Common infections with polyomaviruses and herpesviruses and neuropsychological development at 4 years of age, the Rhea birth cohort in Crete, Greece / Marianna KARACHALIOU in Journal of Child Psychology and Psychiatry, 57-11 (November 2016)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 57-11 (November 2016) . - p.1268-1276 Titre : Common infections with polyomaviruses and herpesviruses and neuropsychological development at 4 years of age, the Rhea birth cohort in Crete, Greece Type de document : Texte imprimé et/ou numérique Auteurs : Marianna KARACHALIOU, Auteur ; Leda CHATZI, Auteur ; Theano ROUMELIOTAKI, Auteur ; Mariza KAMPOURI, Auteur ; Andriani KYRIKLAKI, Auteur ; Katerina KOUTRA, Auteur ; Georgia CHALKIADAKI, Auteur ; Angelika MICHEL, Auteur ; Eftichia STIAKAKI, Auteur ; Manolis KOGEVINAS, Auteur ; Michael PAWLITA, Auteur ; Tim WATERBOER, Auteur ; Silvia DE SANJOSE, Auteur Article en page(s) : p.1268-1276 Langues : Anglais (eng) Mots-clés : Attention-deficit/hyperactivity disorder  preschool children  neural development  epidemiologic studies Index. décimale : PER Périodiques Résumé : Background Viral infections of the central nervous system may have detrimental effects for the developing brain, but the effects of less virulent common infections are unclear. We aim to investigate the impact of common viral infections of early childhood on neuropsychological performance of children at age four. Methods We used cross-sectional data on 674 children participating at the 4 years of age follow-up of the Rhea birth cohort in Crete, Greece. Blood levels of IgG antibodies to 10 polyomaviruses (BKPyV, JCPyV, KIPyV, WUPyV, HPyV6, HPyV7, TSPyV, MCPyV, HPyV9, and HPyV10) and four herpesviruses [Epstein–Barr virus (EBV), cytomegalovirus (CMV), herpes simplex virus-1 (HSV-1), and herpes simplex virus-2 (HSV-2)] were measured using multiplex serology. Child's neuropsychological development at age four was assessed using the McCarthy Scales of Children's Abilities, the Attention-Deficit Hyperactivity Disorder Test (ADHDT), and the Strengths and Difficulties Questionnaire (SDQ). Multiple linear regression models were used to explore the associations. Results Seroprevalence to polyomaviruses ranged from 21% for HPyV9 to 82% for HPyV10. Seroprevalence for EBV was 53%, for CMV 26%, for HSV-1 3.6%, and for HSV-2 1.5%. Children seropositive to ?8 polyomaviruses had lower score in ADHDT inattention subscale [? = ?1.28 (95% CI: ?2.56, ?0.001)] and lower score in SDQ hyperactivity–inattention subscale [? = ?.99 (95% CI: ?1.60, ?0.37)] versus children seropositive to ?3 polyomaviruses. Seropositivity to BKPyV, a potential neurotropic virus, was associated with higher score in ADHDT inattention subscale [? = .87 (95% CI: 0.03, 1.71)]. Conclusions These findings suggest that acquisition of polyomaviruses during development may influence behavioral outcomes in early childhood. En ligne : http://dx.doi.org/10.1111/jcpp.12582 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=295 [article] Common infections with polyomaviruses and herpesviruses and neuropsychological development at 4 years of age, the Rhea birth cohort in Crete, Greece [Texte imprimé et/ou numérique] / Marianna KARACHALIOU, Auteur ; Leda CHATZI, Auteur ; Theano ROUMELIOTAKI, Auteur ; Mariza KAMPOURI, Auteur ; Andriani KYRIKLAKI, Auteur ; Katerina KOUTRA, Auteur ; Georgia CHALKIADAKI, Auteur ; Angelika MICHEL, Auteur ; Eftichia STIAKAKI, Auteur ; Manolis KOGEVINAS, Auteur ; Michael PAWLITA, Auteur ; Tim WATERBOER, Auteur ; Silvia DE SANJOSE, Auteur . - p.1268-1276. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 57-11 (November 2016) . - p.1268-1276 Mots-clés : Attention-deficit/hyperactivity disorder  preschool children  neural development  epidemiologic studies Index. décimale : PER Périodiques Résumé : Background Viral infections of the central nervous system may have detrimental effects for the developing brain, but the effects of less virulent common infections are unclear. We aim to investigate the impact of common viral infections of early childhood on neuropsychological performance of children at age four. Methods We used cross-sectional data on 674 children participating at the 4 years of age follow-up of the Rhea birth cohort in Crete, Greece. Blood levels of IgG antibodies to 10 polyomaviruses (BKPyV, JCPyV, KIPyV, WUPyV, HPyV6, HPyV7, TSPyV, MCPyV, HPyV9, and HPyV10) and four herpesviruses [Epstein–Barr virus (EBV), cytomegalovirus (CMV), herpes simplex virus-1 (HSV-1), and herpes simplex virus-2 (HSV-2)] were measured using multiplex serology. Child's neuropsychological development at age four was assessed using the McCarthy Scales of Children's Abilities, the Attention-Deficit Hyperactivity Disorder Test (ADHDT), and the Strengths and Difficulties Questionnaire (SDQ). Multiple linear regression models were used to explore the associations. Results Seroprevalence to polyomaviruses ranged from 21% for HPyV9 to 82% for HPyV10. Seroprevalence for EBV was 53%, for CMV 26%, for HSV-1 3.6%, and for HSV-2 1.5%. Children seropositive to ?8 polyomaviruses had lower score in ADHDT inattention subscale [? = ?1.28 (95% CI: ?2.56, ?0.001)] and lower score in SDQ hyperactivity–inattention subscale [? = ?.99 (95% CI: ?1.60, ?0.37)] versus children seropositive to ?3 polyomaviruses. Seropositivity to BKPyV, a potential neurotropic virus, was associated with higher score in ADHDT inattention subscale [? = .87 (95% CI: 0.03, 1.71)]. Conclusions These findings suggest that acquisition of polyomaviruses during development may influence behavioral outcomes in early childhood. En ligne : http://dx.doi.org/10.1111/jcpp.12582 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=295

Is there an association between eating behaviour and attention-deficit/hyperactivity disorder symptoms in preschool children? / Vasiliki LEVENTAKOU in Journal of Child Psychology and Psychiatry, 57-6 (June 2016)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 57-6 (June 2016) . - p.676-684 Titre : Is there an association between eating behaviour and attention-deficit/hyperactivity disorder symptoms in preschool children? Type de document : Texte imprimé et/ou numérique Auteurs : Vasiliki LEVENTAKOU, Auteur ; Nadia MICALI, Auteur ; Vaggelis GEORGIOU, Auteur ; Katerina SARRI, Auteur ; Katerina KOUTRA, Auteur ; Stella KOINAKI, Auteur ; Maria VASSILAKI, Auteur ; Manolis KOGEVINAS, Auteur ; Leda CHATZI, Auteur Article en page(s) : p.676-684 Langues : Anglais (eng) Mots-clés : Eating behaviour  child development  attention-deficit hyperactivity disorder Index. décimale : PER Périodiques Résumé : Background There is some evidence that aberrant eating behaviours and obesity co-occur with attention-deficit/hyperactivity disorder (ADHD) symptoms. The present study is the first that aims to investigate the association between eating behaviours and ADHD symptoms in early childhood in a population-based cohort. Methods We included 471 preschool children from the Rhea mother–child cohort in Crete, Greece. Parents completed the Children's Eating Behaviour Questionnaire to assess children's eating behaviour and the 36-item ADHD test (ADHDT) to evaluate ADHD symptoms at 4 years of age. Multivariable linear regression models were used to examine the association of eating behaviours with ADHD symptoms. Results Regarding children's food approach eating behaviours, we observed a positive association between food responsiveness and total ADHD index, as well as impulsivity, inattention and hyperactivity subscale, separately. Similarly, there was a significant positive association between emotional overeating and ADHD symptoms. With regard to children's food avoidant behaviours, food fussiness was found to be significantly associated with the impulsivity subscale. A dose–response association between the food approach behaviours and ADHD symptoms was also observed. Children on the medium and highest tertile of the food responsiveness subscale had increased scores on the ADHD total scale, as compared to those on the lowest tertile. As regards emotional overeating, children in the highest tertile of the scale had higher scores on ADHD total and hyperactivity. Conclusions Our findings provide evidence that food approach eating behaviours such as food responsiveness and emotional overeating are associated with the increased ADHD symptoms in preschool children. Future studies to better understand this overlap will enhance potential interventions. En ligne : http://dx.doi.org/10.1111/jcpp.12504 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=289 [article] Is there an association between eating behaviour and attention-deficit/hyperactivity disorder symptoms in preschool children? [Texte imprimé et/ou numérique] / Vasiliki LEVENTAKOU, Auteur ; Nadia MICALI, Auteur ; Vaggelis GEORGIOU, Auteur ; Katerina SARRI, Auteur ; Katerina KOUTRA, Auteur ; Stella KOINAKI, Auteur ; Maria VASSILAKI, Auteur ; Manolis KOGEVINAS, Auteur ; Leda CHATZI, Auteur . - p.676-684. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 57-6 (June 2016) . - p.676-684 Mots-clés : Eating behaviour  child development  attention-deficit hyperactivity disorder Index. décimale : PER Périodiques Résumé : Background There is some evidence that aberrant eating behaviours and obesity co-occur with attention-deficit/hyperactivity disorder (ADHD) symptoms. The present study is the first that aims to investigate the association between eating behaviours and ADHD symptoms in early childhood in a population-based cohort. Methods We included 471 preschool children from the Rhea mother–child cohort in Crete, Greece. Parents completed the Children's Eating Behaviour Questionnaire to assess children's eating behaviour and the 36-item ADHD test (ADHDT) to evaluate ADHD symptoms at 4 years of age. Multivariable linear regression models were used to examine the association of eating behaviours with ADHD symptoms. Results Regarding children's food approach eating behaviours, we observed a positive association between food responsiveness and total ADHD index, as well as impulsivity, inattention and hyperactivity subscale, separately. Similarly, there was a significant positive association between emotional overeating and ADHD symptoms. With regard to children's food avoidant behaviours, food fussiness was found to be significantly associated with the impulsivity subscale. A dose–response association between the food approach behaviours and ADHD symptoms was also observed. Children on the medium and highest tertile of the food responsiveness subscale had increased scores on the ADHD total scale, as compared to those on the lowest tertile. As regards emotional overeating, children in the highest tertile of the scale had higher scores on ADHD total and hyperactivity. Conclusions Our findings provide evidence that food approach eating behaviours such as food responsiveness and emotional overeating are associated with the increased ADHD symptoms in preschool children. Future studies to better understand this overlap will enhance potential interventions. En ligne : http://dx.doi.org/10.1111/jcpp.12504 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=289

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