Meta-analysis of neuropsychological measures of executive functioning in children and adolescents with high-functioning autism spectrum disorder / Chun Lun Eric LAI in Autism Research, 10-5 (May 2017)  

Public ISBD [article]  inAutism Research > 10-5 (May 2017) . - p.911-939 Titre : Meta-analysis of neuropsychological measures of executive functioning in children and adolescents with high-functioning autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Chun Lun Eric LAI, Auteur ; Zoe LAU, Auteur ; Simon S. Y. LUI, Auteur ; Eugenia LOK, Auteur ; Venus TAM, Auteur ; Quinney CHAN, Auteur ; Koi Man CHENG, Auteur ; Siu Man LAM, Auteur ; Eric F. C. CHEUNG, Auteur Article en page(s) : p.911-939 Langues : Anglais (eng) Mots-clés : executive function  high-functioning autism spectrum disorder  Asperger's syndrome  meta-analysis Index. décimale : PER Périodiques Résumé : Existing literature on the profile of executive dysfunction in autism spectrum disorder showed inconsistent results. Age, comorbid attention-deficit/hyperactivity disorder (ADHD) and cognitive abilities appeared to play a role in confounding the picture. Previous meta-analyses have focused on a few components of executive functions. This meta-analysis attempted to delineate the profile of deficit in several components of executive functioning in children and adolescents with high-functioning autism spectrum disorder (HFASD). Ninety-eight English published case-control studies comparing children and adolescents with HFASD with typically developing controls using well-known neuropsychological measures to assess executive functions were included. Results showed that children and adolescents with HFASD were moderately impaired in verbal working memory (g?=?0.67), spatial working memory (g?=?0.58), flexibility (g?=?0.59), planning (g?=?0.62), and generativity (g?=?0.60) except for inhibition (g?=?0.41). Subgroup analysis showed that impairments were still significant for flexibility (g?=?0.57–0.61), generativity (g?=?0.52–0.68), and working memory (g?=?0.49–0.56) in a sample of autism spectrum disorder (ASD) subjects without comorbid ADHD or when the cognitive abilities of the ASD group and the control group were comparable. This meta-analysis confirmed the presence of executive dysfunction in children and adolescents with HFASD. These deficits are not solely accounted for by the effect of comorbid ADHD and the general cognitive abilities. Our results support the executive dysfunction hypothesis and contribute to the clinical understanding and possible development of interventions to alleviate these deficits in children and adolescents with HFASD. En ligne : http://dx.doi.org/10.1002/aur.1723 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 [article] Meta-analysis of neuropsychological measures of executive functioning in children and adolescents with high-functioning autism spectrum disorder [Texte imprimé et/ou numérique] / Chun Lun Eric LAI, Auteur ; Zoe LAU, Auteur ; Simon S. Y. LUI, Auteur ; Eugenia LOK, Auteur ; Venus TAM, Auteur ; Quinney CHAN, Auteur ; Koi Man CHENG, Auteur ; Siu Man LAM, Auteur ; Eric F. C. CHEUNG, Auteur . - p.911-939. Langues : Anglais (eng) in Autism Research > 10-5 (May 2017) . - p.911-939 Mots-clés : executive function  high-functioning autism spectrum disorder  Asperger's syndrome  meta-analysis Index. décimale : PER Périodiques Résumé : Existing literature on the profile of executive dysfunction in autism spectrum disorder showed inconsistent results. Age, comorbid attention-deficit/hyperactivity disorder (ADHD) and cognitive abilities appeared to play a role in confounding the picture. Previous meta-analyses have focused on a few components of executive functions. This meta-analysis attempted to delineate the profile of deficit in several components of executive functioning in children and adolescents with high-functioning autism spectrum disorder (HFASD). Ninety-eight English published case-control studies comparing children and adolescents with HFASD with typically developing controls using well-known neuropsychological measures to assess executive functions were included. Results showed that children and adolescents with HFASD were moderately impaired in verbal working memory (g?=?0.67), spatial working memory (g?=?0.58), flexibility (g?=?0.59), planning (g?=?0.62), and generativity (g?=?0.60) except for inhibition (g?=?0.41). Subgroup analysis showed that impairments were still significant for flexibility (g?=?0.57–0.61), generativity (g?=?0.52–0.68), and working memory (g?=?0.49–0.56) in a sample of autism spectrum disorder (ASD) subjects without comorbid ADHD or when the cognitive abilities of the ASD group and the control group were comparable. This meta-analysis confirmed the presence of executive dysfunction in children and adolescents with HFASD. These deficits are not solely accounted for by the effect of comorbid ADHD and the general cognitive abilities. Our results support the executive dysfunction hypothesis and contribute to the clinical understanding and possible development of interventions to alleviate these deficits in children and adolescents with HFASD. En ligne : http://dx.doi.org/10.1002/aur.1723 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307

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