Autism-relevant behaviors are minimally impacted by conditional deletion of Pten in oxytocinergic neurons / Amy E. CLIPPERTON-ALLEN in Autism Research, 9-12 (December 2016)  

Public ISBD [article]  inAutism Research > 9-12 (December 2016) . - p.1248-1262 Titre : Autism-relevant behaviors are minimally impacted by conditional deletion of Pten in oxytocinergic neurons Type de document : Texte imprimé et/ou numérique Auteurs : Amy E. CLIPPERTON-ALLEN, Auteur ; Youjun CHEN, Auteur ; Damon T. PAGE, Auteur Article en page(s) : p.1248-1262 Langues : Anglais (eng) Mots-clés : phosphatase and tensin homolog  autism spectrum disorder  oxytocin  social behavior  anxiety-like behavior  hypertrophy Index. décimale : PER Périodiques Résumé : Germline heterozygous mutations in Pten (phosphatase and tensin homolog) are associated with macrocephaly and autism spectrum disorders (ASD). Pten germline heterozygous (Pten+/?) mice approximate these mutations, and both sexes show widespread brain overgrowth and impaired social behavior. Strikingly similar behavior phenotypes have been reported in oxytocin (Oxt) and/or oxytocin receptor (OxtR) knockout mice. Thus, we hypothesized that the behavioral phenotypes of germline Pten+/? mice may be caused by reduced Pten function in Oxt-expressing cells. To investigate this, we tested mice in which Pten was conditionally deleted using oxytocin-Cre (Oxt-Cre+; PtenloxP/+, Oxt-Cre+; PtenloxP/loxP) on a battery including assays of social, repetitive, depression-like, and anxiety-like behaviors. Minimal behavioral abnormalities were found; decreased anxiety-like behavior in the open field test in Oxt-Cre+; PtenloxP/loxP males was the only result that phenocopied germline Pten+/? mice. However, Oxt cell size was dramatically increased in Oxt-Cre+; PtenloxP/loxP mice in adulthood. Thus, conditional deletion of Pten using Oxt-Cre has a profound effect on Oxt cell structure, but not on ASD-relevant behavior. We interpret these results as inconsistent with our starting hypothesis that reduced Pten function in Oxt-expressing cells causes the behavioral deficits observed in germline Pten+/? mice. En ligne : http://dx.doi.org/10.1002/aur.1641 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298 [article] Autism-relevant behaviors are minimally impacted by conditional deletion of Pten in oxytocinergic neurons [Texte imprimé et/ou numérique] / Amy E. CLIPPERTON-ALLEN, Auteur ; Youjun CHEN, Auteur ; Damon T. PAGE, Auteur . - p.1248-1262. Langues : Anglais (eng) in Autism Research > 9-12 (December 2016) . - p.1248-1262 Mots-clés : phosphatase and tensin homolog  autism spectrum disorder  oxytocin  social behavior  anxiety-like behavior  hypertrophy Index. décimale : PER Périodiques Résumé : Germline heterozygous mutations in Pten (phosphatase and tensin homolog) are associated with macrocephaly and autism spectrum disorders (ASD). Pten germline heterozygous (Pten+/?) mice approximate these mutations, and both sexes show widespread brain overgrowth and impaired social behavior. Strikingly similar behavior phenotypes have been reported in oxytocin (Oxt) and/or oxytocin receptor (OxtR) knockout mice. Thus, we hypothesized that the behavioral phenotypes of germline Pten+/? mice may be caused by reduced Pten function in Oxt-expressing cells. To investigate this, we tested mice in which Pten was conditionally deleted using oxytocin-Cre (Oxt-Cre+; PtenloxP/+, Oxt-Cre+; PtenloxP/loxP) on a battery including assays of social, repetitive, depression-like, and anxiety-like behaviors. Minimal behavioral abnormalities were found; decreased anxiety-like behavior in the open field test in Oxt-Cre+; PtenloxP/loxP males was the only result that phenocopied germline Pten+/? mice. However, Oxt cell size was dramatically increased in Oxt-Cre+; PtenloxP/loxP mice in adulthood. Thus, conditional deletion of Pten using Oxt-Cre has a profound effect on Oxt cell structure, but not on ASD-relevant behavior. We interpret these results as inconsistent with our starting hypothesis that reduced Pten function in Oxt-expressing cells causes the behavioral deficits observed in germline Pten+/? mice. En ligne : http://dx.doi.org/10.1002/aur.1641 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298

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