From alcohol initiation to tolerance to problems: Discordant twin modeling of a developmental process / Arielle R. DEUTSCH in Development and Psychopathology, 29-3 (August 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-3 (August 2017) . - p.845-861 Titre : From alcohol initiation to tolerance to problems: Discordant twin modeling of a developmental process Type de document : Texte imprimé et/ou numérique Auteurs : Arielle R. DEUTSCH, Auteur ; Wendy S. SLUTSKE, Auteur ; Michael T. LYNSKEY, Auteur ; Kathleen K. BUCHOLZ, Auteur ; Pamela A. F. MADDEN, Auteur ; Andrew C. HEATH, Auteur ; Nicholas G. MARTIN, Auteur Article en page(s) : p.845-861 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract The current study examined a stage-based alcohol use trajectory model to test for potential causal effects of earlier drinking milestones on later drinking milestones in a combined sample of two cohorts of Australian monozygotic and same-sex dizygotic twins (N = 7,398, age M = 30.46, SD = 2.61, 61% male, 56% monozygotic twins). Ages of drinking, drunkenness, regular drinking, tolerance, first nontolerance alcohol use disorder symptom, and alcohol use disorder symptom onsets were assessed retrospectively. Ages of milestone attainment (i.e., age-of-onset) and time between milestones (i.e., time-to-event) were examined via frailty models within a multilevel discordant twin design. For age-of-onset models, earlier ages of onset of antecedent drinking milestones increased hazards for earlier ages of onset for more proximal subsequent drinking milestones. For the time-to-event models, however, earlier ages of onset for the “starting” milestone decreased risk for a shorter time period between the starting and the “ending” milestone. Earlier age of onset of intermediate milestones between starting and ending drinking milestones had the opposite effect, increasing risk for a shorter time period between the starting and ending milestones. These results are consistent with a causal effect of an earlier age of drinking milestone onset on temporally proximal subsequent drinking milestones. En ligne : http://dx.doi.org/10.1017/s0954579416000523 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=311 [article] From alcohol initiation to tolerance to problems: Discordant twin modeling of a developmental process [Texte imprimé et/ou numérique] / Arielle R. DEUTSCH, Auteur ; Wendy S. SLUTSKE, Auteur ; Michael T. LYNSKEY, Auteur ; Kathleen K. BUCHOLZ, Auteur ; Pamela A. F. MADDEN, Auteur ; Andrew C. HEATH, Auteur ; Nicholas G. MARTIN, Auteur . - p.845-861. Langues : Anglais (eng) in Development and Psychopathology > 29-3 (August 2017) . - p.845-861 Index. décimale : PER Périodiques Résumé : Abstract The current study examined a stage-based alcohol use trajectory model to test for potential causal effects of earlier drinking milestones on later drinking milestones in a combined sample of two cohorts of Australian monozygotic and same-sex dizygotic twins (N = 7,398, age M = 30.46, SD = 2.61, 61% male, 56% monozygotic twins). Ages of drinking, drunkenness, regular drinking, tolerance, first nontolerance alcohol use disorder symptom, and alcohol use disorder symptom onsets were assessed retrospectively. Ages of milestone attainment (i.e., age-of-onset) and time between milestones (i.e., time-to-event) were examined via frailty models within a multilevel discordant twin design. For age-of-onset models, earlier ages of onset of antecedent drinking milestones increased hazards for earlier ages of onset for more proximal subsequent drinking milestones. For the time-to-event models, however, earlier ages of onset for the “starting” milestone decreased risk for a shorter time period between the starting and the “ending” milestone. Earlier age of onset of intermediate milestones between starting and ending drinking milestones had the opposite effect, increasing risk for a shorter time period between the starting and ending milestones. These results are consistent with a causal effect of an earlier age of drinking milestone onset on temporally proximal subsequent drinking milestones. En ligne : http://dx.doi.org/10.1017/s0954579416000523 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=311

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