Impaired downregulation of visual cortex during auditory processing is associated with autism symptomatology in children and adolescents with autism spectrum disorder / R. Joanne JAO KEEHN in Autism Research, 10-1 (January 2017)  

Public ISBD [article]  inAutism Research > 10-1 (January 2017) . - p.130-143 Titre : Impaired downregulation of visual cortex during auditory processing is associated with autism symptomatology in children and adolescents with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : R. Joanne JAO KEEHN, Auteur ; Sandra S. SANCHEZ, Auteur ; Claire R. STEWART, Auteur ; Weiqi ZHAO, Auteur ; Emily L. GRENESKO-STEVENS, Auteur ; Brandon KEEHN, Auteur ; Ralph-Axel MULLER, Auteur Article en page(s) : p.130-143 Langues : Anglais (eng) Mots-clés : autism spectrum disorders  development  visual  auditory  functional magnetic resonance imaging Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) are pervasive developmental disorders characterized by impairments in language development and social interaction, along with restricted and stereotyped behaviors. These behaviors often include atypical responses to sensory stimuli; some children with ASD are easily overwhelmed by sensory stimuli, while others may seem unaware of their environment. Vision and audition are two sensory modalities important for social interactions and language, and are differentially affected in ASD. In the present study, 16 children and adolescents with ASD and 16 typically developing (TD) participants matched for age, gender, nonverbal IQ, and handedness were tested using a mixed event-related/blocked functional magnetic resonance imaging paradigm to examine basic perceptual processes that may form the foundation for later-developing cognitive abilities. Auditory (high or low pitch) and visual conditions (dot located high or low in the display) were presented, and participants indicated whether the stimuli were “high” or “low.” Results for the auditory condition showed downregulated activity of the visual cortex in the TD group, but upregulation in the ASD group. This atypical activity in visual cortex was associated with autism symptomatology. These findings suggest atypical crossmodal (auditory-visual) modulation linked to sociocommunicative deficits in ASD, in agreement with the general hypothesis of low-level sensorimotor impairments affecting core symptomatology. En ligne : http://dx.doi.org/10.1002/aur.1636 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303 [article] Impaired downregulation of visual cortex during auditory processing is associated with autism symptomatology in children and adolescents with autism spectrum disorder [Texte imprimé et/ou numérique] / R. Joanne JAO KEEHN, Auteur ; Sandra S. SANCHEZ, Auteur ; Claire R. STEWART, Auteur ; Weiqi ZHAO, Auteur ; Emily L. GRENESKO-STEVENS, Auteur ; Brandon KEEHN, Auteur ; Ralph-Axel MULLER, Auteur . - p.130-143. Langues : Anglais (eng) in Autism Research > 10-1 (January 2017) . - p.130-143 Mots-clés : autism spectrum disorders  development  visual  auditory  functional magnetic resonance imaging Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) are pervasive developmental disorders characterized by impairments in language development and social interaction, along with restricted and stereotyped behaviors. These behaviors often include atypical responses to sensory stimuli; some children with ASD are easily overwhelmed by sensory stimuli, while others may seem unaware of their environment. Vision and audition are two sensory modalities important for social interactions and language, and are differentially affected in ASD. In the present study, 16 children and adolescents with ASD and 16 typically developing (TD) participants matched for age, gender, nonverbal IQ, and handedness were tested using a mixed event-related/blocked functional magnetic resonance imaging paradigm to examine basic perceptual processes that may form the foundation for later-developing cognitive abilities. Auditory (high or low pitch) and visual conditions (dot located high or low in the display) were presented, and participants indicated whether the stimuli were “high” or “low.” Results for the auditory condition showed downregulated activity of the visual cortex in the TD group, but upregulation in the ASD group. This atypical activity in visual cortex was associated with autism symptomatology. These findings suggest atypical crossmodal (auditory-visual) modulation linked to sociocommunicative deficits in ASD, in agreement with the general hypothesis of low-level sensorimotor impairments affecting core symptomatology. En ligne : http://dx.doi.org/10.1002/aur.1636 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303

Sensory Symptoms and Processing of Nonverbal Auditory and Visual Stimuli in Children with Autism Spectrum Disorder / Claire R. STEWART in Journal of Autism and Developmental Disorders, 46-5 (May 2016)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 46-5 (May 2016) . - p.1590-1601 Titre : Sensory Symptoms and Processing of Nonverbal Auditory and Visual Stimuli in Children with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Claire R. STEWART, Auteur ; Sandra S. SANCHEZ, Auteur ; Emily L. GRENESKO, Auteur ; Christine M. BROWN, Auteur ; Colleen P. CHEN, Auteur ; Brandon KEEHN, Auteur ; Francisco VELASQUEZ, Auteur ; Alan J. LINCOLN, Auteur ; Ralph-Axel MULLER, Auteur Article en page(s) : p.1590-1601 Langues : Anglais (eng) Mots-clés : Autism  Visual  Auditory  Sensory integration  Bisensory facilitation  Sensory profile Index. décimale : PER Périodiques Résumé : Atypical sensory responses are common in autism spectrum disorder (ASD). While evidence suggests impaired auditory–visual integration for verbal information, findings for nonverbal stimuli are inconsistent. We tested for sensory symptoms in children with ASD (using the Adolescent/Adult Sensory Profile) and examined unisensory and bisensory processing with a nonverbal auditory–visual paradigm, for which neurotypical adults show bisensory facilitation. ASD participants reported more atypical sensory symptoms overall, most prominently in the auditory modality. On the experimental task, reduced response times for bisensory compared to unisensory trials were seen in both ASD and control groups, but neither group showed significant race model violation (evidence of intermodal integration). Findings do not support impaired bisensory processing for simple nonverbal stimuli in high-functioning children with ASD. En ligne : http://dx.doi.org/10.1007/s10803-015-2367-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=288 [article] Sensory Symptoms and Processing of Nonverbal Auditory and Visual Stimuli in Children with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Claire R. STEWART, Auteur ; Sandra S. SANCHEZ, Auteur ; Emily L. GRENESKO, Auteur ; Christine M. BROWN, Auteur ; Colleen P. CHEN, Auteur ; Brandon KEEHN, Auteur ; Francisco VELASQUEZ, Auteur ; Alan J. LINCOLN, Auteur ; Ralph-Axel MULLER, Auteur . - p.1590-1601. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 46-5 (May 2016) . - p.1590-1601 Mots-clés : Autism  Visual  Auditory  Sensory integration  Bisensory facilitation  Sensory profile Index. décimale : PER Périodiques Résumé : Atypical sensory responses are common in autism spectrum disorder (ASD). While evidence suggests impaired auditory–visual integration for verbal information, findings for nonverbal stimuli are inconsistent. We tested for sensory symptoms in children with ASD (using the Adolescent/Adult Sensory Profile) and examined unisensory and bisensory processing with a nonverbal auditory–visual paradigm, for which neurotypical adults show bisensory facilitation. ASD participants reported more atypical sensory symptoms overall, most prominently in the auditory modality. On the experimental task, reduced response times for bisensory compared to unisensory trials were seen in both ASD and control groups, but neither group showed significant race model violation (evidence of intermodal integration). Findings do not support impaired bisensory processing for simple nonverbal stimuli in high-functioning children with ASD. En ligne : http://dx.doi.org/10.1007/s10803-015-2367-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=288

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