Impaired Gas Exchange at Birth and Risk of Intellectual Disability and Autism: A Meta-analysis / Amirhossein MODABBERNIA in Journal of Autism and Developmental Disorders, 46-5 (May 2016)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 46-5 (May 2016) . - p.1847-1859 Titre : Impaired Gas Exchange at Birth and Risk of Intellectual Disability and Autism: A Meta-analysis Type de document : Texte imprimé et/ou numérique Auteurs : Amirhossein MODABBERNIA, Auteur ; Josephine MOLLON, Auteur ; Paolo BOFFETTA, Auteur ; Abraham REICHENBERG, Auteur Article en page(s) : p.1847-1859 Langues : Anglais (eng) Mots-clés : Asphyxia  Autism  Hypoxia  Intellectual disability  Neonatal  Perinatal Index. décimale : PER Périodiques Résumé : We conducted meta-analyses of 67 studies on the association between neonatal proxies of impaired gas exchange and intellectual disability (ID) or autism spectrum disorders (ASD). Neonatal acidosis was associated with an odds ratio (OR) of 3.55 [95 % confidence interval (95 % CI) 2.23–5.49] for ID and an OR of 1.10 (95 % CI 0.91–1.31) for ASD. Children with a 5-min Apgar score of <7 had an OR of 5.39 (95 % CI 3.84–7.55) for ID and an OR of 1.67 (95 % CI 1.34–2.09) for ASD. O2 treatment was associated with an OR of 4.32 (95 % CI 3.23–5.78) for ID and an OR of 2.02 (95 % CI 1.45 to 2.83) for ASD. Our meta-analysis demonstrates an increased risk of ID and (to a lesser extent) ASD in children with neonatal hypoxia. Moreover, our findings raise the possibility that concomitant ID might account for the observed association between the gas exchange proxies and ASD. En ligne : http://dx.doi.org/10.1007/s10803-016-2717-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=288 [article] Impaired Gas Exchange at Birth and Risk of Intellectual Disability and Autism: A Meta-analysis [Texte imprimé et/ou numérique] / Amirhossein MODABBERNIA, Auteur ; Josephine MOLLON, Auteur ; Paolo BOFFETTA, Auteur ; Abraham REICHENBERG, Auteur . - p.1847-1859. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 46-5 (May 2016) . - p.1847-1859 Mots-clés : Asphyxia  Autism  Hypoxia  Intellectual disability  Neonatal  Perinatal Index. décimale : PER Périodiques Résumé : We conducted meta-analyses of 67 studies on the association between neonatal proxies of impaired gas exchange and intellectual disability (ID) or autism spectrum disorders (ASD). Neonatal acidosis was associated with an odds ratio (OR) of 3.55 [95 % confidence interval (95 % CI) 2.23–5.49] for ID and an OR of 1.10 (95 % CI 0.91–1.31) for ASD. Children with a 5-min Apgar score of <7 had an OR of 5.39 (95 % CI 3.84–7.55) for ID and an OR of 1.67 (95 % CI 1.34–2.09) for ASD. O2 treatment was associated with an OR of 4.32 (95 % CI 3.23–5.78) for ID and an OR of 2.02 (95 % CI 1.45 to 2.83) for ASD. Our meta-analysis demonstrates an increased risk of ID and (to a lesser extent) ASD in children with neonatal hypoxia. Moreover, our findings raise the possibility that concomitant ID might account for the observed association between the gas exchange proxies and ASD. En ligne : http://dx.doi.org/10.1007/s10803-016-2717-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=288

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