Dépouillements

Issue Information in Autism Research, 10-5 (May 2017)  

Public ISBD [article]  inAutism Research > 10-5 (May 2017) . - p.697-702 Titre : Issue Information Type de document : Texte imprimé et/ou numérique Article en page(s) : p.697-702 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1698 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 [article] Issue Information [Texte imprimé et/ou numérique] . - p.697-702. Langues : Anglais (eng) in Autism Research > 10-5 (May 2017) . - p.697-702 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1698 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307

Heterogeneity of sensory features in autism spectrum disorder: Challenges and perspectives for future research / Mirko ULJAREVIC in Autism Research, 10-5 (May 2017)  

Public ISBD [article]  inAutism Research > 10-5 (May 2017) . - p.703-710 Titre : Heterogeneity of sensory features in autism spectrum disorder: Challenges and perspectives for future research Type de document : Texte imprimé et/ou numérique Auteurs : Mirko ULJAREVIC, Auteur ; Grace T. BARANEK, Auteur ; Giacomo VIVANTI, Auteur ; Darren HEDLEY, Auteur ; Kristelle HUDRY, Auteur ; Alison LANE, Auteur Article en page(s) : p.703-710 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Pronounced heterogeneity is apparent across every facet of autism spectrum disorder (ASD) and it remains difficult to predict likely future potential among individuals who share a common diagnosis of ASD on the basis of early presentation. In this commentary we argue that a fine-grained understanding of individual differences in sensory features and their influence across the life span can constrain noted clinical heterogeneity in ASD. We organize our discussion around the following three critical themes: (a) considering sensory features as dimensional construct; (b) taking an “individual differences” approach; and (c) adopting a comprehensive, multidimensional and multimodal approach to measurement of sensory features. We conclude that future research will need to investigate individual differences in sensory features via: (1) multidimensional and cross-disciplinary examination, (2) prospective longitudinal designs, and (3) dimensional and developmental frameworks that emphasize the potential value of early individual variability as indicators of later outcomes, not only in relation to the categorical diagnostic outcome status but also the presence of other clinical features. This is a key time for sensory-related research and in this commentary we provide some of the steps that, in our opinion, can shape future research in this area. En ligne : http://dx.doi.org/10.1002/aur.1747 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 [article] Heterogeneity of sensory features in autism spectrum disorder: Challenges and perspectives for future research [Texte imprimé et/ou numérique] / Mirko ULJAREVIC, Auteur ; Grace T. BARANEK, Auteur ; Giacomo VIVANTI, Auteur ; Darren HEDLEY, Auteur ; Kristelle HUDRY, Auteur ; Alison LANE, Auteur . - p.703-710. Langues : Anglais (eng) in Autism Research > 10-5 (May 2017) . - p.703-710 Index. décimale : PER Périodiques Résumé : Pronounced heterogeneity is apparent across every facet of autism spectrum disorder (ASD) and it remains difficult to predict likely future potential among individuals who share a common diagnosis of ASD on the basis of early presentation. In this commentary we argue that a fine-grained understanding of individual differences in sensory features and their influence across the life span can constrain noted clinical heterogeneity in ASD. We organize our discussion around the following three critical themes: (a) considering sensory features as dimensional construct; (b) taking an “individual differences” approach; and (c) adopting a comprehensive, multidimensional and multimodal approach to measurement of sensory features. We conclude that future research will need to investigate individual differences in sensory features via: (1) multidimensional and cross-disciplinary examination, (2) prospective longitudinal designs, and (3) dimensional and developmental frameworks that emphasize the potential value of early individual variability as indicators of later outcomes, not only in relation to the categorical diagnostic outcome status but also the presence of other clinical features. This is a key time for sensory-related research and in this commentary we provide some of the steps that, in our opinion, can shape future research in this area. En ligne : http://dx.doi.org/10.1002/aur.1747 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307

In pursuit of neurophenotypes: The consequences of having autism and a big brain / David G. AMARAL in Autism Research, 10-5 (May 2017)  

Public ISBD [article]  inAutism Research > 10-5 (May 2017) . - p.711-722 Titre : In pursuit of neurophenotypes: The consequences of having autism and a big brain Type de document : Texte imprimé et/ou numérique Auteurs : David G. AMARAL, Auteur ; Deana LI, Auteur ; Lauren LIBERO, Auteur ; Marjorie SOLOMON, Auteur ; Judy VAN DE WATER, Auteur ; Ann MASTERGEORGE, Auteur ; Letitia NAIGLES, Auteur ; Sally J ROGERS, Auteur ; Christine W. NORDAHL, Auteur Article en page(s) : p.711-722 Langues : Anglais (eng) Mots-clés : brain development  magnetic resonance imaging  megalencephaly  phenotype  subtypes Index. décimale : PER Périodiques Résumé : A consensus has emerged that despite common core features, autism spectrum disorder (ASD) has multiple etiologies and various genetic and biological characteristics. The fact that there are likely to be subtypes of ASD has complicated attempts to develop effective therapies. The UC Davis MIND Institute Autism Phenome Project is a longitudinal, multidisciplinary analysis of children with autism and age-matched typically developing controls; nearly 400 families are participating in this study. The overarching goal is to gather sufficient biological, medical, and behavioral data to allow definition of clinically meaningful subtypes of ASD. One reasonable hypothesis is that different subtypes of autism will demonstrate different patterns of altered brain organization or development i.e., different neurophenotypes. In this Commentary, we discuss one neurophenotype that is defined by megalencephaly, or having brain size that is large and disproportionate to body size. We have found that 15% of the boys with autism demonstrate this neurophenotype, though it is far less common in girls. We review behavioral and medical characteristics of the large-brained group of boys with autism in comparison to those with typically sized brains. While brain size in typically developing individuals is positively correlated with cognitive function, the children with autism and larger brains have more severe disabilities and poorer prognosis. This research indicates that phenotyping in autism, like genotyping, requires a very substantial cohort of subjects. Moreover, since brain and behavior relationships may emerge at different times during development, this effort highlights the need for longitudinal analyses to carry out meaningful phenotyping. En ligne : http://dx.doi.org/10.1002/aur.1755 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 [article] In pursuit of neurophenotypes: The consequences of having autism and a big brain [Texte imprimé et/ou numérique] / David G. AMARAL, Auteur ; Deana LI, Auteur ; Lauren LIBERO, Auteur ; Marjorie SOLOMON, Auteur ; Judy VAN DE WATER, Auteur ; Ann MASTERGEORGE, Auteur ; Letitia NAIGLES, Auteur ; Sally J ROGERS, Auteur ; Christine W. NORDAHL, Auteur . - p.711-722. Langues : Anglais (eng) in Autism Research > 10-5 (May 2017) . - p.711-722 Mots-clés : brain development  magnetic resonance imaging  megalencephaly  phenotype  subtypes Index. décimale : PER Périodiques Résumé : A consensus has emerged that despite common core features, autism spectrum disorder (ASD) has multiple etiologies and various genetic and biological characteristics. The fact that there are likely to be subtypes of ASD has complicated attempts to develop effective therapies. The UC Davis MIND Institute Autism Phenome Project is a longitudinal, multidisciplinary analysis of children with autism and age-matched typically developing controls; nearly 400 families are participating in this study. The overarching goal is to gather sufficient biological, medical, and behavioral data to allow definition of clinically meaningful subtypes of ASD. One reasonable hypothesis is that different subtypes of autism will demonstrate different patterns of altered brain organization or development i.e., different neurophenotypes. In this Commentary, we discuss one neurophenotype that is defined by megalencephaly, or having brain size that is large and disproportionate to body size. We have found that 15% of the boys with autism demonstrate this neurophenotype, though it is far less common in girls. We review behavioral and medical characteristics of the large-brained group of boys with autism in comparison to those with typically sized brains. While brain size in typically developing individuals is positively correlated with cognitive function, the children with autism and larger brains have more severe disabilities and poorer prognosis. This research indicates that phenotyping in autism, like genotyping, requires a very substantial cohort of subjects. Moreover, since brain and behavior relationships may emerge at different times during development, this effort highlights the need for longitudinal analyses to carry out meaningful phenotyping. En ligne : http://dx.doi.org/10.1002/aur.1755 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307

Autism spectrum disorder in sub-saharan africa: A comprehensive scoping review / Lauren FRANZ in Autism Research, 10-5 (May 2017)  

Public ISBD [article]  inAutism Research > 10-5 (May 2017) . - p.723-749 Titre : Autism spectrum disorder in sub-saharan africa: A comprehensive scoping review Type de document : Texte imprimé et/ou numérique Auteurs : Lauren FRANZ, Auteur ; Nola J. CHAMBERS, Auteur ; Megan VON ISENBURG, Auteur ; Petrus J. DE VRIES, Auteur Article en page(s) : p.723-749 Langues : Anglais (eng) Mots-clés : autism  autism spectrum disorder  low- and middle-income countries  LMIC  low resource environments  Africa Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is recognized as a global public health concern, yet almost everything we know about ASD comes from high-income countries. Here we performed a scoping review of all research on ASD ever published in sub-Saharan Africa (SSA) in order to identify ASD knowledge gaps in this part of the world. Fifty-three publications met inclusion criteria. Themes included the phenotype, genetics and risk factors for ASD in SSA, screening and diagnosis, professional knowledge, interventions for ASD, parental perceptions, and social-cognitive neuroscience. No epidemiological, early intervention, school-based or adult studies were identified. For each identified theme, we aimed to summarize results and make recommendations to fill the knowledge gaps. The quality of study methodologies was generally not high. Few studies used standardized diagnostic instruments, and intervention studies were typically small-scale. Overall, findings suggest a substantial need for large-scale clinical, training, and research programmes to improve the lives of people who live with ASD in SSA. However, SSA also has the potential to make unique and globally-significant contributions to the etiology and treatments of ASD through implementation, interventional, and comparative genomic science. En ligne : http://dx.doi.org/10.1002/aur.1766 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 [article] Autism spectrum disorder in sub-saharan africa: A comprehensive scoping review [Texte imprimé et/ou numérique] / Lauren FRANZ, Auteur ; Nola J. CHAMBERS, Auteur ; Megan VON ISENBURG, Auteur ; Petrus J. DE VRIES, Auteur . - p.723-749. Langues : Anglais (eng) in Autism Research > 10-5 (May 2017) . - p.723-749 Mots-clés : autism  autism spectrum disorder  low- and middle-income countries  LMIC  low resource environments  Africa Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is recognized as a global public health concern, yet almost everything we know about ASD comes from high-income countries. Here we performed a scoping review of all research on ASD ever published in sub-Saharan Africa (SSA) in order to identify ASD knowledge gaps in this part of the world. Fifty-three publications met inclusion criteria. Themes included the phenotype, genetics and risk factors for ASD in SSA, screening and diagnosis, professional knowledge, interventions for ASD, parental perceptions, and social-cognitive neuroscience. No epidemiological, early intervention, school-based or adult studies were identified. For each identified theme, we aimed to summarize results and make recommendations to fill the knowledge gaps. The quality of study methodologies was generally not high. Few studies used standardized diagnostic instruments, and intervention studies were typically small-scale. Overall, findings suggest a substantial need for large-scale clinical, training, and research programmes to improve the lives of people who live with ASD in SSA. However, SSA also has the potential to make unique and globally-significant contributions to the etiology and treatments of ASD through implementation, interventional, and comparative genomic science. En ligne : http://dx.doi.org/10.1002/aur.1766 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307

Association testing of vasopressin receptor 1a microsatellite polymorphisms in non-clinical autism spectrum phenotypes / Tanya L. PROCYSHYN in Autism Research, 10-5 (May 2017)  

Public ISBD [article]  inAutism Research > 10-5 (May 2017) . - p.750-756 Titre : Association testing of vasopressin receptor 1a microsatellite polymorphisms in non-clinical autism spectrum phenotypes Type de document : Texte imprimé et/ou numérique Auteurs : Tanya L. PROCYSHYN, Auteur ; Peter L. HURD, Auteur ; Bernard CRESPI, Auteur Article en page(s) : p.750-756 Langues : Anglais (eng) Mots-clés : attention  autism quotient  autism spectrum  avpr1a  microsatellite analysis  rs1  rs3  vasopressin Index. décimale : PER Périodiques Résumé : Variation in the AVPR1a gene, which codes for a receptor for the neurohormone vasopressin, has been found to relate to autism risk. Interestingly, variation in this gene also relates to differences in social behaviour in non-clinical populations. Variation in this gene may affect expression of AVPR1a receptors in brain areas involved in social behaviour. Here, we tested whether AVPR1a variation was associated with Autism Quotient (AQ) scores, a questionnaire that measures non-clinical manifestations of autism, in a population of 873 healthy university students. The AVPR1a RS1 and RS3 microsatellites were examined, and variants were categorized as “long” or “short”. The RS3 long/long genotype was significantly associated with a higher AQ score (i.e., a more autistic-like phenotype) for the combined population and for females only. Further examination showed that this relationship was due to a specific RS3 variant, termed the “target allele”, which previous research has linked to reduced altruism and increased marital problems in healthy individuals. We also observed that the relationship between RS3 genotype and AQ score was mainly due to the “attention switching” (the ability to shift attention from one task to another) component of the questionnaire; this ability is commonly impaired in autism spectrum disorders. Overall, our study establishes continuity between the existing AVPR1a research in clinical and non-clinical populations. Our results suggest that vasopressin may exert its effects on social behaviour in part by modulating attentional focus between social and non-social cues. En ligne : http://dx.doi.org/10.1002/aur.1716 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 [article] Association testing of vasopressin receptor 1a microsatellite polymorphisms in non-clinical autism spectrum phenotypes [Texte imprimé et/ou numérique] / Tanya L. PROCYSHYN, Auteur ; Peter L. HURD, Auteur ; Bernard CRESPI, Auteur . - p.750-756. Langues : Anglais (eng) in Autism Research > 10-5 (May 2017) . - p.750-756 Mots-clés : attention  autism quotient  autism spectrum  avpr1a  microsatellite analysis  rs1  rs3  vasopressin Index. décimale : PER Périodiques Résumé : Variation in the AVPR1a gene, which codes for a receptor for the neurohormone vasopressin, has been found to relate to autism risk. Interestingly, variation in this gene also relates to differences in social behaviour in non-clinical populations. Variation in this gene may affect expression of AVPR1a receptors in brain areas involved in social behaviour. Here, we tested whether AVPR1a variation was associated with Autism Quotient (AQ) scores, a questionnaire that measures non-clinical manifestations of autism, in a population of 873 healthy university students. The AVPR1a RS1 and RS3 microsatellites were examined, and variants were categorized as “long” or “short”. The RS3 long/long genotype was significantly associated with a higher AQ score (i.e., a more autistic-like phenotype) for the combined population and for females only. Further examination showed that this relationship was due to a specific RS3 variant, termed the “target allele”, which previous research has linked to reduced altruism and increased marital problems in healthy individuals. We also observed that the relationship between RS3 genotype and AQ score was mainly due to the “attention switching” (the ability to shift attention from one task to another) component of the questionnaire; this ability is commonly impaired in autism spectrum disorders. Overall, our study establishes continuity between the existing AVPR1a research in clinical and non-clinical populations. Our results suggest that vasopressin may exert its effects on social behaviour in part by modulating attentional focus between social and non-social cues. En ligne : http://dx.doi.org/10.1002/aur.1716 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307

Infant muscle tone and childhood autistic traits: A longitudinal study in the general population / Fadila SERDAREVIC in Autism Research, 10-5 (May 2017)  

Public ISBD [article]  inAutism Research > 10-5 (May 2017) . - p.757-768 Titre : Infant muscle tone and childhood autistic traits: A longitudinal study in the general population Type de document : Texte imprimé et/ou numérique Auteurs : Fadila SERDAREVIC, Auteur ; Akhgar GHASSABIAN, Auteur ; Tamara VAN BATENBURG-EDDES, Auteur ; Tonya WHITE, Auteur ; Laura M. E. BLANKEN, Auteur ; Vincent W.V. JADDOE, Auteur ; Frank C. VERHULST, Auteur ; Henning TIEMEIER, Auteur Article en page(s) : p.757-768 Langues : Anglais (eng) Mots-clés : infant muscle tone  autistic traits  autism spectrum disorder  prospective Index. décimale : PER Périodiques Résumé : In a longitudinal population-based study of 2,905 children, we investigated if infants' neuromotor development was associated with autistic traits in childhood. Overall motor development and muscle tone were examined by trained research assistants with an adapted version of Touwen's Neurodevelopmental Examination between ages 2 and 5 months. Tone was assessed in several positions and items were scored as normal, low, or high tone. Parents rated their children's autistic traits with the Social Responsiveness Scale (SRS) and the Pervasive Developmental Problems (PDP) subscale of the Child Behavior Checklist at 6 years. We defined clinical PDP if scores were >98th percentile of the norm population. Diagnosis of autism spectrum disorder (ASD) was clinically confirmed in 30 children. We observed a modest association between overall neuromotor development in infants and autistic traits. Low muscle tone in infancy predicted autistic traits measured by SRS (adjusted beta?=?0.05, 95% CI for B: 0.00–0.02, P?=?0.01), and PDP (adjusted beta?=?0.08, 95% CI for B: 0.04–0.10, P? En ligne : http://dx.doi.org/10.1002/aur.1739 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 [article] Infant muscle tone and childhood autistic traits: A longitudinal study in the general population [Texte imprimé et/ou numérique] / Fadila SERDAREVIC, Auteur ; Akhgar GHASSABIAN, Auteur ; Tamara VAN BATENBURG-EDDES, Auteur ; Tonya WHITE, Auteur ; Laura M. E. BLANKEN, Auteur ; Vincent W.V. JADDOE, Auteur ; Frank C. VERHULST, Auteur ; Henning TIEMEIER, Auteur . - p.757-768. Langues : Anglais (eng) in Autism Research > 10-5 (May 2017) . - p.757-768 Mots-clés : infant muscle tone  autistic traits  autism spectrum disorder  prospective Index. décimale : PER Périodiques Résumé : In a longitudinal population-based study of 2,905 children, we investigated if infants' neuromotor development was associated with autistic traits in childhood. Overall motor development and muscle tone were examined by trained research assistants with an adapted version of Touwen's Neurodevelopmental Examination between ages 2 and 5 months. Tone was assessed in several positions and items were scored as normal, low, or high tone. Parents rated their children's autistic traits with the Social Responsiveness Scale (SRS) and the Pervasive Developmental Problems (PDP) subscale of the Child Behavior Checklist at 6 years. We defined clinical PDP if scores were >98th percentile of the norm population. Diagnosis of autism spectrum disorder (ASD) was clinically confirmed in 30 children. We observed a modest association between overall neuromotor development in infants and autistic traits. Low muscle tone in infancy predicted autistic traits measured by SRS (adjusted beta?=?0.05, 95% CI for B: 0.00–0.02, P?=?0.01), and PDP (adjusted beta?=?0.08, 95% CI for B: 0.04–0.10, P? En ligne : http://dx.doi.org/10.1002/aur.1739 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307

Prenatal toxoplasmosis antibody and childhood autism / Marisa N. SPANN in Autism Research, 10-5 (May 2017)  

Public ISBD [article]  inAutism Research > 10-5 (May 2017) . - p.769-777 Titre : Prenatal toxoplasmosis antibody and childhood autism Type de document : Texte imprimé et/ou numérique Auteurs : Marisa N. SPANN, Auteur ; Andre SOURANDER, Auteur ; Heljä-Marja SURCEL, Auteur ; Susanna HINKKA-YLI-SALOMAKI, Auteur ; Alan S. BROWN, Auteur Article en page(s) : p.769-777 Langues : Anglais (eng) Mots-clés : toxoplasmosis  autism  antibody  childhood Index. décimale : PER Périodiques Résumé : There is evidence that some maternal infections during the prenatal period are associated with neurodevelopmental disorders, such as childhood autism. However, the association between autism and Toxoplasma gondii (T. gondii), an intracellular parasite, remains unclear. The authors examined whether serologically confirmed maternal antibodies to T. gondii are associated with odds of childhood autism in offspring. The study is based on a nested case-control design of a large national birth cohort (N?=?1.2 million) and the national psychiatric registries in Finland. There were 874 cases of childhood autism and controls matched 1:1 on date of birth, sex, birthplace and residence in Finland. Maternal sera were prospectively assayed from a national biobank for T. gondii IgM and IgG antibodies; IgG avidity analyses were also performed. High maternal T. gondii IgM antibody was associated with a significantly decreased odds of childhood autism. Low maternal T. gondii IgG antibody was associated with increased offspring odds of autism. In women with high T. gondii IgM antibodies, the IgG avidity was high for both cases and controls, with the exception of three controls. The findings suggest that the relationship between maternal T. gondii antibodies and odds of childhood autism may be related to the immune response to this pathogen or the overall activation of the immune system. En ligne : http://dx.doi.org/10.1002/aur.1722 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 [article] Prenatal toxoplasmosis antibody and childhood autism [Texte imprimé et/ou numérique] / Marisa N. SPANN, Auteur ; Andre SOURANDER, Auteur ; Heljä-Marja SURCEL, Auteur ; Susanna HINKKA-YLI-SALOMAKI, Auteur ; Alan S. BROWN, Auteur . - p.769-777. Langues : Anglais (eng) in Autism Research > 10-5 (May 2017) . - p.769-777 Mots-clés : toxoplasmosis  autism  antibody  childhood Index. décimale : PER Périodiques Résumé : There is evidence that some maternal infections during the prenatal period are associated with neurodevelopmental disorders, such as childhood autism. However, the association between autism and Toxoplasma gondii (T. gondii), an intracellular parasite, remains unclear. The authors examined whether serologically confirmed maternal antibodies to T. gondii are associated with odds of childhood autism in offspring. The study is based on a nested case-control design of a large national birth cohort (N?=?1.2 million) and the national psychiatric registries in Finland. There were 874 cases of childhood autism and controls matched 1:1 on date of birth, sex, birthplace and residence in Finland. Maternal sera were prospectively assayed from a national biobank for T. gondii IgM and IgG antibodies; IgG avidity analyses were also performed. High maternal T. gondii IgM antibody was associated with a significantly decreased odds of childhood autism. Low maternal T. gondii IgG antibody was associated with increased offspring odds of autism. In women with high T. gondii IgM antibodies, the IgG avidity was high for both cases and controls, with the exception of three controls. The findings suggest that the relationship between maternal T. gondii antibodies and odds of childhood autism may be related to the immune response to this pathogen or the overall activation of the immune system. En ligne : http://dx.doi.org/10.1002/aur.1722 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307

The influence of sex and age on prevalence rates of comorbid conditions in autism / Kaustubh SUPEKAR in Autism Research, 10-5 (May 2017)  

Public ISBD [article]  inAutism Research > 10-5 (May 2017) . - p.778-789 Titre : The influence of sex and age on prevalence rates of comorbid conditions in autism Type de document : Texte imprimé et/ou numérique Auteurs : Kaustubh SUPEKAR, Auteur ; Tara IYER, Auteur ; Vinod MENON, Auteur Article en page(s) : p.778-789 Langues : Anglais (eng) Mots-clés : autism comorbidities  epilepsy  schizophrenia  age  sex Index. décimale : PER Périodiques Résumé : Individuals with ASD frequently experience one or more comorbid conditions. Here, we investigate the influence of sex and age—two important, yet understudied factors—on ten common comorbid conditions in ASD, using cross-sectional data from 4790 individuals with ASD and 1,842,575 individuals without ASD. Epilepsy, ADHD, and CNS/cranial anomalies showed exceptionally large proportions in both male (>19%) and female (>15%), children/adolescents with ASD. Notably, these prevalence rates decreased drastically with age in both males and females. In contrast, the prevalence of schizophrenia increased with age affecting a disproportionately large number of older (?35 year) adult males (25%), compared to females (7.7%), with ASD. Bowel disorders showed a complex U-pattern accompanied by changes in sex disparity with age. These results highlight crucial differences between cross-sectional comorbidity patterns and their interactions with sex and age, which may aid in the development of effective sex- and age-specific diagnostic/treatment strategies for ASD and comorbid conditions. En ligne : http://dx.doi.org/10.1002/aur.1741 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 [article] The influence of sex and age on prevalence rates of comorbid conditions in autism [Texte imprimé et/ou numérique] / Kaustubh SUPEKAR, Auteur ; Tara IYER, Auteur ; Vinod MENON, Auteur . - p.778-789. Langues : Anglais (eng) in Autism Research > 10-5 (May 2017) . - p.778-789 Mots-clés : autism comorbidities  epilepsy  schizophrenia  age  sex Index. décimale : PER Périodiques Résumé : Individuals with ASD frequently experience one or more comorbid conditions. Here, we investigate the influence of sex and age—two important, yet understudied factors—on ten common comorbid conditions in ASD, using cross-sectional data from 4790 individuals with ASD and 1,842,575 individuals without ASD. Epilepsy, ADHD, and CNS/cranial anomalies showed exceptionally large proportions in both male (>19%) and female (>15%), children/adolescents with ASD. Notably, these prevalence rates decreased drastically with age in both males and females. In contrast, the prevalence of schizophrenia increased with age affecting a disproportionately large number of older (?35 year) adult males (25%), compared to females (7.7%), with ASD. Bowel disorders showed a complex U-pattern accompanied by changes in sex disparity with age. These results highlight crucial differences between cross-sectional comorbidity patterns and their interactions with sex and age, which may aid in the development of effective sex- and age-specific diagnostic/treatment strategies for ASD and comorbid conditions. En ligne : http://dx.doi.org/10.1002/aur.1741 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307

Investigating diagnostic bias in autism spectrum conditions: An item response theory analysis of sex bias in the AQ-10 / Aja Louise MURRAY in Autism Research, 10-5 (May 2017)  

Public ISBD [article]  inAutism Research > 10-5 (May 2017) . - p.790-800 Titre : Investigating diagnostic bias in autism spectrum conditions: An item response theory analysis of sex bias in the AQ-10 Type de document : Texte imprimé et/ou numérique Auteurs : Aja Louise MURRAY, Auteur ; Carrie ALLISON, Auteur ; Paula L. SMITH, Auteur ; Simon BARON-COHEN, Auteur ; Tom BOOTH, Auteur ; Bonnie AUYEUNG, Auteur Article en page(s) : p.790-800 Langues : Anglais (eng) Mots-clés : sex differences  autism  screening  autism spectrum quotient  AQ-10  item response theory  differential item functioning  differential test functioning Index. décimale : PER Périodiques Résumé : Diagnostic bias is a concern in autism spectrum conditions (ASC) where prevalence and presentation differ by sex. To ensure that females with ASC are not under-identified, it is important that ASC screening tools do not systematically underestimate autistic traits in females relative to males. We evaluated whether the AQ-10, a brief screen for ASC recommended by the National Institute of Clinical Excellence in cases of suspected ASC, exhibits such a bias. Using an item response theory approach, we evaluated differential item functioning and differential test functioning. We found that although individual items showed some sex bias, these biases at times favored males and at other times favored females. Thus, at the level of test scores the item-level biases cancelled out to give an unbiased overall score. Results support the continued use of the AQ-10 sum score in its current form; however, suggest that caution should be exercised when interpreting responses to individual items. The nature of the item level biases could serve as a guide for future research into how ASC affects males and females differently. En ligne : http://dx.doi.org/10.1002/aur.1724 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 [article] Investigating diagnostic bias in autism spectrum conditions: An item response theory analysis of sex bias in the AQ-10 [Texte imprimé et/ou numérique] / Aja Louise MURRAY, Auteur ; Carrie ALLISON, Auteur ; Paula L. SMITH, Auteur ; Simon BARON-COHEN, Auteur ; Tom BOOTH, Auteur ; Bonnie AUYEUNG, Auteur . - p.790-800. Langues : Anglais (eng) in Autism Research > 10-5 (May 2017) . - p.790-800 Mots-clés : sex differences  autism  screening  autism spectrum quotient  AQ-10  item response theory  differential item functioning  differential test functioning Index. décimale : PER Périodiques Résumé : Diagnostic bias is a concern in autism spectrum conditions (ASC) where prevalence and presentation differ by sex. To ensure that females with ASC are not under-identified, it is important that ASC screening tools do not systematically underestimate autistic traits in females relative to males. We evaluated whether the AQ-10, a brief screen for ASC recommended by the National Institute of Clinical Excellence in cases of suspected ASC, exhibits such a bias. Using an item response theory approach, we evaluated differential item functioning and differential test functioning. We found that although individual items showed some sex bias, these biases at times favored males and at other times favored females. Thus, at the level of test scores the item-level biases cancelled out to give an unbiased overall score. Results support the continued use of the AQ-10 sum score in its current form; however, suggest that caution should be exercised when interpreting responses to individual items. The nature of the item level biases could serve as a guide for future research into how ASC affects males and females differently. En ligne : http://dx.doi.org/10.1002/aur.1724 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307

Reduced modulation of thalamocortical connectivity during exposure to sensory stimuli in ASD / Shulamite A. GREEN in Autism Research, 10-5 (May 2017)  

Public ISBD [article]  inAutism Research > 10-5 (May 2017) . - p.801-809 Titre : Reduced modulation of thalamocortical connectivity during exposure to sensory stimuli in ASD Type de document : Texte imprimé et/ou numérique Auteurs : Shulamite A. GREEN, Auteur ; Leanna HERNANDEZ, Auteur ; Susan Y. BOOKHEIMER, Auteur ; Mirella DAPRETTO, Auteur Article en page(s) : p.801-809 Langues : Anglais (eng) Mots-clés : sensory over responsivity  thalamus  amygdala  functional connectivity  fMRI Index. décimale : PER Périodiques Résumé : Recent evidence for abnormal thalamic connectivity in autism spectrum disorders (ASD) and sensory processing disorders suggests the thalamus may play a role in sensory over-responsivity (SOR), an extreme negative response to sensory stimuli, which is common in ASD. However, there is yet little understanding of changes in thalamic connectivity during exposure to aversive sensory inputs in individuals with ASD. In particular, the pulvinar nucleus of the thalamus is implicated in atypical sensory processing given its role in selective attention, regulation, and sensory integration. This study aimed to examine the role of pulvinar connectivity in ASD during mildly aversive sensory input. Functional magnetic resonance imaging was used to examine connectivity with the pulvinar during exposure to mildly aversive auditory and tactile stimuli in 38 youth (age 9–17; 19 ASD, 19 IQ-matched typically developing (TD)). Parents rated children's SOR severity on two standard scales. Compared to TD, ASD participants displayed aberrant modulation of connectivity between pulvinar and cortex (including sensory-motor and prefrontal regions) during sensory stimulation. In ASD participants, pulvinar-amygdala connectivity was correlated with severity of SOR symptoms. Deficits in modulation of thalamocortical connectivity in youth with ASD may reflect reduced thalamo-cortical inhibition in response to sensory stimulation, which could lead to difficulty filtering out and/or integrating sensory information. An increase in amygdala connectivity with the pulvinar might be partially responsible for deficits in selective attention as the amygdala signals the brain to attend to distracting sensory stimuli. En ligne : http://dx.doi.org/10.1002/aur.1726 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 [article] Reduced modulation of thalamocortical connectivity during exposure to sensory stimuli in ASD [Texte imprimé et/ou numérique] / Shulamite A. GREEN, Auteur ; Leanna HERNANDEZ, Auteur ; Susan Y. BOOKHEIMER, Auteur ; Mirella DAPRETTO, Auteur . - p.801-809. Langues : Anglais (eng) in Autism Research > 10-5 (May 2017) . - p.801-809 Mots-clés : sensory over responsivity  thalamus  amygdala  functional connectivity  fMRI Index. décimale : PER Périodiques Résumé : Recent evidence for abnormal thalamic connectivity in autism spectrum disorders (ASD) and sensory processing disorders suggests the thalamus may play a role in sensory over-responsivity (SOR), an extreme negative response to sensory stimuli, which is common in ASD. However, there is yet little understanding of changes in thalamic connectivity during exposure to aversive sensory inputs in individuals with ASD. In particular, the pulvinar nucleus of the thalamus is implicated in atypical sensory processing given its role in selective attention, regulation, and sensory integration. This study aimed to examine the role of pulvinar connectivity in ASD during mildly aversive sensory input. Functional magnetic resonance imaging was used to examine connectivity with the pulvinar during exposure to mildly aversive auditory and tactile stimuli in 38 youth (age 9–17; 19 ASD, 19 IQ-matched typically developing (TD)). Parents rated children's SOR severity on two standard scales. Compared to TD, ASD participants displayed aberrant modulation of connectivity between pulvinar and cortex (including sensory-motor and prefrontal regions) during sensory stimulation. In ASD participants, pulvinar-amygdala connectivity was correlated with severity of SOR symptoms. Deficits in modulation of thalamocortical connectivity in youth with ASD may reflect reduced thalamo-cortical inhibition in response to sensory stimulation, which could lead to difficulty filtering out and/or integrating sensory information. An increase in amygdala connectivity with the pulvinar might be partially responsible for deficits in selective attention as the amygdala signals the brain to attend to distracting sensory stimuli. En ligne : http://dx.doi.org/10.1002/aur.1726 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307

Atypical physiological orienting to direct gaze in low-functioning children with autism spectrum disorder / Terhi M. HELMINEN in Autism Research, 10-5 (May 2017)  

Public ISBD [article]  inAutism Research > 10-5 (May 2017) . - p.810-820 Titre : Atypical physiological orienting to direct gaze in low-functioning children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Terhi M. HELMINEN, Auteur ; Jukka M. LEPPANEN, Auteur ; Kai ERIKSSON, Auteur ; Arto LUOMA, Auteur ; Jari K. HIETANEN, Auteur ; Anneli KYLLIAINEN, Auteur Article en page(s) : p.810-820 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  eye contact  attention  orienting  heart rate Index. décimale : PER Périodiques Résumé : Reduced use of eye contact is a prominent feature in individuals with autism spectrum disorder (ASD). It has been proposed that direct gaze does not capture the attention of individuals with ASD. Experimental evidence is, however, mainly restricted to relatively high-functioning school-aged children or adults with ASD. This study investigated whether 2–5-year-old low-functioning children with severe ASD differ from control children in orienting to gaze stimuli, as measured with the heart rate deceleration response. Responses were measured to computerized presentations of dynamic shifts of gaze direction either toward (direct) or away (averted) from the observing child. The results showed a significant group by gaze direction interaction effect on heart rate responses (permuted P?=?.004), reflecting a stronger orienting response to direct versus averted gaze in typically developing (N?=?17) and developmentally delayed (N?=?16) children but not in children with ASD (N?=?12). The lack of enhanced orienting response to direct gaze in the ASD group was not caused by a lack of looking at the eye region, as confirmed by eye tracking. The results suggest that direct gaze is not a socially salient, attention-grabbing signal for low-functioning children with ASD. En ligne : http://dx.doi.org/10.1002/aur.1738 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 [article] Atypical physiological orienting to direct gaze in low-functioning children with autism spectrum disorder [Texte imprimé et/ou numérique] / Terhi M. HELMINEN, Auteur ; Jukka M. LEPPANEN, Auteur ; Kai ERIKSSON, Auteur ; Arto LUOMA, Auteur ; Jari K. HIETANEN, Auteur ; Anneli KYLLIAINEN, Auteur . - p.810-820. Langues : Anglais (eng) in Autism Research > 10-5 (May 2017) . - p.810-820 Mots-clés : autism spectrum disorder  eye contact  attention  orienting  heart rate Index. décimale : PER Périodiques Résumé : Reduced use of eye contact is a prominent feature in individuals with autism spectrum disorder (ASD). It has been proposed that direct gaze does not capture the attention of individuals with ASD. Experimental evidence is, however, mainly restricted to relatively high-functioning school-aged children or adults with ASD. This study investigated whether 2–5-year-old low-functioning children with severe ASD differ from control children in orienting to gaze stimuli, as measured with the heart rate deceleration response. Responses were measured to computerized presentations of dynamic shifts of gaze direction either toward (direct) or away (averted) from the observing child. The results showed a significant group by gaze direction interaction effect on heart rate responses (permuted P?=?.004), reflecting a stronger orienting response to direct versus averted gaze in typically developing (N?=?17) and developmentally delayed (N?=?16) children but not in children with ASD (N?=?12). The lack of enhanced orienting response to direct gaze in the ASD group was not caused by a lack of looking at the eye region, as confirmed by eye tracking. The results suggest that direct gaze is not a socially salient, attention-grabbing signal for low-functioning children with ASD. En ligne : http://dx.doi.org/10.1002/aur.1738 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307

A pilot study of serotonergic modulation after long-term administration of oxytocin in autism spectrum disorder / Tetsu HIROSAWA in Autism Research, 10-5 (May 2017)  

Public ISBD [article]  inAutism Research > 10-5 (May 2017) . - p.821-828 Titre : A pilot study of serotonergic modulation after long-term administration of oxytocin in autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Tetsu HIROSAWA, Auteur ; Mitsuru KIKUCHI, Auteur ; Yasuomi OUCHI, Auteur ; Tetsuya TAKAHASHI, Auteur ; Yuko YOSHIMURA, Auteur ; Hirotaka KOSAKA, Auteur ; Naoki FURUTANI, Auteur ; Hirotoshi HIRAISHI, Auteur ; Mina FUKAI, Auteur ; Masamichi YOKOKURA, Auteur ; Etsuji YOSHIKAWA, Auteur ; Tomoyasu BUNAI, Auteur ; Yoshio MINABE, Auteur Article en page(s) : p.821-828 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  oxytocin  positron emission tomography  serotonin transporter Index. décimale : PER Périodiques Résumé : Oxytocin (OT) and the serotonergic system putatively play important roles in autism spectrum disorder (ASD) etiology and symptoms, but no direct neurobiological evidence exists for long-term OT administration effects on the brain's serotonergic system. This pilot study examined 10 male participants with ASD who were administered OT intranasally for 8–10 weeks in an open-label, single-arm, nonrandomized, and uncontrolled manner. Positron emission tomography (PET) with a radiotracer (11C)?3-amino-4-(2-[(dimethylamino)methyl]phenylthio)benzonitrile (11C-DASB) was used before and after OT treatment. The binding potential of serotonin transporter (11C-DASB BPND) was then estimated. The main outcome measures were changes in 11C-DASB BPND and their correlation with changes in symptoms. ASD participants showed significantly elevated 11C-DASB BPND in the left inferior frontal gyrus extending to the left middle frontal gyrus. No significant correlation was found between the change in any clinical symptom and the change in 11C-DASB BPND. This report of a pilot study is the first describing long-term effects of OT on the brain's serotonin system in ASD. Additional randomized controlled studies must be conducted to confirm whether activation of the serotonergic system contributes to the prosocial effect of OT in people with ASD. En ligne : http://dx.doi.org/10.1002/aur.1761 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 [article] A pilot study of serotonergic modulation after long-term administration of oxytocin in autism spectrum disorder [Texte imprimé et/ou numérique] / Tetsu HIROSAWA, Auteur ; Mitsuru KIKUCHI, Auteur ; Yasuomi OUCHI, Auteur ; Tetsuya TAKAHASHI, Auteur ; Yuko YOSHIMURA, Auteur ; Hirotaka KOSAKA, Auteur ; Naoki FURUTANI, Auteur ; Hirotoshi HIRAISHI, Auteur ; Mina FUKAI, Auteur ; Masamichi YOKOKURA, Auteur ; Etsuji YOSHIKAWA, Auteur ; Tomoyasu BUNAI, Auteur ; Yoshio MINABE, Auteur . - p.821-828. Langues : Anglais (eng) in Autism Research > 10-5 (May 2017) . - p.821-828 Mots-clés : autism spectrum disorder  oxytocin  positron emission tomography  serotonin transporter Index. décimale : PER Périodiques Résumé : Oxytocin (OT) and the serotonergic system putatively play important roles in autism spectrum disorder (ASD) etiology and symptoms, but no direct neurobiological evidence exists for long-term OT administration effects on the brain's serotonergic system. This pilot study examined 10 male participants with ASD who were administered OT intranasally for 8–10 weeks in an open-label, single-arm, nonrandomized, and uncontrolled manner. Positron emission tomography (PET) with a radiotracer (11C)?3-amino-4-(2-[(dimethylamino)methyl]phenylthio)benzonitrile (11C-DASB) was used before and after OT treatment. The binding potential of serotonin transporter (11C-DASB BPND) was then estimated. The main outcome measures were changes in 11C-DASB BPND and their correlation with changes in symptoms. ASD participants showed significantly elevated 11C-DASB BPND in the left inferior frontal gyrus extending to the left middle frontal gyrus. No significant correlation was found between the change in any clinical symptom and the change in 11C-DASB BPND. This report of a pilot study is the first describing long-term effects of OT on the brain's serotonin system in ASD. Additional randomized controlled studies must be conducted to confirm whether activation of the serotonergic system contributes to the prosocial effect of OT in people with ASD. En ligne : http://dx.doi.org/10.1002/aur.1761 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307

Atypical pupillary light reflex in 2–6-year-old children with autism spectrum disorders / Dinalankara M. R. DINALANKARA in Autism Research, 10-5 (May 2017)  

Public ISBD [article]  inAutism Research > 10-5 (May 2017) . - p.829-838 Titre : Atypical pupillary light reflex in 2–6-year-old children with autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Dinalankara M. R. DINALANKARA, Auteur ; Judith H. MILES, Auteur ; T. NICOLE TAKAHASHI, Auteur ; Gang YAO, Auteur Article en page(s) : p.829-838 Langues : Anglais (eng) Mots-clés : pupillary light reflex  autism  age  latency  pupil size  autonomic dysfunction Index. décimale : PER Périodiques Résumé : The purpose of this study was to investigate pupillary light reflex (PLR) in 2–6-years-old children with autism spectrum disorders (ASD). A total of 117 medication-free 2–6-year-old boys participated in this study. Sixty participants were diagnosed with ASD (the “ASD group”) and the other 57 were in the control group of typical development (the “TD group”). A questionnaire was completed by the parent/guardian for assessing potential dysfunctions in the autonomic nervous system (ANS). The base pupil radius, PLR latency, and constriction time showed a significant age-related trend in both the ASD and TD groups. The base pupil size increased with age in the typically developing children, but not in the ASD group. The ASD group showed more symptoms related to ANS dysfunctions. An association between abnormal sweating with base pupil radius and PLR constriction was observed in the TD group but not the ASD group. The different association of PLR parameters with ANS dysfunction may suggest disrupted autonomic controls in children with ASD. En ligne : http://dx.doi.org/10.1002/aur.1745 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 [article] Atypical pupillary light reflex in 2–6-year-old children with autism spectrum disorders [Texte imprimé et/ou numérique] / Dinalankara M. R. DINALANKARA, Auteur ; Judith H. MILES, Auteur ; T. NICOLE TAKAHASHI, Auteur ; Gang YAO, Auteur . - p.829-838. Langues : Anglais (eng) in Autism Research > 10-5 (May 2017) . - p.829-838 Mots-clés : pupillary light reflex  autism  age  latency  pupil size  autonomic dysfunction Index. décimale : PER Périodiques Résumé : The purpose of this study was to investigate pupillary light reflex (PLR) in 2–6-years-old children with autism spectrum disorders (ASD). A total of 117 medication-free 2–6-year-old boys participated in this study. Sixty participants were diagnosed with ASD (the “ASD group”) and the other 57 were in the control group of typical development (the “TD group”). A questionnaire was completed by the parent/guardian for assessing potential dysfunctions in the autonomic nervous system (ANS). The base pupil radius, PLR latency, and constriction time showed a significant age-related trend in both the ASD and TD groups. The base pupil size increased with age in the typically developing children, but not in the ASD group. The ASD group showed more symptoms related to ANS dysfunctions. An association between abnormal sweating with base pupil radius and PLR constriction was observed in the TD group but not the ASD group. The different association of PLR parameters with ANS dysfunction may suggest disrupted autonomic controls in children with ASD. En ligne : http://dx.doi.org/10.1002/aur.1745 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307

Ensemble perception of color in autistic adults / John MAULE in Autism Research, 10-5 (May 2017)  

Public ISBD [article]  inAutism Research > 10-5 (May 2017) . - p.839-851 Titre : Ensemble perception of color in autistic adults Type de document : Texte imprimé et/ou numérique Auteurs : John MAULE, Auteur ; Kirstie STANWORTH, Auteur ; Elizabeth PELLICANO, Auteur ; Anna FRANKLIN, Auteur Article en page(s) : p.839-851 Langues : Anglais (eng) Mots-clés : autism  color  ensemble perception  visual perception  priors  global processing Index. décimale : PER Périodiques Résumé : Dominant accounts of visual processing in autism posit that autistic individuals have an enhanced access to details of scenes [e.g., weak central coherence] which is reflected in a general bias toward local processing. Furthermore, the attenuated priors account of autism predicts that the updating and use of summary representations is reduced in autism. Ensemble perception describes the extraction of global summary statistics of a visual feature from a heterogeneous set (e.g., of faces, sizes, colors), often in the absence of local item representation. The present study investigated ensemble perception in autistic adults using a rapidly presented (500 msec) ensemble of four, eight, or sixteen elements representing four different colors. We predicted that autistic individuals would be less accurate when averaging the ensembles, but more accurate in recognizing individual ensemble colors. The results were consistent with the predictions. Averaging was impaired in autism, but only when ensembles contained four elements. Ensembles of eight or sixteen elements were averaged equally accurately across groups. The autistic group also showed a corresponding advantage in rejecting colors that were not originally seen in the ensemble. The results demonstrate the local processing bias in autism, but also suggest that the global perceptual averaging mechanism may be compromised under some conditions. The theoretical implications of the findings and future avenues for research on summary statistics in autism are discussed. En ligne : http://dx.doi.org/10.1002/aur.1725 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 [article] Ensemble perception of color in autistic adults [Texte imprimé et/ou numérique] / John MAULE, Auteur ; Kirstie STANWORTH, Auteur ; Elizabeth PELLICANO, Auteur ; Anna FRANKLIN, Auteur . - p.839-851. Langues : Anglais (eng) in Autism Research > 10-5 (May 2017) . - p.839-851 Mots-clés : autism  color  ensemble perception  visual perception  priors  global processing Index. décimale : PER Périodiques Résumé : Dominant accounts of visual processing in autism posit that autistic individuals have an enhanced access to details of scenes [e.g., weak central coherence] which is reflected in a general bias toward local processing. Furthermore, the attenuated priors account of autism predicts that the updating and use of summary representations is reduced in autism. Ensemble perception describes the extraction of global summary statistics of a visual feature from a heterogeneous set (e.g., of faces, sizes, colors), often in the absence of local item representation. The present study investigated ensemble perception in autistic adults using a rapidly presented (500 msec) ensemble of four, eight, or sixteen elements representing four different colors. We predicted that autistic individuals would be less accurate when averaging the ensembles, but more accurate in recognizing individual ensemble colors. The results were consistent with the predictions. Averaging was impaired in autism, but only when ensembles contained four elements. Ensembles of eight or sixteen elements were averaged equally accurately across groups. The autistic group also showed a corresponding advantage in rejecting colors that were not originally seen in the ensemble. The results demonstrate the local processing bias in autism, but also suggest that the global perceptual averaging mechanism may be compromised under some conditions. The theoretical implications of the findings and future avenues for research on summary statistics in autism are discussed. En ligne : http://dx.doi.org/10.1002/aur.1725 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307

Assessment of Autistic Traits in Children Aged 2 to 4½ Years With the Preschool Version of the Social Responsiveness Scale (SRS-P): Findings from Japan / Andrew STICKLEY in Autism Research, 10-5 (May 2017)  

Public ISBD [article]  inAutism Research > 10-5 (May 2017) . - p.852-865 Titre : Assessment of Autistic Traits in Children Aged 2 to 4½ Years With the Preschool Version of the Social Responsiveness Scale (SRS-P): Findings from Japan Type de document : Texte imprimé et/ou numérique Auteurs : Andrew STICKLEY, Auteur ; Yoshiyuki TACHIBANA, Auteur ; Keiji HASHIMOTO, Auteur ; Hideyuki HARAGUCHI, Auteur ; Atsuko MIYAKE, Auteur ; Seiichi MOROKUMA, Auteur ; Hiroshi NITTA, Auteur ; Masako ODA, Auteur ; Yukihiro OHYA, Auteur ; Ayako SENJU, Auteur ; Hidetoshi TAKAHASHI, Auteur ; Takanori YAMAGATA, Auteur ; Yoko KAMIO, Auteur Article en page(s) : p.852-865 Langues : Anglais (eng) Mots-clés : ASD  autistic traits  quantitative measure  reliability  validity  preschool children  questionnaire Index. décimale : PER Périodiques Résumé : The recent development and use of autism measures for the general population has led to a growing body of evidence which suggests that autistic traits are distributed along a continuum. However, as most existing autism measures were designed for use in children older than age 4, to date, little is known about the autistic continuum in children younger than age 4. As autistic symptoms are evident in the first few years, to address this research gap, the current study tested the preschool version of the Social Responsiveness Scale (SRS-P) in children aged 2 to 4½ years in clinical (N?=?74, average age 40 months, 26–51 months) and community settings (N?=?357, average age 39 months, 25–50 months) in Japan. Using information obtained from different raters (mothers, other caregivers, and teachers) it was found that the scale demonstrated a good degree of internal consistency, inter-rater reliability and test-retest reliability, and a satisfactory degree of convergent validity for the clinical sample when compared with scores from diagnostic “gold standard” autism measures. Receiver operating characteristic analyses and the group comparisons also showed that the SRS-P total score discriminated well between children with autism spectrum disorder (ASD) and those without ASD. Importantly, this scale could identify autistic symptoms or traits distributed continually across the child population at this age irrespective of the presence of an ASD diagnosis. These findings suggest that the SRS-P might be a sensitive instrument for case identification including subthreshold ASD, as well as a potentially useful research tool for exploring ASD endophenotypes. En ligne : http://dx.doi.org/10.1002/aur.1742 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 [article] Assessment of Autistic Traits in Children Aged 2 to 4½ Years With the Preschool Version of the Social Responsiveness Scale (SRS-P): Findings from Japan [Texte imprimé et/ou numérique] / Andrew STICKLEY, Auteur ; Yoshiyuki TACHIBANA, Auteur ; Keiji HASHIMOTO, Auteur ; Hideyuki HARAGUCHI, Auteur ; Atsuko MIYAKE, Auteur ; Seiichi MOROKUMA, Auteur ; Hiroshi NITTA, Auteur ; Masako ODA, Auteur ; Yukihiro OHYA, Auteur ; Ayako SENJU, Auteur ; Hidetoshi TAKAHASHI, Auteur ; Takanori YAMAGATA, Auteur ; Yoko KAMIO, Auteur . - p.852-865. Langues : Anglais (eng) in Autism Research > 10-5 (May 2017) . - p.852-865 Mots-clés : ASD  autistic traits  quantitative measure  reliability  validity  preschool children  questionnaire Index. décimale : PER Périodiques Résumé : The recent development and use of autism measures for the general population has led to a growing body of evidence which suggests that autistic traits are distributed along a continuum. However, as most existing autism measures were designed for use in children older than age 4, to date, little is known about the autistic continuum in children younger than age 4. As autistic symptoms are evident in the first few years, to address this research gap, the current study tested the preschool version of the Social Responsiveness Scale (SRS-P) in children aged 2 to 4½ years in clinical (N?=?74, average age 40 months, 26–51 months) and community settings (N?=?357, average age 39 months, 25–50 months) in Japan. Using information obtained from different raters (mothers, other caregivers, and teachers) it was found that the scale demonstrated a good degree of internal consistency, inter-rater reliability and test-retest reliability, and a satisfactory degree of convergent validity for the clinical sample when compared with scores from diagnostic “gold standard” autism measures. Receiver operating characteristic analyses and the group comparisons also showed that the SRS-P total score discriminated well between children with autism spectrum disorder (ASD) and those without ASD. Importantly, this scale could identify autistic symptoms or traits distributed continually across the child population at this age irrespective of the presence of an ASD diagnosis. These findings suggest that the SRS-P might be a sensitive instrument for case identification including subthreshold ASD, as well as a potentially useful research tool for exploring ASD endophenotypes. En ligne : http://dx.doi.org/10.1002/aur.1742 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307

Perceived social support in adults with autism spectrum disorder and attention-deficit/hyperactivity disorder / Sonia ALVAREZ-FERNANDEZ in Autism Research, 10-5 (May 2017)  

Public ISBD [article]  inAutism Research > 10-5 (May 2017) . - p.866-877 Titre : Perceived social support in adults with autism spectrum disorder and attention-deficit/hyperactivity disorder Type de document : Texte imprimé et/ou numérique Auteurs : Sonia ALVAREZ-FERNANDEZ, Auteur ; Hallie R. BROWN, Auteur ; Yihong ZHAO, Auteur ; Jessica A. RAITHEL, Auteur ; Somer L. BISHOP, Auteur ; Sarah B. KERN, Auteur ; Catherine LORD, Auteur ; Eva PETKOVA, Auteur ; Adriana DI MARTINO, Auteur Article en page(s) : p.866-877 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  attention-deficit/hyperactivity disorder  perceived social support  social cognition  adults Index. décimale : PER Périodiques Résumé : Perceived social support (PSS) has been related to physical and mental well-being in typically developing individuals, but systematic characterizations of PSS in autism spectrum disorder (ASD) are limited. We compared self-report ratings of the multidimensional scale of PSS (MSPSS) among age- and IQ-matched groups of adults (18–58 years) with cognitively high-functioning ASD (N?=?41), or attention-deficit/hyperactivity disorder (ADHD; N?=?69), and neurotypical controls (NC; N?=?69). Accompanying group comparisons, we used machine learning random forest (RF) analyses to explore predictors among a range of psychopathological and socio-emotional variables. Relative to both ADHD and NC, adults with ASD showed lower MSPSS ratings, specifically for the friends subscale (MSPSS-f). Across ASD and ADHD, interindividual differences in autism severity, affective empathy, symptoms of anxiety related to social interactions, hyperactivity/impulsivity, and somatization best predicted MSPSS-f. These relationships did not differ between clinical groups. While group comparisons demonstrated greater impairment in individuals with ASD, analyzing individuals' characteristics revealed cross-diagnoses similarities in regard to their MSPSS-f relationships. This is consistent with the Research Domain Criteria framework, supporting a trans-diagnostic approach as on the path toward “precision medicine.” En ligne : http://dx.doi.org/10.1002/aur.1735 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 [article] Perceived social support in adults with autism spectrum disorder and attention-deficit/hyperactivity disorder [Texte imprimé et/ou numérique] / Sonia ALVAREZ-FERNANDEZ, Auteur ; Hallie R. BROWN, Auteur ; Yihong ZHAO, Auteur ; Jessica A. RAITHEL, Auteur ; Somer L. BISHOP, Auteur ; Sarah B. KERN, Auteur ; Catherine LORD, Auteur ; Eva PETKOVA, Auteur ; Adriana DI MARTINO, Auteur . - p.866-877. Langues : Anglais (eng) in Autism Research > 10-5 (May 2017) . - p.866-877 Mots-clés : autism spectrum disorder  attention-deficit/hyperactivity disorder  perceived social support  social cognition  adults Index. décimale : PER Périodiques Résumé : Perceived social support (PSS) has been related to physical and mental well-being in typically developing individuals, but systematic characterizations of PSS in autism spectrum disorder (ASD) are limited. We compared self-report ratings of the multidimensional scale of PSS (MSPSS) among age- and IQ-matched groups of adults (18–58 years) with cognitively high-functioning ASD (N?=?41), or attention-deficit/hyperactivity disorder (ADHD; N?=?69), and neurotypical controls (NC; N?=?69). Accompanying group comparisons, we used machine learning random forest (RF) analyses to explore predictors among a range of psychopathological and socio-emotional variables. Relative to both ADHD and NC, adults with ASD showed lower MSPSS ratings, specifically for the friends subscale (MSPSS-f). Across ASD and ADHD, interindividual differences in autism severity, affective empathy, symptoms of anxiety related to social interactions, hyperactivity/impulsivity, and somatization best predicted MSPSS-f. These relationships did not differ between clinical groups. While group comparisons demonstrated greater impairment in individuals with ASD, analyzing individuals' characteristics revealed cross-diagnoses similarities in regard to their MSPSS-f relationships. This is consistent with the Research Domain Criteria framework, supporting a trans-diagnostic approach as on the path toward “precision medicine.” En ligne : http://dx.doi.org/10.1002/aur.1735 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307

Distinct profiles of social skill in adults with autism spectrum disorder and schizophrenia / Kerrianne E. MORRISON in Autism Research, 10-5 (May 2017)  

Public ISBD [article]  inAutism Research > 10-5 (May 2017) . - p.878-887 Titre : Distinct profiles of social skill in adults with autism spectrum disorder and schizophrenia Type de document : Texte imprimé et/ou numérique Auteurs : Kerrianne E. MORRISON, Auteur ; Amy E. PINKHAM, Auteur ; David L. PENN, Auteur ; Skylar KELSVEN, Auteur ; Kelsey LUDWIG, Auteur ; Noah J. SASSON, Auteur Article en page(s) : p.878-887 Langues : Anglais (eng) Mots-clés : social skills  social interaction  social cognition  social behavior Index. décimale : PER Périodiques Résumé : Overlapping social impairments in Autism Spectrum Disorder (ASD) and Schizophrenia (SCZ) contributed to decades of diagnostic confusion that continues to this day in some clinical settings. The current study provides the first direct and detailed comparison of social behavior in the two disorders by identifying profiles of social skill in adults with ASD (n?=?54), SCZ (n?=?54), and typically developing (TD) controls (n?=?56) during a real-world social interaction. ASD and SCZ groups exhibited poorer social skill, both overall and on most discrete abilities, relative to the TD group. Direct comparison of ASD to SCZ revealed distinct behavioral profiles, with ASD uniquely characterized by fewer interactive behaviors, and SCZ characterized by greater impaired gaze and flat/inappropriate affective responses. Additionally, IQ was associated with both overall social skill and many discrete social skills in SCZ, but was largely unrelated to social skill in ASD. These results indicate that overlapping social deficits in ASD and SCZ are comprised of both shared and distinct social skill impairments. The largest distinctions—reduced social reciprocity but better expressivity in ASD relative to SCZ, and a greater role of IQ in social skill for SCZ than ASD—highlight disorder-specific features that can improve etiological understanding, diagnostic differentiation, and treatment strategies. En ligne : http://dx.doi.org/10.1002/aur.1734 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 [article] Distinct profiles of social skill in adults with autism spectrum disorder and schizophrenia [Texte imprimé et/ou numérique] / Kerrianne E. MORRISON, Auteur ; Amy E. PINKHAM, Auteur ; David L. PENN, Auteur ; Skylar KELSVEN, Auteur ; Kelsey LUDWIG, Auteur ; Noah J. SASSON, Auteur . - p.878-887. Langues : Anglais (eng) in Autism Research > 10-5 (May 2017) . - p.878-887 Mots-clés : social skills  social interaction  social cognition  social behavior Index. décimale : PER Périodiques Résumé : Overlapping social impairments in Autism Spectrum Disorder (ASD) and Schizophrenia (SCZ) contributed to decades of diagnostic confusion that continues to this day in some clinical settings. The current study provides the first direct and detailed comparison of social behavior in the two disorders by identifying profiles of social skill in adults with ASD (n?=?54), SCZ (n?=?54), and typically developing (TD) controls (n?=?56) during a real-world social interaction. ASD and SCZ groups exhibited poorer social skill, both overall and on most discrete abilities, relative to the TD group. Direct comparison of ASD to SCZ revealed distinct behavioral profiles, with ASD uniquely characterized by fewer interactive behaviors, and SCZ characterized by greater impaired gaze and flat/inappropriate affective responses. Additionally, IQ was associated with both overall social skill and many discrete social skills in SCZ, but was largely unrelated to social skill in ASD. These results indicate that overlapping social deficits in ASD and SCZ are comprised of both shared and distinct social skill impairments. The largest distinctions—reduced social reciprocity but better expressivity in ASD relative to SCZ, and a greater role of IQ in social skill for SCZ than ASD—highlight disorder-specific features that can improve etiological understanding, diagnostic differentiation, and treatment strategies. En ligne : http://dx.doi.org/10.1002/aur.1734 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307

Strategies of readers with autism when responding to inferential questions: An eye-movement study / Martina MICAI in Autism Research, 10-5 (May 2017)  

Public ISBD [article]  inAutism Research > 10-5 (May 2017) . - p.888-900 Titre : Strategies of readers with autism when responding to inferential questions: An eye-movement study Type de document : Texte imprimé et/ou numérique Auteurs : Martina MICAI, Auteur ; Holly JOSEPH, Auteur ; Mila VULCHANOVA, Auteur ; David SALDANA, Auteur Article en page(s) : p.888-900 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  inference  reading  language  eye movement Index. décimale : PER Périodiques Résumé : Previous research suggests that individuals with autism spectrum disorder (ASD) have difficulties with inference generation in reading tasks. However, most previous studies have examined how well children understand a text after reading or have measured on-line reading behavior without response to questions. The aim of this study was to investigate the online strategies of children and adolescents with autism during reading and at the same time responding to a question by monitoring their eye movements. The reading behavior of participants with ASD was compared with that of age-, language-, nonverbal intelligence-, reading-, and receptive language skills-matched participants without ASD (control group). The results showed that the ASD group were as accurate as the control group in generating inferences when answering questions about the short texts, and no differences were found between the two groups in the global paragraph reading and responding times. However, the ASD group displayed longer gaze latencies on a target word necessary to produce an inference. They also showed more regressions into the word that supported the inference compared to the control group after reading the question, irrespective of whether an inference was required or not. In conclusion, the ASD group achieved an equivalent level of inferential comprehension, but showed subtle differences in reading comprehension strategies compared to the control group. En ligne : http://dx.doi.org/10.1002/aur.1731 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 [article] Strategies of readers with autism when responding to inferential questions: An eye-movement study [Texte imprimé et/ou numérique] / Martina MICAI, Auteur ; Holly JOSEPH, Auteur ; Mila VULCHANOVA, Auteur ; David SALDANA, Auteur . - p.888-900. Langues : Anglais (eng) in Autism Research > 10-5 (May 2017) . - p.888-900 Mots-clés : autism spectrum disorder  inference  reading  language  eye movement Index. décimale : PER Périodiques Résumé : Previous research suggests that individuals with autism spectrum disorder (ASD) have difficulties with inference generation in reading tasks. However, most previous studies have examined how well children understand a text after reading or have measured on-line reading behavior without response to questions. The aim of this study was to investigate the online strategies of children and adolescents with autism during reading and at the same time responding to a question by monitoring their eye movements. The reading behavior of participants with ASD was compared with that of age-, language-, nonverbal intelligence-, reading-, and receptive language skills-matched participants without ASD (control group). The results showed that the ASD group were as accurate as the control group in generating inferences when answering questions about the short texts, and no differences were found between the two groups in the global paragraph reading and responding times. However, the ASD group displayed longer gaze latencies on a target word necessary to produce an inference. They also showed more regressions into the word that supported the inference compared to the control group after reading the question, irrespective of whether an inference was required or not. In conclusion, the ASD group achieved an equivalent level of inferential comprehension, but showed subtle differences in reading comprehension strategies compared to the control group. En ligne : http://dx.doi.org/10.1002/aur.1731 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307

Autism and emotional face-viewing / Jakob ÅSBERG JOHNELS in Autism Research, 10-5 (May 2017)  

Public ISBD [article]  inAutism Research > 10-5 (May 2017) . - p.901-910 Titre : Autism and emotional face-viewing Type de document : Texte imprimé et/ou numérique Auteurs : Jakob ÅSBERG JOHNELS, Auteur ; Daniel HOVEY, Auteur ; Nicole ZÜRCHER, Auteur ; Loyse HIPPOLYTE, Auteur ; Eric LEMONNIER, Auteur ; Christopher GILLBERG, Auteur ; Nouchine HADJIKHANI, Auteur Article en page(s) : p.901-910 Langues : Anglais (eng) Mots-clés : autism  eye-tracking  mouth  face  autism quotient  social  endophenotype Index. décimale : PER Périodiques Résumé : Atypical patterns of face-scanning in individuals with autism spectrum disorder (ASD) may contribute to difficulties in social interactions, but there is little agreement regarding what exactly characterizes face-viewing in ASD. In addition, little research has examined how face-viewing is modulated by the emotional expression of the stimuli, in individuals with or without ASD. We used eye-tracking to explore viewing patterns during perception of dynamic emotional facial expressions in relatively large groups of individuals with (n?=?57) and without ASD (n?=?58) and examined diagnostic- and age-related effects, after subgrouping children and adolescents (?18 years), on the one hand, and adults (>18 years), on the other. Results showed that children/adolescents with ASD fixated the mouth of happy and angry faces less than their typically developing (TD) peers, and conversely looked more to the eyes of happy faces. Moreover, while all groups fixated the mouth in happy faces more than in other expressions, children/adolescents with ASD did relatively less so. Correlation analysis showed a similar lack of relative orientation towards the mouth of smiling faces in TD children/adolescents with high autistic traits, as measured by the Autism-Spectrum Quotient (AQ). Among adults, participants with ASD only attended less to the eyes for neutral faces. Our study shows that the emotional content of a face influences gaze behaviour, and that this effect is not fully developed in children/adolescents with ASD. Interestingly, this lack of differentiation observed in the younger ASD group was also seen in younger TD individuals with higher AQ scores. En ligne : http://dx.doi.org/10.1002/aur.1730 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 [article] Autism and emotional face-viewing [Texte imprimé et/ou numérique] / Jakob ÅSBERG JOHNELS, Auteur ; Daniel HOVEY, Auteur ; Nicole ZÜRCHER, Auteur ; Loyse HIPPOLYTE, Auteur ; Eric LEMONNIER, Auteur ; Christopher GILLBERG, Auteur ; Nouchine HADJIKHANI, Auteur . - p.901-910. Langues : Anglais (eng) in Autism Research > 10-5 (May 2017) . - p.901-910 Mots-clés : autism  eye-tracking  mouth  face  autism quotient  social  endophenotype Index. décimale : PER Périodiques Résumé : Atypical patterns of face-scanning in individuals with autism spectrum disorder (ASD) may contribute to difficulties in social interactions, but there is little agreement regarding what exactly characterizes face-viewing in ASD. In addition, little research has examined how face-viewing is modulated by the emotional expression of the stimuli, in individuals with or without ASD. We used eye-tracking to explore viewing patterns during perception of dynamic emotional facial expressions in relatively large groups of individuals with (n?=?57) and without ASD (n?=?58) and examined diagnostic- and age-related effects, after subgrouping children and adolescents (?18 years), on the one hand, and adults (>18 years), on the other. Results showed that children/adolescents with ASD fixated the mouth of happy and angry faces less than their typically developing (TD) peers, and conversely looked more to the eyes of happy faces. Moreover, while all groups fixated the mouth in happy faces more than in other expressions, children/adolescents with ASD did relatively less so. Correlation analysis showed a similar lack of relative orientation towards the mouth of smiling faces in TD children/adolescents with high autistic traits, as measured by the Autism-Spectrum Quotient (AQ). Among adults, participants with ASD only attended less to the eyes for neutral faces. Our study shows that the emotional content of a face influences gaze behaviour, and that this effect is not fully developed in children/adolescents with ASD. Interestingly, this lack of differentiation observed in the younger ASD group was also seen in younger TD individuals with higher AQ scores. En ligne : http://dx.doi.org/10.1002/aur.1730 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307

Meta-analysis of neuropsychological measures of executive functioning in children and adolescents with high-functioning autism spectrum disorder / Chun Lun Eric LAI in Autism Research, 10-5 (May 2017)  

Public ISBD [article]  inAutism Research > 10-5 (May 2017) . - p.911-939 Titre : Meta-analysis of neuropsychological measures of executive functioning in children and adolescents with high-functioning autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Chun Lun Eric LAI, Auteur ; Zoe LAU, Auteur ; Simon S. Y. LUI, Auteur ; Eugenia LOK, Auteur ; Venus TAM, Auteur ; Quinney CHAN, Auteur ; Koi Man CHENG, Auteur ; Siu Man LAM, Auteur ; Eric F. C. CHEUNG, Auteur Article en page(s) : p.911-939 Langues : Anglais (eng) Mots-clés : executive function  high-functioning autism spectrum disorder  Asperger's syndrome  meta-analysis Index. décimale : PER Périodiques Résumé : Existing literature on the profile of executive dysfunction in autism spectrum disorder showed inconsistent results. Age, comorbid attention-deficit/hyperactivity disorder (ADHD) and cognitive abilities appeared to play a role in confounding the picture. Previous meta-analyses have focused on a few components of executive functions. This meta-analysis attempted to delineate the profile of deficit in several components of executive functioning in children and adolescents with high-functioning autism spectrum disorder (HFASD). Ninety-eight English published case-control studies comparing children and adolescents with HFASD with typically developing controls using well-known neuropsychological measures to assess executive functions were included. Results showed that children and adolescents with HFASD were moderately impaired in verbal working memory (g?=?0.67), spatial working memory (g?=?0.58), flexibility (g?=?0.59), planning (g?=?0.62), and generativity (g?=?0.60) except for inhibition (g?=?0.41). Subgroup analysis showed that impairments were still significant for flexibility (g?=?0.57–0.61), generativity (g?=?0.52–0.68), and working memory (g?=?0.49–0.56) in a sample of autism spectrum disorder (ASD) subjects without comorbid ADHD or when the cognitive abilities of the ASD group and the control group were comparable. This meta-analysis confirmed the presence of executive dysfunction in children and adolescents with HFASD. These deficits are not solely accounted for by the effect of comorbid ADHD and the general cognitive abilities. Our results support the executive dysfunction hypothesis and contribute to the clinical understanding and possible development of interventions to alleviate these deficits in children and adolescents with HFASD. En ligne : http://dx.doi.org/10.1002/aur.1723 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 [article] Meta-analysis of neuropsychological measures of executive functioning in children and adolescents with high-functioning autism spectrum disorder [Texte imprimé et/ou numérique] / Chun Lun Eric LAI, Auteur ; Zoe LAU, Auteur ; Simon S. Y. LUI, Auteur ; Eugenia LOK, Auteur ; Venus TAM, Auteur ; Quinney CHAN, Auteur ; Koi Man CHENG, Auteur ; Siu Man LAM, Auteur ; Eric F. C. CHEUNG, Auteur . - p.911-939. Langues : Anglais (eng) in Autism Research > 10-5 (May 2017) . - p.911-939 Mots-clés : executive function  high-functioning autism spectrum disorder  Asperger's syndrome  meta-analysis Index. décimale : PER Périodiques Résumé : Existing literature on the profile of executive dysfunction in autism spectrum disorder showed inconsistent results. Age, comorbid attention-deficit/hyperactivity disorder (ADHD) and cognitive abilities appeared to play a role in confounding the picture. Previous meta-analyses have focused on a few components of executive functions. This meta-analysis attempted to delineate the profile of deficit in several components of executive functioning in children and adolescents with high-functioning autism spectrum disorder (HFASD). Ninety-eight English published case-control studies comparing children and adolescents with HFASD with typically developing controls using well-known neuropsychological measures to assess executive functions were included. Results showed that children and adolescents with HFASD were moderately impaired in verbal working memory (g?=?0.67), spatial working memory (g?=?0.58), flexibility (g?=?0.59), planning (g?=?0.62), and generativity (g?=?0.60) except for inhibition (g?=?0.41). Subgroup analysis showed that impairments were still significant for flexibility (g?=?0.57–0.61), generativity (g?=?0.52–0.68), and working memory (g?=?0.49–0.56) in a sample of autism spectrum disorder (ASD) subjects without comorbid ADHD or when the cognitive abilities of the ASD group and the control group were comparable. This meta-analysis confirmed the presence of executive dysfunction in children and adolescents with HFASD. These deficits are not solely accounted for by the effect of comorbid ADHD and the general cognitive abilities. Our results support the executive dysfunction hypothesis and contribute to the clinical understanding and possible development of interventions to alleviate these deficits in children and adolescents with HFASD. En ligne : http://dx.doi.org/10.1002/aur.1723 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307

Executive functioning in men and women with an autism spectrum disorder / Michelle KIEP in Autism Research, 10-5 (May 2017)  

Public ISBD [article]  inAutism Research > 10-5 (May 2017) . - p.940-948 Titre : Executive functioning in men and women with an autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Michelle KIEP, Auteur ; Annelies A. SPEK, Auteur Article en page(s) : p.940-948 Langues : Anglais (eng) Mots-clés : autism  executive functioning  gender differences  females with autism Index. décimale : PER Périodiques Résumé : Executive functioning (EF) is thought to be linked to autism spectrum disorders (ASD) specific symptoms. The majority of research has focused on children and adolescents with ASD and, therefore, little is known about EF in adults. Furthermore, little is known about gender differences. Ninety-nine men and forty women with ASD were compared with and 35 neurotypical men 25 neurotypical women. Participants were matched on age, total intelligence, and verbal ability. The following instruments were used to measure executive functioning: digit span and letter and number sequencing of the WAIS-III, Tower of Hanoi, WCST, and Verbal fluency. Multiple analysis of variance was conducted to determine group differences. Women with ASD performed worse on the working memory tasks of the WAIS-III than neurotypical women. Furthermore, women with ASD had more perseverations on the WCST than neurotypical women. The gender comparison in the ASD group showed differences in performance on mental flexibility (WCST), working memory (WAIS-III), generativity and self-monitoring (Verbal fluency). However, these differences were unequivocal and no gender specific cognitive profile could be pinpointed. Individual strengths and frailties should be highlighted in clinical practice, as impairments in EF can be under influence of the overall cognitive abilities of the individual. Furthermore, gender differences were found. This could explain differences in representation of ASD symptoms in both groups. These differences show how important thorough diagnostics are. En ligne : http://dx.doi.org/10.1002/aur.1721 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 [article] Executive functioning in men and women with an autism spectrum disorder [Texte imprimé et/ou numérique] / Michelle KIEP, Auteur ; Annelies A. SPEK, Auteur . - p.940-948. Langues : Anglais (eng) in Autism Research > 10-5 (May 2017) . - p.940-948 Mots-clés : autism  executive functioning  gender differences  females with autism Index. décimale : PER Périodiques Résumé : Executive functioning (EF) is thought to be linked to autism spectrum disorders (ASD) specific symptoms. The majority of research has focused on children and adolescents with ASD and, therefore, little is known about EF in adults. Furthermore, little is known about gender differences. Ninety-nine men and forty women with ASD were compared with and 35 neurotypical men 25 neurotypical women. Participants were matched on age, total intelligence, and verbal ability. The following instruments were used to measure executive functioning: digit span and letter and number sequencing of the WAIS-III, Tower of Hanoi, WCST, and Verbal fluency. Multiple analysis of variance was conducted to determine group differences. Women with ASD performed worse on the working memory tasks of the WAIS-III than neurotypical women. Furthermore, women with ASD had more perseverations on the WCST than neurotypical women. The gender comparison in the ASD group showed differences in performance on mental flexibility (WCST), working memory (WAIS-III), generativity and self-monitoring (Verbal fluency). However, these differences were unequivocal and no gender specific cognitive profile could be pinpointed. Individual strengths and frailties should be highlighted in clinical practice, as impairments in EF can be under influence of the overall cognitive abilities of the individual. Furthermore, gender differences were found. This could explain differences in representation of ASD symptoms in both groups. These differences show how important thorough diagnostics are. En ligne : http://dx.doi.org/10.1002/aur.1721 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307

The salience of the self: Self-referential processing and internalizing problems in children and adolescents with autism spectrum disorder / Catherine A. BURROWS in Autism Research, 10-5 (May 2017)  

Public ISBD [article]  inAutism Research > 10-5 (May 2017) . - p.949-960 Titre : The salience of the self: Self-referential processing and internalizing problems in children and adolescents with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Catherine A. BURROWS, Auteur ; Lauren V. USHER, Auteur ; Peter C. MUNDY, Auteur ; Heather A. HENDERSON, Auteur Article en page(s) : p.949-960 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  self-referenced processing  self-evaluations  memory Index. décimale : PER Périodiques Résumé : Children and adolescents with autism spectrum disorder (ASD) demonstrate atypical processing of, and memory for, self-referenced information, which may contribute to the heightened rates of co-occurring internalizing problems. We assessed affective and cognitive aspects of self-referential processing in verbally-fluent children with ASD (N?=?79), and an age-matched comparison sample (COM, N?=?73) of children without an autism diagnosis. We examined group differences in these two aspects of the self-system, and their joint contributions to individual differnces in internalizing problems. Using a self-referenced memory (SRM) task, participants indicated whether a series of positive and negative trait adjectives described themselves and a well-known fictional character. Participants were then surprised with a recognition memory test on the same adjectives. Overall, individuals with ASD showed a reduction in the extent to which they preferentially endorsed positive over negative trait adjectives about themselves, and a reduction in their preferential memory for self- over other-referenced information. Across the full sample, these two aspects of self-referential processing jointly predicted self-reported internalizing problems. Specifically, self-evaluations were strongly and inversely associated with internalizing problems but only for children with relatively high SRM. These findings suggest that the salience of the self influences the extent to which affective self-evaluations impact emotional functioning for youth both with and without ASD. Implications for basic (e.g., developmental) and translational (e.g., intervention) research are discussed. En ligne : http://dx.doi.org/10.1002/aur.1727 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 [article] The salience of the self: Self-referential processing and internalizing problems in children and adolescents with autism spectrum disorder [Texte imprimé et/ou numérique] / Catherine A. BURROWS, Auteur ; Lauren V. USHER, Auteur ; Peter C. MUNDY, Auteur ; Heather A. HENDERSON, Auteur . - p.949-960. Langues : Anglais (eng) in Autism Research > 10-5 (May 2017) . - p.949-960 Mots-clés : autism spectrum disorder  self-referenced processing  self-evaluations  memory Index. décimale : PER Périodiques Résumé : Children and adolescents with autism spectrum disorder (ASD) demonstrate atypical processing of, and memory for, self-referenced information, which may contribute to the heightened rates of co-occurring internalizing problems. We assessed affective and cognitive aspects of self-referential processing in verbally-fluent children with ASD (N?=?79), and an age-matched comparison sample (COM, N?=?73) of children without an autism diagnosis. We examined group differences in these two aspects of the self-system, and their joint contributions to individual differnces in internalizing problems. Using a self-referenced memory (SRM) task, participants indicated whether a series of positive and negative trait adjectives described themselves and a well-known fictional character. Participants were then surprised with a recognition memory test on the same adjectives. Overall, individuals with ASD showed a reduction in the extent to which they preferentially endorsed positive over negative trait adjectives about themselves, and a reduction in their preferential memory for self- over other-referenced information. Across the full sample, these two aspects of self-referential processing jointly predicted self-reported internalizing problems. Specifically, self-evaluations were strongly and inversely associated with internalizing problems but only for children with relatively high SRM. These findings suggest that the salience of the self influences the extent to which affective self-evaluations impact emotional functioning for youth both with and without ASD. Implications for basic (e.g., developmental) and translational (e.g., intervention) research are discussed. En ligne : http://dx.doi.org/10.1002/aur.1727 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307

Parent-delivered early intervention in infants at risk for ASD: Effects on electrophysiological and habituation measures of social attention / Emily J. H. JONES in Autism Research, 10-5 (May 2017)  

Public ISBD [article]  inAutism Research > 10-5 (May 2017) . - p.961-972 Titre : Parent-delivered early intervention in infants at risk for ASD: Effects on electrophysiological and habituation measures of social attention Type de document : Texte imprimé et/ou numérique Auteurs : Emily J. H. JONES, Auteur ; Geraldine DAWSON, Auteur ; Jean KELLY, Auteur ; Annette ESTES, Auteur ; Sara JANE WEBB, Auteur Article en page(s) : p.961-972 Langues : Anglais (eng) Mots-clés : autism  ASD  infant  high-risk  neurocognitive  social attention  promoting first relationships Index. décimale : PER Périodiques Résumé : Prospective longitudinal studies of infants with older siblings with autism spectrum disorder (ASD) have indicated that differences in the neurocognitive systems underlying social attention may emerge prior to the child meeting ASD diagnostic criteria. Thus, targeting social attention with early intervention might have the potential to alter developmental trajectories for infants at high risk for ASD. Electrophysiological and habituation measures of social attention were collected at 6, 12, and 18 months in a group of high-risk infant siblings of children with ASD (N?=?33). Between 9 and 11 months of age, infant siblings received a parent-delivered intervention, promoting first relationships (PFR), (n?=?19) or on-going assessment without intervention (n?=?14). PFR has been previously shown to increase parental responsivity to infant social communicative cues and infant contingent responding. Compared to infants who only received assessment and monitoring, infants who received the intervention showed improvements in neurocognitive metrics of social attention, as reflected in a greater reduction in habituation times to face versus object stimuli between 6 and 12 months, maintained at 18 months; a greater increase in frontal EEG theta power between 6 and 12 months; and a more comparable P400 response to faces and objects at 12 months. The high-risk infants who received the intervention showed a pattern of responses that appeared closer to the normative responses of two groups of age-matched low-risk control participants. Though replication is necessary, these results suggest that early parent-mediated intervention has the potential to impact the brain systems underpinning social attention in infants at familial risk for ASD. En ligne : http://dx.doi.org/10.1002/aur.1754 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 [article] Parent-delivered early intervention in infants at risk for ASD: Effects on electrophysiological and habituation measures of social attention [Texte imprimé et/ou numérique] / Emily J. H. JONES, Auteur ; Geraldine DAWSON, Auteur ; Jean KELLY, Auteur ; Annette ESTES, Auteur ; Sara JANE WEBB, Auteur . - p.961-972. Langues : Anglais (eng) in Autism Research > 10-5 (May 2017) . - p.961-972 Mots-clés : autism  ASD  infant  high-risk  neurocognitive  social attention  promoting first relationships Index. décimale : PER Périodiques Résumé : Prospective longitudinal studies of infants with older siblings with autism spectrum disorder (ASD) have indicated that differences in the neurocognitive systems underlying social attention may emerge prior to the child meeting ASD diagnostic criteria. Thus, targeting social attention with early intervention might have the potential to alter developmental trajectories for infants at high risk for ASD. Electrophysiological and habituation measures of social attention were collected at 6, 12, and 18 months in a group of high-risk infant siblings of children with ASD (N?=?33). Between 9 and 11 months of age, infant siblings received a parent-delivered intervention, promoting first relationships (PFR), (n?=?19) or on-going assessment without intervention (n?=?14). PFR has been previously shown to increase parental responsivity to infant social communicative cues and infant contingent responding. Compared to infants who only received assessment and monitoring, infants who received the intervention showed improvements in neurocognitive metrics of social attention, as reflected in a greater reduction in habituation times to face versus object stimuli between 6 and 12 months, maintained at 18 months; a greater increase in frontal EEG theta power between 6 and 12 months; and a more comparable P400 response to faces and objects at 12 months. The high-risk infants who received the intervention showed a pattern of responses that appeared closer to the normative responses of two groups of age-matched low-risk control participants. Though replication is necessary, these results suggest that early parent-mediated intervention has the potential to impact the brain systems underpinning social attention in infants at familial risk for ASD. En ligne : http://dx.doi.org/10.1002/aur.1754 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307

Participation in recreational activities buffers the impact of perceived stress on quality of life in adults with autism spectrum disorder / Lauren BISHOP-FITZPATRICK in Autism Research, 10-5 (May 2017)  

Public ISBD [article]  inAutism Research > 10-5 (May 2017) . - p.973-982 Titre : Participation in recreational activities buffers the impact of perceived stress on quality of life in adults with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Lauren BISHOP-FITZPATRICK, Auteur ; Leann S. DAWALT, Auteur ; Jan S. GREENBERG, Auteur ; Marsha R. MAILICK, Auteur Article en page(s) : p.973-982 Langues : Anglais (eng) Mots-clés : recreational and social activities  perceived stress  quality of life  adults with ASD Index. décimale : PER Périodiques Résumé : As the number of adults with autism spectrum disorder (ASD) grows, the need to identify modifiable correlates of positive outcomes and quality of life (QoL) gains in importance. Research indicates that perceived stress is significantly correlated with QoL in adults with ASD. Studies in the general population of individuals without disabilities indicate that greater participation in social and recreational activities may lessen the negative impact of perceived stress on well-being, and this association may also hold among adults with ASD. We hypothesized that: (1) perceived stress would be negatively associated with QoL; and (2) higher frequency of participation in social activities and recreational activities would moderate the relationship between perceived stress and QoL. We used data collected from 60 adults with ASD aged 24–55 and their mothers to address our hypotheses. Findings indicate that adults with ASD with higher perceived stress are likely to have poorer QoL. Furthermore, greater participation in recreational activities buffers the impact of perceived stress on QoL, but no buffering effect was observed for participation in social activities. These findings suggest that interventions and services that provide supports and opportunities for participation in recreational activities may help adults with ASD manage their stress and lead to better QoL. En ligne : http://dx.doi.org/10.1002/aur.1753 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 [article] Participation in recreational activities buffers the impact of perceived stress on quality of life in adults with autism spectrum disorder [Texte imprimé et/ou numérique] / Lauren BISHOP-FITZPATRICK, Auteur ; Leann S. DAWALT, Auteur ; Jan S. GREENBERG, Auteur ; Marsha R. MAILICK, Auteur . - p.973-982. Langues : Anglais (eng) in Autism Research > 10-5 (May 2017) . - p.973-982 Mots-clés : recreational and social activities  perceived stress  quality of life  adults with ASD Index. décimale : PER Périodiques Résumé : As the number of adults with autism spectrum disorder (ASD) grows, the need to identify modifiable correlates of positive outcomes and quality of life (QoL) gains in importance. Research indicates that perceived stress is significantly correlated with QoL in adults with ASD. Studies in the general population of individuals without disabilities indicate that greater participation in social and recreational activities may lessen the negative impact of perceived stress on well-being, and this association may also hold among adults with ASD. We hypothesized that: (1) perceived stress would be negatively associated with QoL; and (2) higher frequency of participation in social activities and recreational activities would moderate the relationship between perceived stress and QoL. We used data collected from 60 adults with ASD aged 24–55 and their mothers to address our hypotheses. Findings indicate that adults with ASD with higher perceived stress are likely to have poorer QoL. Furthermore, greater participation in recreational activities buffers the impact of perceived stress on QoL, but no buffering effect was observed for participation in social activities. These findings suggest that interventions and services that provide supports and opportunities for participation in recreational activities may help adults with ASD manage their stress and lead to better QoL. En ligne : http://dx.doi.org/10.1002/aur.1753 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307

The impact of caregiver-mediated JASPER on child restricted and repetitive behaviors and caregiver responses / Clare HARROP in Autism Research, 10-5 (May 2017)  

Public ISBD [article]  inAutism Research > 10-5 (May 2017) . - p.983-992 Titre : The impact of caregiver-mediated JASPER on child restricted and repetitive behaviors and caregiver responses Type de document : Texte imprimé et/ou numérique Auteurs : Clare HARROP, Auteur ; Amanda GULSRUD, Auteur ; Wendy SHIH, Auteur ; Lilit HOVSEPYAN, Auteur ; Connie KASARI, Auteur Article en page(s) : p.983-992 Langues : Anglais (eng) Mots-clés : intervention early  restricted/repetitive behaviors  parent training  intervention – behavioral Index. décimale : PER Périodiques Résumé : Restricted and repetitive behaviors (RRBs) are a core feature of autism spectrum disorder (ASD). Compared to the social-communication impairments, we know considerably less about why children engage in RRBs and if and how to intervene with these behaviors. As a result, early intervention has typically focused on social-communication. In this study, we were interested in understanding how child RRBs changed following an intervention targeting social-communication behaviors and if caregiver training changed how they responded to their child's RRBs. Eighty-six toddlers with ASD and their caregivers received one of two interventions: caregivers were either actively coached while playing with their child (JASPER) or attended information sessions about ASD. On three different occasions (when they entered the study, following 10 weeks of intervention and 6-months after) caregivers were filmed playing with their child. From these recordings, we coded child RRBs and caregiver responses to these behaviors. Child RRBs remained relatively stable following intervention in both groups, but increased when the children returned at 6-months. Caregivers who received one-on-one coaching (JASPER) responded to a greater number of their child's RRBs and their responses were rated as more successful. Our study showed that a short-term social-communication intervention delivered through caregivers had “spillover effects” on how they also responded to their child's RRBs. Interventions targeting social-communication behaviors should also examine how these treatments affect child RRBs and how caregiver responses to these behaviors may change following training. En ligne : http://dx.doi.org/10.1002/aur.1732 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 [article] The impact of caregiver-mediated JASPER on child restricted and repetitive behaviors and caregiver responses [Texte imprimé et/ou numérique] / Clare HARROP, Auteur ; Amanda GULSRUD, Auteur ; Wendy SHIH, Auteur ; Lilit HOVSEPYAN, Auteur ; Connie KASARI, Auteur . - p.983-992. Langues : Anglais (eng) in Autism Research > 10-5 (May 2017) . - p.983-992 Mots-clés : intervention early  restricted/repetitive behaviors  parent training  intervention – behavioral Index. décimale : PER Périodiques Résumé : Restricted and repetitive behaviors (RRBs) are a core feature of autism spectrum disorder (ASD). Compared to the social-communication impairments, we know considerably less about why children engage in RRBs and if and how to intervene with these behaviors. As a result, early intervention has typically focused on social-communication. In this study, we were interested in understanding how child RRBs changed following an intervention targeting social-communication behaviors and if caregiver training changed how they responded to their child's RRBs. Eighty-six toddlers with ASD and their caregivers received one of two interventions: caregivers were either actively coached while playing with their child (JASPER) or attended information sessions about ASD. On three different occasions (when they entered the study, following 10 weeks of intervention and 6-months after) caregivers were filmed playing with their child. From these recordings, we coded child RRBs and caregiver responses to these behaviors. Child RRBs remained relatively stable following intervention in both groups, but increased when the children returned at 6-months. Caregivers who received one-on-one coaching (JASPER) responded to a greater number of their child's RRBs and their responses were rated as more successful. Our study showed that a short-term social-communication intervention delivered through caregivers had “spillover effects” on how they also responded to their child's RRBs. Interventions targeting social-communication behaviors should also examine how these treatments affect child RRBs and how caregiver responses to these behaviors may change following training. En ligne : http://dx.doi.org/10.1002/aur.1732 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307

Unique effects of The transporters animated series and of parental support on emotion recognition skills of children with ASD: Results of a randomized controlled trial / Tali GEV in Autism Research, 10-5 (May 2017)  

Public ISBD [article]  inAutism Research > 10-5 (May 2017) . - p.993-1003 Titre : Unique effects of The transporters animated series and of parental support on emotion recognition skills of children with ASD: Results of a randomized controlled trial Type de document : Texte imprimé et/ou numérique Auteurs : Tali GEV, Auteur ; Ruthie ROSENAN, Auteur ; Ofer GOLAN, Auteur Article en page(s) : p.993-1003 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  emotion recognition  randomized controlled trial  technological intervention  parental support Index. décimale : PER Périodiques Résumé : Emotion recognition (ER) and understanding deficits are characteristic of autism spectrum disorder (ASD). The Transporters (TT) animated series has shown promising results in teaching children with ASD to recognize emotions, with mixed findings about generalization and maintenance of effects. This study aimed to evaluate the unique role of TT and of parental support in the acquisition, generalization, and maintenance of acquired ER skills in children with ASD. 77 Israeli children with high functioning ASD, aged 4–7 were randomly assigned into four groups according to a 2 × 2 design of the factors Series (TT, control series) and Parental Support (with/without). Thirty typically developing children, matched to the ASD groups on mental age, were tested with no intervention. Participants' ER (on three generalization levels) and emotional vocabulary (EV) were tested pre and post 8 weeks of intervention, and at 3 months' follow-up. Compared to the control series, watching TT significantly improved children's ER skills at all generalization levels, with good skill maintenance. All groups improved equally on EV. The amount of parental support given, in the groups that had received it, contributed to the generalization and maintenance of ER skills. Autism severity negatively correlated with ER improvement. The current study provides evidence to the unique role of TT in ER skill acquisition, generalization, and maintenance in children with high functioning ASD. In addition, this study provides evidence for a successful cultural adaptation of TT to a non-English speaking culture. En ligne : http://dx.doi.org/10.1002/aur.1717 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 [article] Unique effects of The transporters animated series and of parental support on emotion recognition skills of children with ASD: Results of a randomized controlled trial [Texte imprimé et/ou numérique] / Tali GEV, Auteur ; Ruthie ROSENAN, Auteur ; Ofer GOLAN, Auteur . - p.993-1003. Langues : Anglais (eng) in Autism Research > 10-5 (May 2017) . - p.993-1003 Mots-clés : autism spectrum disorder  emotion recognition  randomized controlled trial  technological intervention  parental support Index. décimale : PER Périodiques Résumé : Emotion recognition (ER) and understanding deficits are characteristic of autism spectrum disorder (ASD). The Transporters (TT) animated series has shown promising results in teaching children with ASD to recognize emotions, with mixed findings about generalization and maintenance of effects. This study aimed to evaluate the unique role of TT and of parental support in the acquisition, generalization, and maintenance of acquired ER skills in children with ASD. 77 Israeli children with high functioning ASD, aged 4–7 were randomly assigned into four groups according to a 2 × 2 design of the factors Series (TT, control series) and Parental Support (with/without). Thirty typically developing children, matched to the ASD groups on mental age, were tested with no intervention. Participants' ER (on three generalization levels) and emotional vocabulary (EV) were tested pre and post 8 weeks of intervention, and at 3 months' follow-up. Compared to the control series, watching TT significantly improved children's ER skills at all generalization levels, with good skill maintenance. All groups improved equally on EV. The amount of parental support given, in the groups that had received it, contributed to the generalization and maintenance of ER skills. Autism severity negatively correlated with ER improvement. The current study provides evidence to the unique role of TT in ER skill acquisition, generalization, and maintenance in children with high functioning ASD. In addition, this study provides evidence for a successful cultural adaptation of TT to a non-English speaking culture. En ligne : http://dx.doi.org/10.1002/aur.1717 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307

Scientific Summaries for Families with ASD in Autism Research, 10-5 (May 2017)  

Public ISBD [article]  inAutism Research > 10-5 (May 2017) . - p.1004-1014 Titre : Scientific Summaries for Families with ASD Type de document : Texte imprimé et/ou numérique Article en page(s) : p.1004-1014 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1815 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 [article] Scientific Summaries for Families with ASD [Texte imprimé et/ou numérique] . - p.1004-1014. Langues : Anglais (eng) in Autism Research > 10-5 (May 2017) . - p.1004-1014 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1815 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307

International Society for Autism Research News www.autism-insar.org in Autism Research, 10-5 (May 2017)  

Public ISBD [article]  inAutism Research > 10-5 (May 2017) . - p.1015-1016 Titre : International Society for Autism Research News www.autism-insar.org Type de document : Texte imprimé et/ou numérique Article en page(s) : p.1015-1016 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1816 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 [article] International Society for Autism Research News www.autism-insar.org [Texte imprimé et/ou numérique] . - p.1015-1016. Langues : Anglais (eng) in Autism Research > 10-5 (May 2017) . - p.1015-1016 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1816 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307