS were identified. This pattern of pathologic features supports the idea that primary defects in neuronal migration, neurogenesis and aging may underlie the neuropathology reported in FXS. En ligne : http://dx.doi.org/10.1186/2040-2392-2-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=121 [article] Neuropathologic features in the hippocampus and cerebellum of three older men with fragile X syndrome [Texte imprimé et/ou numérique] / Claudia M. GRECO, Auteur ; Celestine S. NAVARRO, Auteur ; Michael R. HUNSAKER, Auteur ; Izumi MAEZAWA, Auteur ; John F. SHULER, Auteur ; Flora TASSONE, Auteur ; Mary DELANY, Auteur ; Jacky W. AU, Auteur ; Robert F. BERMAN, Auteur ; Lee-Way JIN, Auteur ; Cynthia M. SCHUMANN, Auteur ; Paul J. HAGERMAN, Auteur ; Randi J. HAGERMAN, Auteur . - 2011 . - 13 p. Langues : Anglais (eng) in Molecular Autism > (February 2011) . - 13 p. Index. décimale : PER Périodiques Résumé : Background Fragile X syndrome (FXS) is the most common inherited form of intellectual disability, and is the most common single-gene disorder known to be associated with autism. Despite recent advances in functional neuroimaging and our understanding of the molecular pathogenesis, only limited neuropathologic information on FXS is available. Methods Neuropathologic examinations were performed on post-mortem brain tissue from three older men (aged 57, 64 and 78 years) who had received a clinical or genetic diagnosis of FXS. In each case, physical and cognitive features were typical of FXS, and one man was also diagnosed with autism. Guided by reports of clinical and neuroimaging abnormalities of the limbic system and cerebellum of individuals with FXS, the current analysis focused on neuropathologic features present in the hippocampus and the cerebellar vermis. Results Histologic and immunologic staining revealed abnormalities in both the hippocampus and cerebellar vermis. Focal thickening of hippocampal CA1 and irregularities in the appearance of the dentate gyrus were identified. All lobules of the cerebellar vermis and the lateral cortex of the posterior lobe of the cerebellum had decreased numbers of Purkinje cells, which were occasionally misplaced, and often lacked proper orientation. There were mild, albeit excessive, undulations of the internal granular cell layer, with patchy foliar white matter axonal and astrocytic abnormalities. Quantitative analysis documented panfoliar atrophy of both the anterior and posterior lobes of the vermis, with preferential atrophy of the posterior lobule (VI to VII) compared with age-matched normal controls. Conclusions Significant morphologic changes in the hippocampus and cerebellum in three adult men with FXS were identified. This pattern of pathologic features supports the idea that primary defects in neuronal migration, neurogenesis and aging may underlie the neuropathology reported in FXS. En ligne : http://dx.doi.org/10.1186/2040-2392-2-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=121

Neuropathology of Autism Spectrum Disorders: Postmortem Studies / Cynthia M. SCHUMANN

Permalink

The Amygdala in Autism Spectrum Disorders / John T. MORGAN

Permalink

---

1 (1 - 7 / 7)