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Auteur Sunbok LEE |
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Neighborhood × Serotonin Transporter Linked Polymorphic Region (5-HTTLPR) interactions for substance use from ages 10 to 24 years using a harmonized data set of African American children / Michael WINDLE in Development and Psychopathology, 28-2 (May 2016)
[article]
Titre : Neighborhood × Serotonin Transporter Linked Polymorphic Region (5-HTTLPR) interactions for substance use from ages 10 to 24 years using a harmonized data set of African American children Type de document : Texte imprimé et/ou numérique Auteurs : Michael WINDLE, Auteur ; Steven M. KOGAN, Auteur ; Sunbok LEE, Auteur ; Yi-Fu CHEN, Auteur ; Karlo Mankit LEI, Auteur ; Gene H. BRODY, Auteur ; Steven R. H. BEACH, Auteur ; Tianyi YU, Auteur Article en page(s) : p.415-431 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : This study investigated the influences of neighborhood factors (residential stability and neighborhood disadvantage) and variants of the serotonin transporter linked polymorphic region (5-HTTLPR) genotype on the development of substance use among African American children aged 10–24 years. To accomplish this, a harmonized data set of five longitudinal studies was created via pooling overlapping age cohorts to establish a database with 2,689 children and 12,474 data points to span ages 10–24 years. A description of steps used in the development of the harmonized data set is provided, including how issues such as the measurement equivalence of constructs were addressed. A sequence of multilevel models was specified to evaluate Gene × Environment effects on growth of substance use across time. Findings indicated that residential instability was associated with higher levels and a steeper gradient of growth in substance use across time. The inclusion of the 5-HTTLPR genotype provided greater precision to the relationships in that higher residential instability, in conjunction with the risk variant of 5-HTTLPR (i.e., the short allele), was associated with the highest level and steepest gradient of growth in substance use across ages 10–24 years. The findings demonstrated how the creation of a harmonized data set increased statistical power to test Gene × Environment interactions for an under studied sample. En ligne : http://dx.doi.org/10.1017/S095457941500053X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=288
in Development and Psychopathology > 28-2 (May 2016) . - p.415-431[article] Neighborhood × Serotonin Transporter Linked Polymorphic Region (5-HTTLPR) interactions for substance use from ages 10 to 24 years using a harmonized data set of African American children [Texte imprimé et/ou numérique] / Michael WINDLE, Auteur ; Steven M. KOGAN, Auteur ; Sunbok LEE, Auteur ; Yi-Fu CHEN, Auteur ; Karlo Mankit LEI, Auteur ; Gene H. BRODY, Auteur ; Steven R. H. BEACH, Auteur ; Tianyi YU, Auteur . - p.415-431.
Langues : Anglais (eng)
in Development and Psychopathology > 28-2 (May 2016) . - p.415-431
Index. décimale : PER Périodiques Résumé : This study investigated the influences of neighborhood factors (residential stability and neighborhood disadvantage) and variants of the serotonin transporter linked polymorphic region (5-HTTLPR) genotype on the development of substance use among African American children aged 10–24 years. To accomplish this, a harmonized data set of five longitudinal studies was created via pooling overlapping age cohorts to establish a database with 2,689 children and 12,474 data points to span ages 10–24 years. A description of steps used in the development of the harmonized data set is provided, including how issues such as the measurement equivalence of constructs were addressed. A sequence of multilevel models was specified to evaluate Gene × Environment effects on growth of substance use across time. Findings indicated that residential instability was associated with higher levels and a steeper gradient of growth in substance use across time. The inclusion of the 5-HTTLPR genotype provided greater precision to the relationships in that higher residential instability, in conjunction with the risk variant of 5-HTTLPR (i.e., the short allele), was associated with the highest level and steepest gradient of growth in substance use across ages 10–24 years. The findings demonstrated how the creation of a harmonized data set increased statistical power to test Gene × Environment interactions for an under studied sample. En ligne : http://dx.doi.org/10.1017/S095457941500053X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=288