Brief Report: Altered Social Behavior in Isolation-Reared Fmr1 Knockout Mice / Andrew M. HEITZER in Journal of Autism and Developmental Disorders, 43-6 (June 2013)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 43-6 (June 2013) . - p.1452-1458 Titre : Brief Report: Altered Social Behavior in Isolation-Reared Fmr1 Knockout Mice Type de document : Texte imprimé et/ou numérique Auteurs : Andrew M. HEITZER, Auteur ; Alexandra K. ROTH, Auteur ; Lauren NAWROCKI, Auteur ; Craige C. WRENN, Auteur ; Maria G. VALDOVINOS, Auteur Article en page(s) : p.1452-1458 Langues : Anglais (eng) Mots-clés : Fragile X syndrome  fmr1 knockout mouse  Social behavior Index. décimale : PER Périodiques Résumé : Social behavior abnormalities in Fragile X syndrome (FXS) are characterized by social withdrawal, anxiety, and deficits in social cognition. To assess these deficits, a model of FXS, the Fmr1 knockout mouse (Fmr1 KO), has been utilized. This mouse model has a null mutation in the fragile X mental retardation 1 gene (Fmr1) and displays physical and behavioral characteristics similar to humans with FXS. Several studies have investigated the social behavior of this model, but the results on the behavioral phenotype have not been consistent. In order to further characterize the social behavior in the knockout, isolation-reared Fmr1 KO were evaluated to determine if they differ in their social behavior compared to wild-type littermate controls. Differences by genotype were not observed in social approach behavior; however, the knockout mice showed a significantly reduced preference for social novelty and decreased sniff time in the sociability phase. These findings add to the growing body of knowledge on the subtle differences in social behavior shown by the Fmr1 knockout mice, and that differences occur when the subjects are isolation-reared. Validity of the model and possible changes to methodology are discussed. En ligne : http://dx.doi.org/10.1007/s10803-012-1670-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=201 [article] Brief Report: Altered Social Behavior in Isolation-Reared Fmr1 Knockout Mice [Texte imprimé et/ou numérique] / Andrew M. HEITZER, Auteur ; Alexandra K. ROTH, Auteur ; Lauren NAWROCKI, Auteur ; Craige C. WRENN, Auteur ; Maria G. VALDOVINOS, Auteur . - p.1452-1458. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 43-6 (June 2013) . - p.1452-1458 Mots-clés : Fragile X syndrome  fmr1 knockout mouse  Social behavior Index. décimale : PER Périodiques Résumé : Social behavior abnormalities in Fragile X syndrome (FXS) are characterized by social withdrawal, anxiety, and deficits in social cognition. To assess these deficits, a model of FXS, the Fmr1 knockout mouse (Fmr1 KO), has been utilized. This mouse model has a null mutation in the fragile X mental retardation 1 gene (Fmr1) and displays physical and behavioral characteristics similar to humans with FXS. Several studies have investigated the social behavior of this model, but the results on the behavioral phenotype have not been consistent. In order to further characterize the social behavior in the knockout, isolation-reared Fmr1 KO were evaluated to determine if they differ in their social behavior compared to wild-type littermate controls. Differences by genotype were not observed in social approach behavior; however, the knockout mice showed a significantly reduced preference for social novelty and decreased sniff time in the sociability phase. These findings add to the growing body of knowledge on the subtle differences in social behavior shown by the Fmr1 knockout mice, and that differences occur when the subjects are isolation-reared. Validity of the model and possible changes to methodology are discussed. En ligne : http://dx.doi.org/10.1007/s10803-012-1670-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=201

Relevance of Donepezil in Enhancing Learning and Memory in Special Populations: A Review of the Literature / J. Helen YOO in Journal of Autism and Developmental Disorders, 37-10 (November 2007)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 37-10 (November 2007) . - p.1883-1901 Titre : Relevance of Donepezil in Enhancing Learning and Memory in Special Populations: A Review of the Literature Type de document : Texte imprimé et/ou numérique Auteurs : J. Helen YOO, Auteur ; Maria G. VALDOVINOS, Auteur ; Dean C. WILLIAMS, Auteur Année de publication : 2007 Article en page(s) : p.1883-1901 Langues : Anglais (eng) Mots-clés : Autism Donepezil-(Aricept) Acetylcholine Index. décimale : PER Périodiques Résumé : This review discusses the laboratory and clinical research supporting the rationale for the efficacy of donepezil (Aricept® USA) in enhancing cognition in autism, Alzheimer disease, Down syndrome, traumatic brain injury, Attention Deficit Hyperactivity Disorder (ADHD), and schizophrenia. While preliminary animal models have shown effective, human studies exclusive of Alzheimer disease are sparse. Although attention and memory are unlikely a sole operation of the cholinergic system, evidence indicates a promising direction for further examination of this hypothesis in autism. Studies that examine changes in operationally defined behaviors and reliable and valid measure of changes in attention and memory are needed. En ligne : http://dx.doi.org/10.1007/s10803-006-0322-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=219 [article] Relevance of Donepezil in Enhancing Learning and Memory in Special Populations: A Review of the Literature [Texte imprimé et/ou numérique] / J. Helen YOO, Auteur ; Maria G. VALDOVINOS, Auteur ; Dean C. WILLIAMS, Auteur . - 2007 . - p.1883-1901. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 37-10 (November 2007) . - p.1883-1901 Mots-clés : Autism Donepezil-(Aricept) Acetylcholine Index. décimale : PER Périodiques Résumé : This review discusses the laboratory and clinical research supporting the rationale for the efficacy of donepezil (Aricept® USA) in enhancing cognition in autism, Alzheimer disease, Down syndrome, traumatic brain injury, Attention Deficit Hyperactivity Disorder (ADHD), and schizophrenia. While preliminary animal models have shown effective, human studies exclusive of Alzheimer disease are sparse. Although attention and memory are unlikely a sole operation of the cholinergic system, evidence indicates a promising direction for further examination of this hypothesis in autism. Studies that examine changes in operationally defined behaviors and reliable and valid measure of changes in attention and memory are needed. En ligne : http://dx.doi.org/10.1007/s10803-006-0322-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=219

Social validity of behavioral practices in the treatment of autism—A review of the Super Nanny / Melissa J. KING in Research in Autism Spectrum Disorders, 3-1 (January 2009)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 3-1 (January 2009) . - p.173-178 Titre : Social validity of behavioral practices in the treatment of autism—A review of the Super Nanny Type de document : Texte imprimé et/ou numérique Auteurs : Melissa J. KING, Auteur ; Maria G. VALDOVINOS, Auteur Année de publication : 2009 Article en page(s) : p.173-178 Langues : Anglais (eng) Mots-clés : Social-validity Autism Pivotal-response-treatment Index. décimale : PER Périodiques Résumé : This study assessed the social validity of behavioral techniques (i.e., pivotal response treatment) used with a child diagnosed with autism as viewed on an episode of the Super Nanny [Frost, J. (Host). (2005). Facente family [television series episode]. In N. Powell (Producer), Super Nanny. New York: American Broadcasting Companies, Inc.]. Social validity refers to the social importance and acceptability of a given intervention. The participants watched an edited version of the Super Nanny in which the presentation of the order of segments (prior to intervention and receipt of intervention) was counterbalanced between two groups of undergraduate students enrolled in an introduction to psychology course. On a 20-item questionnaire, the students rated the acceptability of the family's interactions with the child before and after behavioral techniques were applied as well as the desirability and severity of the child's behavior. The acceptability and desirability of the child's behavior increased after the treatment was implemented. Further research should be conducted evaluating the social acceptability of popular treatments for autism spectrum disorders. En ligne : http://dx.doi.org/10.1016/j.rasd.2008.05.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=648 [article] Social validity of behavioral practices in the treatment of autism—A review of the Super Nanny [Texte imprimé et/ou numérique] / Melissa J. KING, Auteur ; Maria G. VALDOVINOS, Auteur . - 2009 . - p.173-178. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 3-1 (January 2009) . - p.173-178 Mots-clés : Social-validity Autism Pivotal-response-treatment Index. décimale : PER Périodiques Résumé : This study assessed the social validity of behavioral techniques (i.e., pivotal response treatment) used with a child diagnosed with autism as viewed on an episode of the Super Nanny [Frost, J. (Host). (2005). Facente family [television series episode]. In N. Powell (Producer), Super Nanny. New York: American Broadcasting Companies, Inc.]. Social validity refers to the social importance and acceptability of a given intervention. The participants watched an edited version of the Super Nanny in which the presentation of the order of segments (prior to intervention and receipt of intervention) was counterbalanced between two groups of undergraduate students enrolled in an introduction to psychology course. On a 20-item questionnaire, the students rated the acceptability of the family's interactions with the child before and after behavioral techniques were applied as well as the desirability and severity of the child's behavior. The acceptability and desirability of the child's behavior increased after the treatment was implemented. Further research should be conducted evaluating the social acceptability of popular treatments for autism spectrum disorders. En ligne : http://dx.doi.org/10.1016/j.rasd.2008.05.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=648

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