[article] 
inJournal of Autism and Developmental Disorders > 49-2 (February 2019) . - p.647-659

Titre :	Gastrointestinal Symptoms and Oral Antibiotic Use in Children with Autism Spectrum Disorder: Retrospective Analysis of a Privately Insured U.S. Population
Type de document :	Texte imprimé et/ou numérique
Auteurs :	T. VARGASON, Auteur ; D. L. MCGUINNESS, Auteur ; J. HAHN, Auteur
Article en page(s) :	p.647-659
Langues :	Anglais (eng)
Mots-clés :	Administrative claims  Autism spectrum disorder  Gastrointestinal symptoms  Gut microbiome  Oral antibiotics  Retrospective analysis
Index. décimale :	PER Périodiques
Résumé :	A retrospective analysis of administrative claims data from a large U.S. health insurer was performed to study a potential association between oral antibiotic use during early childhood and occurrence of later gastrointestinal (GI) symptoms in children with autism spectrum disorder (ASD). Among 3253 children with ASD, 37.0% had a GI-related diagnosis during the last 2 years of their 5-year health coverage enrollment period, compared to 20.0% of 278,370 children from the general population without an ASD diagnosis. Greater numbers of oral antibiotic fills during the first 3 years of enrollment were found to significantly increase the hazard rate of having a later GI-related diagnosis (adjusted hazard ratio 1.48; 95% confidence interval 1.34, 1.63) in children both with and without ASD.
En ligne :	http://dx.doi.org/10.1007/s10803-018-3743-2
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=382

[article] Gastrointestinal Symptoms and Oral Antibiotic Use in Children with Autism Spectrum Disorder: Retrospective Analysis of a Privately Insured U.S. Population [Texte imprimé et/ou numérique] / T. VARGASON, Auteur ; D. L. MCGUINNESS, Auteur ; J. HAHN, Auteur . - p.647-659.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 49-2 (February 2019) . - p.647-659

Mots-clés :	Administrative claims  Autism spectrum disorder  Gastrointestinal symptoms  Gut microbiome  Oral antibiotics  Retrospective analysis
Index. décimale :	PER Périodiques
Résumé :	A retrospective analysis of administrative claims data from a large U.S. health insurer was performed to study a potential association between oral antibiotic use during early childhood and occurrence of later gastrointestinal (GI) symptoms in children with autism spectrum disorder (ASD). Among 3253 children with ASD, 37.0% had a GI-related diagnosis during the last 2 years of their 5-year health coverage enrollment period, compared to 20.0% of 278,370 children from the general population without an ASD diagnosis. Greater numbers of oral antibiotic fills during the first 3 years of enrollment were found to significantly increase the hazard rate of having a later GI-related diagnosis (adjusted hazard ratio 1.48; 95% confidence interval 1.34, 1.63) in children both with and without ASD.
En ligne :	http://dx.doi.org/10.1007/s10803-018-3743-2
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=382