Modeling Social Communication Deficits in Mouse Models of Autism / Caterina MICHETTI in Autism - Open Access, 2-S ([01/12/2012])  

Public ISBD [article]  inAutism - Open Access > 2-S [01/12/2012] . - 7 p. Titre : Modeling Social Communication Deficits in Mouse Models of Autism Type de document : Texte imprimé et/ou numérique Auteurs : Caterina MICHETTI, Auteur ; Laura RICCERI, Auteur ; Maria Luisa SCATTONI, Auteur Article en page(s) : 7 p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Male and female mice emit ultrasonic vocalizations during infancy when pups are separated from mother and littermates, as well as at adulthood in different experimental/social contexts. Mouse ultrasonic vocalizations had become now a popular assay for behavioral phenotyping throughout the life-span of models of autism since this response represents the best option to detect deficits within the social communication domain in the mouse species. In the present review, we describe the available methods to elicit and record mouse ultrasonic vocalizations in different social contexts and at different ages. Behavioral data collected on autism animal models in these paradigms/contexts are also discussed. Moreover, we strongly emphasized the need of a standardization of the behavioral methods to better compare results from different laboratories. Thanks to the progresses of computer technology, researchers can now perform detailed analyses of the vocal repertoire (classifying ultrasonic vocalizations into different categories) in autism mouse models. Recently, these analyses have revealed unusual vocal patterns in selected mouse lines. This innovative approach allows to detect also qualitative alterations in the social communication repertoire usually not identified with the standard analysis of emission rate. Future studies should be aimed at performing quantitative and qualitative analyses of vocalization patterns also in preclinical studies evaluating potential treatments in validated autism mouse models. En ligne : https://dx.doi.org/10.4172/2165-7890.S1-007 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409 [article] Modeling Social Communication Deficits in Mouse Models of Autism [Texte imprimé et/ou numérique] / Caterina MICHETTI, Auteur ; Laura RICCERI, Auteur ; Maria Luisa SCATTONI, Auteur . - 7 p. Langues : Anglais (eng) in Autism - Open Access > 2-S [01/12/2012] . - 7 p. Index. décimale : PER Périodiques Résumé : Male and female mice emit ultrasonic vocalizations during infancy when pups are separated from mother and littermates, as well as at adulthood in different experimental/social contexts. Mouse ultrasonic vocalizations had become now a popular assay for behavioral phenotyping throughout the life-span of models of autism since this response represents the best option to detect deficits within the social communication domain in the mouse species. In the present review, we describe the available methods to elicit and record mouse ultrasonic vocalizations in different social contexts and at different ages. Behavioral data collected on autism animal models in these paradigms/contexts are also discussed. Moreover, we strongly emphasized the need of a standardization of the behavioral methods to better compare results from different laboratories. Thanks to the progresses of computer technology, researchers can now perform detailed analyses of the vocal repertoire (classifying ultrasonic vocalizations into different categories) in autism mouse models. Recently, these analyses have revealed unusual vocal patterns in selected mouse lines. This innovative approach allows to detect also qualitative alterations in the social communication repertoire usually not identified with the standard analysis of emission rate. Future studies should be aimed at performing quantitative and qualitative analyses of vocalization patterns also in preclinical studies evaluating potential treatments in validated autism mouse models. En ligne : https://dx.doi.org/10.4172/2165-7890.S1-007 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409

Mouse Behavior and Models for Autism Spectrum Disorders / Laura RICCERI  

Public ISBD in Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability / Carlo SALA Titre : Mouse Behavior and Models for Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Laura RICCERI, Auteur ; Caterina MICHETTI, Auteur ; Maria Luisa SCATTONI, Auteur Année de publication : 2016 Importance : p.269-293 Langues : Anglais (eng) Mots-clés : Mouse behavior  Mouse models  Mutants  Olfactory tests  Repetitive behaviors  Social approach  Social communication  Social interaction Index. décimale : SCI-D SCI-D - Neurosciences Résumé : Autism spectrum disorders (ASDs) are behaviorally defined disorders including attenuated or abnormal social interaction and communication, as well as aberrant repetitive behavior, with symptoms emerging early in childhood. Although the cause of autism has not been discovered, several data strongly support the role of genetic factors in its etiology. For this reason, preclinical research has focused on transgenic and knockout mice bearing mutations in genes identified in autistic children, with the aim of understanding the role of those genes in autism etiology, discovering the biological mechanisms underlying behavioral alterations observed and evaluating potential treatments. In past years, a number of behavioral phenotyping assays for rodent models of autism and related disorders have been developed. In the first part of our review, we describe these behavioral paradigms currently used in ASD rodent models; the second part is an overview of valid and robust animal models of ASD. En ligne : http://dx.doi.org/10.1016/B978-0-12-800109-7.00017-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=301 in Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability / Carlo SALA Mouse Behavior and Models for Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Laura RICCERI, Auteur ; Caterina MICHETTI, Auteur ; Maria Luisa SCATTONI, Auteur . - 2016 . - p.269-293. Langues : Anglais (eng) Mots-clés : Mouse behavior  Mouse models  Mutants  Olfactory tests  Repetitive behaviors  Social approach  Social communication  Social interaction Index. décimale : SCI-D SCI-D - Neurosciences Résumé : Autism spectrum disorders (ASDs) are behaviorally defined disorders including attenuated or abnormal social interaction and communication, as well as aberrant repetitive behavior, with symptoms emerging early in childhood. Although the cause of autism has not been discovered, several data strongly support the role of genetic factors in its etiology. For this reason, preclinical research has focused on transgenic and knockout mice bearing mutations in genes identified in autistic children, with the aim of understanding the role of those genes in autism etiology, discovering the biological mechanisms underlying behavioral alterations observed and evaluating potential treatments. In past years, a number of behavioral phenotyping assays for rodent models of autism and related disorders have been developed. In the first part of our review, we describe these behavioral paradigms currently used in ASD rodent models; the second part is an overview of valid and robust animal models of ASD. En ligne : http://dx.doi.org/10.1016/B978-0-12-800109-7.00017-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=301

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