Associations among child abuse, mental health, and epigenetic modifications in the proopiomelanocortin gene (POMC): A study with children in Tanzania / Tobias HECKER in Development and Psychopathology, 28-4 pt2 (November 2016)  

Public ISBD [article]  inDevelopment and Psychopathology > 28-4 pt2 (November 2016) . - p.1401-1412 Titre : Associations among child abuse, mental health, and epigenetic modifications in the proopiomelanocortin gene (POMC): A study with children in Tanzania Type de document : Texte imprimé et/ou numérique Auteurs : Tobias HECKER, Auteur ; Karl M. RADTKE, Auteur ; Katharin HERMENAU, Auteur ; Andreas PAPASSOTIROPOULOS, Auteur ; Thomas ELBERT, Auteur Article en page(s) : p.1401-1412 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Child abuse is associated with a number of emotional and behavioral problems. Nevertheless, it has been argued that these adverse consequences may not hold for societies in which many of the specific acts of abuse are culturally normed. Epigenetic modifications in the genes of the hypothalamus–pituitary–adrenal axis may provide a potential mechanism translating abuse into altered gene expression, which subsequently results in behavioral changes. Our investigation took place in Tanzania, a society in which many forms of abuse are commonly employed as disciplinary methods. We included 35 children with high exposure and compared them to 25 children with low exposure. Extreme group comparisons revealed that children with high exposure reported more mental health problems. Child abuse was associated with differential methylation in the proopiomelanocortin gene (POMC), measured both in saliva and in blood. Hierarchical clustering based on the methylation of the POMC gene found two distinct clusters. These corresponded with children's self-reported abuse, with two-thirds of the children allocated into their respective group. Our results emphasize the consequences of child abuse based on both molecular and behavioral grounds, providing further evidence that acts of abuse affect children, even when culturally acceptable. Furthermore, on a molecular level, our findings strengthen the credibility of children's self-reports. En ligne : http://dx.doi.org/10.1017/s0954579415001248 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 [article] Associations among child abuse, mental health, and epigenetic modifications in the proopiomelanocortin gene (POMC): A study with children in Tanzania [Texte imprimé et/ou numérique] / Tobias HECKER, Auteur ; Karl M. RADTKE, Auteur ; Katharin HERMENAU, Auteur ; Andreas PAPASSOTIROPOULOS, Auteur ; Thomas ELBERT, Auteur . - p.1401-1412. Langues : Anglais (eng) in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1401-1412 Index. décimale : PER Périodiques Résumé : Child abuse is associated with a number of emotional and behavioral problems. Nevertheless, it has been argued that these adverse consequences may not hold for societies in which many of the specific acts of abuse are culturally normed. Epigenetic modifications in the genes of the hypothalamus–pituitary–adrenal axis may provide a potential mechanism translating abuse into altered gene expression, which subsequently results in behavioral changes. Our investigation took place in Tanzania, a society in which many forms of abuse are commonly employed as disciplinary methods. We included 35 children with high exposure and compared them to 25 children with low exposure. Extreme group comparisons revealed that children with high exposure reported more mental health problems. Child abuse was associated with differential methylation in the proopiomelanocortin gene (POMC), measured both in saliva and in blood. Hierarchical clustering based on the methylation of the POMC gene found two distinct clusters. These corresponded with children's self-reported abuse, with two-thirds of the children allocated into their respective group. Our results emphasize the consequences of child abuse based on both molecular and behavioral grounds, providing further evidence that acts of abuse affect children, even when culturally acceptable. Furthermore, on a molecular level, our findings strengthen the credibility of children's self-reports. En ligne : http://dx.doi.org/10.1017/s0954579415001248 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294

Child neglect and its relation to emotional and behavioral problems: A cross-sectional study of primary school-aged children in Tanzania / Tobias HECKER in Development and Psychopathology, 31-1 (February 2019)  

Public ISBD [article]  inDevelopment and Psychopathology > 31-1 (February 2019) . - p.325-339 Titre : Child neglect and its relation to emotional and behavioral problems: A cross-sectional study of primary school-aged children in Tanzania Type de document : Texte imprimé et/ou numérique Auteurs : Tobias HECKER, Auteur ; Victoria S. BOETTCHER, Auteur ; Markus A. LANDOLT, Auteur ; Katharin HERMENAU, Auteur Article en page(s) : p.325-339 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Child maltreatment is known to engender negative emotional and behavioral consequences. Although neglect is the most frequent form of maltreatment, it has thus far only received little attention, especially when looking at low-resource countries. The current study investigated possible associations between neglect and internalizing and externalizing problems. As neglect and abuse often co-occur, the latter was controlled for. In total, 409 Tanzanian primary school students (52% boys, M = 10.5 years, range = 6–15) participated in the cross-sectional study. Structured clinical interviews were conducted assessing maltreatment, internalizing problems, and externalizing problems. Overall, 31% (n = 128) of the children reported at least one type of physical neglect and 31% (n = 127) of emotional neglect. Using structural equation modeling, we found a significant association between neglect and internalizing (? = 0.59, p < .01) and externalizing problems (? = 0.35, p < .05). However, these associations could only be detected in younger children (ages 6–9), whereas in older children (ages 10–15), mental health problems were significantly related to violence and abuse. Our findings suggest that the current age may influence the association between maltreatment type and the development of internalizing and/or externalizing problems. En ligne : http://dx.doi.org/10.1017/S0954579417001882 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=383 [article] Child neglect and its relation to emotional and behavioral problems: A cross-sectional study of primary school-aged children in Tanzania [Texte imprimé et/ou numérique] / Tobias HECKER, Auteur ; Victoria S. BOETTCHER, Auteur ; Markus A. LANDOLT, Auteur ; Katharin HERMENAU, Auteur . - p.325-339. Langues : Anglais (eng) in Development and Psychopathology > 31-1 (February 2019) . - p.325-339 Index. décimale : PER Périodiques Résumé : Child maltreatment is known to engender negative emotional and behavioral consequences. Although neglect is the most frequent form of maltreatment, it has thus far only received little attention, especially when looking at low-resource countries. The current study investigated possible associations between neglect and internalizing and externalizing problems. As neglect and abuse often co-occur, the latter was controlled for. In total, 409 Tanzanian primary school students (52% boys, M = 10.5 years, range = 6–15) participated in the cross-sectional study. Structured clinical interviews were conducted assessing maltreatment, internalizing problems, and externalizing problems. Overall, 31% (n = 128) of the children reported at least one type of physical neglect and 31% (n = 127) of emotional neglect. Using structural equation modeling, we found a significant association between neglect and internalizing (? = 0.59, p < .01) and externalizing problems (? = 0.35, p < .05). However, these associations could only be detected in younger children (ages 6–9), whereas in older children (ages 10–15), mental health problems were significantly related to violence and abuse. Our findings suggest that the current age may influence the association between maltreatment type and the development of internalizing and/or externalizing problems. En ligne : http://dx.doi.org/10.1017/S0954579417001882 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=383

---

1 (1 - 2 / 2)