Are schizophrenia, autistic, and obsessive spectrum disorders dissociable on the basis of neuroimaging morphological findings?: A voxel-based meta-analysis / Franco CAUDA in Autism Research, 10-6 (June 2017)  

Public ISBD [article]  inAutism Research > 10-6 (June 2017) . - p.1079-1095 Titre : Are schizophrenia, autistic, and obsessive spectrum disorders dissociable on the basis of neuroimaging morphological findings?: A voxel-based meta-analysis Type de document : Texte imprimé et/ou numérique Auteurs : Franco CAUDA, Auteur ; Tommaso COSTA, Auteur ; Andrea NANI, Auteur ; Luciano FAVA, Auteur ; Sara PALERMO, Auteur ; Francesca BIANCO, Auteur ; Sergio DUCA, Auteur ; Karina TATU, Auteur ; Roberto KELLER, Auteur Article en page(s) : p.1079-1095 Langues : Anglais (eng) Mots-clés : brain alterations  neuroimaging  schizophrenia spectrum disorder  autism spectrum disorder  obsessive-compulsive spectrum disorder  psychiatric categories  core alterations Index. décimale : PER Périodiques Résumé : Schizophrenia spectrum disorder (SCZD), autism spectrum disorder (ASD), and obsessive-compulsive spectrum disorder (OCSD) are considered as three separate psychiatric conditions with, supposedly, different brain alterations patterns. From a neuroimaging perspective, this meta-analytic study aimed to address whether this nosographical differentiation is actually supported by different brain patterns of gray matter (GM) or white matter (WM) morphological alterations. We explored two possibilities: (a) to find out whether GM alterations are specific for SCZD, ASD, and OCSD; and (b) to associate the identified brain alteration patterns with cognitive dysfunctions by means of an analysis of lesion decoding. Our analysis reveals that these psychiatric spectra do not present clear distinctive patterns of alterations; rather, they all tend to be distributed in two alteration clusters. Cluster 1, which is more specific for SCZD, includes the anterior insular, anterior cingulate cortex, ventromedial prefrontal cortex, and frontopolar areas, which are parts of the cognitive control system. Cluster 2, which is more specific for OCSD, presents occipital, temporal, and parietal alteration patterns with the involvement of sensorimotor, premotor, visual, and lingual areas, thus forming a network that is more associated with the auditory-visual, auditory, premotor visual somatic functions. In turn, ASD appears to be uniformly distributed in the two clusters. The three spectra share a significant set of alterations. Our new approach promises to provide insight into the understanding of psychiatric conditions under the aspect of a common neurobiological substrate, possibly related to neuroinflammation during brain development. En ligne : http://dx.doi.org/10.1002/aur.1759 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=309 [article] Are schizophrenia, autistic, and obsessive spectrum disorders dissociable on the basis of neuroimaging morphological findings?: A voxel-based meta-analysis [Texte imprimé et/ou numérique] / Franco CAUDA, Auteur ; Tommaso COSTA, Auteur ; Andrea NANI, Auteur ; Luciano FAVA, Auteur ; Sara PALERMO, Auteur ; Francesca BIANCO, Auteur ; Sergio DUCA, Auteur ; Karina TATU, Auteur ; Roberto KELLER, Auteur . - p.1079-1095. Langues : Anglais (eng) in Autism Research > 10-6 (June 2017) . - p.1079-1095 Mots-clés : brain alterations  neuroimaging  schizophrenia spectrum disorder  autism spectrum disorder  obsessive-compulsive spectrum disorder  psychiatric categories  core alterations Index. décimale : PER Périodiques Résumé : Schizophrenia spectrum disorder (SCZD), autism spectrum disorder (ASD), and obsessive-compulsive spectrum disorder (OCSD) are considered as three separate psychiatric conditions with, supposedly, different brain alterations patterns. From a neuroimaging perspective, this meta-analytic study aimed to address whether this nosographical differentiation is actually supported by different brain patterns of gray matter (GM) or white matter (WM) morphological alterations. We explored two possibilities: (a) to find out whether GM alterations are specific for SCZD, ASD, and OCSD; and (b) to associate the identified brain alteration patterns with cognitive dysfunctions by means of an analysis of lesion decoding. Our analysis reveals that these psychiatric spectra do not present clear distinctive patterns of alterations; rather, they all tend to be distributed in two alteration clusters. Cluster 1, which is more specific for SCZD, includes the anterior insular, anterior cingulate cortex, ventromedial prefrontal cortex, and frontopolar areas, which are parts of the cognitive control system. Cluster 2, which is more specific for OCSD, presents occipital, temporal, and parietal alteration patterns with the involvement of sensorimotor, premotor, visual, and lingual areas, thus forming a network that is more associated with the auditory-visual, auditory, premotor visual somatic functions. In turn, ASD appears to be uniformly distributed in the two clusters. The three spectra share a significant set of alterations. Our new approach promises to provide insight into the understanding of psychiatric conditions under the aspect of a common neurobiological substrate, possibly related to neuroinflammation during brain development. En ligne : http://dx.doi.org/10.1002/aur.1759 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=309

Diagnostic Characteristics of Psychosis and Autism Spectrum Disorder in Adolescence and Adulthood. A Case Series / Roberto KELLER in Autism - Open Access, 6-1 ([01/01/2016])  

Public ISBD [article]  inAutism - Open Access > 6-1 [01/01/2016] . - 4 p. Titre : Diagnostic Characteristics of Psychosis and Autism Spectrum Disorder in Adolescence and Adulthood. A Case Series Type de document : Texte imprimé et/ou numérique Auteurs : Roberto KELLER, Auteur ; Alessandro PIEDIMONTE, Auteur ; Francesca BIANCO, Auteur ; Stefania BARI, Auteur ; Franco CAUDA, Auteur Article en page(s) : 4 p. Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : https://dx.doi.org/10.4172/2165-7890.1000159 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409 [article] Diagnostic Characteristics of Psychosis and Autism Spectrum Disorder in Adolescence and Adulthood. A Case Series [Texte imprimé et/ou numérique] / Roberto KELLER, Auteur ; Alessandro PIEDIMONTE, Auteur ; Francesca BIANCO, Auteur ; Stefania BARI, Auteur ; Franco CAUDA, Auteur . - 4 p. Langues : Anglais (eng) in Autism - Open Access > 6-1 [01/01/2016] . - 4 p. Index. décimale : PER Périodiques En ligne : https://dx.doi.org/10.4172/2165-7890.1000159 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409

Dissociation between executed and imagined bimanual movements in autism spectrum conditions / Alessandro PIEDIMONTE in Autism Research, 11-2 (February 2018)  

Public ISBD [article]  inAutism Research > 11-2 (February 2018) . - p.376-384 Titre : Dissociation between executed and imagined bimanual movements in autism spectrum conditions Type de document : Texte imprimé et/ou numérique Auteurs : Alessandro PIEDIMONTE, Auteur ; Massimiliano CONSON, Auteur ; Alessandro FROLLI, Auteur ; Stefania BARI, Auteur ; Francesco Della GATTA, Auteur ; Marco RABUFFETTI, Auteur ; Roberto KELLER, Auteur ; Anna BERTI, Auteur ; Francesca GARBARINI, Auteur Année de publication : 2018 Article en page(s) : p.376-384 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Autism spectrum conditions (ASC) are characterized by social?communicative deficits and repetitive stereotyped behaviors. Altered motor coordination is also observed and a dysfunction of motor imagery has been recently reported on implicit tasks. However, no information on explicit motor imagery abilities is available in ASC. Here, we employed a spatial bimanual task to concurrently assess motor coordination and explicit motor imagery in autism. A secondary objective of the study was to evaluate these abilities across two populations of ASC, namely adolescents and adults with ASC. To this aim, we took advantage of the circles?lines task in which where participants were asked to continuously draw: right hand lines (unimanual condition); right hand lines and left hand circles (bimanual condition); right hand lines while imagining to draw left hand circles (imagery condition). For each participant, an Ovalization Index (OI) was calculated as a deviation of the right hand drawing trajectory from an absolute vertical axis. Results showed a significant and similar coupling effect in the bimanual condition (i.e., a significant increase of the OI values with respect to the unimanual condition) in both controls and ASC participants. On the contrary, in the imagery condition, a significant coupling effect was found only in controls. Furthermore, adult controls showed a significantly higher imagery coupling effect in comparison to all the other groups. These results demonstrate that atypical motor imagery processes in ASC are not limited to implicit tasks and suggest that development of neural structures involved in motor imagery are immature in ASC. Autism Res 2018, 11: 376–384. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary Autism spectrum conditions (ASC) are characterized by social?communicative and motor coordination difficulties but in many cases also by an impaired capability to imagine movements. In this study we found that while two handed coordination in ASC can be developed as well as in typically developed persons, the development of motor imagery could still be immature in ASC, leading to difficulties in imagining, understanding as well as programming and coordinating complex movements. En ligne : https://doi.org/10.1002/aur.1902 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=334 [article] Dissociation between executed and imagined bimanual movements in autism spectrum conditions [Texte imprimé et/ou numérique] / Alessandro PIEDIMONTE, Auteur ; Massimiliano CONSON, Auteur ; Alessandro FROLLI, Auteur ; Stefania BARI, Auteur ; Francesco Della GATTA, Auteur ; Marco RABUFFETTI, Auteur ; Roberto KELLER, Auteur ; Anna BERTI, Auteur ; Francesca GARBARINI, Auteur . - 2018 . - p.376-384. Langues : Anglais (eng) in Autism Research > 11-2 (February 2018) . - p.376-384 Index. décimale : PER Périodiques Résumé : Autism spectrum conditions (ASC) are characterized by social?communicative deficits and repetitive stereotyped behaviors. Altered motor coordination is also observed and a dysfunction of motor imagery has been recently reported on implicit tasks. However, no information on explicit motor imagery abilities is available in ASC. Here, we employed a spatial bimanual task to concurrently assess motor coordination and explicit motor imagery in autism. A secondary objective of the study was to evaluate these abilities across two populations of ASC, namely adolescents and adults with ASC. To this aim, we took advantage of the circles?lines task in which where participants were asked to continuously draw: right hand lines (unimanual condition); right hand lines and left hand circles (bimanual condition); right hand lines while imagining to draw left hand circles (imagery condition). For each participant, an Ovalization Index (OI) was calculated as a deviation of the right hand drawing trajectory from an absolute vertical axis. Results showed a significant and similar coupling effect in the bimanual condition (i.e., a significant increase of the OI values with respect to the unimanual condition) in both controls and ASC participants. On the contrary, in the imagery condition, a significant coupling effect was found only in controls. Furthermore, adult controls showed a significantly higher imagery coupling effect in comparison to all the other groups. These results demonstrate that atypical motor imagery processes in ASC are not limited to implicit tasks and suggest that development of neural structures involved in motor imagery are immature in ASC. Autism Res 2018, 11: 376–384. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary Autism spectrum conditions (ASC) are characterized by social?communicative and motor coordination difficulties but in many cases also by an impaired capability to imagine movements. In this study we found that while two handed coordination in ASC can be developed as well as in typically developed persons, the development of motor imagery could still be immature in ASC, leading to difficulties in imagining, understanding as well as programming and coordinating complex movements. En ligne : https://doi.org/10.1002/aur.1902 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=334

Investigating the impact of disposable surgical face-masks on face identity and emotion recognition in adults with autism spectrum disorder / Martina VENTURA in Autism Research, 16-5 (May 2023)  

Public ISBD [article]  inAutism Research > 16-5 (May 2023) . - p.1063-1077 Titre : Investigating the impact of disposable surgical face-masks on face identity and emotion recognition in adults with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Martina VENTURA, Auteur ; Fiorita INNAMORATO, Auteur ; Annalisa PALMISANO, Auteur ; Giovanni CICINELLI, Auteur ; Emanuela NOBILE, Auteur ; Valerio MANIPPA, Auteur ; Roberto KELLER, Auteur ; Davide RIVOLTA, Auteur Article en page(s) : p.1063-1077 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract With the outburst of the COVID-19 pandemic, disposable surgical face-masks (DSFMs) have been widely adopted as a preventive measure. DSFMs hide the bottom half of the face, thus making identity and emotion recognition very challenging, both in typical and atypical populations. Individuals with autism spectrum disorder (ASD) are often characterized by face processing deficits; thus, DSFMs could pose even a greater challenge for this population compared to typically development (TD) individuals. In this study, 48 ASDs of level 1 and 110 TDs underwent two tasks: (i) the Old-new face memory task, which assesses whether DSFMs affect face learning and recognition, and (ii) the Facial affect task, which explores DSFMs' effect on emotion recognition. Results from the former show that, when faces were learned without DSFMs, identity recognition of masked faces decreased for both ASDs and TDs. In contrast, when faces were first learned with DSFMs, TDs but not ASDs benefited from a ''context congruence'' effect, that is, faces wearing DSFMs were better recognized if learned wearing DSFMs. In addition, results from the Facial affect task show that DSFMs negatively impacted specific emotion recognition in both TDs and ASDs, although differentially between the two groups. DSFMs negatively affected disgust, happiness and sadness recognition in TDs; in contrast, ASDs performance decreased for every emotion except anger. Overall, our study demonstrates a general, although different, disruptive effect on identity and emotion recognition both in ASD and TD population. En ligne : http://dx.doi.org/https://doi.org/10.1002/aur.2922 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=503 [article] Investigating the impact of disposable surgical face-masks on face identity and emotion recognition in adults with autism spectrum disorder [Texte imprimé et/ou numérique] / Martina VENTURA, Auteur ; Fiorita INNAMORATO, Auteur ; Annalisa PALMISANO, Auteur ; Giovanni CICINELLI, Auteur ; Emanuela NOBILE, Auteur ; Valerio MANIPPA, Auteur ; Roberto KELLER, Auteur ; Davide RIVOLTA, Auteur . - p.1063-1077. Langues : Anglais (eng) in Autism Research > 16-5 (May 2023) . - p.1063-1077 Index. décimale : PER Périodiques Résumé : Abstract With the outburst of the COVID-19 pandemic, disposable surgical face-masks (DSFMs) have been widely adopted as a preventive measure. DSFMs hide the bottom half of the face, thus making identity and emotion recognition very challenging, both in typical and atypical populations. Individuals with autism spectrum disorder (ASD) are often characterized by face processing deficits; thus, DSFMs could pose even a greater challenge for this population compared to typically development (TD) individuals. In this study, 48 ASDs of level 1 and 110 TDs underwent two tasks: (i) the Old-new face memory task, which assesses whether DSFMs affect face learning and recognition, and (ii) the Facial affect task, which explores DSFMs' effect on emotion recognition. Results from the former show that, when faces were learned without DSFMs, identity recognition of masked faces decreased for both ASDs and TDs. In contrast, when faces were first learned with DSFMs, TDs but not ASDs benefited from a ''context congruence'' effect, that is, faces wearing DSFMs were better recognized if learned wearing DSFMs. In addition, results from the Facial affect task show that DSFMs negatively impacted specific emotion recognition in both TDs and ASDs, although differentially between the two groups. DSFMs negatively affected disgust, happiness and sadness recognition in TDs; in contrast, ASDs performance decreased for every emotion except anger. Overall, our study demonstrates a general, although different, disruptive effect on identity and emotion recognition both in ASD and TD population. En ligne : http://dx.doi.org/https://doi.org/10.1002/aur.2922 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=503

Misdiagnosis of High Function Autism Spectrum Disorders in Adults: An Italian Case Series / Candida Claudia LUCIANO in Autism - Open Access, 4-2 ([01/03/2014])  

Public ISBD [article]  inAutism - Open Access > 4-2 [01/03/2014] . - 8 p. Titre : Misdiagnosis of High Function Autism Spectrum Disorders in Adults: An Italian Case Series Type de document : Texte imprimé et/ou numérique Auteurs : Candida Claudia LUCIANO, Auteur ; Roberto KELLER, Auteur ; Pierluigi POLITI, Auteur ; Eugenio AGUGLIA, Auteur ; Francesca MAGNANO, Auteur ; Lorenzo BURTI, Auteur ; Francesca MURARO, Auteur ; Angela ARESI, Auteur ; Stefano DAMIANI, Auteur ; Domenico BERARDI, Auteur Article en page(s) : 8 p. Langues : Anglais (eng) Mots-clés : Autism  Pervasive development disorder  High function  Adulthood  Misdiagnosis Index. décimale : PER Périodiques Résumé : High Function (HF) Autism Spectrum Disorders (ASD) in adulthood is highly prevalent but insufficiently recognized. In Italy, in particular, awareness of this condition is still insufficient and many psychiatrists have no cases of HF ASD to mention. Adult patients with HF ASD come to the attention of Mental Health Services complaining of difficulties within their social context and interpersonal relationships. Objectives: Describe emblematic clinical examples of misdiagnosed HF ASD to understand reasons that conducted to misdiagnosis. Procedure: We contact five specialized Italian Center in diagnosis of ASD. Each center have to describe two or three emblematic cases of adult patient with diagnosis of ASD validated by ADOS-4 but referred to clinicians with another diagnosis, discussing about possible reasons of misdiagnosis. Sample and Results: We have collected 12 case reports (2 from Bologna center, 3 from Torino center, 3 from Pavia center, 2 from Verona center and 2 from Catania center) of adult HF ASD previously misdiagnosed. These cases shows important similarity across centers and highlight that if are taken into account only problems or symptoms that conduct patients to ask help, cases can easily suggest other psychiatric or personality disorders. Diagnosis becomes clear only after considering all the clinical features and a detailed developmental history. Conclusion: Psychiatrists who have insufficient experience of ASD may overlook some symptoms of the overall clinical picture and misdiagnose ASD as personality disorders, schizophrenia, phobia or even as a non-psychiatric condition, so is hopeful for future increased knowledge about HF ASD in adulthood. En ligne : https://dx.doi.org/10.4172/2165-7890.1000131 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409 [article] Misdiagnosis of High Function Autism Spectrum Disorders in Adults: An Italian Case Series [Texte imprimé et/ou numérique] / Candida Claudia LUCIANO, Auteur ; Roberto KELLER, Auteur ; Pierluigi POLITI, Auteur ; Eugenio AGUGLIA, Auteur ; Francesca MAGNANO, Auteur ; Lorenzo BURTI, Auteur ; Francesca MURARO, Auteur ; Angela ARESI, Auteur ; Stefano DAMIANI, Auteur ; Domenico BERARDI, Auteur . - 8 p. Langues : Anglais (eng) in Autism - Open Access > 4-2 [01/03/2014] . - 8 p. Mots-clés : Autism  Pervasive development disorder  High function  Adulthood  Misdiagnosis Index. décimale : PER Périodiques Résumé : High Function (HF) Autism Spectrum Disorders (ASD) in adulthood is highly prevalent but insufficiently recognized. In Italy, in particular, awareness of this condition is still insufficient and many psychiatrists have no cases of HF ASD to mention. Adult patients with HF ASD come to the attention of Mental Health Services complaining of difficulties within their social context and interpersonal relationships. Objectives: Describe emblematic clinical examples of misdiagnosed HF ASD to understand reasons that conducted to misdiagnosis. Procedure: We contact five specialized Italian Center in diagnosis of ASD. Each center have to describe two or three emblematic cases of adult patient with diagnosis of ASD validated by ADOS-4 but referred to clinicians with another diagnosis, discussing about possible reasons of misdiagnosis. Sample and Results: We have collected 12 case reports (2 from Bologna center, 3 from Torino center, 3 from Pavia center, 2 from Verona center and 2 from Catania center) of adult HF ASD previously misdiagnosed. These cases shows important similarity across centers and highlight that if are taken into account only problems or symptoms that conduct patients to ask help, cases can easily suggest other psychiatric or personality disorders. Diagnosis becomes clear only after considering all the clinical features and a detailed developmental history. Conclusion: Psychiatrists who have insufficient experience of ASD may overlook some symptoms of the overall clinical picture and misdiagnose ASD as personality disorders, schizophrenia, phobia or even as a non-psychiatric condition, so is hopeful for future increased knowledge about HF ASD in adulthood. En ligne : https://dx.doi.org/10.4172/2165-7890.1000131 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409

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