A pilot study of serotonergic modulation after long-term administration of oxytocin in autism spectrum disorder / Tetsu HIROSAWA in Autism Research, 10-5 (May 2017)  

Public ISBD [article]  inAutism Research > 10-5 (May 2017) . - p.821-828 Titre : A pilot study of serotonergic modulation after long-term administration of oxytocin in autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Tetsu HIROSAWA, Auteur ; Mitsuru KIKUCHI, Auteur ; Yasuomi OUCHI, Auteur ; Tetsuya TAKAHASHI, Auteur ; Yuko YOSHIMURA, Auteur ; Hirotaka KOSAKA, Auteur ; Naoki FURUTANI, Auteur ; Hirotoshi HIRAISHI, Auteur ; Mina FUKAI, Auteur ; Masamichi YOKOKURA, Auteur ; Etsuji YOSHIKAWA, Auteur ; Tomoyasu BUNAI, Auteur ; Yoshio MINABE, Auteur Article en page(s) : p.821-828 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  oxytocin  positron emission tomography  serotonin transporter Index. décimale : PER Périodiques Résumé : Oxytocin (OT) and the serotonergic system putatively play important roles in autism spectrum disorder (ASD) etiology and symptoms, but no direct neurobiological evidence exists for long-term OT administration effects on the brain's serotonergic system. This pilot study examined 10 male participants with ASD who were administered OT intranasally for 8–10 weeks in an open-label, single-arm, nonrandomized, and uncontrolled manner. Positron emission tomography (PET) with a radiotracer (11C)?3-amino-4-(2-[(dimethylamino)methyl]phenylthio)benzonitrile (11C-DASB) was used before and after OT treatment. The binding potential of serotonin transporter (11C-DASB BPND) was then estimated. The main outcome measures were changes in 11C-DASB BPND and their correlation with changes in symptoms. ASD participants showed significantly elevated 11C-DASB BPND in the left inferior frontal gyrus extending to the left middle frontal gyrus. No significant correlation was found between the change in any clinical symptom and the change in 11C-DASB BPND. This report of a pilot study is the first describing long-term effects of OT on the brain's serotonin system in ASD. Additional randomized controlled studies must be conducted to confirm whether activation of the serotonergic system contributes to the prosocial effect of OT in people with ASD. En ligne : http://dx.doi.org/10.1002/aur.1761 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 [article] A pilot study of serotonergic modulation after long-term administration of oxytocin in autism spectrum disorder [Texte imprimé et/ou numérique] / Tetsu HIROSAWA, Auteur ; Mitsuru KIKUCHI, Auteur ; Yasuomi OUCHI, Auteur ; Tetsuya TAKAHASHI, Auteur ; Yuko YOSHIMURA, Auteur ; Hirotaka KOSAKA, Auteur ; Naoki FURUTANI, Auteur ; Hirotoshi HIRAISHI, Auteur ; Mina FUKAI, Auteur ; Masamichi YOKOKURA, Auteur ; Etsuji YOSHIKAWA, Auteur ; Tomoyasu BUNAI, Auteur ; Yoshio MINABE, Auteur . - p.821-828. Langues : Anglais (eng) in Autism Research > 10-5 (May 2017) . - p.821-828 Mots-clés : autism spectrum disorder  oxytocin  positron emission tomography  serotonin transporter Index. décimale : PER Périodiques Résumé : Oxytocin (OT) and the serotonergic system putatively play important roles in autism spectrum disorder (ASD) etiology and symptoms, but no direct neurobiological evidence exists for long-term OT administration effects on the brain's serotonergic system. This pilot study examined 10 male participants with ASD who were administered OT intranasally for 8–10 weeks in an open-label, single-arm, nonrandomized, and uncontrolled manner. Positron emission tomography (PET) with a radiotracer (11C)?3-amino-4-(2-[(dimethylamino)methyl]phenylthio)benzonitrile (11C-DASB) was used before and after OT treatment. The binding potential of serotonin transporter (11C-DASB BPND) was then estimated. The main outcome measures were changes in 11C-DASB BPND and their correlation with changes in symptoms. ASD participants showed significantly elevated 11C-DASB BPND in the left inferior frontal gyrus extending to the left middle frontal gyrus. No significant correlation was found between the change in any clinical symptom and the change in 11C-DASB BPND. This report of a pilot study is the first describing long-term effects of OT on the brain's serotonin system in ASD. Additional randomized controlled studies must be conducted to confirm whether activation of the serotonergic system contributes to the prosocial effect of OT in people with ASD. En ligne : http://dx.doi.org/10.1002/aur.1761 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307

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