Polygenic risk, family cohesion, and adolescent aggression in Mexican American and European American families: Developmental pathways to alcohol use / Kit K. ELAM in Development and Psychopathology, 30-5 (December 2018)  

Public ISBD [article]  inDevelopment and Psychopathology > 30-5 (December 2018) . - p.1715-1728 Titre : Polygenic risk, family cohesion, and adolescent aggression in Mexican American and European American families: Developmental pathways to alcohol use Type de document : Texte imprimé et/ou numérique Auteurs : Kit K. ELAM, Auteur ; Laurie A. CHASSIN, Auteur ; Danielle PANDIKA, Auteur Article en page(s) : p.1715-1728 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Poor family cohesion and elevated adolescent aggression are associated with greater alcohol use in adolescence and early adulthood. In addition, evocative gene–environment correlations (rGEs) can underlie the interplay between offspring characteristics and negative family functioning, contributing to substance use. Gene–environment interplay has rarely been examined in racial/ethnic minority populations. The current study examined adolescents’ polygenic risk scores for aggression in evocative rGEs underlying aggression and family cohesion during adolescence, their contributions to alcohol use in early adulthood (n = 479), and differences between Mexican American and European American subsamples. Results suggest an evocative rGE between polygenic risk scores, aggression, and low family cohesion, with aggression contributing to low family cohesion over time. Greater family cohesion was associated with lower levels of alcohol use in early adulthood and this association was stronger for Mexican American adolescents compared to European American adolescents. Results are discussed with respect to integration of culture and racial/ethnic minority samples into genetic research and implications for alcohol use. En ligne : http://dx.doi.org/10.1017/S0954579418000901 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=370 [article] Polygenic risk, family cohesion, and adolescent aggression in Mexican American and European American families: Developmental pathways to alcohol use [Texte imprimé et/ou numérique] / Kit K. ELAM, Auteur ; Laurie A. CHASSIN, Auteur ; Danielle PANDIKA, Auteur . - p.1715-1728. Langues : Anglais (eng) in Development and Psychopathology > 30-5 (December 2018) . - p.1715-1728 Index. décimale : PER Périodiques Résumé : Poor family cohesion and elevated adolescent aggression are associated with greater alcohol use in adolescence and early adulthood. In addition, evocative gene–environment correlations (rGEs) can underlie the interplay between offspring characteristics and negative family functioning, contributing to substance use. Gene–environment interplay has rarely been examined in racial/ethnic minority populations. The current study examined adolescents’ polygenic risk scores for aggression in evocative rGEs underlying aggression and family cohesion during adolescence, their contributions to alcohol use in early adulthood (n = 479), and differences between Mexican American and European American subsamples. Results suggest an evocative rGE between polygenic risk scores, aggression, and low family cohesion, with aggression contributing to low family cohesion over time. Greater family cohesion was associated with lower levels of alcohol use in early adulthood and this association was stronger for Mexican American adolescents compared to European American adolescents. Results are discussed with respect to integration of culture and racial/ethnic minority samples into genetic research and implications for alcohol use. En ligne : http://dx.doi.org/10.1017/S0954579418000901 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=370

Predicting substance use in emerging adulthood: A genetically informed study of developmental transactions between impulsivity and family conflict / Kit K. ELAM in Development and Psychopathology, 28-3 (August 2016)  

Public ISBD [article]  inDevelopment and Psychopathology > 28-3 (August 2016) . - p.673-688 Titre : Predicting substance use in emerging adulthood: A genetically informed study of developmental transactions between impulsivity and family conflict Type de document : Texte imprimé et/ou numérique Auteurs : Kit K. ELAM, Auteur ; Frances L. WANG, Auteur ; Kaitlin BOUNTRESS, Auteur ; Laurie A. CHASSIN, Auteur ; Danielle PANDIKA, Auteur ; Kathryn LEMERY-CHALFANT, Auteur Article en page(s) : p.673-688 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Deviance proneness models propose a multilevel interplay in which transactions among genetic, individual, and family risk factors place children at increased risk for substance use. We examined bidirectional transactions between impulsivity and family conflict from middle childhood to adolescence and their contributions to substance use in adolescence and emerging adulthood (n = 380). Moreover, we examined children's, mothers’, and fathers’ polygenic risk scores for behavioral undercontrol, and mothers’ and fathers’ interparental conflict and substance disorder diagnoses as predictors of these transactions. The results support a developmental cascade model in which children's polygenic risk scores predicted greater impulsivity in middle childhood. Impulsivity in middle childhood predicted greater family conflict in late childhood, which in turn predicted greater impulsivity in late adolescence. Adolescent impulsivity subsequently predicted greater substance use in emerging adulthood. Results are discussed with respect to evocative genotype–environment correlations within developmental cascades and applications to prevention efforts. En ligne : http://dx.doi.org/10.1017/S0954579416000249 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=291 [article] Predicting substance use in emerging adulthood: A genetically informed study of developmental transactions between impulsivity and family conflict [Texte imprimé et/ou numérique] / Kit K. ELAM, Auteur ; Frances L. WANG, Auteur ; Kaitlin BOUNTRESS, Auteur ; Laurie A. CHASSIN, Auteur ; Danielle PANDIKA, Auteur ; Kathryn LEMERY-CHALFANT, Auteur . - p.673-688. Langues : Anglais (eng) in Development and Psychopathology > 28-3 (August 2016) . - p.673-688 Index. décimale : PER Périodiques Résumé : Deviance proneness models propose a multilevel interplay in which transactions among genetic, individual, and family risk factors place children at increased risk for substance use. We examined bidirectional transactions between impulsivity and family conflict from middle childhood to adolescence and their contributions to substance use in adolescence and emerging adulthood (n = 380). Moreover, we examined children's, mothers’, and fathers’ polygenic risk scores for behavioral undercontrol, and mothers’ and fathers’ interparental conflict and substance disorder diagnoses as predictors of these transactions. The results support a developmental cascade model in which children's polygenic risk scores predicted greater impulsivity in middle childhood. Impulsivity in middle childhood predicted greater family conflict in late childhood, which in turn predicted greater impulsivity in late adolescence. Adolescent impulsivity subsequently predicted greater substance use in emerging adulthood. Results are discussed with respect to evocative genotype–environment correlations within developmental cascades and applications to prevention efforts. En ligne : http://dx.doi.org/10.1017/S0954579416000249 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=291

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