Hyperserotonemia in Adults with Autistic Disorder / Dubravka HRANILOVIC in Journal of Autism and Developmental Disorders, 37-10 (November 2007)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 37-10 (November 2007) . - p.1934-1940 Titre : Hyperserotonemia in Adults with Autistic Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Dubravka HRANILOVIC, Auteur ; Zorana BUJAS-PETKOVIC, Auteur ; Renata VRAGOVIC, Auteur ; Tomislav VUK, Auteur ; Karlo HOCK, Auteur ; Branimir JERNEJ, Auteur Année de publication : 2007 Article en page(s) : p.1934-1940 Langues : Anglais (eng) Mots-clés : Autism Hyperserotonemia Platelet-serotonin-level Speech-development Verbal-communication Index. décimale : PER Périodiques Résumé : Hyperserotonemia is the most consistent serotonin-related finding in autism. The basis of this phenomenon, and its relationship to the central serotonergic dysfunction remains unclear. Platelet serotonin level (PSL) in 53 autistic adults and 45 healthy controls was measured. Mean PSL in autistic group (75.7 ± 37.4 ng/μL) was significantly higher than the control sample (59.2 ± 16.2 ng/μL) due to a presence of hyperserotonemic subjects which comprised 32% of the patients. PSL of autistic subjects did not correlate with the severity of symptoms, as measured by total CARS score, or the degree of mental retardation. However, significant negative relationship was observed between PSL and speech development, indicating the relationship between the peripheral 5HT concentrations and verbal abilities in autistic subjects. En ligne : http://dx.doi.org/10.1007/s10803-006-0324-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=219 [article] Hyperserotonemia in Adults with Autistic Disorder [Texte imprimé et/ou numérique] / Dubravka HRANILOVIC, Auteur ; Zorana BUJAS-PETKOVIC, Auteur ; Renata VRAGOVIC, Auteur ; Tomislav VUK, Auteur ; Karlo HOCK, Auteur ; Branimir JERNEJ, Auteur . - 2007 . - p.1934-1940. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 37-10 (November 2007) . - p.1934-1940 Mots-clés : Autism Hyperserotonemia Platelet-serotonin-level Speech-development Verbal-communication Index. décimale : PER Périodiques Résumé : Hyperserotonemia is the most consistent serotonin-related finding in autism. The basis of this phenomenon, and its relationship to the central serotonergic dysfunction remains unclear. Platelet serotonin level (PSL) in 53 autistic adults and 45 healthy controls was measured. Mean PSL in autistic group (75.7 ± 37.4 ng/μL) was significantly higher than the control sample (59.2 ± 16.2 ng/μL) due to a presence of hyperserotonemic subjects which comprised 32% of the patients. PSL of autistic subjects did not correlate with the severity of symptoms, as measured by total CARS score, or the degree of mental retardation. However, significant negative relationship was observed between PSL and speech development, indicating the relationship between the peripheral 5HT concentrations and verbal abilities in autistic subjects. En ligne : http://dx.doi.org/10.1007/s10803-006-0324-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=219

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